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M F M Santos, F C A C Oliveira, R K Kishimoto, D Borri, F P S Santos, P V Campregher, P A A Silveira, N Hamerschlak, C L P Mangueira, F B Duarte, A H Crepaldi, M A Salvino, E D R P Velloso
Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75)...
February 14, 2019: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Marco Villa, Myriam Roy, Giacomo Bergamini, Marc Gingras, Paola Ceroni
Hexakis(phenylthio)benzene compounds carrying six carboxylic acid groups at their periphery combine aggregation-induced phosphorescence, water-solubility and metal-binding properties: the para-isomer is a selective and sensitive turn-on phosphorescent sensor of Pb2+ ions in water.
February 20, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Jörg Rinklebe, Vasileios Antoniadis, Sabry M Shaheen, Oliver Rosche, Manfred Altermann
Floodplain soils across Central Elbe River (CER), Germany, vary considerably in potentially toxic element (PTE) content. However, there has never been a comprehensive study that links PTE levels with human health risk for children and adults. Our objective was to determine the contamination of 13 PTEs in 94 soil profiles along CER and assess the associated health risk via diverse indices for adults and children. Of 94 soil profiles, we measured soil properties and total content of arsenic, barium, chromium, copper, nickel, lead, rubidium, tin, strontium, vanadium, zinc, and zirconium using x-ray fluorescence spectrometer (XRF)...
February 18, 2019: Environment International
Enfeng Liu, Xiaoyu Wang, Huiji Liu, Mengyao Liang, Yuxin Zhu, Zijun Li
Pollution of potentially toxic metals (PTMs) in road dust (RD) is becoming an important threat to the urban environmental quality and human health. The chemical speciation of PTMs is an important index charactering the risks, which may also closely relate to the pollution level and source but it was poorly understood. In this study, the chemical speciation of Cd, Cr, Cu, Ni, Pb and Zn in the RD of a megacity (Nanjing), China was determined following an optimized BCR (proposed by the European Community Bureau of Reference) sequential extraction procedure to assess their pollution and potential eco-risk and to explore the variations of metal chemical speciation with the pollution levels and sources...
February 20, 2019: Ecotoxicology and Environmental Safety
Mingming Zhang, Pei He, Guo Qiao, Jintian Huang, Xiutang Yuan, Qiang Li
This study investigated heavy metals (Ni, Zn, Cr, Cu, As, Pb, Cd and Hg) concentrations in surface sediment of Subei Shoal, China, to illustrate their spatial distribution characteristics, sources and potential ecological risk of pollution. Contents of total organic carbon (TOC), clay, silt and sand were 1.7 ± 0.8%, 3.3 ± 3.2%, 13.6 ± 14.2% and 83.1 ± 17.4%, respectively. The spatial distribution of TOC, clay and silt were similar; however, distribution of Hg was inverse. Concentrations of Ni, Zn, Cr, Cu, As, Pb, Cd and Hg were 47...
February 13, 2019: Chemosphere
Mingming Wang, Liangsuo Ren, Dayang Wang, Zuansi Cai, Xuefeng Xia, Aizhong Ding
Because of its high adsorption capacity, biochar has been used to stabilize metals when remediating contaminated soils; to date, however, it has seldom been used to remediate contaminated sediment. A biochar was used as a stabilization agent to remediate Cu- and Pb-contaminated sediments, collected from three locations in or close to Beijing. The sediments were mixed with a palm sawdust gasified biochar at a range of weight ratios (2.5%, 5%, and 10%) and incubated for 10, 30, or 60 days. The performance of the different treatments and the heavy metal fractions in the sediments were assessed using four extraction methods, including diffusive gradients in thin films, the porewater concentration, a sequential extraction, and the toxicity characteristic leaching procedure...
May 2019: Journal of Environmental Sciences (China)
Manjun Zhao, Ningning Duan, Yi Wang, Hongli Zhu, Hong Liu, Huaquan Wang, Limin Xing, Zonghong Shao
OBJECTIVE: To investigate the quantity and secretion function of cytokines-secreted CD5+ B lymphocytes in Autoimmune Haemolytic Anaemia (AIHA)/Evans syndrome (ES) patients. METHODS: Twenty-five untreated AIHA/ES patients, 28 remission AIHA/ES patients and 25 healthy controls (HCs) were enrolled in this study. The quantity of CD5+ B lymphocytes which produce interleukin-10 (IL-10) (CD5+ IL-10+ ) and transforming growth factor (TGF-β1) (CD5+ TGF-β1+ ) were detected by flow cytometry (FCM)...
February 20, 2019: Autoimmunity
Naman Dogra, Manik Sharma, Anket Sharma, Ali Keshavarzi, Minakshi, Renu Bhardwaj, Ashwani Kumar Thukral, Vinod Kumar
The present work studied the pH, organic carbon, phosphorus (P), calcium (Ca), magnesium (Mg), and heavy metals Cu, Cr, Co and Pb in roadside agricultural soils of Jalandhar environs of Punjab, India. A total of 120 samples in triplicates were collected from different sites for assessment of heavy metal pollution. The mean values of Cu, Cr, Co and Pb were found below the permissible limits of Indian and Swedish soil limits. Principal component analysis (PCA) showed that heavy metals have different sources of origin...
