keyword
https://read.qxmd.com/read/38530321/androgenic-steroids-induce-pathologic-scarring-in-a-preclinical-porcine-model-via-dysfunctional-extracellular-matrix-deposition
#1
JOURNAL ARTICLE
Erik Reiche, Patrick R Keller, Vance Soares, Calvin R Schuster, Siti Rahmayanti, Jessica Mroueh, Vanessa Mroueh, Marie Billaud, Sophia Hu, Hunter Hoover-Watson, Christine G Lian, Yu Tan, Joshua C Doloff, Annie E Newell-Fugate, Devin Coon
Hypertrophic scarring is a major source of morbidity. Sex hormones are not classically considered modulators of scarring. However, based on increased frequency of hypertrophic scarring in patients on testosterone, we hypothesized that androgenic steroids induce abnormal scarring and developed a preclinical porcine model to explore these effects. Mini-swine underwent castration, received no testosterone (noT) or biweekly testosterone therapy (+T), and underwent excisional wounding. To create a delayed wound healing model, a subset of wounds were re-excised at 2 weeks...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38528654/cd44-and-cd133-protein-expression-might-serve-as-a-prognostic-factor-for-early-occurrence-castration-resistant-prostate-cancer
#2
JOURNAL ARTICLE
Yayi Dwina, Litta Septina Mahmelia Zaid, Meilania Saraswati, Lisnawati Rachmadi, Aria Kekalih, Nur Rahadiani, Melva Louisa, Hasrayati Agustina, Chaidir Arif Mochtar, Agus Rizal Ardy Hariandy Hamid
BACKGROUND: The occurrence of castration-resistant prostate cancer (CRPC) varies in patients with advanced prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). The rate of occurrence of CRPC may be related to the presence of prostate cancer stem cells (CSC). Thus, this study aims to evaluate the presence of CSC markers (CD44 and CD133) in histopathology tissue at the time of diagnosis and their correlation with the occurrence of CRPC in patients with advanced PCa within 2 years of ADT...
March 25, 2024: Prostate
https://read.qxmd.com/read/38492111/treatment-intensification-strategies-for-men-undergoing-definitive-radiotherapy-for-high-risk-prostate-cancer
#3
REVIEW
John Nikitas, Amar Kishan, Albert Chang, Sai Duriseti, Nicholas G Nichols, Robert Reiter, Matthew Rettig, Wayne Brisbane, Michael L Steinberg, Luca Valle
PURPOSE: Treatment intensification of external beam radiotherapy (EBRT) plays a crucial role in the treatment of high-risk prostate cancer. METHODS: We performed a critical narrative review of the relevant literature and present new developments in evidence-based treatment intensification strategies. RESULTS: For men with high-risk prostate cancer, there is strong evidence to support prolonging androgen deprivation therapy (ADT) to 18-36 months and escalating the dose to the prostate using a brachytherapy boost...
March 16, 2024: World Journal of Urology
https://read.qxmd.com/read/38477380/hypofractionated-radiation-therapy-combined-with-androgen-deprivation-therapy-for-high-risk-localized-prostate-cancer
#4
JOURNAL ARTICLE
Tae Hoon Lee, Hongryull Pyo, Gyu Sang Yoo, Seong Soo Jeon, Seong Il Seo, Byong Chang Jeong, Hwang Gyun Jeon, Hyun Hwan Sung, Minyong Kang, Wan Song, Jae Hoon Chung, Bong Kyung Bae, Won Park
INTRODUCTION: This study aimed to analyse the treatment outcomes of moderately hypofractionated radiation therapy (RT) combined with androgen deprivation therapy (ADT) and the prognostic implications of prostate-specific antigen (PSA) kinetics in high-risk localized prostate cancer. METHODS: The medical records of 140 patients who underwent definitive RT (70 Gy in 28 fractions) combined with ADT were retrospectively reviewed. ADT consists of a gonadotropin-releasing hormone agonist and an anti-androgen...
March 13, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38464045/antiandrogen-flutamide-induced-restoration-of-mir-449-expression-mitigates-functional-biomarkers-associated-with-ovarian-cancer-risk
#5
Xia Wang, Ho-Hyung Woo, Michele Wei, Steven Gibson, Mitzi Miranda, Demaretta Rush, Janiel Cragun, Wenxin Zheng, Guang Yao, Setsuko K Chambers
BACKGROUND: The involvement of the androgen and androgen receptor (AR) pathway in the development of epithelial ovarian cancer is increasingly recognized. However, the specific mechanisms by which anti-androgen agents, such as flutamide, may prevent ovarian cancer and their efficacy remain unknown. We examined the effects of flutamide on the miRNA expression profile found in women at high risk (HR) for ovarian cancer. METHODS: Ovarian and tubal tissues, free from ovarian, tubal, peritoneal cancers, and serous tubal intraepithelial carcinoma (STIC), were collected from untreated and flutamide-treated HR women...
February 29, 2024: medRxiv
https://read.qxmd.com/read/38392056/quality-of-life-longitudinal-evaluation-in-prostate-cancer-patients-from-radiotherapy-start-to-5-years-after-imrt-igrt
#6
JOURNAL ARTICLE
Angelo Maggio, Tiziana Rancati, Marco Gatti, Domenico Cante, Barbara Avuzzi, Cinzia Bianconi, Fabio Badenchini, Bruno Farina, Paolo Ferrari, Tommaso Giandini, Giuseppe Girelli, Valeria Landoni, Alessandro Magli, Eugenia Moretti, Edoardo Petrucci, Paolo Salmoiraghi, Giuseppe Sanguineti, Elisa Villa, Justyna Magdalena Waskiewicz, Alessia Guarneri, Riccardo Valdagni, Claudio Fiorino, Cesare Cozzarini
PURPOSE: The purpose of this study is to study the evolution of quality of life (QoL) in the first 5 years following Intensity-modulated radiation therapy (IMRT) for prostate cancer (PCa) and to determine possible associations with clinical/treatment data. MATERIAL AND METHODS: Patients were enrolled in a prospective multicentre observational trial in 2010-2014 and treated with conventional (74-80 Gy, 1.8-2 Gy/fr) or moderately hypofractionated IMRT (65-75.2 Gy, 2...
February 1, 2024: Current Oncology
https://read.qxmd.com/read/38388789/-metastasis-directed-therapy-in-prostate-cancer
#7
REVIEW
Angelika Borkowetz, Tobias Hölscher
BACKGROUND: Metastasis-directed therapy (MDT) in oligometastatic prostate cancer (omHSPC) is playing an increasingly important role in therapy with the aim of delaying disease progression, the start of systemic treatment or switching systemic treatment to improve the patient's overall prognosis. Molecular imaging as prostate-specific membrane antigen positron emission tomography (PSMA-PET) imaging allows metastases to be detected with a higher sensitivity and specificity. This means that they can be detected early and made accessible for treatment...
February 22, 2024: Urologie
https://read.qxmd.com/read/38370066/new-value-chain-pentadesma-nuts-and-butter-from-west-africa-to-international-markets-biological-activities-health-benefits-and-physicochemical-properties
#8
JOURNAL ARTICLE
Ifagbémi Bienvenue Chabi, Midimahu Vahid Aïssi, Oscar Zannou, Yénoukounmè E Kpoclou, Bernolde Paul Ayegnon, Marius Eric Badoussi, Vénérande Y Ballogou, Gulden Goksen, Amin Mousavi Khaneghah, Adéchola P Polycarpe Kayodé
The tallow or butter tree ( Pentadesma butyracea Sabine) is a ligneous forest species of multipurpose use largely distributed in Sub-Sahara Africa. Owing to the biological properties of different parts of the tree and physicochemical properties, as well as the numerous benefits of its fruits, research on P. butyracea products, especially kernels and butter, has now gained more interest. Thus, the scientific literature revealed that Pentadesma butter is a more promising product with good physical and technological characteristics...
February 2024: Food Science & Nutrition
https://read.qxmd.com/read/38362126/sex-specific-outcomes-in-cancer-therapy-the-central-role-of-hormones
#9
REVIEW
Parisa Bakhshi, Jim Q Ho, Steven Zanganeh
Sex hormones play a pivotal role in modulating various physiological processes, with emerging evidence underscoring their influence on cancer progression and treatment outcomes. This review delves into the intricate relationship between sex hormones and cancer, elucidating the underlying biological mechanisms and their clinical implications. We explore the multifaceted roles of estrogen, androgens, and progesterone, highlighting their respective influence on specific cancers such as breast, ovarian, endometrial, and prostate...
2024: Frontiers in medical technology
https://read.qxmd.com/read/38353836/cardamonin-loaded-liposomal-formulation-for-improving-percutaneous-penetration-and-follicular-delivery-for-androgenetic-alopecia
#10
JOURNAL ARTICLE
Zhenda Liu, Zehui He, Xinyi Ai, Teng Guo, Nianping Feng
Androgenic alopecia (AGA) has a considerable impact on the physical and mental health of patients. Nano preparations have apparent advantages and high feasibility in the treatment of AGA. Cardamonin (CAR) has a wide range of pharmacological activities, but it has the problems of poor solubility in water and low bioavailability. There are few, if any, researches on the use of nano-loaded CAR to improve topical skin delivery of AGA. In this study, a CAR-loaded liposomal formulation (CAR@Lip and CAR@Lip Gel) was developed and characterized...
