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REVIEW
Lourdes M DelRosso, Daniel L Picchietti, Denise Sharon, Karen Spruyt, Judith A Owens, Arthur S Walters, Marco Zucconi, Raffaele Ferri
This systematic review evaluates the scientific literature on pediatric periodic limb movement disorder (PLMD), adhering to PRISMA guidelines and utilizing PICOS criteria. The search across PubMed, EMBASE, and Scopus yielded 331 articles, with 17 meeting inclusion criteria. Diagnostic criteria evolved, with polysomnography and PLMS index ≥5 required since 2003. Also, PLMD diagnosis mandates clinical consequences like insomnia, hypersomnia, and fatigue, excluding comorbidities causing sleep disruption...
April 16, 2024: Sleep Medicine Reviews
#2
JOURNAL ARTICLE
Tina Kissow Lildal, An Boudewyns, Konstantinos Kamperis, Søren Rittig, Jannik B Bertelsen, Jonas Holm, Thomas Qvist Barrett, Jakob Korsholm, Ali Abood, Therese Ovesen
OBJECTIVE/BACKGROUND: Most children treated for obstructive sleep disordered breathing (oSDB) are not systematically assessed by polysomnography (PSG) nor by structuredsymptom quantification before surgical treatment. The main objective of this study wasto investigate the effect of adeno-tonsillotomy (ATO) on symptom burden and PSGparameters. METHODS: Children aged 2-10 years with oSDB were selected for ATO based uponclinical findings according to current standards of care in Denmark...
April 15, 2024: Sleep Medicine
#3
JOURNAL ARTICLE
Seçil Ekiz Erim, Havva Sert
OBJECTIVES: The study aimed to investigate the effect of the circadian timing program (SİZAP) developed for evening-chronotype individuals with obesity on obesity management and sleep quality. METHODS: This single-site, randomized controlled trial with an experimental research design was registered in ClinicalTrials.gov. It was reported in accordance with the "Consolidated Standards of Reporting Trials" (CONSORT) randomized controlled trial guidelines. The study sample consisted of 38 evening-chronotype individuals with first-degree obesity, with 19 individuals in each study group...
April 16, 2024: Sleep Medicine
#4
JOURNAL ARTICLE
Monica Aggarwal, Brian G Hutchison, Kristina M Kokorelias, Vivian R Ramsden, Noah M Ivers, Andrew Pinto, Ross E G Uphsur, Sabrina T Wong, Nick Pimlott, Steve Slade
BACKGROUND: The generation of research evidence and knowledge in primary health care (PHC) is crucial for informing the development and implementation of interventions and innovations and driving health policy, health service improvements, and potential societal changes. PHC research has broad effects on patients, practices, services, population health, community, and policy formulation. The in-depth exploration of the definition and measures of research impact within PHC is essential for broadening our understanding of research impact in the discipline and how it compares to other health services research...
April 23, 2024: JMIR Research Protocols
#5
JOURNAL ARTICLE
P D Yuan, Y W Hu, X Q Chen, G Y Chen, Y Pan, H Y Lao, D Liang
PURPOSES: This study investigated the feasibility of adalimumab (ADA) dose reduction and withdrawal strategy in children with stable pediatric non-infectious uveitis (PNIU). METHODS: This open-label prospective pilot trial recruited 18 stable PNIU patients (33 eyes) between two and eighteen years old who were treated with standard doses of ADA (20/40 mg every 2 weeks) plus oral methotrexate. The interval of ADA injection was extended to 4 weeks and followed up for 24 weeks...
April 23, 2024: Ocular Immunology and Inflammation
#6
JOURNAL ARTICLE
Anthony Bozzo, James M G Tsui, Sahir Bhatnagar, Jonathan Forsberg
This review article focuses on the applications of deep learning with neural networks and multimodal neural networks in the orthopaedic domain. By providing practical examples of how artificial intelligence (AI) is being applied successfully in orthopaedic surgery, particularly in the realm of imaging data sets and the integration of clinical data, this study aims to provide orthopaedic surgeons with the necessary tools to not only evaluate existing literature but also to consider AI's potential in their own clinical or research pursuits...
April 17, 2024: Journal of the American Academy of Orthopaedic Surgeons
#7
JOURNAL ARTICLE
Luke Muschialli, Santino Coduri-Fulford, Zoë Garbett, Dean J Connolly
Sexual and gender minority (LGBT+) populations continue to experience worse health outcomes and reduced healthcare access compared to their cisgender, heterosexual counterparts, perpetuated by a lack of sufficient LGBT+-specific healthcare education within medical schools. Developing educational material that encourages self-reflective, proactive, and affirmative practice has been identified as a mechanism for increasing the quality of doctor-patient relationships and breaking down barriers in healthcare access for LGBT + communities...
