M Zaid, F Carapeto, A Dai, C P Thunshelle, D Elganainy, K Sun, C Grassberger, L N Kwong, S Lee, T Newhook, H S Tran Cao, J N Vauthey, M Javle, E J Koay
PURPOSE/OBJECTIVE(S): Intrahepatic cholangiocarcinoma (iCCA) remains a highly lethal disease. Biomarkers are needed to identify pts who may benefit from specific therapeutic strategies. Here, we hypothesized that imaging features derived from pre-therapy CT are associated with histopathological and clinical outcomes. MATERIALS/METHODS: Retrospectively, we identified 60 pts with localized iCCA (24 M, 36 F, median age 65 [range 26-84]), who received upfront resection as a discovery cohort (D1) and 87 pts with locally advanced iCCA (49 M, 38 F, median age 64 [range 30-88]) who received chemo and radiation therapy as a validation cohort (D2)...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics