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Cholangiocarcinoma AND imaging

Dong Kyun Kim, Bo Ra Kim, Jin Sook Jeong, Yang Hyun Baek
BACKGROUND: Intrahepatic sarcomatoid chonalgiocarcinoma (s-CCC) is an extremely rare disease, accounting for less than 1% of hepatobiliary system malignancies, and its pathophysiology is not well known. On the hypothesis that its clinical, serologic, or radiologic diagnosis are not fully understood and its prognosis is poor, we investigated the distinguishing features of s-CCC compared with those of intrahepatic bile duct adenocarcinoma [cholangiocellular carcinoma (CCC)] in patients from a single center...
February 7, 2019: World Journal of Gastroenterology: WJG
Wei Wang, Ying Kan, Xu Yang, Jie Liu, Jigang Yang
A 67-year-old man with a history of left upper lobe resection of poorly differentiated adenocarcinoma 1 year ago underwent FDG PET/CT for restaging. The images demonstrated a round cystic lesion with peripheral FDG uptake and centrally photopenic region. Additional focus of increased activity was detected in the left lobe of the liver. The patient underwent the Whipple and partial hepatectomy. The surgical pathology demonstrated concurrently the metastasis to the pancreas from the lung adenocarcinoma and a primary moderately differentiated cholangiocarcinoma...
February 8, 2019: Clinical Nuclear Medicine
Luca Filippi, Giovan Giuseppe Di Costanzo, Raffaella Tortora, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci, Oreste Bagni
BACKGROUND: The aim of this study was to evaluate the safety and efficacy of repeated administration of 90 Y-microspheres in intrahepatic cholangiocarcinoma (ICC) relapsed after the first radioembolization (RE). METHODS: Nine patients with ICC relapsed after the first 90 Y-RE were enrolled. Six patients presented recurrence in the right hepatic lobe, 3 in the left lobe. All subjects underwent a second administration of 90 Y-resin microspheres. Toxicity was assessed according to Common Terminology Criteria for Adverse Events (CTCAE, version 4...
February 13, 2019: Cancer Biotherapy & Radiopharmaceuticals
Matthew C Hernandez, John R Bergquist, Jennifer L Leiting, Tommy Ivanics, Lin Yang, Rory L Smoot, David M Nagorney, Mark J Truty
BACKGROUND: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease. MATERIALS AND METHODS: We maintain a prospective high volume gastrointestinal malignancy PDX program...
February 12, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Marcia P Gaspersz, Stefan Buettner, Jeroen L A van Vugt, Jeroen de Jonge, Wojciech G Polak, Michail Doukas, Jan N M Ijzermans, Bas Groot Koerkamp, François E J A Willemssen
BACKGROUND: The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC). METHODS: All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor-node-metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index)...
February 12, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Zachary P Fricker, David R Lichtenstein
Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. The diagnosis can be confirmed via cholangiography, either magnetic resonance cholangiography (MRCP) or endoscopic retrograde cholangiography if the former is inconclusive...
February 6, 2019: Digestive Diseases and Sciences
Sara Lewis, Steven Peti, Stefanie J Hectors, Michael King, Ally Rosen, Amita Kamath, Juan Putra, Swan Thung, Bachir Taouli
OBJECTIVE: To evaluate the ability of volumetric quantitative apparent diffusion coefficient (ADC) histogram parameters and LI-RADS categorization to distinguish hepatocellular carcinoma (HCC) from other primary liver cancers [intrahepatic cholangiocarcinoma (ICC) and combined HCC-ICC]. METHODS: Sixty-three consecutive patients (44 M/19F; mean age 62 years) with primary liver cancers and pre-treatment MRI including diffusion-weighted imaging (DWI) were included in this IRB-approved single-center retrospective study...
February 2, 2019: Abdominal Radiology
Argha Chatterjee, Camila Lopes Vendrami, Paul Nikolaidis, Pardeep K Mittal, Andrew J Bandy, Christine O Menias, Nancy A Hammond, Vahid Yaghmai, Guang-Yu Yang, Frank H Miller
Intraluminal pathologic conditions of the bile ducts and gallbladder are common, most frequently consisting of calculi and adenocarcinoma. In recent years, intraductal papillary neoplasm of the bile ducts (IPN-B), which is analogous to intraductal papillary mucinous neoplasm of the pancreas, has been recognized as a distinct pathologic entity and a precursor lesion to adenocarcinoma of the bile ducts. Intraductal tubulopapillary neoplasm (ITPN) of the bile duct was subsequently described as a distinct pathologic entity...