April 23, 2024: Medical Teacher
#8
JOURNAL ARTICLE
George Nesr, Simone Claudiani, Dragana Milojkovic, Andrew Innes, Fiona Fernando, Irene Caballes, Patience Mungozi, Richard Szydlo, Silvia Lovato, Channa Jayasena, Jane Apperley
Advancements in the management of patients with chronic myeloid leukemia (CML) allowed them to achieve survival comparable with their healthy counterparts. Consequently, their care has widened with growing focus on quality of life, including parenting children. Although tyrosine kinase inhibitors (TKI) are contraindicated in pregnancy given their teratogenic effect, their effect on male fertility is less clear with contradictory results from animal studies and case reports/series. We compared the sperm analysis parameters, as the gold-standard assessment for male fertility, of 11 patients with CP- CML before and after TKI therapy...
April 23, 2024: Leukemia & Lymphoma
#9
JOURNAL ARTICLE
Stefan Niederauer, Mike Beeman, Andrew Cleveland, Susan Wojtalewicz, Sierra Erickson, Christopher A Reilly, Joseph E Rower, Caroline Garrett, Candace Floyd, Jill Shea, Jay Agarwal, Caleb Lade, Brett Davis
BACKGROUND: Partial-thickness skin wounds are some of the most painful injuries due to large areas of exposed nerve endings. These injuries often require systemic opioid treatments to manage pain adequately. However, in 2021 alone, the CDC reported nearly 17,000 prescription opioid-related deaths in the USA, highlighting the ongoing need for non-opioid treatment strategies. In this manuscript, we developed a novel single-application ropivacaine-eluting primary wound dressing that could provide sustained ropivacaine delivery to partial-thickness wounds and assessed its in vivo feasibility for prolonged non-opioid analgesia...
April 23, 2024: Plastic and Reconstructive Surgery
#10
JOURNAL ARTICLE
Xinyang Li, Yuliang Jin
Can liquid-like and gas-like states be distinguished beyond the critical point, where the liquid-gas phase transition no longer exists and conventionally only a single supercritical fluid phase is defined? Recent experiments and simulations report strong evidence of dynamical crossovers above the critical temperature and pressure. Despite using different criteria, many existing theoretical explanations consider a single crossover line separating liquid-like and gas-like states in the supercritical fluid phase...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#11
JOURNAL ARTICLE
Tezcan Ozrazgat-Baslanti, Yuanfang Ren, Esra Adiyeke, Rubab Islam, Haleh Hashemighouchani, Matthew Ruppert, Shunshun Miao, Tyler Loftus, Crystal Johnson-Mann, R W M A Madushani, Elizabeth A Shenkman, William Hogan, Mark S Segal, Gloria Lipori, Azra Bihorac, Charles Hobson
Standard race adjustments for estimating glomerular filtration rate (GFR) and reference creatinine can yield a lower acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence among African American patients than non-race adjusted estimates. We developed two race-agnostic computable phenotypes that assess kidney health among 139,152 subjects admitted to the University of Florida Health between 1/2012-8/2019 by removing the race modifier from the estimated GFR and estimated creatinine formula used by the race-adjusted algorithm (race-agnostic algorithm 1) and by utilizing 2021 CKD-EPI refit without race formula (race-agnostic algorithm 2) for calculations of the estimated GFR and estimated creatinine...
2024: PloS One
#12
JOURNAL ARTICLE
Juliana Elvira Herdy Guerra Avila, Levy Aniceto Santana, Denise Rabelo Suzuki, Vinícius Zacarias Maldaner da Silva, Marcio Luís Duarte, Aline Mizusaki Imoto, Fábio Ferreira Amorim
INTRODUCTION: Burns are tissue traumas caused by energy transfer and occur with a variable inflammatory response. The consequences of burns represent a public health problem worldwide. Inhalation injury (II) is a severity factor when associated with burn, leading to a worse prognosis. Its treatment is complex and often involves invasive mechanical ventilation (IMV). The primary purpose of this study will be to assess the evidence regarding the frequency and mortality of II in burn patients...
