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Materno fetal medicin

Monica Tang, Kate Webber
Cancer survivors are increasing as improvements in cancer diagnosis and treatment translate to improved outcomes. As cancer survivors in their reproductive years contemplate pregnancy, it is important to understand the impact of cancer and its treatment on fertility and pregnancy outcomes. Cancer treatments such as chemotherapy and radiotherapy can affect patients' fertility, and strategies are available to help preserve the future fertility of survivors. The potential impact of previous cancer diagnoses and treatments on pregnancy and maternal and fetal outcomes needs to be assessed and discussed with survivors, with support from materno-fetal medicine specialists and high-risk antenatal services as needed...
September 2018: Obstetric Medicine
Ioannis G Papanikolaou, Ekaterini Domali, George Daskalakis, Marianna Theodora, Eirini Telaki, Petros Drakakis, Dimitrios Loutradis
Abnormal placentation often requires the involvement of a multidisciplinary team of medical caregivers. Practicing Obstetrics is a challenging and skillful duty. This is more obvious in cases of abnormal placentation, which represents one of the most dangerous and complex clinical conditions in materno-fetal medicine. Pathological placentation involves position and invasion abnormalities and represents a serious and potentially life-threatening condition for both the pregnant woman and the fetus. The dramatic increase in cesarean section rates is an important factor which could explain the rapid raise in abnormal placentation cases, which were considered rare a few years ago...
September 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Manon Vouga, Marco P Alves, Isabelle Eperon, Gilles Eperon, Laurence Rochat, Roland Sahli, Didier Musso, David Baud
Zika virus has recently emerged as new teratogenic agent. Research is drastically increasing to allow a better comprehension of the role of this emerging virus in the induction of fetal cerebral anomalies. Several epidemiological and microbiological aspects may explain a higher virulence of the current strain. Various animal models have been developed and confirm the materno-fetal transmission as well as the induction of cerebral development's disorders. In parallel, various companies are working to develop a vaccine and antiviral medicine against Zika virus...
October 26, 2016: Revue Médicale Suisse
Lisa Hui, Diana W Bianchi
Noninvasive prenatal DNA testing is the vanguard of genomic medicine. In only four years, this screening test has revolutionized prenatal care globally and opened up new prospects for personalized medicine for the fetus. There are widespread implications for increasing the scope of human genetic variation that can be detected before birth, and for discovering more about maternofetal and placental biology. These include an urgent need to develop pretest education for all pregnant women and consistent post-test management recommendations for those with discordant test results...
January 14, 2017: Annual Review of Medicine
Emanuele Pelizzari, Carolina Melendez Valdez, Jamile dos Santos Picetti, André Campos da Cunha, Cristine Dietrich, Paulo Renato Krahl Fell, Luciano Vieira Targa, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa
CONTEXT AND OBJECTIVE: Anencephaly is considered to be the most common type of neural tube defect. Our aim was to assess the clinical and gestational features of a cohort of fetuses with suspected anencephaly. DESIGN AND SETTING: Population-based retrospective cohort study in a referral hospital in southern Brazil. METHODS: The sample consisted of fetuses referred due to suspected anencephaly, to the Fetal Medicine Service of Hospital Materno Infantil Presidente Vargas, between January 2005 and September 2013...
March 2015: São Paulo Medical Journal, Revista Paulista de Medicina
Daniela Denardin, Fabíola Elizabete Savaris, André Campos da Cunha, Rosilene da Silveira Betat, Jorge Alberto Bianchi Telles, Luciano Vieira Targa, Aline Weiss, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa
CONTEXT AND OBJECTIVE: Trisomy 18 (T18), or Edwards syndrome, is a chromosomal disease characterized by a broad clinical picture and a poor prognosis. Our aim was to describe clinical, radiological and survival data of a cohort of patients prenatally diagnosed with T18. DESIGN AND SETTING: Retrospective single cohort in the Fetal Medicine Service of Hospital Materno Infantil Presidente Vargas (HMIPV). METHODS: All sequential patients with T18 registered at the Fetal Medicine Service of HMIPV between January 2005 and September 2013 were considered...
