keyword
https://read.qxmd.com/read/38546726/implementation-of-cyp2c19-and-cyp2d6-genotyping-to-guide-antidepressant-use-in-a-large-rural-health-system
#1
JOURNAL ARTICLE
Natasha J Petry, Joel Van Heukelom, April J Schultz, Kristen Jacobsen, Jordan F Baye, Sarah Mills, Debbie Figueroa, Amanda Massmann
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: We describe the implementation and ongoing maintenance of CYP2C19 and CYP2D6 focused pharmacogenetic (PGx) testing to guide antidepressant and antianxiety medication prescriptions in a large rural, nonprofit health system...
March 28, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38546453/top-ten-tips-palliative-care-clinicians-should-know-about-attending-to-the-existential-experience
#2
JOURNAL ARTICLE
Elise C Tarbi, Caitlyn M Moore, Cara L Wallace, Yvan Beaussant, Elizabeth G Broden, Danielle Chammas, Paul Galchutt, Danielle Gilchrist, Adam Hayden, Brianna Morgan, Leah B Rosenberg, Zachary Sager, Sheldon Solomon, William E Rosa, Harvey Max Chochinov
Identifying and attending to the existential needs of persons with serious illness and their care partners are integral to whole-person palliative care (PC). Yet, many PC clinicians, due to individual factors and wider systemic barriers, are ill-prepared and under-resourced to navigate the existential dimension. In this article, written from clinical, research, and lived experiences, we offer tips to empower PC clinicians to understand, recognize, and respond to patients' and care partners' existential experiences by leveraging their existing skills, collaborating closely with colleagues, exploring their own existential experience, and implementing evidence-based interventions...
March 28, 2024: Journal of Palliative Medicine
https://read.qxmd.com/read/38546448/series-public-engagement-with-research-part-3-sharing-power-and-building-trust-through-partnering-with-communities-in-primary-care-research
#3
JOURNAL ARTICLE
Jessica Drinkwater, Michelle Farr, Gary Hickey, Esther Van Vliet, Sophie Söderholm Werkö, Ingrid Klingmann, Steven Blackburn
BACKGROUND: This article focuses on potential strategies to support primary care researchers in working in partnership with the public and healthcare professionals. Partnership working can potentially to improve the relevance and usefulness of research and ensure better research and health outcomes. DISCUSSION: We describe what we mean by partnership working and the importance of reflecting on power and building trusting relationships. To share power in partnership working, it is essential to critically reflect on the multiple dimensions of power, their manifestations, and your own power...
December 2024: European Journal of General Practice
https://read.qxmd.com/read/38541897/sociodemographic-and-medical-characteristics-of-women-applied-for-emergency-contraception-a-retrospective-observational-study
#4
JOURNAL ARTICLE
Richárd Tóth, Lotti Lőczi, Marianna Török, Attila Keszthelyi, Gergő Leipold, Nándor Ács, Szabolcs Várbíró, Márton Keszthelyi, Balázs Lintner
Background : Lifestyle factors significantly impact overall health. Our aim was to assess reproductive health awareness among patients who applied for emergency contraceptive pills. Methods : This present retrospective observational study between July 2021 and September 2021 is embedded in the MEEC (Motivation and Epidemiology of Emergency Contraceptive Pill) based on the study cohort of a Hungarian data bank containing follow-up data of 447 women who applied for EC telemedicine consultation. Collected data: age, history of previous pregnancy, lifestyle factors like smoking, alcohol consumption, sexual characteristics: partner consistency and protection during intercourse, cervical cancer screening within the past 2 years, previous HPV screening, and the preference for future contraceptive methods...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38539462/multimodal-technology-assisted-intervention-for-the-management-of-menopause-after-cancer-improves-cancer-related-quality-of-life-results-from-the-menopause-after-cancer-mac-study
#5
JOURNAL ARTICLE
Fionán Donohoe, Yvonne O'Meara, Aidin Roberts, Louise Comerford, Ivaila Valcheva, Una Kearns, Marie Galligan, Michaela J Higgins, Alasdair L Henry, Catherine M Kelly, Janice M Walshe, Martha Hickey, Donal J Brennan
BACKGROUND: Vasomotor symptoms (VMSs) associated with menopause represent a significant challenge for many patients after cancer treatment, particularly if conventional menopausal hormone therapy (MHT) is contraindicated. METHODS: The Menopause after Cancer (MAC) Study (NCT04766229) was a single-arm phase II trial examining the impact of a composite intervention consisting of (1) the use of non-hormonal pharmacotherapy to manage VMS, (2) digital cognitive behavioral therapy for insomnia (dCBT-I) using Sleepio (Big Health), (3) self-management strategies for VMS delivered via the myPatientSpace mobile application and (4) nomination of an additional support person/partner on quality of life (QoL) in women with moderate-to-severe VMS after cancer...
