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JOURNAL ARTICLE
Luca D Bertzbach, Marina Kohn, Yu You, Lisa Kossak, Mohammad A Sabsabi, Ahmed Kheimar, Sonja Härtle, Benedikt B Kaufer
Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects immune cells and causes a deadly lymphoproliferative disease in chickens. Cytokines and monoclonal antibodies promote the survival of chicken lymphocytes in vitro. Here, we describe protocols for the isolation, maintenance, and efficient MDV infection of primary chicken lymphocytes and lymphocyte cell lines. This facilitates the investigation of key aspects of the MDV life cycle in the primary target cells of viral replication, latency, genome integration, and reactivation...
June 3, 2023: STAR protocols
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JOURNAL ARTICLE
Lisa Hartling, Sarah A Elliott, Matthew Munan, Shannon D Scott
BACKGROUND: Acute gastroenteritis (AGE) in children is a leading cause of emergency department (ED) visits, resulting in substantial health care costs and stress for families and caregivers. The majority of pediatric AGE cases are caused by viral infections and can be managed at home using strategies to prevent dehydration. To increase knowledge of, and support health decision-making for, pediatric AGE, we developed a knowledge translation (KT) tool (fully automated web-based whiteboard animation video)...
May 25, 2023: JMIR Formative Research
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JOURNAL ARTICLE
James R A Benoit, Lisa Hartling, Shannon D Scott
BACKGROUND: Smartphone applications offer a novel platform for delivering health information to parents. This study created and evaluated an app-based symptom checker that recommends educational tools to parents based on their child's symptoms. METHODS: Symptoms extracted from 23 knowledge translation (KT) tools for 10 children's illnesses comprised a set of plain-language symptoms. The symptom checker works by producing confusion matrices evaluating a child's reported symptoms against possible illnesses, comparing precision scores to examine how well each illness matched reported symptoms, and ordering possible illnesses by performance score...
December 2023: PEC Innov
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REVIEW
Sholeh Rahman, Sarah A Elliott, Shannon D Scott, Lisa Hartling
OBJECTIVE: To explore parents' self-reported experiences and information needs regarding recognition and management of pediatric anaphylaxis. METHODS: We searched Ovid Medline, Ovid PsychInfo, CINAHL Plus, the Cochrane Library, and grey literature to identify primary studies in English or French published since 2000. We used a mixed-method appraisal tool and convergent integrated approach to assess quality and synthesize data, respectively. RESULTS: 43 studies were included (22 quantitative, 19 qualitative, and 2 mixed-method); 77% of studies had high methodological quality...
December 2022: PEC Innov
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JOURNAL ARTICLE
Naveen Poonai, Christopher Creene, Ariel Dobrowlanski, Rishika Geda, Lisa Hartling, Samina Ali, Maala Bhatt, Evelyne D Trottier, Vikram Sabhaney, Katie O'Hearn, Rini Jain, Martin H Osmond
OBJECTIVES: The objective of this study was to synthesize indication-based evidence for N2 O for distress and pain in children. STUDY DESIGN: We included trials of N2 O in participants 0-21 years, reporting distress or pain for emergency department procedures. The primary outcome was procedural distress. Where meta-analysis was not possible, we used Tricco et al.'s classification of "neutral" (p ≥ 0.05), "favorable," or "unfavorable" (p < 0...
June 2023: CJEM
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JOURNAL ARTICLE
Lindsay A Gaudet, Jennifer Pillay, Sabrina Saba, Dianne Zakaria, Nicholas Cheta, Hélène Gardiner, Larry Shaver, Jacqueline Middleton, Maria Tan, Ben Vandermeer, Lisa Hartling
Because of the large number of infected individuals, an estimate of the future burdens of the long-term consequences of SARS-CoV-2 infection is needed. This systematic review examined associations between SARS-CoV-2 infection and incidence of categories of and selected chronic conditions, by age and severity of infection (inpatient vs. outpatient/mixed care). MEDLINE and EMBASE were searched (Jan 1, 2020 to Oct 4, 2022) and reference lists scanned. We included observational studies from high-income OECD countries with a control group adjusting for sex and comorbidities...
