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https://read.qxmd.com/read/30769368/-dopamine-transporter-spect-with-i-123-labelled-fp-cit-datscantm
#1
Klaus Tatsch, Ralph Buchert, Peter Bartenstein, Henryk Barthel, Henning Boecker, Peter Brust, Alexander Drzezga, Christian la Fougère, Gerhard Gründer, Frank Grünwald, Bernd-J Krause, Torsten Kuwert, Karl-Josef Langen, Axel Rominger, Osama Sabri, Mathias Schreckenberger, Philipp T Meyer
The aim of the S1 guideline is to assist in establishing the indication and in performing, interpreting and reporting SPECT investigations of the dopamine transporter (DAT) with DaTSCANTM . Compared to the preceding version dated from 2007 the current update considers relevant new publications, the guidelines of the European (EANM) and Society of Nuclear Medicine (SNM), and the current version of the S3 guideline of the German Society of Neurology on "Idiopathic Parkinsonsian Syndrome". In addition new technical developments are incorporated...
February 2019: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/30769303/combined-life-cycle-assessment-and-artificial-intelligence-for-prediction-of-output-energy-and-environmental-impacts-of-sugarcane-production
#2
Ali Kaab, Mohammad Sharifi, Hossein Mobli, Ashkan Nabavi-Pelesaraei, Kwok-Wing Chau
This study aims to employ two artificial intelligence (AI) methods, namely, artificial neural networks (ANNs) and adaptive neuro fuzzy inference system (ANFIS) model, for predicting life cycle environmental impacts and output energy of sugarcane production in planted or ratoon farms. The study is performed in Imam Khomeini Sugarcane Agro-Industrial Company (IKSAIC) in Khuzestan province of Iran. Based on the cradle to grave approach, life cycle assessment (LCA) is employed to evaluate environmental impacts and study environmental impact categories of sugarcane production...
February 6, 2019: Science of the Total Environment
https://read.qxmd.com/read/30769300/are-sensorimotor-experiences-the-key-for-successful-early-intervention-in-infants-with-congenital-brain-lesion
#3
REVIEW
Anina Ritterband-Rosenbaum, Mikkel Damgaard Justiniano, Jens Bo Nielsen, Mark Schram Christensen
Living with a congenital brain lesion may have detrimental effects on the ability to do everyday activities, but contrary to acquired brain lesions, people and in particular children, with congenital brain lesions may have limited or no experience of how their bodies work. This absence of experience gives rise to challenges for habilitation of sensorimotor abilities and derived cognitive abilities. How can motor and cognitive abilities be achieved and trained in an individual with no experience of potential abilities? In this article, we aim to review the existing knowledge about the development of sensorimotor integration...
February 12, 2019: Infant Behavior & Development
https://read.qxmd.com/read/30769295/overlapping-genetic-effects-between-suicidal-ideation-and-neurocognitive-functioning
#4
Leslie A Brick, Marisa E Marraccini, Lauren Micalizzi, Chelsie E Benca-Bachman, Valerie S Knopik, Rohan H C Palmer
BACKGROUND: Suicide is the second leading cause of death among adolescents and young adults. Several studies have indicated significant genetic influences on suicide-related phenotypes and mounting evidence from neurobiological research has linked deficits in neurocognitive abilities to suicide phenotypes. The goal of the present study was to estimate the heritability of suicidal ideation (SI) in a large sample of adolescents and determine if SI is genetically correlated with neurocognitive functioning...
February 6, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30769291/tetrabromobisphenol-a-induced-depolarization-of-rat-cerebellar-granule-cells-ex-vivo-and-in-vitro-studies
#5
Dominik Diamandakis, Elzbieta Zieminska, Marcin Siwiec, Krzysztof Tokarski, Elzbieta Salinska, Jacek Lenart, Grzegorz Hess, Jerzy W Lazarewicz
The brominated flame retardant tetrabromobisphenol A (TBBPA) is toxic to cultured brain neurons, and glutamate receptors partially mediate this effect; consequently, the depolarizing effect of TBBPA on neurons is to be expected, but it is yet to be actually demonstrated. The aim of this study was to detect TBBPA-evoked depolarization and identify the underlying mechanisms. The plasma membrane potential of rat cerebellar granule cells (CGC) in cerebellar slices or in primary cultures was measured using whole-cell current clamp recordings, or the fluorescent probe oxonol VI, respectively...
