keyword
https://read.qxmd.com/read/38547314/strongyloidiasis-in-auckland-a-ten-year-retrospective-study-of-diagnosis-treatment-and-outcomes-of-a-predominantly-polynesian-and-fijian-migrant-cohort
#1
JOURNAL ARTICLE
Tim Cutfield, Soana Karuna Motuhifonua, Matthew Blakiston, Hasan Bhally, Eamon Duffy, Rebekah Lane, Erik Otte, Terri Swager, Amanda Maree Taylor, Veronica Playle
BACKGROUND: Strongyloides stercoralis is not endemic in Aotearoa New Zealand (AoNZ). However, approximately one third of Auckland residents are born in endemic countries. This study aimed to describe the epidemiology and management of strongyloidiasis in Auckland, with a focus on migrants from Pacific Island Countries and Territories. METHODS: This study retrospectively reviewed clinical, laboratory and pharmacy records data for all people diagnosed with strongyloidiasis in the Auckland region between July 2012 and June 2022...
March 28, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38546931/high-frequency-of-transient-congenital-hypothyroidism-among-infants-referred-for-suspected-congenital-hypothyroidism-from-the-turkish-national-screening-program-thyroxine-dose-may-guide-the-prediction-of-transients
#2
JOURNAL ARTICLE
Y Özer, A Anık, U Sayılı, U Tercan, R Deveci Sevim, S Güneş, M Buhur Pirimoğlu, S Elmaoğulları, I Dündar, D Ökdemir, Ö Besci, A Jalilova, D Çiçek, B Singin, Ş E Ulu, H Turan, S Albayrak, Z Kocabey Sütçü, B S Eklioğlu, E Eren, S Çetinkaya, Ş Savaş-Erdeve, I Esen, K Demir, Ş Darcan, N Hatipoğlu, M Parlak, F Dursun, Z Şıklar, M Berberoğlu, M Keskin, Z Orbak, B Tezel, E Yürüker, B Keskinkılıç, F Kara, E Erginöz, F Darendeliler, O Evliyaoğlu
PURPOSE: We aimed to determine the frequency of transient congenital hypothyroidism (TCH) in 17 participating centers in Türkiye, evaluate the etiological distribution in permanent congenital hypothyroidism (PCH) cases, and investigate the role of laboratory and clinical findings in predicting TCH. METHODS: This retrospective observational multicenter study included patients from 17 pediatric endocrinology centers identified by "National Newborn Screening Program" (NNSP) who were born in 2015 and followed for 6 years...
March 28, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38546856/definitions-of-hospital-acquired-pneumonia-in-trauma-research-a-systematic-review
#3
REVIEW
Tim Kobes, Diederik P J Smeeing, Falco Hietbrink, Kim E M Benders, R Marijn Houwert, Mark P C M van Baal
PURPOSE: What are reported definitions of HAP in trauma patient research? METHODS: A systematic review was performed using the PubMed/MEDLINE database. We included all English, Dutch, and German original research papers in adult trauma patients reporting diagnostic criteria for hospital-acquired pneumonia diagnosis. The risk of bias was assessed using the MINORS criteria. RESULTS: Forty-six out of 5749 non-duplicate studies were included. Forty-seven unique criteria were reported and divided into five categories: clinical, laboratory, microbiological, radiologic, and miscellaneous...
March 28, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38546745/clinical-and-laboratory-characteristics-of-early-onset-and-delayed-onset-lupus-nephritis-patients-a-single-center-retrospective-study
#4
JOURNAL ARTICLE
Joanna Kosałka-Węgiel, Radosław Dziedzic, Andżelika Siwiec-Koźlik, Magdalena Spałkowska, Mamert Milewski, Joanna Żuk-Kuwik, Lech Zaręba, Stanisława Bazan-Socha, Mariusz Korkosz
BACKGROUND: Lupus nephritis (LN) manifests systemic lupus erythematosus (SLE) and is characterized by various clinical and laboratory features. This study aimed to comprehensively evaluate the characteristics of LN patients according to the time of LN diagnosis: early-onset (LN diagnosed within one year from SLE diagnosis) vs. delayed-onset (LN diagnosed more than one year after SLE diagnosis). METHODS: We conducted a retrospective analysis of medical records from all SLE patients treated at the University Hospital in Kraków, Poland, from 2012 to 2022...
