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Altenative medicine

C Sommer, R Alten, K-J Bär, M Bernateck, W Brückle, E Friedel, P Henningsen, F Petzke, T Tölle, N Üçeyler, A Winkelmann, W Häuser
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017. METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest...
June 2017: Der Schmerz
Murat Seyit, Mert Ozen, Alten Oskay, Emine Kadioglu
OBJECTIVES: Synthetic cannabinoid or "Bonzai" use is a public health issue as its use has increased in Turkey as well as all over the world. The aim of this study is to evaluate the effectiveness of the "Synthetic Cannabinoids Seminar" that was provided to physicians who work in emergency services, using multiple choice questionnaires before and after the seminar as a tool for evaluation. MATERIAL AND METHOD: Synthetic cannabinoids seminars were provided to physicians who work in emergency services in two different cities, with the participation of 20 physicians in each scheduled seminar...
June 2016: Turkish Journal of Emergency Medicine
R Alten
BACKGROUND: This article presents the design of clinical trials for the development of biosimilars in the European Union and the United States, with special focus on inflammatory diseases. METHODS: All information available in PubMed and the Internet relating to the clinical development of biosimilars in inflammatory rheumatic conditions (e.g. rheumatoid arthritis, psoriasis, psoriatic arthritis and ankylosing spondylitis) was collated. The European Medicines Agency (EMA) and US Food and Drug Administration (FDA) websites were screened for guidelines on biosimilars...
October 2015: Zeitschrift Für Rheumatologie
Rieke Alten, Bruce N Cronstein
OBJECTIVES: Discuss issues regarding clinical trial design for the development of biosimilars in the European Union and the United States, with special focus on monoclonal antibodies used in the treatment of inflammatory diseases. METHODS: A search of the Internet as well as PubMed was conducted through June 2014 for information related to the clinical development of biosimilars using the keywords biosimilar, rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and ankylosing spondylitis...
June 2015: Seminars in Arthritis and Rheumatism
M Englbrecht, J Wendler, R Alten
BACKGROUND: The importance of depressive diseases in the treatment of rheumatism patients cannot be denied. It is well-known from publications in the English speaking literature that the proportion of depressive diseases lies between 10% and 45% in patients with rheumatoid arthritis (RA). However, clearly increased numbers can also be seen in a direct comparison with corresponding prevalence rates in the normal population for other diseases included in the category of rheumatism. OBJECTIVE: This manuscript focusses on the possibilities and challenges in measuring states of depressive mood that might serve as an indicator of depressive diseases in the context of treatment of rheumatism...
October 2014: Zeitschrift Für Rheumatologie
R Alten
Protein kinase inhibitors represent a novel and promising approach to the treatment of rheumatoid arthritis (RA). By targeting intracellular signaling pathways of cytokine-mediated reactions, these substances are able to interfere with critical immune processes that underly the pathology of RA. With tofacitinib, the first Janus kinase (JAK) inhibitor has been approved in the USA, as well as in Switzerland and other countries. Several other substances are currently undergoing phase II or phase III trials.A crucial question that will shape the future of these new drugs is whether they are safe and in particular, whether they are safer than biological therapies...
November 2013: Zeitschrift Für Rheumatologie
Katinka Albrecht, Klaus Krüger, Jürgen Wollenhaupt, Rieke Alten, Marina Backhaus, Christoph Baerwald, Wolfgang Bolten, Jürgen Braun, Harald Burkhardt, Gerd R Burmester, Markus Gaubitz, Angela Gause, Erika Gromnica-Ihle, Herbert Kellner, Jens Kuipers, Andreas Krause, Hans-Martin Lorenz, Bernhard Manger, Hubert Nüßlein, Hans-Georg Pott, Andrea Rubbert-Roth, Matthias Schneider, Christof Specker, Hendrik Schulze-Koops, Hans-Peter Tony, Siegfried Wassenberg, Ulf Müller-Ladner
The German Society of Rheumatology approved new German guidelines for the sequential medical treatment of rheumatoid arthritis (RA) based on the European League Against Rheumatism (EULAR) recommendations for the management of RA published in 2010. An update of the EULAR systematic literature research was performed in Medline, Embase, and Cochrane databases. Meta-analyses, controlled trials, cohort studies, and registry data addressing traditional and biologic disease-modifying antirheumatic drugs, glucocorticoids, and treatment strategies published between January 2009 and August 2011 were included...
January 2014: Rheumatology International
C Sommer, W Häuser, R Alten, F Petzke, M Späth, T Tölle, N Uçeyler, A Winkelmann, E Winter, K J Bär
BACKGROUND: The scheduled update to the German S3 guidelines on fibromyalgia syndrome (FMS) by the Association of the Scientific Medical Societies ("Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften", AWMF; registration number 041/004) was planned starting in March 2011. MATERIALS AND METHODS: The development of the guidelines was coordinated by the German Interdisciplinary Association for Pain Therapy ("Deutsche Interdisziplinären Vereinigung für Schmerztherapie", DIVS), 9 scientific medical societies and 2 patient self-help organizations...
