keyword
https://read.qxmd.com/read/38409691/an-overview-of-the-dichotomous-role-of-microbiota-in-cancer-progression-and-management
#1
JOURNAL ARTICLE
Pooja Jain, Sradhanjali Mohapatra, Uzma Farooq, Nazia Hassan, Mohd Aamir Mirza, Zeenat Iqbal
It is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as Fusobacterium nucleatum and Porphyromonas gingivalis...
February 21, 2024: Current Cancer Drug Targets
https://read.qxmd.com/read/38379784/-helicobacter-pylori-and-immunotherapy-for-gastrointestinal-cancer
#2
JOURNAL ARTICLE
Keren Jia, Yang Chen, Yi Xie, Xicheng Wang, Yajie Hu, Yu Sun, Yanshuo Cao, Liyan Zhang, Yakun Wang, Zhenghang Wang, Zhihao Lu, Jian Li, Xiaotian Zhang, Lin Shen
Helicobacter pylori infection is associated with the risk of gastrointestinal (GI) cancers; however, its impact on immunotherapy for GI cancers remains uncertain. In this study, we included 10,122 patients who underwent 13 C-urea breath tests. Among 636 patients with Epstein-Barr virus-negative microsatellite-stable gastric cancer (GC) who were treated with anti-PD-1/PD-L1 therapy, H. pylori -positive patients exhibited significantly longer immune-related progression-free survival (irPFS) compared with H...
March 4, 2024: The innovation
https://read.qxmd.com/read/37849565/comprehensive-review-of-red-meat-consumption-and-the-risk-of-cancer
#3
REVIEW
Barath Prashanth Sivasubramanian, Mihir Dave, Viraj Panchal, Johnnie Saifa-Bonsu, Srujana Konka, Farahnaz Noei, Sanchitha Nagaraj, Umabalan Terpari, Priya Savani, Pratikkumar H Vekaria, Vikramaditya Samala Venkata, Lokesh Manjani
Red and processed meat consumption rates are increasing in the United States. In this review, we present the current evidence that links red meat consumption and cancer development. A literature search was conducted in the PubMed and Google Scholar databases to review red meat consumption and its association with breast cancer and gastrointestinal cancer. Due to the presence of heme iron, which triggers oxidative reactions that eventually result in tumor formation, red meat consumption is strongly associated with the development of breast cancer...
September 2023: Curēus
https://read.qxmd.com/read/37576886/effects-of-ranitidine-and-nizatidine-on-the-risk-of-gastrointestinal-cancer
#4
JOURNAL ARTICLE
Hyejung Kang, Chung Mo Nam, Dong-Woo Choi, Sohee Park
PURPOSE: Gastrointestinal (GI) cancer occurs in digestive organs such as the stomach, colon, liver, esophagus, and pancreas. About 83,034 cases occurred in Korea alone in 2020. Dietary factors, alcohol consumption, Helicobacter pylori ( H. pylori ), and lifestyle factors increase the incidence of diseases such as gastritis, peptic ulcer, pancreatitis, and gastroesophageal reflux disease (GERD), which can develop into GI cancer. However, in 2019, the US Food and Drug Administration announced that the drugs ranitidine and nizatidine, which are used for digestive disorders, contain carcinogens...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37357161/the-link-between-helicobacter-pylori-infection-and-gallbladder-and-biliary-tract-diseases-a-review
#5
REVIEW
Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G Shelat
Helicobacter pylori is a gram-negative pathogen commonly associated with peptic ulcer disease and gastric cancer. H. pylori infection has also been reported in cholelithiasis, cholecystitis, gallbladder polyps, and biliary tract cancers. However, the association between H. pylori and gallbladder and biliary tract pathologies remains unclear due to the paucity of literature. In response to the current literature gap, we aim to review and provide an updated summary of the association between H. pylori with gallbladder and biliary tract diseases and its impact on their clinical management...
