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808 nm

Qing Cao, Xin Guo, Wenlong Zhang, Guoqiang Guan, Xiaojuan Huang, Shu-Ang He, Mingdong Xu, Rujia Zou, Xinwu Lu, Junqing Hu
Although various photothermal therapy (PTT) nanoagents have been developed in recent years, the rational design and easy synthesis of a PTT nanoplatform with improved near-infrared (NIR) absorption have remained challenging. Herein, via a facile one-pot solvothermal strategy, hydrophilic nanosheet-assembled flower-like Fe7S8/Bi2S3 superstructures were fabricated successfully. Such nanoflowers exhibit improved NIR absorption, which is 1.54 times higher than that of pure Bi2S3 nanosheets at a wavelength of 808 nm...
February 20, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Xiao Zhang, Jiangfeng Du, Zhao Guo, Jie Yu, Qin Gao, Wenyan Yin, Shuang Zhu, Zhanjun Gu, Yuliang Zhao
Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2 S3 ) nanoparticles and bis- N -nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola do Amaral, Maira Felonato, Thiago Antônio Moretti de Andrade, Gláucia Maria Tech Dos Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton Santamaria, Fernanda Aparecida Sampaio Mendonça
OBJECTIVES: Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT). MATERIAL AND METHODS: One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated...
February 15, 2019: Clinical Oral Investigations
Jing Liu, Fenfen Zhai, Hong Zhou, Wenrong Yang, Shusheng Zhang
Chemo-photothermal therapy has become a promising tool for clinical noninvasive tumor therapy, which is able to efficiently avoid drug resistance and other side effects from chemical anticarcinogenic drugs. The ability to selectively fast-heat tumor tissues over surrounding compartments is of fundamental importance and makes effective treatment of tumor margins and complex tumor geometries. Currently existing chemo-photothermal methods mainly show slow light-to-heat conversion with increased temperature up to around 45-57 °C for 5-20 min or a longer time in vitro under regular near-infrared laser irradiation, and during tumor therapy, worse performance in temperature changes are obtained due to the much longer penetration distance in vivo...
February 15, 2019: Advanced Healthcare Materials
Chanjuan Liu, Changping Ruan, Rui Shi, Bang-Ping Jiang, Shichen Ji, Xing-Can Shen
Indocyanine green (ICG), a multifunctional near-infrared (NIR) imaging agent approved by the FDA, has been extensively used in clinical cancer theranosis, but limited by its inherent instability, short plasma half-life and lack of targeting ability. Herein, an in situ formed photothermal network based thermosensitive hydrogel (PNT-gel) constructed by using supramolecular cross-linking conjugated polymers was developed for the stabilization of ICG and efficient combinatorial photothermal/photodynamic antitumor therapy...
February 13, 2019: Biomaterials Science
Man Yang, Han Wang, Zhaohui Wang, Zhihao Han, Yueqing Gu
The efficacy of photodynamic therapy (PDT) was greatly hindered by the use of a 980 nm laser with undesired overheating effects as well as low reactive oxygen species (ROS) yields. Herein, we address these problems using a dual-photosensitizer (PS) loaded upconversion nanoparticle (UCNP) system. In detail, the NaYF4:Yb/Er/Nd@NaYF4:Nd core-shell UCNP system was designed to exhibit 808 nm laser excitation ability to avoid unfavorable thermal effects. More importantly, the co-encapsulation of dual PS, in terms of merocyanine 540 (MC540) and zinc phthalocyanine (ZnPc), could be respectively triggered by the dual emissions of UCNPs, which could generate sufficient ROS with improved efficiency...
February 11, 2019: Biomaterials Science
Iuliia Golovynska, Sergii Golovynskyi, Yurii V Stepanov, Liudmyla V Garmanchuk, Ludmila I Stepanova, Junle Qu, Tymish Y Ohulchanskyy
Red and near-infrared (NIR) light effect on Ca2+ ions flux through the influence on N-methyl-D-aspartate receptors (NMDARs) and their functioning in HeLa cells was studied in vitro. Cells were irradiated by 650 and 808 nm laser light at different power densities and doses and the obtained effect was compared with that caused by the pharmacological agents. The laser light was found to elevate Ca2+ influx into cell cytoplasm in a dose-dependent manner without changes of the NMDAR functioning. Furthermore, the light of both wavelengths demonstrated the ability to elevate Ca2+ influx under the pharmacological blockade of NMDARs and also might partially abolish the blockade enhancing Ca2+ influx after selective stimulation of the receptors with NMDA...
February 11, 2019: Journal of Cellular Physiology
Cheng Zhang, Wen-Long Liu, Xue-Feng Bai, Si-Xue Cheng, Zhen-Lin Zhong, Xian-Zheng Zhang
Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatform based on carbon sphere dotted with cerium oxide and coated by cell membrane (MCSCe) was designed and synthesized with good biocompatibility, homologous targeting ability, and improved photophysical activity...