February 14, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38324981/genome-wide-association-study-identifies-genetic-regulation-of-oestrone-concentrations-and-association-with-endometrial-cancer-risk-in-postmenopausal-women
#11
JOURNAL ARTICLE
Chenglong Yu, Andrew Bakshi, Robin J Bell, Rakibul M Islam, David J Handelsman, John J McNeil, Paul Lacaze, Susan R Davis
BACKGROUND: Oestrone, predominantly made in fat, is the main circulating oestrogen and important for target tissue oestradiol production in women after menopause. The present study was undertaken to determine the genetic regulation of blood oestrone, measured with precision, in postmenopausal women and to explore associations between the identified genetic loci and endometrial cancer in a large, independent cohort. METHODS: A genome-wide association study (GWAS) was undertaken in women aged at least 70 years to identify genetic associations with blood oestrone concentrations measured by liquid chromatography and tandem mass spectrometry...
February 6, 2024: EBioMedicine
https://read.qxmd.com/read/38318809/real-world-effectiveness-and-safety-of-goserelin-10-8-mg-depot-in-chinese-patients-with-localized-or-locally-advanced-prostate-cancer
#12
MULTICENTER STUDY
Nanhui Chen, Zengjun Wang, Ming Chen, Qi Ma, Yi He, Yujie Wang, Xin Li, Mingxing Qiu, Lei Shi, Shaoxing Zhu, Qun Xie, Xiuheng Liu, Benkang Shi, Guowen Lin, Weizhong Yang, Yongbin Liao, Haibin Zhang, Shusheng Wang, Jiexian Li, Shaogang Wang, Lijun Dong, Hui Chen, Jiaju Lu, Yongyi Cheng, Xiaoping Zhang, Lulin Ma, Liqun Zhou, He Wang, Shen Li, Dingwei Ye
OBJECTIVE: Real-word data on long-acting luteinizing hormone-releasing hormone (LHRH) agonists in Chinese patients with prostate cancer are limited. This study aimed to determine the real-world effectiveness and safety of the LHRH agonist, goserelin, particularly the long-acting 10.8-mg depot formulation, and the follow-up patterns among Chinese prostate cancer patients. METHODS: This was a multicenter, prospective, observational study in hormone treatment-naïve patients with localized or locally advanced prostate cancer who were prescribed goserelin 10...
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38305451/determination-of-enzalutamide-long-term-safety-and-efficacy-for-castration-resistant-prostate-cancer-patients-after-combined-anti-androgen-blockade-followed-by-alternative-anti-androgen-therapy-a-multicenter-prospective-delc-study
#13
JOURNAL ARTICLE
Akira Nagahara, Motohide Uemura, Mototaka Sato, Wataru Nakata, Masao Tsujihata, Tetsuya Takao, Soichi Matsumura, Kensaku Nishimura, Shingo Takada, Toshichika Iwanishi, Yasuyuki Kobayashi, Yu Ishizuya, Tsuyoshi Takada, Koichi Okada, Hitoshi Inoue, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Kazutoshi Fujita, Norio Nonomura
BACKGROUND: Alternative anti-androgen therapy has been widely used as a first-line treatment for castration-resistant prostate cancer, and it may affect treatment outcome of subsequent agents targeting the androgen receptor axis. We conducted the prospective observational DELC (Determination of Enzalutamide Long-term safety and efficacy for Castration-resistant prostate cancer patients after combined anti-androgen blockade followed by alternative anti-androgen therapy) study to evaluate the efficacy of enzalutamide in patients with castration-resistant prostate cancer who underwent prior combined androgen blockade with bicalutamide and then alternative anti-androgen therapy with flutamide...
February 1, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38296003/cypermethrin-induces-sertoli-cell-apoptosis-through-endoplasmic-reticulum-mitochondrial-coupling-involving-ip3r1-grp75-vdac1
#14
REVIEW
Rui Zhang, Xu-Xu Wang, Jia-Fei Xie, Ting-Ting Yao, Qian-Wen Guo, Qi Wang, Zhen Ding, Jin-Peng Zhang, Mei-Rong Zhang, Li-Chun Xu
A widely used type II pyrethroid pesticide cypermethrin (CYP) is one of endocrine disrupting chemicals (EDCs) with anti-androgenic activity to induce male reproductive toxicology. However, the mechanisms have not been fully elucidated. This study was to explore the effects of CYP on apoptosis of mouse Sertoli cells (TM4) and the roles of endoplasmic reticulum (ER)-mitochondria coupling involving 1,4,5-trisphosphate receptor type1-glucose-regulated protein 75-voltage-dependent anion channel 1 (IP3R1-GRP75-VDAC1)...
