Mohamed Jawed Ahsan, Krishna Gautam, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, Salahuddin, Manal A Alossaimi, S V V N S M Lakshmi, Md Faiyaz Ahsan
In the current study, we described the synthesis of ten new 5-(3-Bromophenyl)- N -aryl-4 H -1,2,4-triazol-3-amine analogs ( 4a-j ), as well as their characterization, anticancer activity, molecular docking studies, ADME, and toxicity prediction. The title compounds ( 4a-j ) were prepared in three steps, starting from substituted anilines in a satisfactory yield, followed by their characterization via spectroscopic techniques. The National Cancer Institute (NCI US) protocol was followed to test the compounds' ( 4a-j ) anticancer activity against nine panels of 58 cancer cell lines at a concentration of 10-5 M, and growth percent (GP) as well as percent growth inhibition (PGI) were calculated...
October 5, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry