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Chanjuan Liu, Changping Ruan, Rui Shi, Bang-Ping Jiang, Shichen Ji, Xing-Can Shen
Indocyanine green (ICG), a multifunctional near-infrared (NIR) imaging agent approved by the FDA, has been extensively used in clinical cancer theranosis, but limited by its inherent instability, short plasma half-life and lack of targeting ability. Herein, an in situ formed photothermal network based thermosensitive hydrogel (PNT-gel) constructed by using supramolecular cross-linking conjugated polymers was developed for the stabilization of ICG and efficient combinatorial photothermal/photodynamic antitumor therapy...
February 13, 2019: Biomaterials Science
Guangxu Lan, Kaiyuan Ni, Wenbin Lin
Phototherapy involves the irradiation of tissues with light, and is commonly implemented in the forms of photodynamic therapy (PDT) and photothermal therapy (PTT). Photosensitizers (PSs) are often needed to improve the efficacy and selectivity of phototherapy via enhanced singlet oxygen generation in PDT and photothermal responses in PTT. In both cases, efficient and selective delivery of PSs to the diseased tissues is of paramount importance. Nanoscale metal-organic frameworks (nMOFs), a new class of hybrid materials built from metal connecting points and bridging ligands, have been examined as nanocarriers for drug delivery due to their compositional and structural tunability, highly porous structures, and good biocompatibility...
January 15, 2019: Coordination Chemistry Reviews
Xiaocheng Wang, Bing Ma, Jianmin Xue, Jinfu Wu, Jiang Chang, Chengtie Wu
Current challenges in cutaneous tumor therapy are healing the skin wounds resulted from surgical resection and eliminating possible residual tumor cells to prevent recurrence. To address this issue, bifunctional biomaterials equipped with effective tumor therapeutic capacity for skin cancers and simultaneous tissue regenerative ability for wound closure are highly recommended. Herein, we report an injectable thermosensitive hydrogel (named as BT-CTS thermogel) by integration of nano-sized black titania (B-TiO2-x, ~ 50 nm) nanoparticles into a chitosan (CTS) matrix...
February 5, 2019: Nano Letters
Cheng Zhang, Wen-Long Liu, Xue-Feng Bai, Si-Xue Cheng, Zhen-Lin Zhong, Xian-Zheng Zhang
Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatform based on carbon sphere dotted with cerium oxide and coated by cell membrane (MCSCe) was designed and synthesized with good biocompatibility, homologous targeting ability, and improved photophysical activity...
January 31, 2019: Biomaterials
Jianhua Zou, Peng Wang, Ya Wang, Gongyuan Liu, Yewei Zhang, Qi Zhang, Jinjun Shao, Weili Si, Wei Huang, Xiaochen Dong
Improving the deep-tissue phototherapy (PDT) efficiency in the near-infrared (NIR) region has become one of the major challenges in clinics for cancer treatment. Developing intelligent photosensitizers (PSs) responding to tumor-specific signals sensitively to minimize side effects is another major challenge for tumor phototherapy. Herein, three phenyl-based boron dipyrromethene (BODIPY) compounds with different numbers of diethylaminophenyl groups introduced onto the BODIPY core have been designed and synthesized by the Knoevenagel condensation reaction...
January 7, 2019: Chemical Science
Xianlei Li, Xuan Wang, Caiyan Zhao, Leihou Shao, Jianqing Lu, Yujia Tong, Long Chen, Xinyue Cui, Huiling Sun, Junxing Liu, Mingjun Li, Xiongwei Deng, Yan Wu
BACKGROUND: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. RESULTS: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT)...
February 2, 2019: Journal of Nanobiotechnology
Bing Yu, Xuemei Wang, Zhongmin Geng, Hailin Cong, Youqing Shen
In recent years, semiconducting polymer nanoparticles (SPNs) have attracted considerable attention because of their outstanding characteristics such as higher light and thermal stability. It is widely used in the field of biomedicine such as photoacoustic (PA) imaging, photodynamic (PDT) and photothermal (PTT). Photoacoustic imaging, a novel imaging modality based on photoacoustic effect, shows great promise in biomedical applications. The SPNs which possess a strong optical absorbance in the visible and near-infrared (NIR) region, can be a promising candidate for in vivo PTT and PA imaging...