March 12, 2024: Cancers
https://read.qxmd.com/read/38539187/benchmark-findings-from-a-veteran-electronic-patient-reported-outcomes-evaluation-from-a-chronic-pain-management-telehealth-program
#6
JOURNAL ARTICLE
Jolie N Haun, Christopher A Fowler, Bridget M Smith, Lishan Cao, Kevin T Stroupe, William A Lapcevic, Michael S Saenger, Rachel C Benzinger, Dustin D French
BACKGROUND: Chronic pain is a leading cause of disability and negatively impacts biological/physical, psychological, and social aspects of life resulting in significant pain interference or disability. This project was part of a longitudinal mixed-methods implementation evaluation of the TelePain-Empower Veterans Program (EVP), a non-pharmacological chronic pain intervention. The purpose of this quality management project was to examine electronic patient-reported outcome measures (ePROs) including primary pain-related (intensity, interference, catastrophizing, kinesiophobia) and secondary outcomes (physical, psychological, acceptance, social) to determine TelePain-EVP effectiveness...
March 28, 2024: BMC Health Services Research
https://read.qxmd.com/read/38539174/evaluation-of-a-peer-support-mentor-mother-program-in-gaza-mozambique-a-qualitative-study
#7
JOURNAL ARTICLE
Leila Katirayi, Sozinho Ndima, Amgad Farah, Whitney Ludwig, Atanásio Mabote, Ismail Chiposse, Ana Muteerwa, Jessica Greenberg Cowan, Ivete Meque
BACKGROUND: Retention in prevention of mother-to-child transmission of HIV programs is critical to reduce vertical transmission. To addresses challenges with retention, Mozambique launched a peer-support program in 2018, in which HIV-positive mothers provide adherence support as mentor mothers (MMs) for HIV-positive pregnant and lactating women and HIV-exposed and infected children. METHODS: A descriptive qualitative evaluation was conducted across nine facilities in Gaza Province to assess the acceptability and barriers to implementation of the mentor mother program (MMP) among those receiving services and providing services...
March 27, 2024: BMC Health Services Research
https://read.qxmd.com/read/38538813/new-technologies-developed-for-treatment-of-premature-ejaculation
#8
REVIEW
Arik Shechter, Ilan Gruenwald
Premature ejaculation (PE), lifelong and acquired, is the most common male sexual disorder, with serious impacts on the patient and his partner's quality of life, sexual well-being, and psychosocial health. The most popular treatment options are on-demand topical anesthetics and off-label daily or on-demand selective serotonin reuptake inhibitors (SSRIs), followed by behavioral therapy. While SSRI treatments are reportedly safe, they are associated with limited efficacy and provide only a temporary delay in ejaculation latency time...
