Read by QxMD icon Read

One put synthesis

Maha Fadel, Kawser Kassab, Tareq Youssef, Abdullah Ibrahim El-Kholy
This study introduces a simple method for one-step synthesis of highly stable non-toxic polymer-coated gold nanospheres for use in drug delivery, focuses on the ability of chloroauric acid to induce polyphenols polymerization, puts up an easy procedure for loading hydrophobic drugs onto gold nanoparticles with ultra-high loading efficiency and studies the cytotoxicity of free and gold nanoparticles-loaded resveratrol. Gold nanospheres were synthesized simply by direct reaction between resveratrol itself and chloroauric acid in aqueous medium...
February 8, 2019: Drug Development and Industrial Pharmacy
Gerard J Puts, Philip Crouse, Bruno M Ameduri
This Review aims to be a comprehensive, authoritative, and critical review of general interest to the chemistry community (both academia and industry) as it contains an extensive overview of all published data on the homopolymerization of tetrafluoroethylene (TFE), detailing the TFE homopolymerization process and the resulting chemical and physical properties. Several reviews and encyclopedia chapters on the properties and applications of fluoropolymers in general have been published, including various reviews that extensively report copolymers of TFE (listed below)...
January 28, 2019: Chemical Reviews
W Oscar Fleming, Alexsandra A Apostolico, Amy J Mullenix, Katie Starr, Lewis Margolis
Purpose This article describes how implementation science informed the design of a national training and technical assistance (TA) center, and how implementation best practices have been used to improve the quality of training and technical assistance services offered to states/jurisdictions. Description An existing tool, based on the Implementation Drivers Framework (in: Fixsen et al., Implementation research: a synthesis of the literature, University of South Florida, The National Implementation Research Network, Tampa, 2005), was adapted to assess efforts of the National MCH Workforce Development Center (the Center) against known implementation best practices...
January 25, 2019: Maternal and Child Health Journal
Wei Qian, Xin Tan, Qian Su, Weiguo Cheng, Fei Xu, Li Dong, Suojiang Zhang
Green synthesis of high-molecular-weight isosorbide-based polycarbonate (PIC) with excellent properties is a tremendous challenge, which is profoundly influenced by the precursor. Herein, we employed an eco-friendly catalyst to achieve the more reactive PIC precursor dicarboxymethyl isosorbide (DC) selectivity of 99.0% through the transesterfication reaction of isosorbide with dimethyl carbonate (DMC), which is the indispensable stage of one-pot green synthesis of PIC, playing a critical role in insight into the polymerization mechanism of polymers synthesis by melt transesterfication reaction...
January 8, 2019: ChemSusChem
Alison Callwood, Johanna E Groothuizen, Helen Therese Allan
AIM: To explore how adult, child, mental health nursing and midwifery students describe their 'values journey' after completing their second year following exposure to the clinical practice environment. BACKGROUND: Where student nurses and midwives are selected using multiple mini interviews, in a values-based recruitment process, the conservancy and or development of their personal values remains unclear. DESIGN: A hermeneutic, cross-professional longitudinal study was commenced at one university in England in 2016 with data collection points at the end of years one (DC1), two (DC2) and three (DC3)...
December 26, 2018: Journal of Advanced Nursing
Cristiana Faria, Nuno Borges, Isabel Rocha, Helena Santos
BACKGROUND: Mannosylglycerate (MG) is one of the most widespread compatible solutes among marine microorganisms adapted to hot environments. This ionic solute holds excellent ability to protect proteins against thermal denaturation, hence a large number of biotechnological and clinical applications have been put forward. However, the current prohibitive production costs impose severe constraints towards large-scale applications. All known microbial producers synthesize MG from GDP-mannose and 3-phosphoglycerate via a two-step pathway in which mannosyl-3-phosphoglycerate is the intermediate metabolite...