March 28, 2024: Rheumatology International
https://read.qxmd.com/read/38546305/peripartum-cardiac-arrest-with-terminal-qrs-distortion-a-case-report
#5
JOURNAL ARTICLE
Timothy D Kelly, Nicholas E Harrison
INTRODUCTION: Peripartum cardiac arrest is increasing in incidence. While pulmonary embolism (PE) remains an important cause of peripartum morbidity and mortality, other cardiovascular emergencies such as myocardial infarction (MI) are now the leading cause of pregnancy-related death. Emergency physicians (EP) need to be well versed in subtle electrocardiographic (ECG) signs of coronary ischemia to better care for peripartum patients in cardiac arrest. CASE REPORT: A 38-year-old gravida 2 parity1 female three days post-partum presented in cardiac arrest...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38545656/clinical-exome-sequencing-uncovers-genetic-disorders-in-neonates-with-suspected-hypoxic-ischemic-encephalopathy-a-retrospective-analysis
#6
JOURNAL ARTICLE
Christian M Parobek, Roni Zemet, Matthew A Shanahan, Brian A Burnett, Elizabeth Mizerik, Jill A Rosenfeld, Liesbeth Vossaert, Steven L Clark, Jill V Hunter, Seema R Lalani
Hypoxic-ischemic encephalopathy (HIE) occurs in up to 7 out of 1000 births and accounts for almost a quarter of neonatal deaths worldwide. Despite the name, many newborns with HIE have little evidence of perinatal hypoxia. We hypothesized that some infants with HIE have genetic disorders that resemble encephalopathy. We reviewed genetic results for newborns with HIE undergoing exome or genome sequencing at a clinical laboratory (2014-2022). Neonates were included if they had a diagnosis of HIE and were delivered ≥35 weeks...
March 28, 2024: Clinical Genetics
https://read.qxmd.com/read/38545111/an-analysis-of-neutrophil-to-lymphocyte-ratios-and-monocyte-to-lymphocyte-ratios-with-six-month-prognosis-after-cerebral-contusions
#7
JOURNAL ARTICLE
Dangui Zhang, Dongzhou Zhuang, Tian Li, Xueer Liu, Zelin Zhang, Lihong Zhu, Fei Tian, Xiaoxuan Chen, Kangsheng Li, Weiqiang Chen, Jiangtao Sheng
BACKGROUND AND PURPOSE: Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) have been identified as potential prognostic markers in various conditions, including cancer, cardiovascular disease, and stroke. This study aims to investigate the dynamic changes of NLR and MLR following cerebral contusion and their associations with six-month outcomes. METHODS: Retrospective data were collected from January 2016 to April 2020, including patients diagnosed with cerebral contusion and discharged from two teaching-oriented tertiary hospitals in Southern China...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544554/desquamative-interstitial-pneumonia-a-case-report
#8
Hailong Zhang, Guohua Yu, Ben Yang, Shengyao Ma, Yubing Wang, Xiaoqi Zhang, Yong Zhang, Mei-Hua Qu
Diffuse cystic lung diseases (DCLDs) are a group of heterogeneous lung diseases that are characterized by inflated spaces or cysts within the lung parenchyma. They also exhibit similar imaging characteristics and clinical manifestations compared with those of cystic lesions, such as pulmonary cavities, emphysema, bronchiectasis and honeycomb lung. The most common DCLDs encountered in the clinic include lymphangioleiomyomatosis, Birt-Hogg-Dubé syndrome, Langerhans cell histiocytosis and lymphocytic interstitial pneumonia...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38543779/evaluation-of-congenital-cytomegalovirus-infection-in-pregnant-women-admitted-to-a-university-hospital-in-istanbul
#9
JOURNAL ARTICLE
Evrim Ozdemir, Tugba Sarac Sivrikoz, Kutay Sarsar, Dilruba Tureli, Mustafa Onel, Mehmet Demirci, Gizem Yapar, Eray Yurtseven, Recep Has, Ali Agacfidan, Hayriye Kirkoyun Uysal
Cytomegalovirus (CMV) can cause serious complications in immunocompromised individuals and fetuses with congenital infections. These can include neurodevelopmental impairments and congenital abnormalities in newborns. This paper emphasizes the importance of concurrently evaluating ultrasonography findings and laboratory parameters in diagnosing congenital CMV infection. To examine the prenatal characteristics of CMV DNA-positive patients, we assessed serum and amniotic fluid from 141 pregnant women aged 19-45 years, each with fetal anomalies...
March 8, 2024: Viruses
https://read.qxmd.com/read/38542743/plant-derived-substances-for-prevention-of-necrotising-enterocolitis-a-systematic-review-of-animal-studies
#10
REVIEW
Cheryl Anne Mackay, Chandra Rath, Shripada Rao, Sanjay Patole
Inflammation, oxidative injury, and gut dysbiosis play an important role in the pathogenesis of necrotising enterocolitis (NEC). Plant-derived substances have historically been used as therapeutic agents due to their anti-inflammatory, antioxidant, and antimicrobial properties. We aimed to review pre-clinical evidence for plant-derived substances in the prevention and treatment of NEC. A systematic review was conducted using the following databases: PubMed, EMBASE, EMCARE, MEDLINE and Cochrane Library (PROSPERO CRD42022365477)...
March 14, 2024: Nutrients
https://read.qxmd.com/read/38541829/atypical-manifestations-of-syphilis-a-10-year-retrospective-study
#11
JOURNAL ARTICLE
Giulia Ciccarese, Antonio Facciorusso, Mario Mastrolonardo, Astrid Herzum, Aurora Parodi, Francesco Drago
Background : The incidence of syphilis has increased in high-income countries in the past few decades, especially among men who have sex with men. In the present study, we aimed to analyze the correlations between atypical syphilis manifestations and the demographic, clinical, and laboratory features of patients and to review unusual presentations of syphilis reported in the literature. Methods : We conducted a retrospective analysis of 307 patients with syphilis diagnosed between 1 January 2013 and 31 October 2023 at the sexually transmitted infection (STI) centers of the University of Genoa and University of Foggia with both typical and atypical manifestations of disease...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541796/the-road-to-sepsis-in-geriatric-polytrauma-patients-can-we-forecast-sepsis-in-trauma-patients
#12
JOURNAL ARTICLE
Cédric Niggli, Philipp Vetter, Jan Hambrecht, Hans-Christoph Pape, Ladislav Mica
Background: Sepsis is a leading cause of mortality in polytrauma patients, especially beyond the first week, and its management is vital for reducing multiorgan failure and improving survival rates. This is particularly critical in geriatric polytrauma patients due to factors such as age-related physiological alterations and weakened immune systems. This study aimed to investigate various clinical and laboratory parameters associated with sepsis in polytrauma patients aged < 65 years and ≥65 years, with the secondary objective of comparing sources of infection in these patient groups...
March 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38539617/artificial-intelligence-as-a-complementary-tool-for-clincal-decision-making-in-stroke-and-epilepsy
#13
REVIEW
Smit P Shah, John D Heiss
Neurology is a quickly evolving specialty that requires clinicians to make precise and prompt diagnoses and clinical decisions based on the latest evidence-based medicine practices. In all Neurology subspecialties-Stroke and Epilepsy in particular-clinical decisions affecting patient outcomes depend on neurologists accurately assessing patient disability. Artificial intelligence [AI] can predict the expected neurological impairment from an AIS [Acute Ischemic Stroke], the possibility of ICH [IntraCranial Hemorrhage] expansion, and the clinical outcomes of comatose patients...
February 28, 2024: Brain Sciences
https://read.qxmd.com/read/38539528/cachexia-affected-survival-based-on-inflammatory-parameters-compared-to-complex-conventional-nutritional-assessments-in-patients-with-pancreatic-cancer-and-other-gastrointestinal-tumors-the-conko-020-investigation
#14
JOURNAL ARTICLE
Johanna W Meyer-Knees, Janina Falkenthal, Dominik Geisel, Christopher C M Neumann, Georg Hilfenhaus, Lars U Stephan, Wenzel Schöning, Thomas Malinka, Johann Pratschke, Sebastian Stintzing, Uwe Pelzer
BACKGROUND: Pancreatic adenocarcinoma (PDAC) is still a complex, devastating disease. Cachexia symptoms frequently impair patient survival. This accompanying syndrome is commonly diagnosed late, when clinical signs become evident. Early diagnosis using conventional measurement methods is often difficult, and the discrimination of this disease from cancer progression is challenging and often overlaps. The aim of this study was to analyze whether conventional nutritional assessments or laboratory biomarkers are better predictive tools for the early detection of patients at risk of reduced survival...
March 18, 2024: Cancers
https://read.qxmd.com/read/38539179/association-of-hormone-receptors-and-human-epidermal-growth-factor-receptor-2-neu-expressions-with-clinicopathologic-factors-of-breast-carcinoma-a-cross-sectional-study-in-a-tertiary-care-hospital-kabul-afghanistan
#15
JOURNAL ARTICLE
Esmatullah Esmat, Ahmed Maseh Haidary, Ramin Saadaat, Syeda Naghma Rizvi, Syeda Aleena, Mujtaba Haidari, Sayed Murtaza Sadat Hofiani, Nasrin Hussaini, Ahmadullah Hakimi, Abdullatif Khairy, Jamshid Abdul-Ghafar
BACKGROUND: Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challenges to the health system and economy of every nation. METHODOLOGY: A cross-sectional analytical study was conducted at the Department of Pathology and Clinical Laboratory of the French Medical Institute for Mothers and Children (FMIC) to demonstrate the association of human epidermal growth factor receptor 2 (Her2/Neu) and estrogen receptor (ER)/ progesterone receptor (PR) with clinical as well as pathological parameters among women with BC...
