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https://read.qxmd.com/read/30746737/testicular-torsion-and-reperfusion-germ-cell-dna-damage-and-development
#1
Hatef Talebi, Mohammad Reza Farahpour
This study is aimed to analyse the cross-link between cyclin D1, cdk-4, p21, PCNA and DNA damage during different periods of reperfusion following experimental torsion in rats. Thirty mature male Wistar rats (N = 6) were used. Following 4 hr from torsion induction, the reperfusion was induced. Animals were subdivided into groups, including 4 hr torsion-induced (T1), 1 hr post-reperfusion (T2), 2 hr post-reperfusion (T3), 4 hr post-reperfusion (T4) and 8 hr post-reperfusion (T5) groups. The seminiferous tubules differentiation (TDI) and spermatogenesis indices were evaluated...
February 11, 2019: Andrologia
https://read.qxmd.com/read/30720172/microrna-625-3p-promotes-cell-migration-of-oral-squamous-cell-carcinoma-by-regulating-scai-expression
#2
D Xu, M Gu, H-L Liu
OBJECTIVE: The aim of this study was to investigate the role of microRNA-625-3p in the occurrence and progression of oral squamous cell carcinoma (OSCC) and its underlying mechanism. PATIENTS AND METHODS: Expression levels of microRNA-625-3p, SCAI and E-cadherin in OSCC tissues and paracancerous tissues were detected by quantitative real time-polymerase chain reaction (qRT-PCR). MicroRNA-625-3p expression in OSCC tissues with different tumor stages and lymph node metastasis stages was analyzed...
January 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/30702285/synthesis-and-characterization-of-a-rare-transition-metal-oxothiostannate-and-investigation-of-its-photocatalytic-properties
#3
Assma Benkada, Helge Reinsch, Michael Poschmann, Jan Krahmer, Nicole Pienack, Wolfgang Bensch
The new transition-metal oxothiostannate [Ni(cyclen)(H2 O)2 ]4 [Sn10 S20 O4 ]·∼13H2 O (1) was prepared under hydrothermal conditions using Na4 SnS4 ·14H2 O as the precursor in the presence of [Ni(cyclen)(H2 O)2 ](ClO4 )2 ·H2 O. Compound 1 comprises the [Sn10 S20 O4 ]8- anion constructed by the T3-type supertetrahedron [Sn10 S20 ] and the [Sn10 O4 ] anti-T2 cluster. Channels host the H2 O molecules, and the sample can be reversibly dehydrated and rehydrated without significantly affecting the crystallinity of the material...
January 31, 2019: Inorganic Chemistry
https://read.qxmd.com/read/30689222/a-randomized-trial-comparing-triiodothyronine-t3-with-thyroxine-t4-for-hemodynamically-unstable-brain-dead-organ-donors
#4
Rajat Dhar, Emily Stahlschmidt, Yan Yan, Gary Marklin
RATIONALE: Brain-dead (BD) organ donors frequently exhibit hemodynamic instability and/or reversible cardiac dysfunction. Retrospective studies have suggested that thyroid hormone may stabilize hemodynamics and enhance myocardial recovery. Intravenous levothyroxine (T4) is most frequently utilized but studies have suggested that triiodothyronine (T3) may be superior. We performed a randomized comparative-effectiveness trial to address this uncertainty in donor management. METHODS: All heart-eligible donors managed at a single OPO underwent standardized fluid resuscitation...
January 28, 2019: Clinical Transplantation
https://read.qxmd.com/read/30623852/a-higher-flavonoid-intake-is-associated-with-less-likelihood-of-nonalcoholic-fatty-liver-disease-results-from-a-multiethnic-study
#5
Mohsen Mazidi, Niki Katsiki, Maciej Banach
Limited information exists on the impact of flavonoid intake on nonalcoholic fatty liver disease (NAFLD). We evaluated the link between flavonoid intake, liver tests and risk of NAFLD in a randomly selected sample of US adults (from the National Health and Nutrition Examination Survey, NHANES, 2005-2010). Of the 17,685 participants, 46.9% were men and 45.4% had NAFLD. NAFLD patients had a significantly lower mean flavonoid intake than healthy individuals (111.3±3.6 vs. 201.3±2.3 mg/d, respectively; P<...