November 16, 2018: Microbial Cell Factories
Max R Friedfeld, Jennifer L Stein, Andrew Ritchhart, Brandi M Cossairt
Clusters are unique molecular species that can be viewed as a bridge between phases of matter and thus between disciplines of chemistry. The structural and compositional complexity observed in cluster chemistry serves as an inspiration to the material science community and motivates our search for new phases of matter. Moreover, the formation of kinetically persistent cluster molecules as intermediates in the nucleation of crystals makes these materials of great interest for determining and controlling mechanisms of crystal growth...
November 2, 2018: Accounts of Chemical Research
Emmeli Vallin, Hanna Nestander, Michael B Wells
BACKGROUND: Fathers' attendance during pregnancy and childbirth has increased in recent decades. During childbirth, complications may occur that may put the woman and/or child in danger. To experience such situations may be traumatic for the father, as well as may increase his risk of childbirth-related mental illness during the postpartum period. AIM: The aim of this literature review was to describe expectant fathers' experiences of complications during childbirth...
October 18, 2018: Midwifery
Dimiter Kunnev, Anastas Gospodinov
One of the most intriguing questions in biological science is how life originated on Earth. A large number of hypotheses have been proposed to explain it, each putting an emphasis on different events leading to functional translation and self-sustained system. Here, we propose a set of interactions that could have taken place in the prebiotic environment. According to our hypothesis, hybridization-induced proximity of short aminoacylated RNAs led to the synthesis of peptides of random sequence. We postulate that among these emerged a type of peptide(s) capable of stimulating the interaction between specific RNAs and specific amino acids, which we call "bridge peptide" (BP)...
October 2, 2018: Life
Abdur Rahman, Muddanna S Rao, Khalid M Khan
BACKGROUND: Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory. Pb activates astrocytes and microglia, which in turn induce the synthesis of QA. We hypothesized increased QA production in response to Pb exposure as a novel mechanism of Pb-neurotoxicity. METHODS: Two experimental paradigms were used. In experiment one, Wistar rat pups were exposed to Pb via their dams' drinking water from postnatal day 1 to 21...
September 14, 2018: Journal of Neuroinflammation
Tianyi Yang, Feng Zhu, Maciej A Walczak
Oligosaccharides, one of the most abundant biopolymers, are involved in numerous biological processes. Although many efforts have been put in preparative carbohydrate chemistry, achieving optimal anomeric and regioselectivities remains challenging. Herein we describe an oxidative glycosylation method between anomeric stannanes and oxygen nucleophiles resulting in the formation of a C-O bond with consistently high anomeric control for glycosyl donors bearing a free C2-hydroxyl group. These reactions are promoted by hypervalent iodine reagents with catalytic or stoichiometric amounts of Cu or Zn salts...
September 7, 2018: Nature Communications
Daniel Keefer, Regina de Vivie-Riedle
In 1998, the first successful quantum control experiment with application to a molecular framework was conducted with a shaped laser pulse, optimizing the branching ratio between different organometallic reaction channels. This work induced a vast activity in quantum control during the next 10 years, and different optimization aims were achieved in the gas phase, liquid phase, and even in biologically relevant molecules like light-harvesting complexes. Accompanying and preceding this development were important advances in theoretical quantum control simulations...
September 18, 2018: Accounts of Chemical Research
Mohamad Baydoun, Debra L Barton, Cynthia Arslanian-Engoren
AIM: This article describes the development of a middle-range theory of symptom self-care management for adults with cancer. BACKGROUND: Current evidence indicates that people with cancer may benefit from engagement in self-care management behaviours, one of which is symptom management. A middle-range theory that explains and guides symptom self-care management in people with cancer is lacking. DESIGN: This paper combines and expands prior work related to symptom management and self-care management to introduce a newly synthesized theory of symptom self-care management for adult people with cancer...
