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Zheng Liu, Ming Yang, Song Wang, Hai-Peng Chen, Xu Guan, Zhi-Xun Zhao, Zheng Jiang, Ji-Chuan Quan, Run-Kun Yang, Xi-Shan Wang
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. GGN is a germ cell-specific gene, but its function in CRC has been rarely reported to date. The aim of this study was to investigate the potential role of GGN in CRC tumorigenesis. Therefore, in this study, we examined the expression of GGN in CRC cell lines and tissues and its effects on cellular proliferation and apoptosis. We then explored the underlying mechanism. Our results showed that GGN was significantly overexpressed in both CRC cell lines and tissues...
February 5, 2019: Pathology Oncology Research: POR
Q Wang, W Jiang, L Wang, J J Xi
Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. In clinical practice, the size of GGN, the size of consolidation, dynamic change during follow-up are the factors that help surgeons to decide the timing of surgery...
January 23, 2019: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Zhihua Teng, Wen Chen, Dongyong Yang, Zhenghua Zhang, Lifei Zhu, Fubing Wu
The present study investigated the expression of p53 in ground-glass nodule (GGN) of lung cancer and non-lung cancer patients, and explored the correlation with prognosis. A total of 120 GGN patients admitted to the Department of Respiratory Medicine in the Second Affiliated Hospital of Zhejiang University School of Medicine during the period from March 2010 to March 2014 were selected. These patients included 60 lung cancer patients and 60 non-tumor patients. Biopsy or surgical specimens were collected. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were used to detect p53 gene and protein expression in the two groups of GGN tissues...
February 2019: Oncology Letters
S McDermott, A Kilcoyne, Y Wang, J A Scott, E F Halpern, J B Ackman
AIM: To determine if pure ground-glass opacities (GGOs) and the subgroup of ground-glass nodules (GGNs) typically demonstrate higher 2-[18 F]-fluoro-2-deoxy-d-glucose (18 F-FDG) uptake at positron-emission tomography (PET) when benign than when malignant. MATERIALS AND METHODS: Informed consent was waived for this institutional review board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA) compliant, retrospective study. A review of all 1,864 combined PET/computed tomography (CT) examinations performed in 2011 on a single system to identify pure GGOs with mean diameter ≥1 cm yielded 166 GGOs...
January 9, 2019: Clinical Radiology
Hualong Yu, Chuanyu Zhang, Shihe Liu, Gang Jiang, Shaoke Li, Liang Zhang, Enhao Kang, Bingping Zhang, Wenjian Xu
Objective: The objective of the study is to evaluate the clinical efficacy and accuracy of coaxial biopsy puncture applied to make a diagnosis in 76 patients diagnosed with focal ground-glass density nodule (GGN). Materials and Methods: In total, 76 patients were diagnosed with pure GGN (pGGN), 24 males and 52 females, aged (52 ± 1.2) years on average (range: 47-72 years). All patients underwent computed tomography (CT)-guided coaxial biopsy puncture to localize the position and measure the size of pGGN...
2018: Journal of Cancer Research and Therapeutics
Huahui Bian, Youyou Wang, Weibo Chen, Yusong Zhang, Zhixiang Zhuang, Rui Xia, Hong Dai, Junchao Feng, Wangyang Pu, Lei Chen, Wu Cai, Wentao Hu, Yulong Liu
The patient was contaminated with multiple radionuclides 38 years ago due to an accident. To investigate the effects of radionuclide contamination on humans, he has been followed up by examinations for many years. Long-term effects gradually emerge in these years. Lung cancer was diagnosed by medical examinations. Besides, chronic gastritis with intestinal metaplasia was indicated by gastroscopic biopsies, while colorectal polyps found by colonoscopy. All 13 colorectal polyps were removed, and radical surgery for lung cancer was performed...
October 2018: Dose-response: a Publication of International Hormesis Society
Arjun Nair, Emily C Bartlett, Simon L F Walsh, Athol U Wells, Neal Navani, Georgia Hardavella, Sanjeev Bhalla, Lucio Calandriello, Anand Devaraj, Jin Mo Goo, Jeffrey S Klein, Heber MacMahon, C M Schaefer-Prokop, Joon-Beom Seo, Nicola Sverzellati, Sujal R Desai
Radiological evaluation of incidentally detected lung nodules on computed tomography (CT) influences management. We assessed international radiological variation in 1) pulmonary nodule characterisation; 2) hypothetical guideline-derived management; and 3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: 1) first-choice composition (solid, part-solid or ground-glass, with percentage confidence); 2) morphological features; 3) dimensions; 4) recommended management; and 5) decision-influencing factors...