March 27, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38537902/using-the-behaviour-change-wheel-to-identify-barriers-and-targeted-strategies-to-improve-adherence-in-randomised-clinical-trials-the-example-of-mel-self-trial-of-patient-led-surveillance-for-melanoma
#9
JOURNAL ARTICLE
Deonna M Ackermann, Jolyn K Hersch, Monika Janda, Karen Bracken, Robin M Turner, Katy J L Bell
BACKGROUND: Adherence to self-management interventions is critical in both clinical settings and trials to ensure maximal effectiveness. This study reports how the Behaviour Change Wheel may be used to assess barriers to self-management behaviours and develop strategies to maximise adherence in a trial setting (the MEL-SELF trial of patient-led melanoma surveillance). METHODS: The Behaviour Change Wheel was applied by (i) using the Capability, Opportunity, Motivation-Behaviour (COMB) model informed by empirical and review data to identify adherence barriers, (ii) mapping identified barriers to corresponding intervention functions, and (iii) identifying appropriate behaviour change techniques and developing potential solutions using the APEASE (Affordability, Practicability, Effectiveness and cost-effectiveness, Acceptability, Side-effects and safety, Equity) criteria...
March 25, 2024: Contemporary Clinical Trials
https://read.qxmd.com/read/38536971/quality-of-life-of-women-who-underwent-breast-cancer-treatment-relative-to-sociodemographic-behavioral-and-clinical-factors
#10
JOURNAL ARTICLE
Angélica Atala Lombelo Campos, Maria Teresa Bustamante-Teixeira, Rafaela Russi Ervilha, Vivian Assis Fayer, Jane Rocha Duarte Cintra, Renata Mendes de Freitas, Daniela Pereira de Almeida, Maximiliano Ribeiro Guerra
OBJECTIVE: Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, and clinical factors related to the post-treatment quality of life of women with breast cancer. METHODS: This cross-sectional study involved 101 women diagnosed with breast cancer between 2014 and 2016 and treated at a Brazilian Oncology Reference Service...
2024: Einstein
https://read.qxmd.com/read/38536227/patient-education-and-decision-support-for-long-acting-injectable-hiv-antiretroviral-therapy-protocol-for-tool-development-and-pilot-testing-with-ryan-white-hiv-aids-program-medical-case-management-programs-in-new-york
#11
JOURNAL ARTICLE
Mary Kathryn Irvine, Rebecca Zimba, Tigran Avoundjian, Meghan Peterson, Connor Emmert, Sarah G Kulkarni, Morgan M Philbin, Elizabeth A Kelvin, Denis Nash
BACKGROUND: Long-acting injectable (LAI) HIV antiretroviral therapy (ART) presents a major opportunity to facilitate and sustain HIV viral suppression, thus improving health and survival among people living with HIV and reducing the risk of onward transmission. However, realizing the public health potential of LAI ART requires reaching patients who face barriers to daily oral ART adherence and thus can clinically benefit from alternative treatment modalities. Ryan White HIV/AIDS Program Part A medical case management (MCM) programs provide an array of services to address barriers to HIV care and treatment among economically and socially marginalized people living with HIV...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536214/health-behavior-change-intervention-preferences-expressed-by-american-indian-cancer-survivors-from-a-southwest-tribal-community-semistructured-interview-study
#12
JOURNAL ARTICLE
Jennifer Erdrich, Felina M Cordova-Marks, William O Carson, Jennifer W Bea, William R Montfort, Cynthia A Thomson
BACKGROUND: While many factors, including social determinants of health, affect cancer mortality, one modifiable risk factor that may contribute to cancer disparities is obesity. The prevalence of obesity in the American Indian/Alaska Native population is 48.1% per the Centers for Disease Control and Prevention. The overall cancer mortality for the American Indian/Alaska Native population is 18% higher than the White population as reported by the American Cancer Society. Interventions tailored to American Indian/Alaska Native communities that promote healthy lifestyle behaviors after cancer diagnosis and prior to cancer surgery (prehab) might improve cancer outcomes for this population...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536139/integration-of-partner-notification-services-at-a-sexually-transmitted-infections-clinic
#13
JOURNAL ARTICLE
Philip A Chan, Danielle L Le Brazidec, Kevin Cormier, Alexi Almonte, Siena Napoleon, Laura C Chambers, Jun Tao, Thomas E Bertrand
OBJECTIVES: PNS is critical to prevent the spread of STIs. We evaluated the feasibility of integrating PNS into an STI clinic focused on MSM. DESIGN/METHODS: The RI STI Clinic, in partnership with the RIDOH, implemented a PNS program in 2019. Interviews with patients diagnosed with gonorrhea/ syphilis were conducted. RIDOH attempted outreach to partners identified. We utilized interview data among MSM diagnosed with gonorrhea/syphilis in clinic from 1/1/19-12/31/2021...