April 18, 2023: Emerging Microbes & Infections
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JOURNAL ARTICLE
Lisa Knisley, Janice Linton, S Michelle Driedger, Lisa Hartling, Yuting Sun, Shannon D Scott
OBJECTIVE: Mapping literature on Indigenous families' experiences seeking child health information and identifying barriers and facilitators to information access. DESIGN: Scoping review. DATA SOURCES: We searched Medline, EMBASE, PsycINFO, Scopus and CINAHL for peer-reviewed literature and Google Advanced for grey literature. We screened tables of contents of two Indigenous research journals not consistently indexed in online health databases and used snowball sampling to supplement searches...
March 22, 2023: BMJ Open
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JOURNAL ARTICLE
Michelle Gates, Jennifer Pillay, Megan Nuspl, Aireen Wingert, Ben Vandermeer, Lisa Hartling
BACKGROUND: To inform recommendations by the Canadian Task Force on Preventive Health Care, we reviewed evidence on the benefits, harms, and acceptability of screening and treatment, and on the accuracy of risk prediction tools for the primary prevention of fragility fractures among adults aged 40 years and older in primary care. METHODS: For screening effectiveness, accuracy of risk prediction tools, and treatment benefits, our search methods involved integrating studies published up to 2016 from an existing systematic review...
March 21, 2023: Systematic Reviews
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JOURNAL ARTICLE
Rana Charide, Lisa Stallwood, Matthew Munan, Shahab Sayfi, Lisa Hartling, Nancy J Butcher, Martin Offringa, Sarah Elliott, Dawn P Richards, Joseph L Mathew, Elie A Akl, Tamara Kredo, Lawrence Mbuagbaw, Ashley Motillal, Ami Baba, Matthew Prebeg, Jacqueline Relihan, Shannon D Scott, Jozef Suvada, Maicon Falavigna, Miloslav Klugar, Tamara Lotfi, Adrienne Stevens, Kevin Pottie, Holger J Schünemann
INTRODUCTION: The COVID-19 pandemic underlined that guidelines and recommendations must be made more accessible and more understandable to the general public to improve health outcomes. The objective of this study is to evaluate, quantify, and compare the public's understanding, usability, satisfaction, intention to implement, and preference for different ways of presenting COVID-19 health recommendations derived from the COVID-19 Living Map of Recommendations and Gateway to Contextualization (RecMap)...
January 14, 2023: Trials
#30
JOURNAL ARTICLE
David Chromy, David Bauer, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, Philipp Schwabl, Teresa Binter, Lisa Steininger, Caroline Schwarz, Armin Rieger, Katharina Grabmeier-Pfistershammer, Michael Trauner, Peter Ferenci, Markus Peck-Radosavljevic, Mattias Mandorfer, Thomas Reiberger
BACKGROUND & AIMS: Interferon(IFN)-based hepatitis C virus (HCV) therapy has been replaced by direct-acting antivirals (DAAs). We assessed temporal trends in patient characteristics, transmission risks, treatment initiation, and cure rates in eras of IFN, restricted DAA-access, and unrestricted DAA-access in Viennese HCV/HIV-coinfected patients (HIV/HCV). METHODS: Consecutive HIV/HCV-coinfected patients starting HCV treatment at the Vienna General Hospital between 2002 and 2020 were retrospectively enrolled...
December 9, 2022: Infectious Diseases
#31
JOURNAL ARTICLE
Gail M Thornton, Emily Kroeker, Brian A Fleck, Lexuan Zhong, Lisa Hartling
BACKGROUND: Background: The 2019 novel coronavirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak was declared a pandemic by the World Health Organization (WHO) in March 2020. Almost two years later (early-February 2022), the WHO reported over 383 million cases of the disease caused by the virus with over 5.6 million deaths worldwide. Debate regarding routes of transmission was substantial early in the pandemic; however, airborne transmission emerged as an important consideration...