December 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Jae Ho Lee, Tae Hoon Kim, Sungsoo Lee, Kyunghwa Han, Min Kwang Byun, Yoon Soo Chang, Hyung Jung Kim, Geun Dong Lee, Chul Hwan Park
OBJECTIVES: To evaluate and compare the diagnostic accuracy of high versus low attenuation thresholds for determining the solid component of ground-glass opacity nodules (GGNs) for the differential diagnosis of adenocarcinoma in situ (AIS) from minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA). METHODS: Eighty-six pathologically confirmed GGNs < 3 cm observed in 86 patients (27 male, 59 female; mean age, 59.3 ± 11.0 years) between January 2013 and December 2015 were retrospectively included...
2018: PloS One
En-Kuei Tang, Chi-Shen Chen, Carol C Wu, Ming-Ting Wu, Tseng-Lung Yang, Huei-Lung Liang, Hui-Ting Hsu, Fu-Zong Wu
BACKGROUND: The long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified. METHODS: Between 2002 and 2016, 128 subjects with persistent SSNs of 3cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings during the follow-up period were subsequently reviewed. RESULTS: The mean follow-up period was 3.57±2...
September 14, 2018: Heart, Lung & Circulation
Feng Gao, Yingli Sun, Guozhen Zhang, Xiangpeng Zheng, Ming Li, Yanqing Hua
OBJECTIVE: To explore the CT characteristics of small lung nodules and improve the diagnosis of pulmonary ground-glass nodules less than 10  mm in size. METHODS: We retrospectively analyzed CT images of 161 pulmonary nodules (less than 10  mm in size) with spiculation, lobulation, vacuoles, and pleural indentation and compared these images with pathological results or follow-up CT images. The relationships between the ground-glass nodules (GGNs) and blood vessels were observed...
October 9, 2018: British Journal of Radiology
Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi
Pulmonary ground-glass nodules (GGNs) are hazy radiological findings on computed tomography (CT). GGNs are detected more often in never-smokers. Retrospective and prospective studies have revealed that approximately 20% of pure GGNs and 40% of part-solid GGNs gradually grow or increase their solid components, whereas others remain stable for years. Most persistent or growing GGNs are lung adenocarcinomas or their preinvasive lesions. To distinguish GGNs with growth from those without growth, GGNs should be followed for at least 5 years...
August 2018: Translational Lung Cancer Research
You Meng, Chen-Lu Liu, Qing Cai, Yu-Ying Shen, Shuang-Qing Chen
PURPOSE: To perform contrast analysis of the relationship between high-resolution computed tomography (HRCT) signs and new pathologic classification of small GGNs-like lung adenocarcinoma. MATERIALS AND METHODS: The HRCT data from 145 pathologically confirmed cases of small GGNs of lung adenocarcinoma were analysed retrospectively. The 145 cases of GGNs were divided into pre-invasive (PI) group (n = 46), micro-invasive adenocarcinoma (MIA) group (n = 48), and invasive adenocarcinoma (IAC) group (n = 51)...
September 6, 2018: La Radiologia Medica
Kaimin Guo, Yan He, Lingyun Liu, Zuowen Liang, Xian Li, Lu Cai, Zi-Jian Lan, Junmei Zhou, Hongliang Wang, Zhenmin Lei
Gametogenetin (GGN) binding protein 2 (GGNBP2) is a zinc finger protein expressed abundantly in spermatocytes and spermatids. We previously discovered that Ggnbp2 resection caused metamorphotic defects during spermatid differentiation and resulted in an absence of mature spermatozoa in mice. However, whether GGNBP2 affects meiotic progression of spermatocytes remains to be established. In this study, flow cytometric analyses showed a decrease in haploid, while an increase in tetraploid spermatogenic cells in both 30- and 60-day-old Ggnbp2 knockout testes...
October 2018: Journal of Cellular and Molecular Medicine
Takuya Inagaki, Yasuro Futagawa, Shuji Sato, Tomoyoshi Okamoto, Mitsuo Yabe, Hideki Matsudaira, Jun Hirano, Toshiaki Morikawa
Pulmonary cryptococcosis is difficult to distinguish from lung cancer clinically, and is often diagnosed by surgery. A 72-year-old woman, who underwent distal pancreatectomy and splenectomy for pancreatic carcinoma. Four months after surgery, a tumor shadow was detected in the left lung as a groundglass nodule (GGN)of 12 mm in diameter, which was found to change to 15 mm with increased density by the computed tomography(CT)scan after 2 months. The nodule showed positive accumulation of fluorodeoxyglucose(FDG)by positron emission tomography(PET), and was suspected of malignant tumor...