January 29, 2024: Reproductive Toxicology
https://read.qxmd.com/read/38266860/glycolysis-related-lncrna-snhg3-mir-139-5p-pkm2-axis-promotes-castration-resistant-prostate-cancer-crpc-development-and-enzalutamide-resistance
#15
JOURNAL ARTICLE
Yicong Yao, Xi Chen, Xinan Wang, Haopeng Li, Yaru Zhu, Xilei Li, Zhihui Xiao, Tong Zi, Xin Qin, Yan Zhao, Tao Yang, Licheng Wang, Gang Wu, Xia Fang, Denglong Wu
Although androgen deprivation therapy (ADT) by the anti-androgen drug enzalutamide (Enz) may improve the survival level of patients with castration-resistant prostate cancer (CRPC), most patients may eventually fail due to the acquired resistance. The reprogramming of glucose metabolism is one type of the paramount hallmarks of cancers. PKM2 (Pyruvate kinase isozyme typeM2) is a speed-limiting enzyme in the glycolytic mechanism, and has high expression in a variety of cancers. Emerging evidence has unveiled that microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have impact on tumor development and therapeutic efficacy by regulating PKM2 expression...
January 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38262096/paternal-p-p-dde-exposure-and-pre-pubertal-high-fat-diet-increases-the-susceptibility-to-fertility-impairment-and-sperm-igf2-dmr2-hypo-methylation-in-male-offspring
#16
JOURNAL ARTICLE
Liping Lu, Yuzhou Cheng, Wei Wu, Lijun Wang, Shuqi Li, Qianyu Li, Liangjing Chen, Jianyun Zhang, Rong Chen, Xiaohua Tan, Yu Hong, Lei Yang, Yang Song
The hypothesis of paternal origins of health and disease (POHaD) indicates that paternal exposure to adverse environment could alter the epigenetic modification in germ line, increasing the disease susceptibility in offspring or even in subsequent generations. p,p'-Dichlorodiphenyldichloroethylene (p,p'-DDE) is an anti-androgenic chemical and male reproductive toxicant. Gestational p,p'-DDE exposure could impair reproductive development and fertility in male offspring. However, the effect of paternal p,p'-DDE exposure on fertility in male offspring remains uncovered...
January 22, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38256338/androgen-deprivation-therapy-for-prostate-cancer-focus-on-cognitive-function-and-mood
#17
REVIEW
Allison B Reiss, Shelly Gulkarov, Aaron Pinkhasov, Katie M Sheehan, Ankita Srivastava, Joshua De Leon, Aaron E Katz
Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer's disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs...
December 30, 2023: Medicina
https://read.qxmd.com/read/38254786/g%C3%AE-i-2-protein-inhibition-blocks-chemotherapy-and-anti-androgen-induced-prostate-cancer-cell-migration
#18
JOURNAL ARTICLE
Silvia Caggia, Alexis Johnston, Dipak T Walunj, Aanya R Moore, Benjamin H Peer, Ravyn W Everett, Adegboyega K Oyelere, Shafiq A Khan
We have previously shown that heterotrimeric G-protein subunit alphai2 (Gαi 2) is essential for cell migration and invasion in prostate, ovarian and breast cancer cells, and novel small molecule inhibitors targeting Gαi 2 block its effects on migratory and invasive behavior. In this study, we have identified potent, metabolically stable, second generation Gαi 2 inhibitors which inhibit cell migration in prostate cancer cells. Recent studies have shown that chemotherapy can induce the cancer cells to migrate to distant sites to form metastases...
January 10, 2024: Cancers
https://read.qxmd.com/read/38254687/identification-of-molecular-markers-associated-with-prostate-cancer-subtypes-an-integrative-bioinformatics-approach
#19
JOURNAL ARTICLE
Ilaria Granata, Paola Barboro
Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges, characterised by heterogeneous cell populations that, over time, lead to the development of different androgen-dependent or -independent phenotypes. Despite important advances in therapeutic strategies, CRPC remains incurable. Context-specific essential genes represent valuable candidates for targeted anti-cancer therapies. Through the investigation of gene and protein annotations and the integration of published transcriptomic data, we identified two consensus lists to stratify PCa patients' risk and discriminate CRPC phenotypes based on androgen receptor activity...
January 10, 2024: Biomolecules
https://read.qxmd.com/read/38249107/early-female-transgender-identity-after-prenatal-exposure-to-diethylstilbestrol-report-from-a-french-national-diethylstilbestrol-des-cohort
#20
JOURNAL ARTICLE
Laura Gaspari, Marie-Odile Soyer-Gobillard, Scott Kerlin, Françoise Paris, Charles Sultan
Diagnostic of transsexualism and gender incongruence are terms to describe individuals whose self-identity does not match their sex assignment at birth. A transgender woman is an individual assigned male at birth (AMAB) on the basis of the external or internal genitalia who identifies and lives as a woman. In recent decades, a significant increase in the number of transgender people has been reported. Although, its etiology is unknown, biological, anatomical, genetic, environmental and cultural factors have been suggested to contribute to gender variation...
January 12, 2024: Journal of Xenobiotics
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