January 28, 2019: Chembiochem: a European Journal of Chemical Biology
Si-Han Chen, Wan-Wen Huang, Khalilalrahman Dehvari, Yong-Chien Ling, Anil V Ghule, Shen-Long Tsai, Jia-Yaw Chang
Photo-activated therapy is a non-invasive and promising medical technology for the treatment of cancers. Herein, we present Ce6-HA-CIS phototherapeutic nanohybrids composed of Cu-In-S (CIS) heterostructured nanorod (HS-rod), chlorin e6 (Ce6), and hyaluronic acid (HA) for the use in targeted photodynamic/photothermal therapy (PDT/PTT). In the Ce6-HA-CIS nanohybrids, the CIS HS-rod was investigated as a PTT agent to convert light into thermal energy, with Ce6 acting as a PDT agent to generate singlet oxygen (1 O2 )...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Shan Yang, Qing You, Lifang Yang, Peishan Li, Qianglan Lu, Siyu Wang, Fengping Tan, Yanhui Ji, Nan Li
Recently, rod-like nanomaterials with specific aspect ratio (AR) for efficient cellular uptake have received enormous attention. For functional nanomaterials, such as photothermal agents, large surface areas for their rod-shape exterior that increase the amount of light absorbed would lead to the higher absorption coefficient as well as drug loading property. In this project, we coated rod-like mesoporous silica with gold nanoshell (MSNR@Au hybrid), modifying with ultrasmall gadolinium (Gd) chelated supramolecular photosensitizers TPPS4 (MSNR@Au-TPPS4(Gd)), which could be applied to near-infrared fluorescence (NIRF) / multispectral optoacoustic tomography (MSOT) / computed tomography (CT) / magnetic resonance (MR) imaging and imaging guided remotely controlled PTT/PDT combined antitumor therapy...
January 22, 2019: ACS Applied Materials & Interfaces
Lihong Sun, Mengmeng Hou, Lei Zhang, Dongxiang Qian, Qingquan Yang, Zhigang Xu, Yuejun Kang, Peng Xue
Taking advantage of the mesoporous structure of bismuth sulfide nanostars (Bi2 S3 NSs), a chemotherapeutic drug of doxorubicin (DOX) and a photosensitizer of chlorin e6 (Ce6) were concurrently loaded in the PEGylated Bi2 S3 NSs to formulate a multifunctional nanocomplex (BPDC NSs) for tumor theranostics. BPDC NSs have excellent photothermal conversion efficiency and a capacity of yielding reactive oxygen species (ROS) upon laser irradiation, and can realize on-demand drug release by either pH-activation or thermal induction...
January 14, 2019: Nanomedicine: Nanotechnology, Biology, and Medicine
Peishan Li, Li Liu, Qianglan Lu, Shan Yang, Lifang Yang, Yu Cheng, Yidan Wang, Siyu Wang, Yilin Song, Fengping Tan, Nan Li
Recently, we developed ultrasmall molybdenum disulfide (MoS2) quantum dots for computed tomography (CT) and multispectral optoacoustic tomography (MSOT) image-guided phuotothermal therapy (PTT). But, due to the rapid body elimination and the limited blood circulation time, the tumor uptake of the dots is low. In our study, this problem was solved via designing an amino modified biodegradable nanomaterial based on MoS2 quantum dots doped disulfide-based SiO2 nanoparticles (denoted MoS2@ss-SiO2) for multimodal application...
January 17, 2019: ACS Applied Materials & Interfaces
Shan Sun, Jingqin Chen, Kai Jiang, Zhongdi Tang, Yuhui Wang, Zhongjun Li, Chengbo Liu, Aiguo Wu, Hengwei Lin
Photo-mediated cancer therapy, mainly including photothermal therapy (PTT) and photodynamic therapy (PDT), have received tremendous attention in recently years thanks to their noninvasive and stimuli-responsive features. The single mode of PTT or PDT, however, shows obvious drawbacks, either requiring high power laser irradiation to generate enough heat or only providing limited efficacy due to the hypoxia nature inside tumors. In addition, the reported synergistic PTT/PDT usually utilized two excitation sources to separately activate PTT and PDT, and the problem of high power laser irradiation for PTT was still not well solved...
January 16, 2019: ACS Applied Materials & Interfaces
Chuan Zhang, Yuzhuo Wang, Yue Zhao, Hou Liu, Yueqi Zhao, Xiangwei Li, Quan Lin
The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate)...