July 2015: São Paulo Medical Journal, Revista Paulista de Medicina
Ludivine Doridot, Francisco Miralles, Sandrine Barbaux, Daniel Vaiman
MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous trophoblast, or extravillous trophoblast constitutes a good example of such a choice, where miRNAs have recently been shown to play an important role. The aim of this review is to provide a snapshot of what is known today in placentation mechanisms that are mediated by miRNA, under the angles of materno-fetal immune dialog regulation, trophoblast differentiation, and angiogenesis at the materno-fetal interface...
2013: Frontiers in Genetics
Antonio Rodríguez-Burgos
After defining the term 'foreign embryonic isoantigens', the author describes the experimental sequence which has allowed this new fetoprotein class to be identified. Experiments have followed three different directions, namely (i) passive immunization, by which conceptus antibodies raised in another animal species are transferred to the female animal, the effects on the offspring becoming apparent after pregnancy; (ii) laboratory techniques, where the presence of conceptus antibodies in serum from aborting women has been demonstrated by use of analytical techniques or by testing the serum on cultured embryos; and (iii) active isoimmunization, by which the female animal is immunized against a conceptus extract from the same species, and the effects on the offspring are observed after pregnancy...
March 2013: American Journal of Reproductive Immunology: AJRI
Stella Liong, Megan K W Di Quinzio, Yujing J Heng, Gabrielle Fleming, Michael Permezel, Gregory E Rice, Harry M Georgiou
A significant obstetric complication facing contemporary materno-fetal medicine is preterm premature rupture of the fetal membranes (preterm PROM), which occurs in 30% of all preterm births. The objective of this study was to identify differentially expressed proteins in the cervicovaginal fluid of asymptomatic women before the clinical manifestation of preterm PROM. The preterm PROM group comprised of women with samples collected 6-23 days before PROM, who subsequently delivered preterm (n=5). Women who spontaneously delivered at term served as gestation-matched controls (n=10)...
February 2013: Reproduction: the Official Journal of the Society for the Study of Fertility
N Winer
OBJECTIVES: Define methods of induction of labour for the population of pregnant women at the end of 41 SA and beyond, including membranes sweeping, mechanical and pharmacological procedures as oxytocin, prostaglandin E1 (misoprostol) and E2 (dinoprostone) and other methods as well for the scarred uterus. METHODS: Bibliographic research done by consulting databases PubMed, and Cochrane. RESULTS: Membrane sweeping reduces by 41% the need of induction of labour at 41 SA and 72% for postterm (42 SA)...
December 2011: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Radu Vlădăreanu
The exceptional progress in obstetrics, especially in the second half of the 20th century, creates a series of dilemmas, without having yet the answer to old, basic questions, such as premature delivery and prevention of preeclampsia. Sexual liberty and the delay of the first pregnancy are responsible for the drop in natality rate and the increasing demand for assisted reproductive technologies. Their success is marked, though, by a drastic increase in the multiple birth rate and its complications. The advancing maternal age brings along a number of cardiovascular pathologies that endanger not only the present pregnancy, but also the long distance health prognosis...
January 2008: Journal of Medicine and Life
Carlos Enrique Cabrera Pivaral, Elizabeth Rivera Clara, Luz María Adriana Balderas Peña, Mayari Cabrera Centeno, Carlos Alonso Reynoso
BACKGROUND: Gestational diabetes mellitus complicates 7% of all pregnancies. Recognizing and treating this entity result in a diminished number of materno-fetal complications; this study explores the family physician clinical aptitude to identify risk factors, to diagnose and treat gestational diabetes. OBJECTIVE: Identify clinical aptitude level of family physician to the treatment of diabetes gestational patients. PARTICIPANTS AND METHODS: Transversal study to describe the level of clinical aptitude in 85 family physicians working in Guadalajara...
