Saritha Krishna, Abrar Choudhury, Michael B Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M Molinaro, Humsa S Venkatesh, Andy G S Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F Chang, Anne Findlay, Joanna J Phillips, Srikantan Nagarajan, David R Raleigh, David Brang, Michelle Monje, Shawn L Hervey-Jumper
Gliomas synaptically integrate into neural circuits1,2 . Previous research has demonstrated bidirectional interactions between neurons and glioma cells, with neuronal activity driving glioma growth1-4 and gliomas increasing neuronal excitability2,5-8 . Here we sought to determine how glioma-induced neuronal changes influence neural circuits underlying cognition and whether these interactions influence patient survival. Using intracranial brain recordings during lexical retrieval language tasks in awake humans together with site-specific tumour tissue biopsies and cell biology experiments, we find that gliomas remodel functional neural circuitry such that task-relevant neural responses activate tumour-infiltrated cortex well beyond the cortical regions that are normally recruited in the healthy brain...
May 3, 2023: Nature