June 2012: Der Schmerz
Tuulikki Sokka, Hannu Kautiainen, Theodore Pincus, Suzanne M M Verstappen, Amita Aggarwal, Rieke Alten, Daina Andersone, Humeira Badsha, Eva Baecklund, Miguel Belmonte, Jürgen Craig-Müller, Licia Maria Henrique da Mota, Alexander Dimic, Nihal A Fathi, Gianfranco Ferraccioli, Wataru Fukuda, Pál Géher, Feride Gogus, Najia Hajjaj-Hassouni, Hisham Hamoud, Glenn Haugeberg, Dan Henrohn, Kim Horslev-Petersen, Ruxandra Ionescu, Dmitry Karateew, Reet Kuuse, Ieda Maria Magalhaes Laurindo, Juris Lazovskis, Reijo Luukkainen, Ayman Mofti, Eithne Murphy, Ayako Nakajima, Omondi Oyoo, Sapan C Pandya, Christof Pohl, Denisa Predeteanu, Mjellma Rexhepi, Sylejman Rexhepi, Banwari Sharma, Eisuke Shono, Jean Sibilia, Stanislaw Sierakowski, Fotini N Skopouli, Sigita Stropuviene, Sergio Toloza, Ivo Valter, Anthony Woolf, Hisashi Yamanaka et al.
INTRODUCTION: Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly with demographic, functional, occupational, and societal variables. Recent reports suggest that the use of biologic agents offers potential for reduced work disability rates, but the conclusions are based on surrogate disease activity measures derived from studies primarily from Western countries. METHODS: The Quantitative Standard Monitoring of Patients with RA (QUEST-RA) multinational database of 8,039 patients in 86 sites in 32 countries, 16 with high gross domestic product (GDP) (>24K US dollars (USD) per capita) and 16 low-GDP countries (<11K USD), was analyzed for work and disability status at onset and over the course of RA and clinical status of patients who continued working or had stopped working in high-GDP versus low-GDP countries according to all RA Core Data Set measures...
2010: Arthritis Research & Therapy
Clifton O Bingham, Christoph Pohl, Thasia G Woodworth, Sarah E Hewlett, James E May, Mahboob U Rahman, James P Witter, Daniel E Furst, C Vibeke Strand, Maarten Boers, Rieke E Alten
OBJECTIVE: Traditional outcome measures in randomized controlled trials (RCT) include well-established response criteria as well as ACR EULAR responses using Disease Activity Score 44 (DAS44)/DAS28 to assess improvement; however, a measure to assess worsening of disease has yet to be developed. This special interest group (SIG) was established to develop an evidence-based, consensus-driven standard definition of "flare" in rheumatoid arthritis (RA). METHODS: At OMERACT 8, the need for a standardized definition of RA flare was recognized; interested individuals developed a proposal to form a SIG...
October 2009: Journal of Rheumatology
Jeffrey Alten, M Michele Mariscalco
OBJECTIVE: To review the findings and discuss the implications of jugular venous bulb oxygenation monitoring in children with severe traumatic brain injury. DESIGN: A critical appraisal of Perez et al, Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury. FINDINGS: Two episodes of jugular venous bulb desaturation and abnormal values of arteriovenous difference in lactate content are associated with poor neurologic outcome in children with severe traumatic brain injury-risk ratio 6...
July 2005: Pediatric Critical Care Medicine
Mehmet Tanyuksel, Engin Araz, Kadir Dundar, Gunalp Uzun, Tuna Gumus, Bulent Alten, Fatma Saylam, Aysegul Taylan-Ozkan, Kosta Y Mumcuoglu
BACKGROUND: The medicinal use of maggots for the biological debridement of chronic wounds is increasing around the world, due to its efficacy, safety and simplicity. Thousands of patients have been treated in private and governmental hospitals during the last 10 years. OBJECTIVE: To examine the efficacy of maggot debridement therapy (MDT) in the debridement of chronic wounds in a military hospital. METHODS: MDT was applied for 1-9 days to 7 male and 4 female soldiers or their family members (21-72 years old) with chronic wounds...
2005: Dermatology: International Journal for Clinical and Investigative Dermatology
Aleksandra Hallmann-Mikołajczak
In 2nd century B.C. Clemens Alexanrinus was sure, that the Egyptians collected all their knowledge in 42 secret books. of which last six contained medical knowledge. Despite this and records of other ancient authors, for long time the opinion about the history of medicine was not changed. In traditional view the role of Hippocrates and the Greeks was emphasized. In 19th century egyptologist began finding Egyptian papyri, whose contents concerned medical matters. The first medical papyrus was published by Georg Ebers in 1875...
2004: Archiwum Historii i Filozofii Medycyny
M Schneider, M Lelgemann, C Baerwald, J Braun, M Hammer, P Kern, A Krause, R Alten, U Faubel, M Hammer, J Lakomek, W Liman, Th Pauly, A Schnabel
Our aim was to analyze the existing body of evidence about inpatient care of patients suffering from rheumatoid arthritis (RA). The report was induced by the executive board of the German Society of Rheumatology which assigned the "Oliver-Sangha committee" to dissect and point out the tasks of inpatient care during the next few years. A systemic search of the literature was performed covering the years 1966 to 2001. A total of 16 studies were selected and thoroughly appraised in a systematic way. Four randomized controlled trials addressing the question could be identified...
October 2004: Zeitschrift Für Rheumatologie
No abstract text is available yet for this article.
January 1962: Revue International des Services de Santé des Armées de Terre, de Mer et de L'air
D Brandenburg
No abstract text is available yet for this article.
1972: Janus; Revue Internationale de L'histoire des Sciences, de la Médecine, de la Pharmacie, et de la Technique
T h in der Smitten W
No abstract text is available yet for this article.
1974: Janus; Revue Internationale de L'histoire des Sciences, de la Médecine, de la Pharmacie, et de la Technique
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