July 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Masaaki Sato, Taiji Kuwata, Atsushi Kitamura, Kenji Misawa, Kota Imashimizu, Keiji Yamanashi, Masaki Ikeda, Terumoto Koike, Masashi Kobayashi, Shinji Kosaka, Ryuta Fukai, Noritaka Isowa, Kazuhiro Nagayama, Akihiro Aoyama, Hiroshi Date, Jun Nakajima
Background: Virtual-assisted lung mapping (VAL-MAP), a bronchoscopic multi-spot dye-marking technique, was tested for its ability to resect ground glass nodules (GGNs) in sublobar lung resections. Methods: All patients were prospectively registered in the multi-institutional lung mapping (MIL-MAP) study using VAL-MAP. The data were retrospectively analyzed, focusing on GGNs. GGN characteristics, pathological findings, operation type, and the surgical contribution of VAL-MAP were evaluated...
May 2018: Journal of Thoracic Disease
Patrick J Cimino, Lisa McFerrin, Hans-Georg Wirsching, Sonali Arora, Hamid Bolouri, Raul Rabadan, Michael Weller, Eric C Holland
Background: Copy number alterations form prognostic molecular subtypes of glioblastoma with clear differences in median overall survival. In this study, we leverage molecular data from several glioblastoma cohorts to define the distribution of copy number subtypes across random cohorts as well as cohorts with selection biases for patients with inherently better outcome. Methods: Copy number subtype frequency was established for 4 glioblastoma patient cohorts. Two randomly selected cohorts include The Cancer Genome Atlas (TCGA) and the German Glioma Network (GGN)...
September 3, 2018: Neuro-oncology
Miloje M Rakočević
A new approach to understanding of the genetic code is developed. In order to overcome the key paradox (and Darwinian selection problem) that the highly complex amino acid Phe is encoded by the simplest codons (UUY), and the simplest Gly encoded by the most complex codons (GGN); as well as the paradox of the duplication of some amino acids in the encoding process (Leu, Ser, Arg), we proposed an extension of the notion (and concept) of genetic code. For a better (and lighter) understanding of genetic coding, we proposed a hypothesis after that (under the conditions of allowed metaphoricity and modeling in biology) genetic code has to be understood, analogously in cryptology, as the unity of three entities: the code, the cipher of the code and the key of the cipher...
September 2018: Bio Systems
Liming Wang, Masaki Anraku, Masaaki Sato, Jun-Ichi Nitadori, Kazuhiro Nagayama, Kentaro Kitano, Jun Nakajima
PURPOSE: Early lung adenocarcinoma has been more frequently found recently. The 8th edition of the Union for International Cancer Control (UICC)-Tumor Node Metastasis (TNM) classification for lung cancer has been effective since January 2017. This study aims to elucidate advantages of the current classification for patients with clinical stage 0-IA lung adenocarcinoma, in comparison with the older one. METHODS: We retrospectively reviewed the data of clinical stage IA (7th edition) lung adenocarcinoma patients who underwent surgery at our institute from 2001 to 2012, and reclassified them by the 8th edition...
October 19, 2018: Annals of Thoracic and Cardiovascular Surgery
Hang Su, Chenyang Dai, Huikang Xie, Yijiu Ren, Yunlang She, Xiermaimaiti Kadeer, Dong Xie, Hui Zheng, Gening Jiang, Chang Chen
BACKGROUND: In this study we aimed to identify the risk factors of recurrence in patients with clinical stage IA adenocarcinoma presented as ground glass nodule (GGN) on computed tomography scans. PATIENTS AND METHODS: The study included 245 patients with clinical stage IA adenocarcinoma presented as GGN who underwent surgery during 2010 to 2013. All patients were divided into 2 subgroups on the basis of consolidation diameter to tumor diameter (C/T) ratio on lung window: (1) ground-glass opacity (GGO)-dominant subgroup (C/T ≤ 0...
September 2018: Clinical Lung Cancer
Laura Evangelista, Annalori Panunzio, Elena Scagliori, Paolo Sartori
Objective: to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancies and to evaluate the role of computed tomography (CT) and positron emission tomography (PET)/CT in their diagnosis and follow-up. Methods: A total of 130 nodules in 68 patients were revealed: 119 GGNs and 11 MPNs. GGN lesions were found in 58 patients, MPNs in eight, and in two cases, both...
2018: European journal of hybrid imaging
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