August 21, 2018: Journal of Advanced Nursing
Yating Zhao, Yanwen Lv, Wujiong Xia
Cyclic compounds constitute a great important class of substances in the science of medicine and biology, which renders the research on facile and efficient construction of such complex scaffolds from simple starting materials to be hot and appealing. Recently, the radical cascade reaction involving multiple bond formation/cleavage has emerged as an ideal and powerful route to give high-value cyclic products, along with diminished cost and waste. As a simple and benign methodology, photoredox catalysis offers a readily available access to the generation of radical species...
July 18, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Rachel Codd, Cho Zin Soe, Amalie A H Pakchung, Athavan Sresutharsan, Christopher J M Brown, William Tieu
Dihydroxamic acid macrocyclic siderophores comprise four members: putrebactin (putH2 ), avaroferrin (avaH2 ), bisucaberin (bisH2 ), and alcaligin (alcH2 ). This mini-review collates studies of the chemical biology and coordination chemistry of these macrocycles, with an emphasis on putH2 . These Fe(III)-binding macrocycles are produced by selected bacteria to acquire insoluble Fe(III) from the local environment. The macrocycles are optimally pre-configured for Fe(III) binding, as established from the X-ray crystal structure of dinuclear [Fe2 (alc)3 ] at neutral pH...
October 2018: Journal of Biological Inorganic Chemistry: JBIC
Lezio S Bueno-Junior, Joao P Leite
Executive functions and working memory are long known to involve the prefrontal cortex (PFC), and two PFC-projecting areas: midline/paramidline thalamus (MLT) and cornus ammonis 1 (CA1)/subiculum of the hippocampal formation (HF). An increasing number of rodent electrophysiology studies are examining these substrates together, thus providing circuit-level perspectives on input convergence, synaptic plasticity and functional coupling, as well as insights into cognition mechanisms and brain disorders. Our review article puts this literature into a method-oriented narrative...
2018: Frontiers in Neural Circuits
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Seyed Abdulmajid Ayatollahi
The interest in the synthesis of metallic complexes of different drugs to make them more efficient in biological environment of the human body is seen for the last few decades. Wide range of metal complexes are already used in clinical practice which encourages additional research for innovating new metal based drugs, such as metal-mediated antibiotics, anti-parasitic, antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as one of the most disastrous disease putting burden on health system worldwide...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Jessie M Barra, Hubert M Tse
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic ╬▓-cells inside the islets of Langerhans. The loss of this vital population leaves patients with a lifelong dependency on exogenous insulin and puts them at risk for life-threatening complications. One method being investigated to help restore insulin independence in these patients is islet cell transplantation. However, challenges associated with transplant rejection and islet viability have prevented long-term ╬▓-cell function...
2018: Frontiers in Endocrinology
Sara S El Zahed, Garima Kumar, Madeline Tong, Eric D Brown
Clinically approved antibiotics target a narrow spectrum of cellular processes, namely cell wall synthesis, DNA replication, and protein synthesis. Numerous screens have been designed to identify inhibitors that target one of these cellular processes. Indeed, this narrow range of drug mechanisms and a reliance on chemical classes discovered many decades ago are thought to be principally responsible for the current crisis of antibiotic drug resistance. Seeking to expand the target base of antibacterial drug discovery, we developed a nutrient stress screening platform that identifies inhibitors of the growth of in Escherichia coli under nutrient limitation...
2018: Methods in Molecular Biology
Yi-Mou Liu, Xue-Dong Tian, Jing Wang, Chu-Hui Fan, Feng Gao, Qian-Qian Bao
We study the optical response of a double optomechanical cavity system assisted by two Rydberg atoms. The target atom is only coupled with one side cavity by a single cavity mode, and gate one is outside the cavities. It has been realized that a long-range manipulation of optical properties of a hybrid system, by controlling the Rydberg atom decoupled with the optomechanical cavity. Switching on the coupling between atoms and cavity mode, the original spatial inversion symmetry of the double cavity structure has been broken...
April 30, 2018: Optics Express
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"