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JOURNAL ARTICLE
Julia Hildebrandt, Ulrich Koehler, Regina Conradt, Olaf Hildebrandt, Werner Cassel, Mikail Aykut Degerli, Christian Viniol
Tinnitus has a lifetime prevalence of 25% in Germany. A common comorbidity in chronic cases are sleep disorders. The aims of this study were to detect sleep disorders and to identify possible associations with tinnitus parameters.Fifty patients with chronic tinnitus were recruited. The patients underwent audiometry, polysomnography, and completed standardised questionnaires on tinnitus and sleep behaviour.Data were available in 30 men and 9 women (age 50.2 ± 11 y, BMI 28.8 ± 4.4 kg/m²). The median duration of tinnitus was 36 (9; 120) months with a severity score of 2...
July 20, 2023: Laryngo- Rhino- Otologie
#22
Göker Utku Değer, Baris Gorgun, Soner Koçak, Veli Muzaffer Murat Hız
Extremity muscle hernias are rare pathologies, most of which are managed conservatively. In symptomatic cases, surgical intervention may be required. This study represents a case of a rarer muscle hernia, semimembranosus, in a 43-year-old patient and describes the surgical technique of grafting with synthetic nonabsorbable polypropylene surgical mesh as well as the review of the literature about extremity muscle hernias.
June 2023: Curēus
#23
JOURNAL ARTICLE
Medine Nur Özata Değerli, Onur Altuntaş
Problems with sensory processing may have an impact on the behavioral and psychological symptoms that can be seen in Alzheimer's patients. Examining the relationship between the two factors may provide a new perspective for the management of behavioral and psychological symptoms of dementia. Mid-stage Alzheimer's patients completed the Neuropsychiatric Inventory and Adolescent/Adult Sensory Profile. The relationship between behavioral and psychological symptoms of dementia and sensory processing was investigated...
July 6, 2023: Applied Neuropsychology. Adult
#24
JOURNAL ARTICLE
Isam A Mohamed Ahmed, Zeliha Değerli, Mehmet Musa Özcan, Elfadil E Babiker
BACKROUND: Environmental conditions such as variety, genetic, soil structure and plant diseases are effective on the oil amount and properties of flaxseed. By applying heat and extraction techniques treatment to flaxseed, the storage ability of the seed is increased by the removal of moisture, and the stability of the phytochemicals in the seed against heat is determined. RESULTS: Total carotenoid and phenol results of flaxseeds change between 0.13 (control) and 0...
June 20, 2023: Journal of the Science of Food and Agriculture
#25
JOURNAL ARTICLE
Sibel Deger Aker, Sedef Tamburaci, Funda Tihminlioglu
Nowadays, antibiotic-loaded biomaterials have been widely used in wound healing applications. However, the use of natural extracts has come into prominence as an alternative to these antimicrobial agents in the recent period. Among natural sources, Cissus quadrangularis (CQ) herbal extract is used for treatment of bone and skin diseases in ayurvedic medicine due to its antibacterial and anti-inflammatory effects. In this study, chitosan-based bilayer wound dressings were fabricated with electrospinning and freeze-drying techniques...
June 6, 2023: ACS Omega
#26
JOURNAL ARTICLE
Timothy Wu, Jennifer M Deger, Hui Ye, Caiwei Guo, Justin Dhindsa, Brandon T Pekarek, Rami Al-Ouran, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M Shulman
Aging is a major risk factor for Alzheimer's disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in Drosophila with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle pathology. Whereas tau- and aging-induced gene expression strongly overlap (93%), they differ in the affected cell types. In contrast to the broad impact of aging, tau-triggered changes are strongly polarized to excitatory neurons and glia...
May 23, 2023: ELife
#27
JOURNAL ARTICLE
Lale A Ertuglu, Melis Sahinoz, Aseel Alsouqi, Serpil Muge Deger, Andrew Guide, Thomas G Stewart, Mindy Pike, Cassianne Robinson-Cohen, Elvis Akwo, Michael Pridmore, Rachelle Crescenzi, Meena S Madhur, David G Harrison, Friedrich C Luft, Jens Titze, T Alp Ikizler
BACKGROUND AND AIMS: High sodium intake is associated with obesity and insulin resistance, and high extracellular sodium content may induce systemic inflammation, leading to cardiovascular disease. In this study, we aim to investigate whether high tissue sodium accumulation relates with obesity-related insulin resistance and whether the pro-inflammatory effects of excess tissue sodium accumulation may contribute to such association. METHODS AND RESULTS: In a cross-sectional study of 30 obese and 53 non-obese subjects, we measured insulin sensitivity determined as glucose disposal rate (GDR) using hyperinsulinemic euglycemic clamp, and tissue sodium content using 23 Na magnetic resonance imaging...
April 10, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#28
JOURNAL ARTICLE
The effect of ambient air pollution on office, home and 24-h ambulatory blood pressure measurements.