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38535715/the-rising-challenge-of-poor-health-literacy-of-patients-with-systemic-sclerosis-preliminary-data-identify-important-unmet-needs-in-an-italian-cohort
#14
JOURNAL ARTICLE
Khadija El Aoufy, Maria Ramona Melis, Paolo Iovino, Stefano Bambi, Chiara Lorini, Guglielmo Bonaccorsi, Ilaria Galetti, Carla Garbagnati, Paola Canziani, Silvia Tonolo, Marco Mitola, Serena Guiducci, Daniel E Furst, Marco Matucci-Cerinic, Laura Rasero, Silvia Bellando-Randone
RATIONALE AND AIM: Health literacy (HL) is pivotal for the successful self-management of chronic diseases. Little HL information is currently available in SSc patients; therefore, the present study aims at evaluating the HL levels in an Italian cohort of SSc patients. METHODS: SSc patients were enrolled with the support of Italian patient associations, from September 2022 to March 2023. Health literacy characteristics were derived from the Health Literacy Scale European Questionnaire-16 (HLS-EU-Q16), consisting of 16 items designed on a four-point Likert scale ranging from "very difficult" to "very easy", and three HL levels were identified: inadequate HL (0-8 score); problematic HL (9-12 score); and sufficient HL (13-16 score)...
March 5, 2024: Nursing Reports
https://read.qxmd.com/read/38533390/a-patient-centered-documentation-skills-curriculum-for-preclerkship-medical-students-in-an-open-notes-era
#15
JOURNAL ARTICLE
Kathleen Eng, Katherine Johnston, Ivo Cerda, Kushal Kadakia, Alison Mosier-Mills, Anita Vanka
INTRODUCTION: New legislation allows patients (with permitted exceptions) to read their clinical notes, leading to both benefits and ethical dilemmas. Medical students need a robust curriculum to learn documentation skills within this challenging context. We aimed to teach note-writing skills through a patient-centered lens with special consideration for the impact on patients and providers. We developed this session for first-year medical students within their foundational clinical skills course to place bias-free language at the forefront of how they learn to construct a medical note...
2024: MedEdPORTAL Publications
https://read.qxmd.com/read/38532503/the-repair-study-oral-antibiotics-to-prevent-infection-and-wound-dehiscence-after-obstetric-perineal-tear-a-double-blinded-placebo-controlled-randomized-trial
#16
JOURNAL ARTICLE
Kathrine Perslev, Niels Klarskov, Thomas Bergholt, Hanna Jangö
BACKGROUND: Approximately 85% of women experience an obstetric tear at delivery and up to 25% subsequently experience wound dehiscence and/or infection. Previous publications suggest that intravenous antibiotics administrated during delivery reduces this risk. We do not know if oral antibiotics given after delivery can reduce the risk of wound dehiscence or infection. Our aim is to investigate whether three doses of oral antibiotics (amoxicillin 500 mg/clavulanic acid 125 mg) given after delivery can reduce the risk of wound dehiscence and infection in patients with a second-degree obstetric tear or episiotomy...
