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JOURNAL ARTICLE
Yong H Sheng, Garrett Z Ng, Kim M Summers, Alison L Every, Gareth Price, Sumaira Z Hasnain, Philip Sutton, Michael A McGuckin
The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori ) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated gene expression profiles in response to H. pylori infection in wild type (WT) and MUC1-deficient mice using microarray-determined mRNA expression, gene network analysis and Ingenuity Pathway Analysis (IPA)...
2020: Frontiers in Cellular and Infection Microbiology
#22
JOURNAL ARTICLE
Alexander C Ford, Yuhong Yuan, David Forman, Richard Hunt, Paul Moayyedi
BACKGROUND: Gastric cancer is the third most common cause of cancer death worldwide. Individuals infected with Helicobacter pylori have a higher likelihood of developing gastric cancer than individuals who are not infected. Eradication of H. pylori in healthy asymptomatic individuals in the general population may reduce the incidence of gastric cancer, but the magnitude of this effect is unclear. OBJECTIVES: To assess the effectiveness of eradication of H. pylori in healthy asymptomatic individuals in the general population in reducing the incidence of gastric cancer...
July 6, 2020: Cochrane Database of Systematic Reviews
#23
REVIEW
Irina N Grigor'eva, Tatyana I Romanova
Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out-both in humans and in animal models-confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum...
June 2, 2020: Microorganisms
#24
JOURNAL ARTICLE
Rika Omote, Yuka Gion, Shizuma Omote, Akira Tari, Takehiro Tanaka, Asami Nishikori, Tadashi Yoshino, Yasuharu Sato
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is mainly associated with Helicobacter pylori infection, and H. pylori eradication therapy is often effective. However, 20-30% of the cases of MALT lymphoma are resistant to the eradication therapy, and translocation of the API2-MALT1 gene is often found in these cases. Most cases without translocation of API2-MALT1 are localized to the stomach, whereas some cases with this translocation are a more advanced stage of MALT lymphoma that spreads to other organs...
September 2020: Medical Molecular Morphology
#25
JOURNAL ARTICLE
Xinjie Yao, Dongyan Liu, Linyan Zhou, Ying Xie, Yan Li
Helicobacter pylori (H. pylori) infection can promote the development of gastric cancer (GC); however, the underlying mechanism is not clear. FAM60A has been found showing high levels in some cancer cells, including lung cancer (A549), and pancreatic cancer (Capan-2) cell lines. Data in oncomine showed that FAM60A overexpression was an critical prognostic factor in GC. In this study, we showed that knockdown of FAM60A could revert the increase of proliferation and the decrease of apoptosis caused by H.pylori infection in HGC-27 and AGS cells...
November 11, 2019: Biochemical and Biophysical Research Communications
#26
REVIEW
Mohsen Sagheb R Shirazi, K Z K Al-Alo, Mohammed Hashim Al-Yasiri, Zainab M Lateef, Abdolmajid Ghasemian
PURPOSE: To evaluate bacterial agents as cancer biomarkers. METHODS AND RESULTS: Various bacterial species have been demonstrated to involve in human cancers. However, the data is not enough for better understanding of predominant specific species. Application of a rapid and early-diagnostic, cost-effective, non-invasive, and inclusive method is a crucial approach for obtaining valid results. The role of Helicobacter pylori (H. pylori) in gastric and duodenal cancer has been confirmed...
September 2020: Journal of Gastrointestinal Cancer
#27
JOURNAL ARTICLE
Mayo Hirabayashi, Manami Inoue, Norie Sawada, Eiko Saito, Sarah K Abe, Akihisa Hidaka, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shoichiro Tsugane
Helicobacter pylori (H. pylori), an established risk factor for gastric cancer, is suggested to also play a role in the development of pancreatic cancer; however, the association remains inconclusive. We examined this association among Japanese men and women. H. pylori and atrophic gastritis (AG) status were determined serologically, using blood sample collected during health checkups. A total of 20,116 subjects enrolled in the Japan Public Health Center-based Prospective Study Cohort II with available data on H...
April 15, 2019: Scientific Reports
#28
JOURNAL ARTICLE
Mei-Yan Xu, Bing Cao, Yan Chen, Natalie Musial, Shuai Wang, Jian Yin, Lan Liu, Qing-Bin Lu
OBJECTIVE: Helicobacter pylori infection is a major cause of several cancers such as gastric, pancreatic and lung. The relationship between H. pylori and tumour markers continues to remain unclear. The primary goal of this study is to clarify the associations between H. pylori infection and six tumour markers (ie, carcinoembryonic antigen (CEA), cancer antigen (CA) 153, CA199, CA724, CA125 and alpha-fetoprotein (AFP)). The secondary goal is to provide understanding for further research about H...