November 5, 2022: Interactive Journal of Medical Research
#32
JOURNAL ARTICLE
Jennifer Pillay, Sholeh Rahman, Samantha Guitard, Aireen Wingert, Lisa Hartling
This systematic review examined pre-existing and clinical risk factors for post Covid-19 condition (≥12 weeks after positive test/symptom onset), and interventions during the acute and post-acute phases of the illness that could potentially prevent post Covid-19 condition. The review focuses on studies collecting data during the early phases of the pandemic and prior to the emergence of variants of concern and of widespread vaccination. We searched bibliographic databases and grey literature. Two investigators independently reviewed abstracts and full-text articles, and data extraction and risk of bias assessments were verified...
October 27, 2022: Emerging Microbes & Infections
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JOURNAL ARTICLE
Gail M Thornton, Brian A Fleck, Dhyey Dandnayak, Emily Kroeker, Lexuan Zhong, Lisa Hartling
The aerosol route has been a pathway for transmission of many viruses. Similarly, recent evidence has determined aerosol transmission for SARS-CoV-2 to be significant. Consequently, public health officials and professionals have sought data regarding the role of Heating, Ventilation, and Air Conditioning (HVAC) features as a means to mitigate transmission of viruses, particularly coronaviruses. Using international standards, a systematic review was conducted to comprehensively identify and synthesize research examining the effect of humidity on transmission of coronaviruses and influenza...
2022: PloS One
#34
JOURNAL ARTICLE
Michele P Dyson, Kathryn Dong, William Sevcik, Samir Z Graham, Sabrina Saba, Lisa Hartling, Samina Ali
Objective: To quantify unused opioids among adult and pediatric patients discharged from the emergency department (ED) or ambulatory care settings with a prescription for acute pain. Methods: We searched MEDLINE, Embase, CINHAL, PsycINFO, the Cochrane Library, and the gray literature from inception to April 29, 2021. We included observational studies in which any patient with an acutely painful condition received a prescription for an opioid on discharge from an outpatient care setting, and unused opioids were quantified...
October 2022: Journal of the American College of Emergency Physicians open
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JOURNAL ARTICLE
Sarah A Elliott, Jason Kreutz, Kelsey S Wright, Sherri Di Lallo, Shannon D Scott, Lisa Hartling
BACKGROUND: Our research groups have developed a number of parental knowledge translation (KT) tools to help families understand common childhood illnesses and make informed decisions regarding when to seek urgent care. We have developed a series of videos to help parents understand how to manage common acute childhood illnesses at home and when to contact emergency health care services. It is unclear whether the videos in their current form and language are useful for a wider range of populations, including Indigenous groups...
October 5, 2022: JMIR Formative Research
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JOURNAL ARTICLE
Daniel Mrak, Daniela Sieghart, Elisabeth Simader, Selma Tobudic, Helga Radner, Peter Mandl, Lisa Göschl, Maximilian Koblischke, Nikolaus Hommer, Angelika Wagner, Margareta Mayer, Lorenz Schubert, Lukas Hartl, Karin Kozbial, Philipp Hofer, Felix Kartnig, Thomas Hummel, Andreas Kerschbaumer, Thomas Deimel, Antonia Puchner, Venugopal Gudipati, Renate Thalhammer, Petra Munda, Keziban Uyanik-Ünal, Andreas Zuckermann, Gottfried Novacek, Thomas Reiberger, Erika Garner-Spitzer, Roman Reindl-Schwaighofer, Renate Kain, Stefan Winkler, Josef S Smolen, Karin Stiasny, Gottfried F Fischer, Thomas Perkmann, Helmuth Haslacher, Markus Zeitlinger, Ursula Wiedermann, Judith H Aberle, Daniel Aletaha, Leonhard X Heinz, Michael Bonelli
Impaired response to COVID-19 vaccination is of particular concern in immunosuppressed patients. To determine the best vaccination strategy for this vulnerable group we performed a single center, 1:1 randomized blinded clinical trial. Patients who failed to seroconvert upon two mRNA vaccinations (BNT162b2 or mRNA-1273) are randomized to receive either a third dose of the same mRNA or the vector vaccine ChAdOx1 nCoV-19. Primary endpoint is the difference in SARS-CoV-2 spike antibody seroconversion rate between vector and mRNA vaccinated patients four weeks after the third dose...