March 27, 2024: Trials
https://read.qxmd.com/read/38532326/spousal-collaboration-mediates-the-relation-between-self-rated-health-and-depressive-symptoms-of-chinese-older-couples-an-actor-partner-interdependence-approach
#17
JOURNAL ARTICLE
Huiying Liu, Xinyi Zhou, Mi Zhang, Bixia Chen, Jiayuan Du, Vivian Weiqun Lou
BACKGROUND: Dyadic coping resources have been considered a potential explanatory mechanism of spousal interdependence in health, but the mediation of spousal collaboration for the relationship between self-rated health and depressive symptoms has yet to be examined. This study aimed to investigate the within- (actor effect) and between-partner effects of self-rated health on depressive symptoms in community-dwelling older couples facing physical functioning limitations and to examine the role of spousal collaboration in mediating the actor and cross-partner effects of self-rated health on depressive symptoms...
March 26, 2024: BMC Geriatrics
https://read.qxmd.com/read/38530827/use-of-a-health-worker-targeted-smartphone-app-to-support-quality-malaria-rdt-implementation-in-busia-county-kenya-a-feasibility-and-acceptability-study
#18
JOURNAL ARTICLE
Malia Skjefte, Shawna Cooper, Stephen Poyer, Christopher Lourenço, Sam Smedinghoff, Brett Keller, Tonny Wambua, Christine Oduor, Sasha Frade, Wycliffe Waweru
Malaria rapid diagnostic tests (mRDTs) are an essential diagnostic tool in low-resource settings; however, administration and interpretation errors reduce their effectiveness. HealthPulse, a smartphone mRDT reader application, was developed by Audere to aid health workers in mRDT administration and interpretation, with an aim to improve the mRDT testing process and facilitate timely decision making through access to digitized results. Audere partnered with PSI and PS Kenya to conduct a pilot study in Busia County, Kenya between March and September 2021 to assess the feasibility and acceptability of HealthPulse to support malaria parasitological diagnosis by community health volunteers (CHVs) and private clinic health workers (private clinic HWs)...
2024: PloS One
https://read.qxmd.com/read/38530614/responsiveness-and-minimal-important-change-of-the-family-reported-outcome-measure-from-16
#19
JOURNAL ARTICLE
R Shah, A Y Finlay, M S Salek, H Allen, S J Nixon, M Nixon, K Otwombe, F M Ali, J R Ingram
BACKGROUND: The FROM-16 is a generic family quality of life (QoL) instrument that measures the QoL impact of patients' disease on their family members/partners. The study aimed to assess the responsiveness of FROM-16 to change and determine Minimal Important Change (MIC). METHODS: Responsiveness and MIC for FROM-16 were assessed prospectively with patients and their family members recruited from outpatient departments of the University Hospital Wales and University Hospital Llandough, Cardiff, United Kingdom...
March 26, 2024: Journal of Patient-Reported Outcomes
https://read.qxmd.com/read/38530349/equity-centered-postdischarge-support-for-medicaid-insured-people-protocol-for-a-type-1-hybrid-effectiveness-implementation-stepped-wedge-cluster-randomized-controlled-trial
#20
JOURNAL ARTICLE
J Margo Brooks Carthon, Heather Brom, Marsha Grantham-Murrillo, Kathy Sliwinski, Aleigha Mason, Mindi Roeser, Donna Miles, Dianne Garcia, Jovan Bennett, Michael O Harhay, Emilia Flores, Kelvin Amenyedor, Rebecca Clark
BACKGROUND: Disparities in posthospitalization outcomes for people with chronic medical conditions and insured by Medicaid are well documented, yet interventions that mitigate them are lacking. Prevailing transitional care interventions narrowly target people aged 65 years and older, with specific disease processes, or limitedly focus on individual-level behavioral change such as self-care or symptom management, thus failing to adequately provide a holistic approach to ensure an optimal posthospital care continuum...
March 26, 2024: JMIR Research Protocols
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