August 31, 2023: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/37009972/incidence-of-gastrointestinal-malignancies-increases-in-persons-received-eradication-therapy-for-helicobacter-pylori-a-cohort-study
#6
JOURNAL ARTICLE
Timo U Kosunen, Anna A Nieminen, Arto Kokkola, Perttu Arkkila, Eero Pukkala, Hilpi Rautelin
BACKGROUND: Long-term Helicobacter pylori infection increases the risk of gastric malignancies. Since the symptoms for H. pylori gastritis, as well as for several malignancies, may be nonexisting or highly unspecific, even H. pylori-positive subjects with underlying malignancies may receive eradication therapy. The aim was to assess the incidence of gastrointestinal and various other malignancies in individuals after eradication therapy for H. pylori infection. MATERIALS AND METHODS: A cohort of 217,554 subjects (120,344 women and 97,210 men), who had purchased specific combinations of drugs for H...
April 3, 2023: Helicobacter
https://read.qxmd.com/read/36890981/is-helicobacter-pylori-infection-associated-with-pancreatic-cancer-a-systematic-review-and-meta-analysis-of-observational-studies
#7
JOURNAL ARTICLE
Ben-Gang Zhou, Yu-Zhou Mei, Jing-Shu Wang, Jian-Lei Xia, Xin Jiang, Sheng-Yong Ju, Yan-Bing Ding
BACKGROUND AND OBJECTIVES: Recent observational studies have investigated the association between Helicobacter pylori ( H. pylori ) infection and pancreatic cancer with conflicting data. Therefore, we conducted a systematic review and meta-analysis to assess the potential association. DESIGN: This is a systematic review and meta-analysis. METHODS: We searched three databases (PubMed, Embase, and Web of Science) from inception to 30 August 2022...
2023: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/36854058/helicobacter-pylori-seropositivity-abo-blood-type-and-pancreatic-cancer-risk-from-5-prospective-cohorts
#8
JOURNAL ARTICLE
Alice A Lee, Qiao-Li Wang, Jihye Kim, Ana Babic, Xuehong Zhang, Kimberly Perez, Kimmie Ng, Jonathan Nowak, Nader Rifazzzzzzzzgi, Howard D Sesso, Julie E Buring, Garnet L Anderson, Jean Wactawski-Wende, Robert Wallace, JoAnn E Manson, Edward L Giovannucci, Meir J Stampfer, Peter Kraft, Charles S Fuchs, Chen Yuan, Brian M Wolpin
BACKGROUND: Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa. METHODS: We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts...
March 1, 2023: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/36381762/gastric-cancer-after-helicobacter-pylori-eradication-for-nodular-gastritis-in-an-adolescent
#9
Takuma Okmaura, Yugo Iwaya, Mai Iwaya, Tomonobu Koizumi, Tadanobu Nagaya
A 16-year-old girl underwent esophagogastroduodenoscopy (EGD) after the detection of Helicobacter pylori ( H. pylori ) antibodies in her urine during a school health screening, which revealed nodular gastritis (NG). She was diagnosed as having H. pylori infection histologically and by biopsy culture specimens and soon commenced eradication therapy. Eight weeks later, eradication was confirmed by a urea breath test. At the age of 19, however, she was referred to our hospital with epigastralgia and lower back pain...
October 2022: Curēus
https://read.qxmd.com/read/36185865/association-between-helicobacter-pylori-infection-and-the-risk-of-pancreatic-cancer-a-systematic-review-based-on-observational-studies
#10
REVIEW
Venkatesh Panthangi, Adrienne R Cyril Kurupp, Anjumol Raju, Gaurav Luthra, Mahrukh Shahbaz, Halah Almatooq, Paul Foucambert, Faith D Esbrand, Sana Zafar, Safeera Khan
Helicobacter pylori ( H. pylori ) bacterial infection has long been scrutinized as one of the potential risk factors for the development of pancreatic cancer with quite inconsistent and unequivocal data. Little is known about the risk factors involved with this malignancy. In this systematic review, we aimed to examine the relationship between H. pylori infection and pancreatic cancer based on the evidence from the existing observational studies across the world. We searched major electronic databases such as PubMed, MEDLINE, Science Direct, and Cochrane Library...