February 2008: Ginecología y Obstetricia de México
Wen-Hui Zhou, Lin Dong, Mei-Rong Du, Xiao-Yong Zhu, Da-Jin Li
Immune regulation during pregnancy is complex, and thus an optimal therapy for pregnancy complications is always a big challenge to reproductive medicine. Cyclosporin A (CsA), a potent immunosuppressant, prevents rejection of allografts by hosts, but little is known about the modulating effect of CsA on the materno-fetal relationship. Here, pregnant CBA/J females mated with DBA/2 males as an abortion-prone model were administered with CsA on day 4.5 of gestation, and the pregnant CBA/J females mated with BALB/c males were established as successful pregnancy control...
March 2008: Reproduction: the Official Journal of the Society for the Study of Fertility
C Allen, R Greene, J Higgins
A specialised clinic for the antenatal care of high-risk patients was established in Cork in January 2004. It is led by 2 specialists in materno-fetal medicine and provides care for patients from a large catchment area. Small clinic numbers, specialised midwives, ready access to medical experts and fetal assessment facilities, facilitate an efficient use of resources. We report on the experience and utcomes of this clinic after the first year in operation. A database was set up to store relevant information on patients who attended the clinic in 2004...
October 2007: Irish Medical Journal
Piotr Hincz, Adam Bielak, Dariusz Borowski, Edyta Wojciechowska, Michał Wojciechowski, Jan Wilczyński
The HELLP syndrome is a variant of severe preeclampsia. Its leading symptoms are: hemolysis, increased liver enzymes and low platelet count. The treatment of the HELLP syndrome remains controversial as there are no standards of proven efficacy. The article presents a case of a 27- year-old patient, G1P0, 30 wk of gestation, reporting no fetus movements for several hours, who was admitted to The Materno-Fetal Medicine Department, Polish Mother's Memorial Hospital in Lódź, with symptoms of the onset of the HELLP syndrome...
March 2007: Ginekologia Polska
(no author information available yet)
No abstract text is available yet for this article.
May 2003: Zentralblatt Für Gynäkologie
No abstract text is available yet for this article.
1964: La Rassegna di Clinica, Terapia e Scienze Affini
Małgorzata Czyzewska, Monika Lachowska, Elzbieta Gajewska
UNLABELLED: Systemic bacterial infections still remain one of the major causes of neonatal morbidity and mortality. Early detection of neonatal sepsis can be difficult, because the first signs of the disease may be unspecific and similar to symptoms of other non-infectious processes. Procalcitonin became a new, sensitive marker of bacterial infections in newborns. The aim of our study was to assess the value of PCT as a diagnostic and prognostic tool of neonatal maternofetal infections...
2002: Przegla̧d Lekarski
F Petraglia, E Zanin, A Faletti, F M Reis
A great deal of new information has arisen in the past 2 years concerning the physiology of inhibins and their clinical relevance in reproductive medicine. It is now recognized that the two inhibin isoforms, inhibin A and inhibin B, are produced by the gonads in the course of gamete maturation and have different patterns of secretion during the menstrual cycle. Inhibins are also produced by the placenta and fetal membranes and may be involved in physiological adaptation of pregnancy. Clinically, inhibins may serve as sensitive tumor markers in postmenopausal women, or as useful tools for evaluating ovarian reserve in infertile women; they may also be used in the diagnosis of materno-fetal disorders...
June 1999: Current Opinion in Obstetrics & Gynecology
P Edelman
The antiphospholipid syndrome, recently described, associates thromboembolism risks, fetal losses and thrombopenia. An obstetrical survey of this syndrome implies previous analyses of maternal and fetal risks and leads to treatment which may associate low doses of aspirin, heparin, corticoids. This complex syndrome offers the best example of materno-fetal medicine usefulness.
November 1993: Contraception, Fertilité, Sexualité
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