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PNES AND Seizures

Shaik Afshan Jabeen, Padmaja Gaddamanugu, Ajith Cherian, Kandadai Mridula Mridula, Dasari Uday Kumar, Angamuttu Kanikannan Meena
Objectives To study the clinical profile and outcome in patients with epilepsy who developed psychogenic non-epileptic seizures (PNES) associated with levetiracetam (LEV) use.   Methods In this prospective observational study, conducted over 1 year, 13 patients with epilepsy and PNES, documented by video electroencephalogram (VEEG) while on LEV, were included. Those with past history of psychiatric illnesses were excluded. VEEG, high-resolution magnetic resonance imaging, neuropsychological and psychiatric evaluation were performed...
July 11, 2018: Journal of Population Therapeutics and Clinical Pharmacology
Saher Hoda Kamil, Mustafa Qureshi, Rikinkumar S Patel
Psychogenic non-epileptic seizures (PNES) are classified as a somatoform conversion disorder. We present a case of a 24-year-old male with a past psychiatric history of posttraumatic stress disorder (PTSD) and anxiety disorder, admitted to our inpatient psychiatric unit. The patient experienced multiple episodes of seizures during hospitalization. Work up was unremarkable, and PNES were suspected and later confirmed with video-electroencephalography (video-EEG). He underwent supervised withdrawal of antiepileptic medications with the initiation of cognitive behavioral therapy (CBT), which reduced the frequency of seizures...
January 29, 2019: Behavioral Sciences
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate the frequency of dramatic presentations of psychogenic nonepileptic seizures (PNES) (i.e., urine incontinence and ictal injury) and to characterize the patients' historical risk factors that may be associated with such dramatic manifestations. METHODS: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 until 2018, were studied...
January 24, 2019: Seizure: the Journal of the British Epilepsy Association
Véronique Latreille, Barbara A Dworetzky, Gaston Baslet, Milena Pavlova
PURPOSE: Patients with psychogenic non-epileptic seizures (PNES) frequently complain of poor sleep, yet there are few and inconsistent data supporting objective sleep disturbances in this population. In this prospective observational study, we aimed to compare objective and subjective sleep-wake patterns in patients with PNES with those with epilepsy. METHODS: Subjects were recruited through the Brigham and Women's Epilepsy Monitoring Unit (EMU) over a 6-month period, and were diagnosed as having PNES or epilepsy by experts using video-electroencephalography (v-EEG)...
January 17, 2019: Seizure: the Journal of the British Epilepsy Association
Alaric M Indranada, Saul A Mullen, Melanie J Wong, Wendyl J D'Souza, Richard A A Kanaan
OBJECTIVES: Psychogenic nonepileptic seizures (PNES) resemble seizures but are psychological in origin. The etiology of PNES remains poorly understood, yet several theories argue for the importance of autonomic dysregulation in its pathophysiology. We therefore conducted a retrospective study to investigate autonomic dynamics leading up to a seizure to inform their mechanistic relevance. METHODS: One hundred one patients with PNES and 45 patients with epileptic seizure (ES) were analyzed for preictal heart rate (HR) and respiratory rate (RR) at baseline and at minute intervals from 5 min to onset...
January 23, 2019: Epilepsy & Behavior: E&B
Lorna Myers, Robert Trobliger, Kirsty Bortnik, Ruifan Zeng, Ethan Saal, Marcelo Lancman
OBJECTIVE: The objective of this study was to compare patients with intractable epilepsy with patients with psychogenic nonepileptic seizures (PNES) on the presence of psychological traumas, clinical factors, and psychological measures of somatization and dissociation. BACKGROUND: Several studies have reported a high prevalence of psychological trauma in patients with PNES, while less have examined the prevalence of psychological trauma in patients with epilepsy and compared both groups...
January 14, 2019: Epilepsy & Behavior: E&B
Alberto Vogrig, Jen Chun Hsiang, Jacqueline Ng, Joshua Rolnick, Jessica Cheng, Josef Parvizi
OBJECTIVE: The objective of this study was to quantify the features of stereotypy in epileptic seizures and compare it with that of stereotypy in psychogenic nonepileptic seizure-like events (PNES) confirmed by video-electroencephalography (VEEG) monitoring. METHODS: Video-electroencephalography monitoring records of 20 patients with temporal lobe seizures (TLS) and 20 with PNES were retrospectively reviewed (n = 138 seizures, 48 TLS and 90 PNES). We analyzed the semiology of 59 behaviors of interest for their presence, duration, sequence, and continuity using quantified measures that were entered into statistical analysis...
December 20, 2018: Epilepsy & Behavior: E&B
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate any possible association between education and psychogenic nonepileptic seizures (PNES) and any potential effects education might have on clinical characteristics of patients with PNES. METHODS: In this retrospective study, all patients with PNES, who were studied at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 until 2018, were recruited. We categorized the patients as 1...
January 2019: Seizure: the Journal of the British Epilepsy Association
Elisa Bianchi, Giuseppe Erba, Ettore Beghi, Giorgia Giussani
Questionnaires or symptom lists have proved effective for differentiating epileptic seizures (ES) from psychogenic nonepileptic seizures (PNES). However, monitoring the events, corroborated by medical history gathered by experts, remains the gold standard. We directly compared symptoms and characteristic of the events self-reported by patients/eyewitnesses (Questionnaire A/B) with the information contained in the clinical charts of 50 patients with undefined diagnosis undergoing long-term monitoring. Data extracted from medical records were reformatted to fit the questionnaires' templates (A1/B1) for comparison...