August 2022: Curēus
https://read.qxmd.com/read/36093540/the-relationship-between-helicobacter-pylori-and-pancreatic-cancer-a-meta-analysis
#11
JOURNAL ARTICLE
Wei Xu, Xiaochong Zhou, Minyue Yin, Jingwen Gao, Zhen Weng, Chunfang Xu
Background: The relationship between Helicobacter pylori ( H. pylori , HP) infection and pancreatic cancer would be investigated in this article. Methods: All cohort studies and case-control studies about H. pylori infection and pancreatic cancer up to October 2021 were searched in the databases of PubMed, Embase and Cochrane. The combined odds ratio (OR) and 95% confidence interval (CI) were calculated by R 4.1.0 software. Funnel plot and Egger test were used to evaluate publication bias...
August 2022: Translational Cancer Research
https://read.qxmd.com/read/35672698/clinicopathological-characteristics-of-pancreatic-acinar-cell-metaplasia-associated-with-helicobacter-pylori-infection
#12
JOURNAL ARTICLE
Takafumi Fuchino, Yasuhiro Wada, Masaaki Kodama, Ken-Ichi Mukaisho, Kazuhiro Mizukami, Tadayoshi Okimoto, Ryoji Kushima, Kazunari Murakami
BACKGROUND: Pancreatic acinar cell metaplasia (PACM) has been rarely reported in the gastric mucosa. In the present study, we aimed to elucidate the clinical and pathological characteristics of PACM associated with Helicobacter pylori (H. pylori). METHOD: 5930 patients who underwent five- or two-point gastric biopsy according to the updated Sydney system (USS) by upper gastrointestinal endoscopy were enrolled. The patients were categorized into current H. pylori infection (CHI), post-H...
June 7, 2022: BMC Gastroenterology
https://read.qxmd.com/read/35005807/prevalence-estimates-of-helicobacter-species-infection-in-pancreatic-and-biliary-tract-cancers
#13
JOURNAL ARTICLE
Takako Osaki, Yingsong Lin, Naoki Sasahira, Makoto Ueno, Hideo Yonezawa, Fuhito Hojo, Masumi Okuda, Masato Matsuyama, Takashi Sasaki, Satoshi Kobayashi, Shun Tezuka, Kei Tanaka, Naoaki Dan, Sawako Kuruma, Naoto Egawa, Shigeru Kamiya, Shogo Kikuchi
BACKGROUND: Helicobacter pylori infection is a well-established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non-H. pylori helicobacters to the pathophysiology of these diseases remains unclear. MATERIALS AND METHODS: We estimated the prevalence of two enterohepatic non-H. pylori helicobacters (Helicobacter hepaticus and Helicobacter bilis) in the framework of a hospital-based case-control study involving 121 patients with biliary tract cancer, pancreatic cancer, or other gastrointestinal diseases...
January 10, 2022: Helicobacter
https://read.qxmd.com/read/34997478/association-between-helicobacter-pylori-and-periampullary-and-pancreatic-cancer-a-case-control-study
#14
JOURNAL ARTICLE
Giri B Laya, Amaranathan Anandhi, Balakrishnan Gurushankari, Jharna Mandal, Vikram Kate
INTRODUCTION: Helicobacter pylori has been implicated in the etiopathogenesis of various malignant conditions; however, there is a dearth of studies on the correlation between H. pylori infection and pancreatic cancers. Hence, this study was carried out to evaluate the association between H. pylori infection and periampullary and pancreatic cancer. METHODS: This was a single-centre, retrospective, case-control study in which all consecutive patients of periampullary or pancreatic cancer were included...
January 8, 2022: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/34919227/the-potential-of-gut-microbiome-as-a-non-invasive-predictive-biomarker-for-early-detection-of-pancreatic-cancer-and-hepatocellular-carcinoma
#15
REVIEW
K Kaźmierczak-Siedlecka, E Stachowska, M Folwarski, K Przewłócka, W Makarewicz, E Bryl
OBJECTIVE: The aim of this paper was to discuss the potency of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma. MATERIALS AND METHODS: We analysed the available up-to-date literature (PubMed, Embase, Google Scholar databases) regarding the link between gut microbiome and early detection of pancreatic cancer, as well as hepatocellular carcinoma. The following search linked to gut microbiome and aforementioned cancers was used: 'gut microbiome', 'gut microbiota', 'pancreatic cancer', 'pancreatic ductal adenocarcinoma', hepatocellular carcinoma', 'microbial biomarkers', 'fungal microbiota', 'mycobiota'...