January 31, 2019: Biomaterials
Shuyue Ren, Qiaofeng Li, Ye Li, Shuang Li, Tie Han, Jiang Wang, Yuan Peng, Jialei Bai, Baoan Ning, Zhixian Gao
This study describes an upconversion fluorescent aptasensor based on black phosphorus nanohybrids and self-assembled DNA tetrahedrons dual-amplification strategy for rapid detection of the environmental estrogens bisphenol A (BPA) and 17β-estradiol (E2). Tetrahedron complementary DNAs (T-cDNAs) were self-assembled in an oriented fashion on a 2D nanohybrid composed of black phosphorus (BP) and gold to give a materials of architecture BP-Au@T-cDNAs. In parallel, core-shell upconversion nanoparticles were modified with aptamers (UCNPs@apts) and used as capture probes...
February 2, 2019: Mikrochimica Acta
Xianlei Li, Xuan Wang, Caiyan Zhao, Leihou Shao, Jianqing Lu, Yujia Tong, Long Chen, Xinyue Cui, Huiling Sun, Junxing Liu, Mingjun Li, Xiongwei Deng, Yan Wu
BACKGROUND: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. RESULTS: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT)...
February 2, 2019: Journal of Nanobiotechnology
Lile Dong, Peng Zhang, Xiangjian Liu, Ruiping Deng, Kaimin Du, Jing Feng, Hongjie Zhang
Recent development of precise nanomedicine has aroused overwhelming interest in integration of diagnosis and treatment for cancers. To design renal clearable and targeting nanoparticles (NPs) have specific cancer theranostics implications and it remains a challenging task. In this work, the ultrasmall folic acid and bovine serum albumin modified Bi-Bi2S3 heterostructure nanoparticles (Bi-Bi2S3/BSA&FA NPs) with excellent CT and photoacoustic imaging abilities and outstanding photothermal performance were synthesized in aqueous phase via a simple method...
January 30, 2019: ACS Applied Materials & Interfaces
Huan-Huan Wang, Zhi-Guang Fu, Wei Li, Yun-Xia Li, Li-Sheng Zhao, Li Wen, Jian-Jun Zhang, Ning Wen
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies, with high rates of mortality and morbidity worldwide. Owing to the special anatomical location of this tumor, an effective, minimally invasive treatment with low systemic toxicity is highly desirable. Hydrogels have shown great potential for tumor-targeting therapy, with excellent performance. However, there have been few reports on co-loading photosensitizers and chemotherapeutic drugs into hydrogels...
2019: International Journal of Nanomedicine
Xianmei Zou, Xiaobo Zhou, Cong Cao, Wenyi Lu, Wei Yuan, Qingyun Liu, Wei Feng, Fuyou Li
Ratiometric fluorescent sensors, which can provide a built-in correction for environmental effects, have attracted significant attention for analytical sensing and optical imaging with the potential to provide a precise and quantitative analysis. Herein, we report a strategy based on dye-sensitized upconversion for the design of dual-excitation upconverion ratiometric probes possessing same emission peaks under a large separation in the excitation spectra (980 nm and 808 nm). Specifically, effective enhancement of upconversion luminescence could be attributed to Cy787 dyes present on the surface of nanoparticles, and it subsequently decreased upon the addition of ClO- under an 808 nm irradiation, whereas the signal under 980 nm excitation remained essentially constant, thus allowing for quantitative ratiometric monitoring of ClO-...
January 29, 2019: Nanoscale
Hua Shi, Yidan Sun, Runqi Yan, Shunli Liu, Li Zhu, Song Liu, Yuzhang Feng, Peng Wang, Jian He, Zhengyang Zhou, Deju Ye
Targeted delivery of enzyme-activatable probes into cancer cells to facilitate accurate imaging and on-demand photothermal therapy (PTT) of cancers with high spatiotemporal precision promises to advance cancer diagnosis and therapy. Here, we report a tumor-targeted and matrix metalloprotease-2 (MMP-2)-activatable nanoprobe (T-MAN) formed by covalent modification of Gd-doping CuS micellar nanoparticles with cRGD and an MMP-2-cleavable fluorescent substrate. T-MAN displays a high r1 relaxivity (~60.0 mM-1s-1 per Gd3+ at 1 T) and a large near-infrared (NIR) fluorescence turn-on ratio (~185-fold) in response to MMP-2, allowing high-spatial-resolution magnetic resonance imaging (MRI) and low-background fluorescence imaging of gastric tumors as well as lymph node (LN) metastasis in living mice...