February 20, 2019: International Journal of Environmental Health Research
Ebrahem M Eid, Kamal H Shaltout, Farahat S Moghanm, Mohamed S G Youssef, Eithar El-Mohsnawy, Soliman A Haroun
The current research was carried out to estimate the potential of water hyacinth (WH) for removal of nine heavy metals (HMs) from three irrigation canals in Nile Delta. Sampling was achieved in monospecific and homogeneous WH stands at three irrigation canals in the study area, and WH biomass was sampled at monthly intervals from April 2014 to November 2014 using five randomly distributed quadrats (each 0.5 × 0.5 m) at each canal. All HM concentrations were significantly higher in the roots compared with the other WH organs...
February 20, 2019: International Journal of Phytoremediation
Benjamin W Redan, Joseph E Jablonski, Catherine Halverson, James Jaganathan, Md Abdul Mabud, Lauren S Jackson
Filtration methods for alcoholic fermented beverages often use filter aids such as diatomaceous earth (DE), which may contain elevated amounts of the heavy metals arsenic (As), lead (Pb), and cadmium (Cd). Here, we evaluated factors affecting transfer of these heavy metals from DE to beer and wine. A laboratory-scale filtration system was used to process unfiltered ale, lager, red wine, and white wine with three types of food-grade DE. Filtrate and DE were analyzed for heavy metals using ICP-MS, in addition to LC-ICP-MS for As-speciation analysis...
February 20, 2019: Journal of Agricultural and Food Chemistry
Hong Yang, Yanling Hu, Xiaoyu Wang, Weng Fu, Huijuan Tian, Easar Alam
Removal of the heavy metal ions in aqueous solution is an important technology for waste water treatment. The effects of using ultrasonic and microwave on synthesizing Pb2+ , Zn2+ , and Cu2+ imprinted mesoporous adsorbents (Pb-IMA-UM, Zn-IMA-UM, and Cu-IMA-UM) and their dynamic adsorption properties were studied. The microstructure and composition of the ion-imprinted mesoporous adsorbents were discussed in detail by TEM, FTIR, N2 adsorption-desorption, XRD, and EDS. The pore sizes of mesoporous absorbents were improved more uniformly by using ultrasonic agitation than magnetic stirring...
February 20, 2019: Environmental Science and Pollution Research International
Maria Paches, Remedios Martínez-Guijarro, Daniel Aguado, Jose Ferrer
A comprehensive study was carried out to evaluate the occurrence, significance of concentrations and spatial distribution of heavy metals (Cr, Cd, Ni, Cu, Pb, Hg, Zn and As) in sediments along the Valencia coastline (Spain). The sampling campaign covered 476 km of the coastline in a 4-year period. The highest concentrations of metals in the sediments were mainly Cr, Ni, Zn and Cd (up to 28.93 mg Cr kg-1 dw, 15.80 mg Ni kg-1 dw, 57.13 mg Zn kg-1 dw and 0.293 mg Cd kg-1 dw), obtained in the northern areas, some central areas and in an isolated area on the southern coastline...
February 19, 2019: Environmental Science and Pollution Research International
Ekabal Siddiqui, Jitendra Pandey
We investigated eight heavy metals (Cr, Cd, Cu, Ni, Pb, Zn, Mn, and Fe) in water and bed sediment at 9 study sites along with 2320 km stretch of the Ganga River. Principal component analysis (PCA) and indices such as geo-accumulation index (Igeo ), contamination factor (CF), enrichment factor (EF), pollution indices, and sediment quality guidelines were used to assess source apportionment and magnitude of contamination. Concentrations of Cr, Cd, Pb, Ni, Cu, and Fe in water have exceeded their respective standards in the middle and lower reaches of the river...
February 19, 2019: Environmental Science and Pollution Research International
Tian-Tian Zuo, Yao-Lei Li, Huai-Zhen He, Hong-Yu Jin, Lei Zhang, Lei Sun, Fei Gao, Qi Wang, Yuan-Jun Shen, Shuang-Cheng Ma, Lang-Chong He
Little is known about the extent of heavy metal accumulation in traditional Chinese medicines (TCMs). In this study, the levels of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) in traditional animal medicines were monitored using inductively coupled plasma mass spectroscopy (ICP-MS). Additionally, for the first time, a heavy metal risk assessment strategy was used to evaluate the potential risks of traditional animal medicines by calculating estimated daily intake (EDI), target hazard quotient (THQ), and cancer risk (CR)...