December 2021: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/34901696/a-case-control-study-of-the-seroprevalence-of-helicobacter-pylori-proteins-and-their-association-with-pancreatic-cancer-risk
#16
JOURNAL ARTICLE
Jennifer B Permuth, Shams Rahman, Dung-Tsa Chen, Tim Waterboer, Anna R Giuliano
Background: The association between Helicobacter pylori ( H. pylori ) infection and pancreatic cancer (PC) risk remains inconclusive. We examined the association between H. pylori antibodies and PC risk in a case-control study at a comprehensive cancer center. Methods: Multiplex serology using a glutathione S-transferase capture immunosorbent assay in conjunction with fluorescent bead technology was used to measure antibodies to 15 H. pylori proteins in serum or plasma from 131 incident cases with PC or a PC precursor and 131 healthy controls...
2021: Journal of Pancreatic Cancer
https://read.qxmd.com/read/34457189/-helicobacter-pylori-infection-and-other-bacteria-in-pancreatic-cancer-and-autoimmune-pancreatitis
#17
REVIEW
Lumir Kunovsky, Petr Dite, Petr Jabandziev, Jiri Dolina, Jitka Vaculova, Martin Blaho, Martina Bojkova, Jana Dvorackova, Magdalena Uvirova, Zdenek Kala, Jan Trna
Helicobacter pylori ( H. pylori ) is an infectious agent influencing as much as 50% of the world's population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer's disease, demyelinating multiple sclerosis and Parkinson's disease...
August 15, 2021: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/33552244/muc4-is-a-novel-mediator-in-h-pylori-infection-related-pancreatic-cancer
#18
JOURNAL ARTICLE
Yu Gong, Shuai Chen, Yue Fu, Yu Liu, Yipeng Wang, Haojun Yang, Hanyang Liu, Liming Tang
Pancreatic cancer (PC) is a common malignant disease worldwide. Among the potential pathogenic factors, Helicobacter pylori ( H. pylori ) infection has been associated with the tumorigenesis of PC. The present study aimed to identify the differentially expressed genes (DEGs) of H. pylori infection-associated PC and to investigate the key factors involved in PC tumorigenesis. Using bioinformatics methods, overlapping DEGs and key gene were identified from H. pylori -infected gastric mucosa (GM) and H. pylori infection-associated PC...
February 2021: Oncology Letters
https://read.qxmd.com/read/32793510/influence-of-the-muc1-cell-surface-mucin-on-gastric-mucosal-gene-expression-profiles-in-response-to-helicobacter-pylori-infection-in-mice
#19
JOURNAL ARTICLE
Yong H Sheng, Garrett Z Ng, Kim M Summers, Alison L Every, Gareth Price, Sumaira Z Hasnain, Philip Sutton, Michael A McGuckin
The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori ) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated gene expression profiles in response to H. pylori infection in wild type (WT) and MUC1-deficient mice using microarray-determined mRNA expression, gene network analysis and Ingenuity Pathway Analysis (IPA)...
2020: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/32628791/helicobacter-pylori-eradication-for-the-prevention-of-gastric-neoplasia
#20
JOURNAL ARTICLE
Alexander C Ford, Yuhong Yuan, David Forman, Richard Hunt, Paul Moayyedi
BACKGROUND: Gastric cancer is the third most common cause of cancer death worldwide. Individuals infected with Helicobacter pylori have a higher likelihood of developing gastric cancer than individuals who are not infected. Eradication of H. pylori in healthy asymptomatic individuals in the general population may reduce the incidence of gastric cancer, but the magnitude of this effect is unclear. OBJECTIVES: To assess the effectiveness of eradication of H. pylori in healthy asymptomatic individuals in the general population in reducing the incidence of gastric cancer...
July 6, 2020: Cochrane Database of Systematic Reviews
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