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Darryl S Watkins, Jason D True, Amber L Mosley, Anthony J Baucum
The author wishes to make the following corrections to the methods section of their paper [...].
February 13, 2019: Proteomes
Soonjae Ahn, Jongman Kim, Bummo Koo, Youngho Kim
In this study, pre-impact fall detection algorithms were developed based on data gathered by a custom-made inertial measurement unit (IMU). Four types of simulated falls were performed by 40 healthy subjects (age: 23.4 ± 4.4 years). The IMU recorded acceleration and angular velocity during all activities. Acceleration, angular velocity, and trunk inclination thresholds were set to 0.9 g, 47.3°/s, and 24.7°, respectively, for a pre-impact fall detection algorithm using vertical angles (VA algorithm); and 0...
February 13, 2019: Sensors
Tomohisa Tasaki, Satoko Takase, Youichi Shimizu
A sensitive an impedancemetric acetylene (C₂H₂) gas sensor device could be fabricated by using perovskite-type SmFeO₃ thin-film as a sensor material. The uniform SmFeO₃ thin-films were prepared by spin-coating and focusing on the effects of polymer precursor solutions. The prepared precursors and thin-films were characterized by means of thermal analysis, Fourier-transform infrared spectroscopy, ultraviolet⁻visible spectroscopy, X-ray diffraction analysis, scanning electron microscopy and X-ray photoelectron spectroscopy...
February 13, 2019: Sensors
Kai Guo, Liansheng Liu, Shuhui Shi, Datong Liu, Xiyuan Peng
Fault detection for sensors of unmanned aerial vehicles is essential for ensuring flight security, in which the flight control system conducts real-time control for the vehicles relying on the sensing information from sensors, and erroneous sensor data will lead to false flight control commands, causing undesirable consequences. However, because of the scarcity of faulty instances, it still remains a challenging issue for flight sensor fault detection. The one-class support vector machine approach is a favorable classifier without negative samples, however, it is sensitive to outliers that deviate from the center and lacks a mechanism for coping with them...
February 13, 2019: Sensors
Junling Pang, Xia Zhang, Xuhui Ma, Jun Zhao
Long non-coding RNAs (lncRNAs) have emerged as important regulators in plant stress response. Here, we report a genome-wide lncRNA transcriptional analysis in response to drought stress using an expanded series of maize samples collected from three distinct tissues spanning four developmental stages. In total, 3488 high-confidence lncRNAs were identified, among which 1535 were characterized as drought responsive. By characterizing the genomic structure and expression pattern, we found that lncRNA structures were less complex than protein-coding genes, showing shorter transcripts and fewer exons...
February 13, 2019: Genes
Juanjuan Li, Guoying Meng, Guangming Xie, Aiming Wang, Jun Ding, Wei Zhang, Xingwei Wan
This paper presents a method for calculating the health degree (HD) of a braking system of a mine hoist combined with three-level fuzzy comprehensive assessment (TLFCA) and a back-propagation neural network (BPNN). Firstly, the monitored values of a sensor are fused by multi-time fusion and the fuzzy comprehensive assessment values (FCAVs) of the health condition (HC) of the sensor are obtained. Secondly, the FCAVs of all sensors in a subsystem are fused by multi-sensor fusion, and FCAVs of the subsystem are obtained...
February 13, 2019: Sensors
Hemant Ghayvat, Muhammad Awais, Sharnil Pandya, Hao Ren, Saeed Akbarzadeh, Subhas Chandra Mukhopadhyay, Chen Chen, Prosanta Gope, Arpita Chouhan, Wei Chen
Ambiguities and anomalies in the Activity of Daily Living (ADL) patterns indicate deviations from Wellness. The monitoring of lifestyles could facilitate remote physicians or caregivers to give insight into symptoms of the disease and provide health improvement advice to residents; Objective: This research work aims to apply lifestyle monitoring in an ambient assisted living (AAL) system by diagnosing conduct and distinguishing variation from the norm with the slightest conceivable fake alert. In pursuing this aim, the main objective is to fill the knowledge gap of two contextual observations (i...