October 11, 2018: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/30607221/tooth-discoloration-and-internal-bleaching-after-the-use-of-ledermix-paste-with-various-bleaching-agents-an-in-vitro-study
#6
Asokan Yogha-Padhma, Athikesavan Jayasenthil, Ramaraj Pandeeswaran
Background: To assess the reversal of discolouration caused by Ledermix using various bleaching agents. Material and Methods: Twenty six extracted human mandibular premolars were taken and divided into four groups. Six teeth were divided into three each which are taken as positive and negative controls. The remaining twenty are divided into two groups (n=10). After conventional access preparation, the Ledermix paste was sealed in the pulp chamber for twelve weeks...
November 2018: Journal of Clinical and Experimental Dentistry
https://read.qxmd.com/read/30604511/a-validated-lc-ms-ms-method-for-4-4-methylenedianiline-quantitation-in-human-urine-as-a-measure-of-4-4-methylene-diphenyl-diisocyanate-exposure
#7
Maggy Lépine, Lekha Sleno, Jacques Lesage, Sébastien Gagné
RATIONALE: 4,4'-methylene diphenyl diisocyanate (MDI) is a highly reactive isocyanate used in the production of polyurethanes. Workers exposed to these products may develop sensitization to the diisocyanate compounds, leading to occupational asthma. Quantifying MDI levels is necessary to ensure workplace safety. MDI is metabolized by acetylation and/or conjugation to macromolecules for excretion into urine. All metabolites can be chemically hydrolysed to form the free diamine 4,4'-methylenedianiline (MDA) as a urinary biomarker of MDI exposure...
January 2, 2019: Rapid Communications in Mass Spectrometry: RCM
https://read.qxmd.com/read/30564196/bioactivity-of-thyroid-hormone-analogs-at-cancer-cells
#8
REVIEW
Paul J Davis, Heng-Yuan Tang, Aleck Hercbergs, Hung-Yun Lin, Kelly A Keating, Shaker A Mousa
In the context of genomic thyroid hormone actions in normal (noncancer) cells that involve primary interactions with nuclear thyroid hormone receptors (TRs), L-thyroxine (T4), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) have little bioactivity. In terms of TRs, T4 is a prohormone from which the active nuclear ligand, 3,5,3'-triido-L-thyronine (T3), is generated by deiodination. Deaminated T4 and T3 metabolites have different genomic effects: tetraiodothyroacetic acid (tetrac) is a low grade thyromimetic derivative of T4, whereas triiodothyroacetic acid (triac), the acetic acid metabolite of T3, has substantial thyromimetic activity...
2018: Frontiers in Endocrinology
https://read.qxmd.com/read/30535921/hemodynamic-effects-of-extended-prone-position-sessions-in-ards
#9
Martin Ruste, Laurent Bitker, Hodane Yonis, Zakaria Riad, Aurore Louf-Durier, Floriane Lissonde, Sophie Perinel-Ragey, Claude Guerin, Jean-Christophe Richard
BACKGROUND: Hemodynamic response to prone position (PP) has never been studied in a large series of patients with acute respiratory distress syndrome (ARDS). The primary aim of this study was to estimate the rate of PP sessions associated with cardiac index improvement. Secondary objective was to describe hemodynamic response to PP and during the shift from PP to supine position. METHODS: The study was a single-center retrospective observational study, performed on ARDS patients, undergoing at least one PP session under monitoring by transpulmonary thermodilution...
December 7, 2018: Annals of Intensive Care
https://read.qxmd.com/read/30526600/longitudinal-analysis-of-physical-activity-sedentary-behaviour-and-anthropometric-measures-from-ages-6-to-11-years
#10
Phillipp Schwarzfischer, Dariusz Gruszfeld, Piotr Socha, Veronica Luque, Ricardo Closa-Monasterolo, Déborah Rousseaux, Melissa Moretti, Benedetta Mariani, Elvira Verduci, Berthold Koletzko, Veit Grote
BACKGROUND/OBJECTIVES: The aim of this study was to examine the effect of physical activity (PA) and sedentary behaviour (SB) on body mass index (BMI) and fat mass index (FMI) in children over the course of five years and identify potential bi-directional associations. SUBJECTS/METHODS: Data were drawn from the EU Childhood Obesity Project (CHOP). PA and SB were measured with the SenseWear Armband 2 at the ages of 6 (T1), 8 (T2) and 11 (T3) years. Height and weight were measured and BMI was calculated at each time point, resulting in 1254 complete observations from 600 children...
December 7, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://read.qxmd.com/read/30517476/effect-of-at-home-bleaching-on-oxygen-saturation-levels-in-the-dental-pulp-of-maxillary-central-incisors
#11
Caroline Solda, Fernando Branco Barletta, José Roberto Vanni, Paula Lambert, Marcus Vinícius Reis Só, Carlos Estrela
The present study assessed oxygen saturation (SaO2) levels before, during, and after at-home bleaching treatment in the pulps of healthy maxillary central incisors. SaO2 levels were measured in 136 healthy maxillary central incisors using a pulse oximeter. The bleaching protocol consisted of 10% carbamide peroxide gel placed in individual trays and used for four hours daily for 14 days. SaO2 levels were assessed before bleaching (T0), immediately after the first session (T1), on the 7th day of treatment (T2), on the 15th day (the day following the last session) (T3), and 30 days after completion of the bleaching protocol (T4)...
November 2018: Brazilian Dental Journal
https://read.qxmd.com/read/30486759/vdr-gene-foki-polymorphism-as-a-poor-prognostic-factor-for-papillary-thyroid-cancer
#12
Selvihan Beysel, Nilnur Eyerci, Ferda Alparslan Pinarli, Mahmut Apaydin, Muhammed Kizilgul, Mustafa Caliskan, Ozgur Ozcelik, Seyfullah Kan, Erman Cakal
This is the first study to investigate the effect of vitamin D receptor ( VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case-control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://read.qxmd.com/read/30475172/bone-changes-in-the-lower-limbs-from-participation-in-an-fes-rowing-exercise-program-implemented-within-two-years-after-traumatic-spinal-cord-injury
#13
Rebecca L Lambach, Nicole E Stafford, Julie A Kolesar, B Jenny Kiratli, Graham H Creasey, Robin S Gibbons, Brian J Andrews, Gary S Beaupre
OBJECTIVE: To determine the effect of a functional electrical stimulation (FES) rowing program on bone mineral density (BMD) when implemented within two years after SCI. DESIGN: Prospective. SETTING: Health Care Facility. PARTICIPANTS: Convenience sample; four adults with recent (<2 years) traumatic, motor complete SCI (C7-T12 AIS A-B). INTERVENTION: A 90-session FES rowing exercise program; participants attended 30-minute FES training sessions approximately three times each week for the duration of their participation...
November 26, 2018: Journal of Spinal Cord Medicine
https://read.qxmd.com/read/30468736/improving-tcr-affinity-on-293-t-cells
#14
Rieko Ohta, Ayako Demachi-Okamura, Yoshiki Akatsuka, Hiroshi Fujiwara, Kiyotaka Kuzushima
This study presents an efficient method to improve TCR affinity, comprising 1) CDR-directed saturation mutation of TCR cDNA, 2) transient TCR display on CD3-expressing HEK293T (CD3-293 T) cells by simple plasmid transfection, 3) staining with HLA-tetramers, and 4) multi-round sorting of cells with CD8-independent tetramer binding on a flow cytometer. Using these procedures, we successfully identified mutant TCRs with enhanced binding from an HLA-A*24:02-restricted, human telomerase reverse transcriptase (hTERT)-specific TCR...