February 19, 2019: Environmental Monitoring and Assessment
Fabio Forghieri, Giovanni Riva, Ivana Lagreca, Patrizia Barozzi, Daniela Vallerini, Monica Morselli, Ambra Paolini, Paola Bresciani, Elisabetta Colaci, Monica Maccaferri, Andrea Gilioli, Vincenzo Nasillo, Andrea Messerotti, Valeria Pioli, Laura Arletti, Davide Giusti, Francesca Bettelli, Melania Celli, Francesca Donatelli, Giorgia Corradini, Sabrina Basso, Antonella Gurrado, Monica Cellini, Tommaso Trenti, Roberto Marasca, Franco Narni, Maria Paola Martelli, Brunangelo Falini, Leonardo Potenza, Mario Luppi, Patrizia Comoli
Nucleophosmin(NPM1)-mutated protein, a leukemia-specific antigen, represents an ideal target for AML immunotherapy. We investigated the dynamics of NPM1-mutated-specific T cells on PB and BM samples, collected from 31 adult NPM1 -mutated AML patients throughout the disease course, and stimulated with mixtures of 18 short and long peptides (9-18mers), deriving from the complete C-terminal of the NPM1-mutated protein. Two 9-mer peptides, namely LAVEEVSLR and AVEEVSLRK (13.9-14.9), were identified as the most immunogenic epitopes...
January 25, 2019: Oncotarget
Rob Cook, Vaughan Thomas, Rosie Martin
The studyHome treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluationEchevarria C, Gray J, Hartley T, Miller J, Simpson AJ, Gibson GJ, Bourke SCPublished on 24 April 2018 Thorax 2018;73:713-22This project was funded by the National Institute for Health Research-Research for Patient Benefit Programme (project number PB-PG-0213-30105).To read the full NIHR Signal, go to:
February 19, 2019: BMJ: British Medical Journal
Pascal Duenk, Mario P L Calus, Yvonne C J Wientjes, Vivian P Breen, John M Henshall, Rachel Hawken, Piter Bijma
BACKGROUND: In pig and poultry breeding programs, the breeding goal is to improve crossbred (CB) performance, whereas selection in the purebred (PB) lines is often based on PB performance. Thus, response to selection may be suboptimal, because the genetic correlation between PB and CB performance ([Formula: see text]) is generally lower than 1. Accurate estimates of the [Formula: see text] are needed, so that breeders can decide if they should collect data from CB animals. [Formula: see text] can be estimated either from pedigree or genomic relationships, which may produce different results...
February 19, 2019: Genetics, Selection, Evolution: GSE
Kevin Honeychurch
Carbon rod electrodes (CREs) were obtained from recycled zinc⁻carbon batteries and were used without further modification for the measurement of trace concentrations of lead (Pb). The electrochemical behavior of Pb at these electrodes in a variety of supporting electrolytes was investigated by cyclic voltammetry. The anodic peaks obtained on the reverse scans were indicative of Pb being deposited as a thin layer on the electrode surface. The greatest signal⁻to⁻noise ratios were obtained in organic acids compared to mineral acids, and acetic acid was selected as the supporting electrolyte for further studies...
February 13, 2019: Sensors
Xiaoyao Ma, Zhenghui Xiao, Lizhi He, Zongbo Shi, Yunjiang Cao, Zhe Tian, Tuan Vu, Jisong Liu
Xiangtan, South China, is characterized by year-round high relative humidity and very low wind speeds. To assess levels of PM2.5 , daily samples were collected from 2016 to 2017 at two urban sites. The mass concentrations of PM2.5 were in the range of 30⁻217 µg/m³, with the highest concentrations in winter and the lowest in spring. Major water-soluble ions (WSIIs) and total carbon (TC) accounted for 58⁻59% and 21⁻24% of the PM2.5 mass, respectively. Secondary inorganic ions (SO₄2- , NO₃- , and NH₄⁺) dominated the WSIIs and accounted for 73% and 74% at the two sites...
February 13, 2019: International Journal of Environmental Research and Public Health
Salim Lamine, George P Petropoulos, Paul A Brewer, Nour-El-Islam Bachari, Prashant K Srivastava, Kiril Manevski, Chariton Kalaitzidis, Mark G Macklin
Technological advances in hyperspectral remote sensing have been widely applied in heavy metal soil contamination studies, as they are able to provide assessments in a rapid and cost-effective way. The present work investigates the potential role of combining field and laboratory spectroradiometry with geochemical data of lead (Pb), zinc (Zn), copper (Cu) and cadmium (Cd) in quantifying and modelling heavy metal soil contamination (HMSC) for a floodplain site located in Wales, United Kingdom. The study objectives were to: (i) collect field- and lab-based spectra from contaminated soils by using ASD FieldSpec® 3, where the spectrum varies between 350 and 2500 nm; (ii) build field- and lab-based spectral libraries; (iii) conduct geochemical analyses of Pb, Zn, Cu and Cd using atomic absorption spectrometer; (iv) identify the specific spectral regions associated to the modelling of HMSC; and (v) develop and validate heavy metal prediction models (HMPM) for the aforementioned contaminants, by considering their spectral features and concentrations in the soil...
February 13, 2019: Sensors
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