Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, Mohsen Ghanbari, Peter J van der Most, Rui Climaco Pinto, Matthias Wielscher, Matthias Farlik, Verena Zuber, Robert J de Knegt, Harold Snieder, André G Uitterlinden, Julie A Lynch, Xiyun Jiang, Saredo Said, David E Kaplan, Kyung Min Lee, Marina Serper, Rotonya M Carr, Philip S Tsao, Stephen R Atkinson, Abbas Dehghan, Ioanna Tzoulaki, M Arfan Ikram, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Behrooz Z Alizadeh, Christopher J O'Donnell, Danish Saleheen, Benjamin F Voight, Kyong-Mi Chang, Mark R Thursz, Paul Elliott
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Genetic risk score analysis using the identified SNPs is strongly associated with serum activity of liver enzymes in two independent European descent studies (The Airwave Health Monitoring study and the Northern Finland Birth Cohort 1966)...
May 10, 2021: Nature Communications