November 22, 2018: Journal of Immunological Methods
https://read.qxmd.com/read/30431698/correlation-between-sall4-stemness-marker-and-bone-morphogenetic-protein-signaling-genes-in-esophageal-squamous-cell-carcinoma
#15
Sogand Assarnia, Sima Ardalan Khales, Mohammad Mahdi Forghanifard
SALL4, as a stemness marker, plays a key role in the maintenance of pluripotency and self-renewal of cancer stem cells. To elucidate probable linkage between SALL4 stemness marker and bone morphogenetic protein (BMP) cell signaling pathway, we aimed to analyze the expression levels of the related genes in esophageal squamous cell carcinoma (ESCC) patients. Tumoral and corresponding margin normal tissues from 50 treatment-naive ESCC patients were subjected for expression analysis using relative comparative real-time reverse transcription polymerase chain reaction...
November 15, 2018: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/30411239/finding-my-way-results-of-a-multicentre-rct-evaluating-a-web-based-self-guided-psychosocial-intervention-for-newly-diagnosed-cancer-survivors
#16
Lisa Beatty, Emma Kemp, Joseph R Coll, Jane Turner, Phyllis Butow, Donna Milne, Patsy Yates, Sylvie Lambert, Addie Wootten, Desmond Yip, Bogda Koczwara
PURPOSE: This multicentre randomised controlled trial examined the efficacy of Finding My Way (FMW), a 6-week/6-module online self-guided psychotherapeutic intervention for newly diagnosed curatively treated cancer survivors, in reducing cancer-related distress and improving quality of life compared to an online attention control. METHODS: Participants were randomised on a 1:1 ratio using a gender-stratified block design to intervention (n = 94) or attention control (n = 97), and were blinded to condition...
November 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30406874/triiodothyronine-promotes-cell-proliferation-of-breast-cancer-via-modulating-mir-204-amphiregulin
#17
Li Zhang, Fengxiang Zhang, Yanxin Li, Xiangjun Qi, Yaming Guo
Breast cancer (BC) severely threatens women's life, and Triiodothyronine (T3) shows a positive role on BC cell proliferation, while the potential mechanism underlying it is still unclear. T3 was used to stimulate BC cell lines MCF-7 and T47-D. Real-time PCR was performed to determine the expression of miRNAs, while western blot was used to measure protein expression of Amphiregulin (AREG), AKT and p-AKT. The interaction between miR-204 and AREG was determined using luciferase reporter assay. MTT was performed to detect cell viability...
November 8, 2018: Pathology Oncology Research: POR
https://read.qxmd.com/read/30399572/focal-selective-chemo-ablation-of-spinal-cardiac-afferent-nerve-by-resiniferatoxin-protects-the-heart-from-pressure-overload-induced-hypertrophy
#18
Deguo Wang, Yong Wu, Yueyun Chen, Ancai Wang, Kun Lv, Xiang Kong, Yang He, Nengwei Hu
Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. The present study determined the effects of intrathecal RTX administration on transverse aortic constriction (TAC)-induced cardiac dysfunction and cardiac remodeling in rats. Five days before TAC, RTX (2 μg/10 μl) was injected intrathecally into the T2/T3 interspace of rats. Cardiac sympathetic nerve activities (CSNAs) and cardiac structure and function were determined eight weeks after TAC...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30381011/transcutaneous-electrical-acupoint-stimulation-improves-immunological-function-during-the-perioperative-period-in-patients-with-non-small-cell-lung-cancer-undergoing-video-assisted-thoracic-surgical-lobectomy
#19
Qing Tu, Zhou Yang, Jianhui Gan, Jian Zhang, Bin Que, Qiaofeng Song, Yan Wang
The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS...
January 1, 2018: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30350155/inert-gas-narcosis-in-scuba-diving-different-gases-different-reactions
#20
Monica Rocco, P Pelaia, P Di Benedetto, G Conte, L Maggi, S Fiorelli, M Mercieri, C Balestra, R A De Blasi
PURPOSE: Underwater divers face several potential neurological hazards when breathing compressed gas mixtures including nitrogen narcosis which can impact diver's safety. Various human studies have clearly demonstrated brain impairment due to nitrogen narcosis in divers at 4 ATA using critical flicker fusion frequency (CFFF) as a cortical performance indicator. However, recently some authors have proposed a probable adaptive phenomenon during repetitive exposure to high nitrogen pressure in rats, where they found a reversal effect on dopamine release...
October 22, 2018: European Journal of Applied Physiology
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