February 1, 2019: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Stephen A Rosenberg, Lauren E Henke, Narek Shaverdian, Kathryn Mittauer, Andrzej P Wojcieszynski, Craig R Hullett, Mitchell Kamrava, James Lamb, Minsong Cao, Olga L Green, Rojano Kashani, Bhudatt Paliwal, John Bayouth, Paul M Harari, Jeffrey R Olsen, Percy Lee, Parag J Parikh, Michael Bassetti
Purpose: Daily magnetic resonance (MR)-guided radiation has the potential to improve stereotactic body radiation therapy (SBRT) for tumors of the liver. Magnetic resonance imaging (MRI) introduces unique variables that are untested clinically: electron return effect, MRI geometric distortion, MRI to radiation therapy isocenter uncertainty, multileaf collimator position error, and uncertainties with voxel size and tracking. All could lead to increased toxicity and/or local recurrences with SBRT...
January 2019: Advances in Radiation Oncology
Petko Karagyozov, Irina Boeva, Ivan Tishkov
Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy (SOC), biliary indications and possible adverse events...
January 16, 2019: World Journal of Gastrointestinal Endoscopy
M-W You, S J Yun
AIM: To identify magnetic resonance imaging (MRI) features for differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (IHCC) and summarise their diagnostic accuracy. MATERIALS AND METHODS: PubMed and EMBASE were searched for studies that employed MRI features to differentiate HCC from IHCC. Overlapping descriptors used to denote the same imaging finding in different studies were subsumed under a single feature. The pooled diagnostic accuracies, including the diagnostic odds ratios (DORs) and 95% confidence intervals (CIs) of the identified features, were calculated using a bivariate random-effects model...
January 28, 2019: Clinical Radiology
Masako Akatsuka, Takayoshi Nakajima, Shinichi Ikuta, Tsukasa Aihara, Kurando Kusunoki, Yu Kitamura, Noriko Ichise, Ikumi Hamano, Ryo Okamoto, Yoshihiko Nakamoto, Fumihiko Kimura, Hidenori Yanagi, Ayako Kakuno, Naoki Yamanaka
A 74-year-old man was admitted to a local hospital with liver dysfunction. Imaging modalities revealed bile duct stenosis at the bifurcation of the anterior and posterior trunk. Exfoliative cytology of the bile and brushing cytology of the bile duct both revealed Class Ⅴ, and biopsy from the stenotic bile duct showed well differentiated adenocarcinoma. We diagnosed the patient with hilar cholangiocarcinoma and performed extended right bisectionectomy and biliary reconstruction after percuta- neous transhepatic right portal vein embolization(PTPE)...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masahiro Shiihara, Ryota Higuchi, Satoru Morita, Toru Furukawa, Takehisa Yazawa, Shuichiro Uemura, Wataru Izumo, Masakazu Yamamoto
BACKGROUND: This study aimed to demonstrate the diagnostic ability of 64-row multidetector computed tomography (64-row MDCT) for longitudinal superficial extension of distal cholangiocarcinoma (LSEDC). METHODS: Twenty-seven patients with distal cholangiocarcinoma (DC) underwent preoperative 64-row MDCT without drainage tubes. LSEDC was diagnosed using curved planar reconstruction images reconstructed from 64-row MDCT, which were compared with pathologic findings...
March 2019: Journal of Surgical Research
Seowoo Lee, Jae Hwan Lee, Hyun Beom Kim, In Joon Lee
Sixty-four-year-old female who underwent hemi-hepatectomy for intrahepatic cholangiocarcinoma a year ago presented with biliary sputum, cough and fever. Cross-sectional imaging showed a recurred tumor involving right diaphragmatic area and an abscess formation in liver dome with adjacent right lower lobe of lung. Percutaneous transhepatic biliary drainage and percutaneous drainage of lung abscess were performed. Tubogram showed connections between the lung abscess cavity and multiple distal bronchi, suggesting bronchobiliary fistulas...
January 25, 2019: Cardiovascular and Interventional Radiology
Silvia Bisello, Matteo Renzulli, Milly Buwenge, Lucia Calculli, Giuseppina Sallustio, Gabriella Macchia, Francesco Deodato, Giancarlo Mattiucci, Silvia Cammelli, Alessandra Arcelli, Lucia Giaccherini, Francesco Cellini, Giovanni Brandi, Sara Guerri, Savino Cilla, Rita Golfieri, Lorenzo Fuccio, Alessio G Morganti, Alessandra Guido
Radiotherapy (RT) is a treatment option for advanced biliary tract cancer (BTC), often combined with sequential and/or concurrent chemotherapy. The use of modern RT techniques requires accurate clinical target volume (CTV) definition and delineation. However, guidelines for CTV delineation in BTC are lacking. Therefore, the aim of this study was to propose a computer tomography (CT) atlas for CTV definition of BTC. We previously proposed guidelines to define the nodal CTV (CTV-N) in BTC. In this study, based on a literature analysis, we defined the margins to be added to the gross tumor volume (GTV; subclinical and microscopic disease) to define the primary tumor CTV (CTV-T)...
February 2019: Oncology Letters
Ken Nagata, Takahiro Einama, Akifumi Kimura, Michinori Murayama, Hiroteru Takeo, Makoto Nishikawa, Mayumi Hoshikawa, Takuji Noro, Sho Ogata, Suefumi Aosasa, Yoshiki Kajiwara, Eiji Shinto, Yoshihisa Yaguchi, Shuichi Hiraki, Hironori Tsujimoto, Kazuo Hase, Hideki Ueno, Junji Yamamoto
The present study reports a case of mass-forming intrahepatic cholangiocarcinoma (ICC), which mimicked cholangiocellular carcinoma (CoCC) during imaging and a needle biopsy examination. A 51-year-old female with no relevant medical history was referred to the National Defense Medical College hospital with an intrahepatic tumor. Computed tomography demonstrated non-homogeneous enhancement in the early arterial phase and persistent enhancement in the portal and equilibrium phases, together with notable swelling of the para-aortic lymph nodes...
January 2019: Oncology Letters
Wenwu Ling, Changli Lu, He Huang, Tingting Qiu, Qiang Lu, Chengwu Huang, Ping Gong, Yan Luo, Shigao Chen
RATIONALE: Epstein-Barr virus (EBV)-related lymphoepithelioma-like cholangiocarcinoma (LELCC) is an extremely rare primary liver tumor with nonspecific clinical manifestations. The clinicopathological features of EBV-associated LELCC have been reported in a few cases. But reports of the tumor's imaging characteristics, particularly ultrasonographic findings, are very rare. PATIENT CONCERNS: The first patient was a 64-year-old man with left upper quadrant pain and no nausea and dizziness for about 3 months...
January 2019: Medicine (Baltimore)
Prakriti Gupta, Shashi Dhawan, Vivek Mangla, Siddharth Mehrotra, Shailendra Lalwani, Naimish N Mehta, Samiran Nundy
Obstructive jaundice in the setting of a hilar mass raises strong suspicion of a cholangiocarcinoma, with diagnosis usually made on imaging. Jaundice, when present in patients with hepatocellular carcinoma, is mostly related to underlying liver disease (i.e. cirrhosis) and only rarely to diffuse tumor infiltration of liver parenchyma or hilar invasion. We report here the good outcome of a 67 year-old patient who presented with obstructive jaundice, underwent surgery and was given a diagnosis of hepatocellular carcinoma, which was made only at histopathological examination of resected specimen...
December 28, 2018: Journal of Clinical and Translational Hepatology
Ji Young Park, Tae Joo Jeon
Background/Aims: Pathological diagnosis of biliary strictures with atypical or suspicious cells on endoscopic retrograde brush cytology and indeterminate strictures on imaging is challenging. The aim of this study was to identify markers for malignant strictures in such cases. Methods: We retrospectively analyzed data collected from 146 consecutive patients with indeterminate biliary strictures on imaging who underwent endoscopic retrograde brush cytology from 2007 to 2013...
January 9, 2019: Clinical Endoscopy
Ji Hye Min, Young Kon Kim, Seo-Youn Choi, Tae Wook Kang, Soon Jin Lee, Jong Man Kim, Soohyun Ahn, Hyun Cho
Purpose To identify whether arterial enhancement pattern at MRI could predict the prognosis after surgical resection of intrahepatic mass-forming cholangiocarcinoma (IMCC). Materials and Methods Patients who underwent curative hepatic resection and preoperative MRI for IMCC from November 2007 to September 2016 were retrospectively evaluated. MRI enhancement pattern was classified by two radiologists. Recurrence and death data were retrieved until September 31, 2017. Prognostic factor analysis was performed by using preoperative and postoperative clinical-pathologic factors, as well as imaging findings...
January 8, 2019: Radiology
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