March 27, 2024: BMC Cancer
https://read.qxmd.com/read/38538918/semiautomated-approach-focused-on-new-genomic-information-results-in-time-and-effort-efficient-reannotation-of-negative-exome-data
#16
JOURNAL ARTICLE
Alejandro Ferrer, Patrick Duffy, Rory J Olson, Michael A Meiners, Laura Schultz-Rogers, Erica L Macke, Stephanie Safgren, Joel A Morales-Rosado, Margot A Cousin, Gavin R Oliver, David Rider, Megan Williams, Pavel N Pichurin, David R Deyle, Eva Morava, Ralitza H Gavrilova, Radhika Dhamija, Klass J Wierenga, Brendan C Lanpher, Dusica Babovic-Vuksanovic, Charu Kaiwar, Carolyn R Vitek, Tammy M McAllister, Myra J Wick, Lisa A Schimmenti, Konstantinos N Lazaridis, Filippo Pinto E Vairo, Eric W Klee
Most rare disease patients (75-50%) undergoing genomic sequencing remain unsolved, often due to lack of information about variants identified. Data review over time can leverage novel information regarding disease-causing variants and genes, increasing this diagnostic yield. However, time and resource constraints have limited reanalysis of genetic data in clinical laboratories setting. We developed RENEW, (REannotation of NEgative WES/WGS) an automated reannotation procedure that uses relevant new information in on-line genomic databases to enable rapid review of genomic findings...
March 27, 2024: Human Genetics
https://read.qxmd.com/read/38538240/-analysis-of-clinical-characteristics-of-129-acute-and-chronic-occupational-brucellosis-in-hulunbuir-city
#17
JOURNAL ARTICLE
C Liang, W Wei
Objective: To analyze the epidemiological characteristics and clinical data of acute and chronic occupational brucellosis patients in order to provide a scientific basis for the prevention and treatment of occupational brucellosis. Methods: In October 2022, a study was conducted on 129 patients diagnosed with occupational brucellosis by HulunBuir Center for Disease Control and Prevention from January 2016 to December 2021. The epidemiological characteristics, clinical features, and laboratory test results of patients in the acute and chronic phases were compared and analyzed using chi-square test and student's t test...
March 20, 2024: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://read.qxmd.com/read/38538076/benchmarking-digital-displays-monitors-for-histological-diagnoses-the-nephropathology-use-case
#18
JOURNAL ARTICLE
Giorgio Cazzaniga, Francesco Mascadri, Stefano Marletta, Alessandro Caputo, Gabriele Guidi, Giovanni Gambaro, Albino Eccher, Angelo Paolo Dei Tos, Fabio Pagni, Vincenzo L'Imperio
AIM: The digital transformation of the pathology laboratory is being continuously sustained by the introduction of innovative technologies promoting whole slide image (WSI)-based primary diagnosis. Here, we proposed a real-life benchmark of a pathology-dedicated medical monitor for the primary diagnosis of renal biopsies, evaluating the concordance between the 'traditional' microscope and commercial monitors using WSI from different scanners. METHODS: The College of American Pathologists WSI validation guidelines were used on 60 consecutive renal biopsies from three scanners (Aperio, 3DHISTECH and Hamamatsu) using pathology-dedicated medical grade (MG), professional grade (PG) and consumer-off-the-shelf (COTS) monitors, comparing results with the microscope diagnosis after a 2-week washout period...
March 27, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#19
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38536220/benchmarking-mental-health-status-using-passive-sensor-data-protocol-for-a-prospective-observational-study
#20
JOURNAL ARTICLE
Robyn E Kilshaw, Abigail Boggins, Olivia Everett, Emma Butner, Feea R Leifker, Brian R W Baucom
BACKGROUND: Computational psychiatry has the potential to advance the diagnosis, mechanistic understanding, and treatment of mental health conditions. Promising results from clinical samples have led to calls to extend these methods to mental health risk assessment in the general public; however, data typically used with clinical samples are neither available nor scalable for research in the general population. Digital phenotyping addresses this by capitalizing on the multimodal and widely available data created by sensors embedded in personal digital devices (eg, smartphones) and is a promising approach to extending computational psychiatry methods to improve mental health risk assessment in the general population...
March 27, 2024: JMIR Research Protocols
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