January 28, 2019: Nano Letters
M Gorgizadeh, N Azarpira, R Dehdari Veis, N Sattarahmady
Nanosized carbonaceous materials are favorable in biomedicine applications including photothermal therapy (PTT) of cancer. Since conventional strategies of cancer treatment have not responded to this serious disease, development of efficient alternative and promising strategies is highly desirable. In this study, carbon xerogel nanoparticles (CX-NPs) were synthesized as a novel photothermal nanomaterial and activated upon laser light of 808-nm wavelength for cancer phototherapy application. The synthesized CX-NPs had a spherical shape with a size of about 16 nm that showed nice photothermal conversion ability...
January 17, 2019: Colloids and Surfaces. B, Biointerfaces
Yanxiao Ao, Kanghua Zeng, Bin Yu, Yu Miao, Wesley Hung, Zhongzheng Yu, Yanhong Xue, Timothy Thatt Yang Tan, Tao Xu, Mei Zhen, Xiangliang Yang, Yan Zhang, Shangbang Gao
Near-infrared (NIR) light penetrates tissue deeply, but its application to motor behavior stimulation has been limited by the lack of known genetic NIR light-responsive sensors. We designed and synthesized a Yb3+/Er3+/Ca2+-based lanthanide-doped upconversion nanoparticle (UCNP) that effectively converts 808 nm NIR light to green light emission. This UCNP is compatible with Chrimson, a cation channel activated by green light; as such, it can be used in the optogenetic manipulation of the motor behaviors of C...
January 25, 2019: ACS Nano
Shunko A Inada, Hayao Nakanishi, Masahiro Oda, Kensaku Mori, Akihiro Ito, Junichi Hasegawa, Kazunari Misawa, Shingo Fuchi
Laparoscopic surgery is now a standard treatment for gastric cancer. Currently, the location of the gastric cancer is identified during laparoscopic surgery via the preoperative endoscopic injection of charcoal ink around the primary tumor; however, the wide spread of injected charcoal ink can make it difficult to accurately visualize the specific site of the tumor. To precisely identify the locations of gastric tumors, we developed a fluorescent detection system comprising clips with glass phosphor (Yb3+ , Nd3+ doped to Bi₂O₃-B₂O₃-based glasses, size: 2 mm × 1 mm × 3 mm) fixed in the stomach and a laparoscopic fluorescent detection system for clip-derived near-infrared (NIR) light (976 nm)...
January 24, 2019: Micromachines
Yanlin Feng, Yun Chang, Xiujuan Sun, Yan Cheng, Runxiao Zheng, Xiaqing Wu, Li Wang, Xiaomin Ma, Xi Li, Haiyuan Zhang
Various gold (Au) nanostructures have shown promising near infrared (NIR) light-activated phototherapeutic effects; however, their reported photothermal or photodynamic performance behavior is usually inconsistent or even conflicted, dramatically limiting the improvement of phototherapeutic Au nanostructures. The potential reason for this uncertainty is mainly because the photoactivities of Au nanostructures are not evaluated under identical energy conditions. Herein, three Au nanostructures, Au nanorods (NRs), nanoshells (NSs), and nanocages (NCs), were prepared to provide the same localized surface plasmon resonance (LSPR) peaks at 808 nm...
January 22, 2019: Biomaterials Science
Mengxue Ma, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Yanqin Liang, Zhaoyang Li, Yufeng Zheng, Kelvin Wai Kwok Yeung, Shuilin Wu
Implant materials are prone to bacterial infections and cause serious consequences, while traditional antibiotic therapy has a long treatment cycle and even causes bacterial resistance. In this work, a photothermal therapy (PTT) assisted drug release system has been developed on the implant surface for in situ rapid disinfection under 808 nm light irradiation within a short time, in which gentamicin (Gent) is loaded by polyethylene glycol (PEG) modified molybdenum disulfide (MoS2) on Ti surface, and then encapsulated with chitosan (CS) (CS/Gent/PEG/MoS2-Ti)...
January 22, 2019: Biomaterials Science
Luodan Yang, Yan Dong, Chongyun Wu, Yong Li, Yichen Guo, Baocheng Yang, Xuemei Zong, Michael R Hamblin, Timon Cheng-Yi Liu, Quanguang Zhang
Neonatal hypoxia-ischemia (HI) injury caused by oxygen deprivation is the most common cause of mortality and severe neurologic deficits in neonates. The present work evaluated the preventative effect of photobiomodulation (PBM) preconditioning, and its underlying mechanism of action on brain damage in a HI model in neonatal rats. According to the optimal time response of ATP levels in brain samples removed from normal rats, a PBM preconditioning regimen (808 nm CW laser, 1 cm2 spot, 100 mW/cm2 , 12 J/cm2 ) was delivered to the scalp 6 hours before HI...
January 16, 2019: Journal of Biophotonics
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