January 11, 2019: Nanomaterials
Meng Li, Ying Wang, Huiming Lin, Fengyu Qu
Here, hollow CuS nanocubes about 250-300 nm in size were synthesized based on the Kirkendall effect by using CuO nanocubeas precursor and template. The reactant concentration and reaction time could be adopted to adjust the final composition and hollow structure. The as-synthetic CuS nanocube was assembled by a great deal of nanoparticles (15-20 nm), making abundant porous structure in the shell layer. The localized surface plasmon resonance and the novel porous hollow structure (improve light reflex) further make sure the enhanced Near-infrared (NIR) light absorption as well as photothermal conversion efficiency (30...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Changwei Ji, Ahu Yuan, Liu Xu, Feifei Zhang, Shiwei Zhang, Xiaozhi Zhao, Guangxiang Liu, Wei Chen, Hongqian Guo
Prostate cancer is one of the leading causes of death in men worldwide. Photodynamic therapy (PDT) is a new emerging and promising strategy for the treatment of prostate cancer. PDT uses a combination of light and a photosensitizer (PS) to kill cancer cells. However, most photosensitizers (PS) accumulate in normal tissues, in particular the skin and eyes, and can be activated by sunlight, causing severe side effects such as prolonged skin photosensitivity that have limited the clinical application of PDT. Herein, a novel strategy is presented to overcome these limitations using Indocyanine green (ICG) as an activatable PDT agent...
February 1, 2019: Journal of Biomedical Nanotechnology
Jooran Lee, Young Hwa Lee, Chan Bae Jeong, Joon Sig Choi, Ki Soo Chang, Minjoong Yoon
BACKGROUND: Recently, a combination of photodynamic therapy (PDT) and photothermal therapy (PTT) to generate reactive oxygen species (ROS) and heat to kill cancer cells, respectively has attracted considerable attention because it gives synergistic effects on the cancer treatment by utilizing the radiation of nontoxic low-energy photons such as long wavelength visible light and near IR (NIR) penetrating into subcutaneous region. For the effective combination of the phototherapies, various organic photosensitizer-conjugated gold nanocomplexes have been developed, but they have still some disadvantages due to photobleaching and unnecessary energy transfer of the organic photosensitizers...
December 20, 2018: Journal of Nanobiotechnology
Srivani Veeranarayanan, M Sheikh Mohamed, Aby Cheruvathoor Poulose, Masuko Rinya, Yasushi Sakamoto, Toru Maekawa, D Sakthi Kumar
Materials with efficient potential in imaging as well as therapy are gaining particular attention in current medical research. Photodynamic therapy (PDT) has been recently recognized as a promising treatment option for solid tumors. Still, most of the nanomaterial-based PDT modules either employ an additional photosensitizer or require high power laser sources. Also, they suffer from a lack of responsiveness in the near-infrared (NIR) region. Nanomaterials that could realize PDT independently (without any photosensitizer), at safe laser dose and in the deep tissue penetrative NIR region would definitely be better solid tumor treatment options...
2018: Theranostics
Lei Liu, Hong-Jun Xie, Li-Min Mu, Rui Liu, Zhan-Bo Su, Yi-Nuo Cui, Ying Xie, Wan-Liang Lu
Background: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. Methods: Functional chlorin gold nanorods (Ce6-AuNR@SiO2 -d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO2 as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP)...
2018: International Journal of Nanomedicine
Ya Wang, Xiaoyu Huang, Yunyun Tang, Jianhua Zou, Peng Wang, Yewei Zhang, Weili Si, Wei Huang, Xiaochen Dong
Emerging treatment approaches, such as gas therapy (GT), photodynamic therapy (PDT) and photothermal therapy (PTT), have received widespread attention. The development of an intelligent multifunctional nano-platform responding to tumor microenvironments for multimodal therapy is highly desirable. Herein, a near-infrared (NIR) light-responsive nitric oxide (NO) photodonor (4-nitro-3-trifluoromethylaniline, NF) and a pH-sensitive group (dimethylaminophenyl) have been introduced into a diketopyrrolopyrrole core (denoted as DPP-NF)...
November 14, 2018: Chemical Science
Bo Huang, Lei Tan, Xiangmei Liu, Jun Li, Shuilin Wu
Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment in vivo . Thus, the development of novel implant materials is quite urgent. Red phosphorus has great biocompatibility and exhibits efficient photothermal ability. Herein, a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine (RGDC) coating on titanium bone-implant was prepared...
March 2019: Bioactive Materials
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