Şükrü Ulusoy, Gülsüm Özkan, Gamze Varol, Yunus Erdem, Ülver Derici, Rahmi Yılmaz, Serpil Müge Değer, Turgay Arınsoy, T Akpolat
BACKGROUND: Air pollution has recently been linked to a number of cardiovascular diseases, particularly hypertension (HT). In our study, we aimed to evaluate the association between air pollution and BP and compare the relationship BP measurement results obtained using different methods (office, home, and 24-h ambulatory BP monitoring (24-h ABPM)). METHODS: This retrospective nested panel study performed with prospective Cappadocia cohort data investigated the relationships between particulate matter (PM) 10 and sulfur dioxide (SO2) and concurrent home, office, and 24-h ABPM data at each control performed over a two-year period...
April 14, 2023: American Journal of Hypertension
#29
JOURNAL ARTICLE
S Samanci, M Celik, O Akdeniz, I Deger, N Özgün, B Kanar, H Tüzün
OBJECTIVE: The neonatal period is the most vulnerable time for the development of seizures, particularly in the first weeks after birth. These seizures often signify serious malfunction or damage to the immature brain and constitute a neurological emergency, necessitating urgent diagnosis and management. This study was performed to identify the etiology of convulsions during the neonatal period and to determine the rate of congenital metabolic disease. PATIENTS AND METHODS: A total of 107 term and preterm infants 0-28 days old who were treated and followed-up in the neonatal intensive care unit of our hospital between January 2014 and December 2019 were analyzed retrospectively based on data obtained by scanning the hospital information system and patient files...
February 2023: European Review for Medical and Pharmacological Sciences
#30
JOURNAL ARTICLE
Abigail K Grootveld, Wunna Kyaw, Veera Panova, Angelica W Y Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A Hume, Peter I Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show by multiple redundant and complementary methods that TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle. Non-migratory TBMs use cytoplasmic processes to chase and capture migrating dead cell fragments using a "lazy" search strategy...
March 16, 2023: Cell
#31
JOURNAL ARTICLE
Ulrich Koehler, Mikail Aykut Degerli, Olaf Hildebrandt, Regina Conradt
Adolf Kussmaul (1822-1902) studied medicine in Heidelberg. The name Kussmaul is known worldwide for the panarteritis nodosa, the pulsus paradoxus and the venous pulse in callous mediastinopericarditis as well as the high-frequency and deep breathing in diabetic ketoacidosis. Kussmaul was also a pioneer in the endoscopic diagnosis and treatment of diseases of the oesophagus and stomach. He had to close the medical practice he had started in 1850 in the black Forrest town of Kandern after three years, having developed health problems...
February 17, 2023: Pneumologie
#32
Gizem Akkas Akgun, Anvar Ahmedov, Ali Xc Xb Hsan Parlar, Mehmet Hüseyin Metineren, Ayse Nur Deger
Low-grade malignant eccrine spiradenoma (spiradenocarcinoma) is a rare sweat gland tumor, which usually arises from a pre-existing benign eccrine spiradenoma. This paper presents the case of a 55-year-old male who had a lesion in his right elbow for 10 years. The microscopic examination revealed a well-demarcated, multilobulated tumor in the dermis and subcutis, which presented with many blood-filled vessels and extensive hemorrhage. The tumor was composed of hyperchromatic, round to oval cells with nucleolar prominence, mild to moderate atypia, and increased mitotic index...
February 2023: Annals of Dermatology
#33
JOURNAL ARTICLE
Ulrich Koehler, Christian Viniol, Olaf Hildebrandt, Karl Kesper, Mikail Aykut Degerli, Regina Conradt, Keywan Sohrabi
The nasal cycle refers to the anticyclic swelling and decongestion of the two nasal cavities that occur during the day and during sleep, while the overall nasal flow remains constant. The nasal cycle was first described by R. Kayser in 1895. Each cycle consists of a working phase and a subsequent resting phase, the purpose of which is the rehydration and regeneration of the mucosa. A nasal cycle occurs in about 70-90% of people. The duration of the phase is affected by age, body position, physical activity, mucociliary clearance and time of day...
March 2023: Pneumologie
#34
JOURNAL ARTICLE
Julia Degering, Benjamin Egenlauf, Satenik Harutyunova, Nicola Benjamin, Amina Salkić, Panagiota Xanthouli, Christina A Eichstaedt, Rebekka Seeger, Olivier Sitbon, Ekkehard Grünig
BACKGROUND: Epoprostenol AS (Veletri® ), a thermostable epoprostenol formulation, provides better drug stability and improved clinical use compared to previous epoprostenol formulations. This study aims to expand clinical experience in the use of Veletri® , especially regarding tolerability, safety and survival. METHODS: Pulmonary arterial hypertension (PAH) patients at high risk despite pretreatment with at least double oral combination therapy and with clinical indication for epoprostenol (Veletri® ) treatment were consecutively included in this prospective, open label, observational, non-interventional study...