2024: PloS One
#13
JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#14
JOURNAL ARTICLE
Chelsea K Brown, Cara L Wallace
With increased need for palliative care and limited staffing resources, non-social workers are increasingly responsible for screening for urgent psychosocial distress. The National Consensus Project guidelines call for all palliative care team members to be competent in screening across domains. Yet, in contrast to an abundance of evidence-informed tools for palliative social work assessments, standardization for interprofessional psychosocial screening is lacking. This lack of standardized practice may lead to harmful disparities in care delivery...
April 23, 2024: Journal of Social Work in End-of-life & Palliative Care
#15
JOURNAL ARTICLE
Peter M Socha, Kari Johansson, Lisa M Bodnar, Jennifer A Hutcheon
BACKGROUND: High gestational weight gain is associated with excess postpartum weight retention, yet excess postpartum weight retention is not an exclusion criterion for current gestational weight gain charts. We aimed to assess the impact of excluding individuals with high interpregnancy weight change (a proxy for excess postpartum weight retention) on gestational weight gain distributions. METHODS: We included individuals with an index birth from 2008 to 2014 and a subsequent birth before 2019, in the population-based Stockholm-Gotland Perinatal Cohort...
April 23, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
#16
REVIEW
George Kassianos, Jean-Marie Cohen, Rok Civljak, Nadav Davidovitch, Oana Falup Pecurariu, Filipe Froes, Andrei Galev, Inga Ivaskeviciene, Kadri Kõivumägi, Zuzana Kristufkova, Ernest Kuchar, Jan Kyncl, Helena C Maltezou, Miloš Marković, Aneta Nitsch-Osuch, Raul Ortiz de Lejarazu, Alessandro Rossi, Jörg Schelling, Gerrit A van Essen, Dace Zavadska
INTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel. AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza seasons...
April 23, 2024: Expert Review of Respiratory Medicine
#17
JOURNAL ARTICLE
Meng Sun, Zhibin Chen, Guoyi Li, Yingfeng Weng, Yangbo Hou
Abstract： Objective: To explore the relationship between risk factors of cognitive dysfunction and blood pressure variability after acute ischemic stroke in northwest Shanghai to establish a model for early identification of high-risk groups of cognitive dysfunction and formulation of more targeted prevention and treatment measures. Methods: Spearman test was used to evaluate the correlation between blood pressure variability and Montreal Cognitive Assessment (MoCA) score in patients with acute ischemic stroke and the partial regression coefficient model was constructed based on the above independent risk factors, and the receiver operating characteristic (ROC) curve was described to analyze the relevant independent risk factors...
April 23, 2024: International Journal of Neuroscience
#18
JOURNAL ARTICLE
Julia de Lange, Liam J Burrows, Cheryl Quenneville
Ballistic shields protect users from a variety of threats, including projectiles. Shield back-face deformation (BFD) is the result of the shield deflecting or absorbing a projectile and deforming towards the user. Back-face deformation can result in localized blunt loading to the upper extremity, where the shield is supported by the user. Two vulnerable locations along the upper extremity were investigated - the wrist and elbow - on eight post-mortem human subjects (PMHS) using a pneumatic impacting apparatus for investigating the fracture threshold as a result of behind shield blunt trauma (BSBT)...
April 23, 2024: Journal of Biomechanical Engineering
#19
JOURNAL ARTICLE
Molly Rubin, Stewart H Lecker, Nirupama Ramkumar, Stephen M Sozio, Robert S Hoover, Mark L Zeidel, Benjamin S Ko
In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney TREKS (Tutored Research and Education for Kidney Scholars) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral fellows. The program combines a one-week intensive exposure to kidney physiology with a longitudinal mentorship program at the participants' home institutions. Ten years in, an analysis was conducted to assess its effectiveness...
April 23, 2024: Journal of the American Society of Nephrology: JASN
#20
JOURNAL ARTICLE
Kahabi Ganka Isangula, Rogers John Haule
BACKGROUND: Respiratory diseases, including active tuberculosis (TB), asthma, and chronic obstructive pulmonary disease (COPD), constitute substantial global health challenges, necessitating timely and accurate diagnosis for effective treatment and management. OBJECTIVE: This research seeks to develop and evaluate a noninvasive user-friendly artificial intelligence (AI)-powered cough audio classifier for detecting these respiratory conditions in rural Tanzania. METHODS: This is a nonexperimental cross-sectional research with the primary objective of collection and analysis of cough sounds from patients with active TB, asthma, and COPD in outpatient clinics to generate and evaluate a noninvasive cough audio classifier...
April 23, 2024: JMIR Research Protocols
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