August 23, 2018: BMJ Open
#29
REVIEW
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
August 2018: International Journal of Molecular Medicine
#30
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
#31
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
June 2018: Histochemistry and Cell Biology
#32
JOURNAL ARTICLE
Jiaqi Huang, Ulrika Zagai, Göran Hallmans, Olof Nyrén, Lars Engstrand, Rachael Stolzenberg-Solomon, Eric J Duell, Kim Overvad, Verena A Katzke, Rudolf Kaaks, Mazda Jenab, Jin Young Park, Raul Murillo, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kathryn E Bradbury, Elio Riboli, Dagfinn Aune, Konstantinos K Tsilidis, Gabriel Capellá, Antonio Agudo, Vittorio Krogh, Domenico Palli, Salvatore Panico, Elisabete Weiderpass, Anne Tjønneland, Anja Olsen, Begoña Martínez, Daniel Redondo-Sanchez, Maria-Dolores Chirlaque, Petra Hm Peeters, Sara Regnér, Björn Lindkvist, Alessio Naccarati, Eva Ardanaz, Nerea Larrañaga, Marie-Christine Boutron-Ruault, Vinciane Rebours, Amélie Barré, H B As Bueno-de-Mesquita, Weimin Ye
The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
#33
COMMENT
Jeffrey K Aronson
Inhibition of the H+ /K+ -adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
#34
REVIEW
Marino Venerito, Riccardo Vasapolli, Peter Malfertheiner
Helicobacter pylori (H. pylori) is a Gram negative spiraliform bacterium that is commonly found in the stomach. H. pylori infection is still one of the world's most frequent infections, present in the stomachs of approximately one-half of the world's people. H. pylori infection is etiologically linked to histologic chronic active gastritis, peptic ulcer disease, and primary B-cell gastric lymphoma (gastric MALT lymphoma) and represents the major risk factor for the development of sporadic non-cardia gastric cancer (GC) of both intestinal and diffuse type...
2016: Advances in Experimental Medicine and Biology
#35
JOURNAL ARTICLE
Jorie Buijs, Djuna L Cahen, Marianne J van Heerde, Bettina E Hansen, Henk R van Buuren, Maikel P Peppelenbosch, Gwenny M Fuhler, Marco J Bruno
OBJECTIVES: Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, clinically mimicking pancreatic cancer. In 2009, a serological diagnostic test detecting antibodies against plasminogen-binding protein (PBP) of Helicobacter pylori was reported with outstanding test performances (NEJM 361:135). We aimed to validate these findings. METHODS: Between March 2007 and May 2011, sera were collected from consecutive patients presenting with type 1 AIP, pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), primary sclerosing cholangitis (PSC), and healthy controls (HC) with or without antibodies against H...
November 2016: American Journal of Gastroenterology
#36
JOURNAL ARTICLE
Birol Baysal, Ali Tüzün İnce, Bilge Gültepe, Zuhal Gücin, Fatma Ümit Malya, Mukaddes Tozlu, Hakan Şentürk, Pelin Bağcı, Çiğdem Ataizi Çelikel, Fügen Aker, Selvinaz Özkara, Esra Paşaoğlu, Nevra Dursun, Banu Yılmaz Özgüven, Deniz Tunçel
BACKGROUND: About half of the world population is infected with Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer and considered to be a risk factor for pancreatic ductal adenocarcinoma. Whether the bacterium is associated with intraductal papillary mucinous neoplasm, believed to be a precursor of pancreatic ductal adenocarcinoma, is unknown. The aim of this study was to investigate the presence of H. pylori DNA in tissue sections of intraductal papillary mucinous neoplasm...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#37
JOURNAL ARTICLE
Y B Wang, Y P Wang, J Zou, B J Bai, G C Ren, B Q Cai
AIM: To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS: An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This investigation included medical history evaluations, physical, gastroscopic and pathological examinations, tests for Helicobacter pylori (H. pylori) infection, and analysis of the nitrate content in their drinking water...
September 15, 1997: World Journal of Gastroenterology: WJG
#38
JOURNAL ARTICLE
A A Svistunov, N V Kireeva, M A Osadchuk, I M Kvetnoy
AIM: To study the role of the vascular endothelial growth factor (VEGF), Ki-67, BCL-2, and endocrine cells (EC) of gastric mucosa producing somatostatin (SS), glucagon (GL), and pancreatic polypeptide (PP) in diseases associated with Helicobacter pylori. To use the data obtained to develop early diagnostic criteria for the progress of structural changes in gastric mucosa of the patients with stomach ulcer disease [SUD), chronic atrophic gastritis (CAG), gastric adenomatous polyps (GAP), and gastric cancer (GC) before and after surgical intervention and eradication of H...
2015: Klinicheskaia Meditsina
#39
JOURNAL ARTICLE
Xin-Zu Chen, Ben Schöttker, Felipe Andres Castro, Hongda Chen, Yan Zhang, Bernd Holleczek, Hermann Brenner
OBJECTIVES: To assess the association of H. pylori and chronic atrophic gastritis (AG) with colonic, pancreatic and gastric cancer in a population-based prospective cohort. METHODS: Serum antibodies against H. pylori in general and specific to cytotoxin-associated gene A (CagA), as well as serum pepsinogen I and II were analyzed in 9,506 men and women, aged 50-75 years in a cohort study from Saarland, Germany. Incident cases of colonic, pancreatic and gastric cancer were ascertained by record linkage with data from the Saarland Cancer Registry...
March 29, 2016: Oncotarget
#40
REVIEW
Elizabeth Ma Rabelo-Gonçalves, Bruna M Roesler, José Mr Zeitune
Helicobacter pylori (H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases...
December 28, 2015: World Journal of Hepatology
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