September 12, 2022: Nature Communications
#37
JOURNAL ARTICLE
Lukas Hartl, Mathias Jachs, David Bauer, Benedikt Simbrunner, David Chromy, Teresa Binter, Lisa Steininger, Caroline Schwarz, Michael Schwarz, Lukas Burghart, Robert Strassl, Michael Trauner, Michael Gschwantler, Mattias Mandorfer, Thomas Reiberger
The COVID-19 pandemic necessitates healthcare restrictions that also affected ongoing hepatitis C virus (HCV) elimination efforts. We assessed the value of a physician-operated HCV hotline on treatment and cure rates throughout the pandemic. All HCV patients undergoing HCV therapy at the Vienna General Hospital from 2019 to 2021 were included. An HCV hotline was established in 2019 and provided services including phone calls, text messages and voicemails. Patients were stratified by date of HCV therapy: 2019 (pre-COVID) vs...
September 5, 2022: Journal of Viral Hepatitis
#38
JOURNAL ARTICLE
Reham Hassan, Adrian Friebel, Lisa Brackhagen, Zaynab Hobloss, Maiju Myllys, Daniela González, Wiebke Albrecht, Elsayed S I Mohammed, Abdel-Latif Seddek, Rosemarie Marchan, Cristina Cadenas, Benedikt Cramer, Hans-Ulrich Humpf, Lukas Hartl, Benedikt Simbrunner, Thomas Reiberger, Michael Trauner, Stefan Hoehme, Gisela H Degen, Jan G Hengstler, Ahmed Ghallab
Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in liver disease. However, the influence of HA on the pharmacokinetics and toxicity of compounds with high plasma albumin binding remained insufficiently studied. The 'lack-of-delivery-concept' postulates that HA leads to less carrier mediated uptake of albumin bound substances into hepatocytes and to less glomerular filtration; in contrast, the 'concept-of-higher-free-fraction' argues that increased concentrations of non-albumin bound compounds facilitate hepatocellular uptake and enhance glomerular filtration...
August 13, 2022: Archives of Toxicology
#39
JOURNAL ARTICLE
Michelle Gates, Allison Gates, Dawid Pieper, Ricardo M Fernandes, Andrea C Tricco, David Moher, Sue E Brennan, Tianjing Li, Michelle Pollock, Carole Lunny, Dino Sepúlveda, Joanne E McKenzie, Shannon D Scott, Karen A Robinson, Katja Matthias, Konstantinos I Bougioukas, Paolo Fusar-Poli, Penny Whiting, Stephana J Moss, Lisa Hartling
OBJECTIVE: To develop a reporting guideline for overviews of reviews of healthcare interventions. DESIGN: Development of the preferred reporting items for overviews of reviews (PRIOR) statement. PARTICIPANTS: Core team (seven individuals) led day-to-day operations, and an expert advisory group (three individuals) provided methodological advice. A panel of 100 experts (authors, editors, readers including members of the public or patients) was invited to participate in a modified Delphi exercise...
August 9, 2022: BMJ: British Medical Journal
#40
REVIEW
Jennifer Pillay, Lindsay Gaudet, Aireen Wingert, Liza Bialy, Andrew S Mackie, D Ian Paterson, Lisa Hartling
OBJECTIVES: To synthesise evidence on incidence rates and risk factors for myocarditis and pericarditis after use of mRNA vaccination against covid-19, clinical presentation, short term and longer term outcomes of cases, and proposed mechanisms. DESIGN: Living evidence syntheses and review. DATA SOURCES: Medline, Embase, and the Cochrane Library were searched from 6 October 2020 to 10 January 2022; reference lists and grey literature (to 13 January 2021)...
July 13, 2022: BMJ: British Medical Journal
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