December 18, 2018: Epilepsy & Behavior: E&B
Udaya Seneviratne, Zhi Mei Low, Zhi Xuen Low, Angela Hehir, Sahira Paramaswaran, Monica Foong, Henry Ma, Thanh G Phan
OBJECTIVE: To investigate the health care utilization cost of patients presenting with psychogenic nonepileptic seizures (PNES) to a tertiary hospital in Australia. METHODS: This is a retrospective analysis of adult patients with PNES based on video-electroencephalographic confirmation over a 5-year period. We used an itemized list to collect detailed health care utilization data. The items included emergency room visits, hospital ward admissions, intensive care unit (ICU) admissions, outpatient neurology clinic visits, medical interventions, Code Blue and Medical Emergency Team calls for seizures, medications, and investigations...
December 21, 2018: Epilepsia
Shobi Sivathamboo, Sarah Farrand, Zhibin Chen, Elise J White, Andrew Andreas Pattichis, Callum Hollis, John Carino, Caitlin J Roberts, Thomas Minogue, Nigel C Jones, Raju Yerra, Christopher French, Piero Perucca, Patrick Kwan, Dennis Velakoulis, Terence J O'Brien, Jeremy Goldin
OBJECTIVE: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychogenic nonepileptic seizures (PNES). METHODS: We conducted a cross-sectional study of consecutive patients admitted for inpatient video-EEG monitoring at The Royal Melbourne Hospital, Australia, between December 1, 2011, and July 31, 2017. Participants underwent routine clinical investigations during their monitoring period including polysomnography, neurocognitive testing, and screening instruments of daytime somnolence, sleep quality, and quality of life...
December 14, 2018: Neurology
Shitanshu Kusmakar, Chandan Karmakar, Bernard Yan, Ramanathan Muthuganapathy, Patrick Kwan, Terence J O'Brien, Marimuthu Swami Palaniswami
OBJECTIVE: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES. METHODS: In this study, motor data were recorded using wrist-worn ACM-based devices. A total of 83 clinical events were recorded: 39 generalized tonic-clonic seizures (GTCS) from 12 patients with epilepsy, and 44 convulsive PNES from 7 patients (one patient had both GTCS and PNES)...
December 9, 2018: Epilepsia
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice. METHODS: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included...
December 7, 2018: Epilepsy & Behavior: E&B
Ali A Asadi-Pooya, Raidah AlBaradie, Tyson Sawchuk, Zahra Bahrami, Abeer Al Amer, Jeffrey Buchhalter
PURPOSE: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders. METHODS: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada...
January 2019: Epilepsy & Behavior: E&B
Shitanshu Kusmakar, Chandan K Karmakar, Bernard Yan, Terence J OrBrien, Marimuthu Palaniswami, Ramanathan Muthuganapathy
A high number of patients with epileptic seizures (ES) are misdiagnosed due to prevalence of mimic conditions. The clinical characteristics of mimics are often similar to ES. The events mostly misdiagnosed are of psychogenic origin and are termed as psychogenic non-epileptic seizures (PNES). The gold standard for diagnosis of PNES is video-electroencephalography monitoring (VEM), which is a resource demanding process. Hence, need for a more object method of PNES diagnosis is created. Accelerometer sensors have been used previously for the diagnosis of ES...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Rana Raoof, Sebastian Bauer, Hany El Naggar, Niamh M C Connolly, Gary P Brennan, Elizabeth Brindley, Thomas Hill, Hazel McArdle, Elaine Spain, Robert J Forster, Jochen H M Prehn, Hajo Hamer, Norman Delanty, Felix Rosenow, Catherine Mooney, David C Henshall
BACKGROUND: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to brain excitability, and stable detection in biofluids. Altered levels of circulating microRNAs have been reported in human epilepsy, but most studies collected samples from one clinical site, used a single profiling platform or conducted minimal validation...
November 2, 2018: EBioMedicine
Mansur A Kutlubaev, Ying Xu, Maree L Hackett, Jon Stone
Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) represent a serious challenge for the clinicians. However, the frequency, associations, and outcomes of dual diagnosis of epilepsy and PNES are unclear. The aim of the review was to determine the frequency, correlates, and outcomes of a dual diagnosis. A systematic review of all published observational studies (from inception to Dec. 2016) was conducted to determine the frequency, correlates, and outcomes of dual diagnosis. We included studies of individuals of any age reporting a dual diagnosis of epilepsy and PNES...
December 2018: Epilepsy & Behavior: E&B
F Brigo, S Lattanzi
No abstract text is available yet for this article.
October 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Bhargavi Ramanujam, Deepa Dash, Manjari Tripathi
PURPOSE: To assess the contribution home-videos made on mobile phones can make to the diagnosis of Psychogenic Nonepileptic Seizures (PNES). METHODS: Consecutive patients 10-50 years old, with episodes of altered behavior or abnormal movements, unresponsiveness, or falls, were recruited after they had obtained 'good' or 'fair' quality (quality of video scale (QOV)) home-videos of their episodes on personal mobile phones; these subjects underwent video-electroencephalography (VEEG)...
October 3, 2018: Seizure: the Journal of the British Epilepsy Association
Iliana Kotwas, Jean-Arthur Micoulaud-Franchi, Stéphanie Khalfa, Aileen McGonigal, Mireille Bastien-Toniazzo, Fabrice Bartolomei
BACKGROUND: Temporal lobe epilepsy (TLE) and psychogenic non-epileptic seizures (PNES) are conditions frequently associated with dysfunction in emotional regulation leading to increased risk of affective disorders. This study investigates emotional processing with an objective measure of emotional reactivity in patients with TLE and patients with PNES. METHODS: 34 patients with TLE and 14 patients with PNES were evaluated on skin conductance responses (SCR) to emotions induced by short films and compared to 34 healthy controls...
February 1, 2019: Journal of Affective Disorders
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