Xiaomin Gao, Binwei Lin, Chen Chen, Ziyu Fang, Jinzhao Yang, Shuzhi Wu, Qing Chen, Kewen Zheng, Zhixian Yu, Yeping Li, Xiaofeng Gao, Guanyang Lin, Lianguo Chen
Several mechanisms underlying nephrolithiasis, one of the most common urological diseases, involve calcium oxalate formation, including oxidative stress, inflammatory reactions, fibrosis, pyroptosis, and apoptosis. Although lycopene has strong antioxidant activity, its protective effects against CaOx-induced injury have not yet been reported. This study aimed to systematically investigate the protective effects of lycopene and explore its mechanisms and molecular targets. Crystal deposition, renal function, oxidative stress, inflammatory response, fibrosis, pyroptosis, and apoptosis were assessed to evaluate the renoprotective effects of lycopene against crystal formation in a CaOx rat model and oxalate-stimulated NRK-52E and HK-2 cells...
April 8, 2024: Food & Function