January 18, 2023: Respiratory Research
#35
JOURNAL ARTICLE
Hacer Kundakcioglu, Sabahattin Destek, Zuhal Gucin, Kamuran Cumhur Değer
No abstract text is available yet for this article.
2022: Przegla̜d Gastroenterologiczny
#36
JOURNAL ARTICLE
Mehmet Tugay Eren, Serpil Değerli, Özlem Yönem
OBJECTIVE: In this study, it was aimed to investigate the presence of Entamoeba histolytica, Giardia intestinalis and Cryptosporidium spp. in the samples taken during the procedure from patients who underwent endoscopy and/or colonoscopy with different prediagnoses, and in the stools of the same patients, by ELISA and direct microscopy methods. METHODS: A total of 88 patients' endoscopic and colonoscopic pre-washed materials, which consisted of 49 individuals who belong former group and 39 individuals to the next group, were, respectively, obtained, and the stool samples were also included to study from the same group...
November 28, 2022: Türkiye Parazitolojii Dergisi
#37
JOURNAL ARTICLE
Ayse Gul Ferlengez, Cihad Tatar, Mahmut Said Degerli, Adil Koyuncu, Fatih Alper Ahlatci, Ali Emre Nayci, Aziz Ari, Ufuk Oguz Idiz
BACKGROUND: Acute pancreatitis (AP) is a disease that can still be fatal despite rapid advances in medicine. The relationship between serum nesfatin-1 levels and AP is still to be fully resolved. OBJECTIVES: To investigate the utility of serum nesfatin-1 levels in the diagnosis of AP. MATERIAL AND METHODS: Twenty-four male Sprague Dawley rats were divided into control, mild pancreatitis and severe pancreatitis groups (n = 8/group). Acute pancreatitis was induced by cerulein injection and the control group received saline injections...
November 25, 2022: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
#38
JOURNAL ARTICLE
Dongryeoul Bae, Kwang-Young Song, Donah Mary Macoy, Min Gab Kim, Chul-Kyu Lee, Yu-Seong Kim
Infectious diseases of livestock caused by novel pathogenic viruses and bacteria are a major threat to global animal health and welfare and their effective control is crucial for agronomic health and for securing global food supply. It has been widely recognized that the transmission of infectious agents can occur between people and/or animals in indoor spaces. Therefore, infection control practices are critical to reduce the transmission of the airborne pathogens. ViKiller® -high-pressure sprayer and Deger® -disinfectant are newly developed spraying systems that can produce an optimal size of disinfectants to reduce airborne microbes...
November 7, 2022: Microorganisms
#39
JOURNAL ARTICLE
Cihan Erol, Abdullah Sakin, Tuğba Başoğlu, Ercan Özden, Devrim Çabuk, Mutlu Doğan, Berna Öksüzoğlu, Hasan Çağrı Yıldırım, İrem Öner, Melek Karakurt Eryılmaz, Özgecan Dülgar, Dinçer Aydın, Neslihan Doğan, Miraç Özen, İlhan Hacıbekiroğlu, Nuriye Özdemir, Fatih Gürler, Nail Paksoy, Senem Karabulut, Asude Aksoy, Mutlu Hızal, Seda Kahraman, Erdem Şen, Semra Paydaş, Ebru Çılbır, Feyza Fırat, Nadiye Akdeniz, Melike Özçelik, Abdilkerim Oyman, Naziyet Köse Baytemür, Ramazan Acar, Elvina Almuradova, Bülent Karabulut, Teoman Şakalar, Hacı Arak, Ezgi Değerli, Sema Türker, Özkan Alan, Özlem Er, Elif Şenocak Taşçı, Nazan Demir, Eyyüp Çavdar, Serdar Turhal, Didem Şener Dede, Muhammed Bülent Akıncı, Bülent Yalçın, Fulden Yumuk, Şuayib Yalçın, Mehmet Ali Nahit Şendur
BACKGROUND: Perioperative FLOT regimen is a standard of care in locally advanced operable gastric and GEJ adenocarcinoma. We aimed to determine the efficacy, prognostic factors of perioperative FLOT chemotherapy in real-life gastric and GEJ tumors. METHODS: The data of patients who were treated with perioperative FLOT chemotherapy were retrospectively analyzed from 34 different oncology centers in Turkey. Baseline clinical and demographic characteristics, pretreatment laboratory values, histological and molecular characteristics were recorded...
August 2022: Turkish Journal of Medical Sciences
#40
JOURNAL ARTICLE
C E Sahin, M S Deger, M A Sezerol, M Y Ozdemir
Background: The COVID-19 (coronavirus disease-2019) outbreak has its social, economic, and political effects on wider society, as well as physical and mental health effects on individuals. The psychological and social impacts are more apparent and common on emergency health care workers who have close contact with patients. Aim: Our study aims to investigate coronaphobia in emergency health care workers. Subjects and Methods: A cross-sectional study was carried out in July 2020 with 253 people working under the Bingöl 112 Provincial Ambulance Service Chief of Staff...
August 2022: Nigerian Journal of Clinical Practice
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