February 13, 2019: Sensors
Kai Song, Yejing Wang, Yu Li, Chaoxiang Ding, Rui Cai, Gang Tao, Ping Zhao, Qingyou Xia, Huawei He
Enzymatic activity assays are essential and critical for the study of enzyme kinetics. Adenylate kinase (Adk) plays a fundamental role in cellular energy and nucleotide homeostasis. To date, assays based on different principles have been used for the determination of Adk activity. Here, we show a spectrophotometric analysis technique to determine Adk activity with bromothymol blue as a pH indicator. We analyzed the effects of substrates and the pH indicator on the assay using orthogonal design and then established the most optimal assay for Adk activity...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Giuseppe Egidio De Benedetto, Sabrina Di Masi, Antonio Pennetta, Cosimino Malitesta
Herein, we report the application of a chemometric tool for the optimisation of electrochemical biosensor performances. The experimental design was performed based on the responses of an amperometric biosensor developed for metal ions detection using the flow injection analysis. The electrode preparation and the working conditions were selected as experimental parameters, and thus, were modelled by a response surface methodology (RSM). In particular, enzyme concentration, flow rates, and number of cycles were reported as continuous factors, while the sensitivities of the biosensor (S, µA·mM-1 ) towards metals, such as Bi3+ and Al3+ were collected as responses and optimised by a central composite design (CCD)...
February 13, 2019: Biosensors
Fengling Feng, Jin Zhao, Pingchao Li, Ruiting Li, Ling Chen, Caijun Sun
Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased susceptibility to Ad infection, when compared with that of Ad-seronegative individuals. But the underlying mechanisms for this enhancement of viral infection are not completely clarified. In this study, we found that the efficacy of Ad infection into CD14+ monocytes was significantly decreased after CD3+ T lymphocytes depletion from PBMC samples of Ad-seropositive individuals...
February 13, 2019: Viruses
Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
The regulation of oxygen (O₂) levels is crucial in embryogenesis and adult life, as O₂ controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for tissue physiology as they are integral to adequate metabolism regulation and cell fate. Hence, the hypoxia response is of utmost importance for cell, organ and organism function and is dependent on the hypoxia-inducible factor (HIF) pathway. HIF pathway activity is strictly regulated by the family of oxygen-sensitive HIF prolyl hydroxylase domain (PHD) proteins...
February 13, 2019: Cells
Mohd Farhan, Arshi Malik, Mohammad Fahad Ullah, Sarah Afaq, Mohd Faisal, Ammad Ahmad Farooqi, Bernhard Biersack, Rainer Schobert, Aamir Ahmad
Garcinol, a dietary factor obtained from Garcinia indica , modulates several key cellular signaling pathways as well as the expression of miRNAs. Acquired resistance to standard therapies, such as erlotinib and cisplatin, is a hallmark of non-small cell lung cancer (NSCLC) cells that often involves miRNA-regulated epithelial-to-mesenchymal transition (EMT). We used A549 cells that were exposed to transforming growth factor beta 1 (TGF-β1), resulting in A549M cells with mesenchymal and drug resistant phenotype, and report that garcinol sensitized resistant cells with mesenchymal phenotype to erlotinib as well as cisplatin with significant decrease in their IC50 values...
February 13, 2019: International Journal of Molecular Sciences
Joshua Y C Yang, Stijn E Verleden, Arya Zarinsefat, Bart M Vanaudenaerde, Robin Vos, Geert M Verleden, Reuben D Sarwal, Tara K Sigdel, Juliane M Liberto, Izabella Damm, Drew Watson, Minnie M Sarwal
Standard methods for detecting chronic lung allograft dysfunction (CLAD) and rejection have poor sensitivity and specificity and have conventionally required bronchoscopies and biopsies. Plasma cell-free DNA (cfDNA) has been shown to be increased in various types of allograft injury in transplant recipients and CXCL10 has been reported to be increased in the lung tissue of patients undergoing CLAD. This study used a novel cfDNA and CXCL10 assay to evaluate the noninvasive assessment of CLAD phenotype and prediction of survival from bronchoalveolar lavage (BAL) fluid...
February 13, 2019: Journal of Clinical Medicine
Muhammad Nadeem, Jiajia Li, Muhammad Yahya, Minghua Wang, Asif Ali, Andong Cheng, Xiaobo Wang, Chuanxi Ma
Salinity is an ever-present major constraint and a major threat to legume crops, particularly in areas with irrigated agriculture. Legumes demonstrate high sensitivity, especially during vegetative and reproductive phases. This review gives an overview of legumes sensitivity to salt stress (SS) and mechanisms to cope with salinity stress under unfavorable conditions. It also focuses on the promising management approaches, i.e., agronomic practices, breeding approaches, and genome editing techniques to improve performance of legumes under SS...
February 13, 2019: International Journal of Molecular Sciences
Zheng Wei, Xiaoping Cai, Junping Zhang, Junming Fan, Jiangyan Xu, Liran Xu
Progastrin-releasing peptide (ProGRP), which is known to be highly specific and sensitive to small cell lung cancer (SCLC), has been proven to be a valuable substitute for neuron-specific enolase in SCLC diagnostics and monitoring, especially in its early stages. The detection of ProGRP levels also facilitates a selection of therapeutic treatments. For the fabrication of our proposed biosensor, titanium (IV) oxide microparticles were first used, followed by dispersing gold nanoparticles into chitosan and immobilizing them onto a carbon paste electrode (CPE) surface...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Vincenzo Guarino, Rosaria Altobelli, Tania Caputo, Luigi Ambrosio, Sergio Caserta, Paola Calcagnile, Christian Demitri
In recent years, different processing technologies have been engineered to fabricate capsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro and sub-micrometric size scale, to be used as carriers for controlled drug and molecular release. Herein, the development of cellulose acetate (CA) micro-carriers with mono- (MC) or bi-phasic (BC) composition is proposed, fabricated via electrohydrodynamic atomization (EHDA)-an electro-dropping technology able to micro-size polymer solution by the application of high voltage electrostatic forces...
February 18, 2019: Pharmaceutics
Sudip Banerjee, Tyler Alexander, Debajyoti Majumdar, Thomas Groves, Frederico Kiffer, Jing Wang, Akshita Gorantla, Antiño R Allen, Snehalata A Pawar
Aging is characterized by increased inflammation and deterioration of the cellular stress responses such as the oxidant/antioxidant equilibrium, DNA damage repair fidelity, and telomeric attrition. All these factors contribute to the increased radiation sensitivity in the elderly as shown by epidemiological studies of the Japanese atomic bomb survivors. There is a global increase in the aging population, who may be at increased risk of exposure to ionizing radiation (IR) as part of cancer therapy or accidental exposure...
February 18, 2019: International Journal of Molecular Sciences
Nicola Amodio, Maria Eugenia Gallo Cantafio, Cirino Botta, Valter Agosti, Cinzia Federico, Daniele Caracciolo, Domenica Ronchetti, Marco Rossi, Christoph Driessen, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone
Aberrant expression of microRNAs (miRNAs) has been associated to the pathogenesis of multiple myeloma (MM). While miR-155 is considered a therapeutic target in several malignancies, its role in MM is still unclear. The analysis of miR-155 expression indicates its down-regulation in MM patient-derived as compared to healthy plasma cells, thus pointing to a tumor suppressor role in this malignancy. On this finding, we investigated miR-155 replacement as a potential anti-tumor strategy in MM. The miR-155 enforced expression triggered anti-proliferative and pro-apoptotic effects in vitro...
February 18, 2019: Cancers
Min Wang, Biao Jiang, Wenrui Liu, Yu'e Lin, Zhaojun Liang, Xiaoming He, Qingwu Peng
Temperature rising caused by global warming has imposed significant negative effects on crop qualities and yields. To get the well-known molecular mechanism upon the higher temperature, we carefully analyzed the RNA sequencing-based transcriptomic responses of two contrasting chieh-qua genotypes: A39 (heat-tolerant) and H5 (heat-sensitive). In this study, twelve cDNA libraries generated from A39 and H5 were performed with a transcriptome assay under normal and heat stress conditions, respectively. A total of 8705 differentially expressed genes (DEGs) were detected under normal conditions (3676 up-regulated and 5029 down-regulated) and 1505 genes under heat stress (914 up-regulated and 591 down-regulated), respectively...
February 18, 2019: International Journal of Molecular Sciences
Hanbing Liu, Xin He, Yubo Jiao, Xirui Wang
Structural health monitoring (SHM) has been widely used in all kinds of bridges. It is significant to accurately assess the serviceability and reliability of bridge subjected to severe conditions by SHM technique. Bridge deflection as an essential evaluation index can reflect structural condition perfectly. In this study, an approach for deflection calculation and reliability assessment of simply supported bridge is presented. Firstly, a bridge deflection calculation method is proposed based on modal flexibility and Kriging method improved by artificial bee colony algorithm...
February 18, 2019: Sensors
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