February 8, 2019: Chemosphere
https://read.qxmd.com/read/30769286/cx3cr1-deficient-microglia-shows-impaired-signalling-of-the-transcription-factor-nrf2-implications-in-tauopathies
#6
Sara Castro-Sánchez, Ángel J García-Yagüe, Sebastian Kügler, Isabel Lastres-Becker
TAU protein aggregation is the main characteristic of neurodegenerative diseases known as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates crosstalk between damaged neurons and glial cells. Previously, we have demonstrated that neurons overexpressing TAUP301L release CX3CL1, which activates the transcription factor NRF2 signalling to limit over-activation in microglial cells in vitro and in vivo. However, the connection between CX3CL1/CX3CR1 and NRF2 system and its functional implications in microglia are poorly described...
February 6, 2019: Redox Biology
https://read.qxmd.com/read/30769283/biasing-the-native-%C3%AE-synuclein-conformational-ensemble-towards-compact-states-abolishes-aggregation-and-neurotoxicity
#7
Anita Carija, Francisca Pinheiro, Jordi Pujols, Inês C Brás, Diana Fernandes Lázaro, Carlo Santambrogio, Rita Grandori, Tiago F Outeiro, Susanna Navarro, Salvador Ventura
The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. The disordered nature of α-syn has hampered the use of structure-based protein engineering approaches to elucidate the molecular determinants of this transition. The recent 3D structure of a pathogenic α-syn fibril provides a template for this kind of studies...
February 5, 2019: Redox Biology
https://read.qxmd.com/read/30769278/lestaurtinib-cep-701-modulates-the-effects-of-early-life-hypoxic-seizures-on-cognitive-and-emotional-behaviors-in-immature-rats
#8
Yasser Medlej, Houssein Salah, Lara Wadi, Sarah Saad, Bashir Bashir, Jad Allam, Zahraa Atoui, Nora Darwish, Nabil Karnib, Hala Darwish, Firas Kobeissy, Kevin K W Wang, Eva Hamade, Makram Obeid
Hypoxic encephalopathy of the newborn is a major cause of long-term neurological sequelae. We have previously shown that CEP-701 (lestaurtinib), a drug with an established safety profile in children, attenuates short-term hyperexcitability and tropomyosin-related kinase B (TrkB) receptor activation in a well-established rat model of early life hypoxic seizures (HS). Here, we investigated the potential long-term neuroprotective effects of a post-HS transient CEP-701 treatment. Following exposure to global hypoxia, 10 day old male Sprague-Dawley pups received CEP-701 or its vehicle and were sequentially subjected to the light-dark box test (LDT), forced swim test (FST), open field test (OFT), Morris water maze (MWM), and the modified active avoidance (MAAV) test between postnatal days 24 and 44 (P24-44)...
February 12, 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30769255/a-case-of-neuromyelitis-optica-spectrum-disorder-following-seasonal-influenza-vaccination
#9
Jeong Hee Cho, Yoonseon Park, Naeun Woo
There have been reports of central nervous systemic inflammatory disease associated with vaccination. We describe a female patient who developed longitudinally extensive transverse myelitis following seasonal influenza vaccination. A 38-year-old woman had severe neck and back pain with urinary retention. She received influenza vaccine 3 days before symptom onset. Examination revealed mild quadriparesis with diffuse hyperreflexia. Magnetic resonance imaging (MRI) of the spine showed a T2 hyperintense lesion with gadolinium enhancement in the spinal cord extending from the cervicomedullary junction to the level of T10...
February 5, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30769222/application-of-diffusion-weighted-mr-imaging-with-adc-measurement-for-distinguishing-between-the-histopathological-types-of-sinonasal-neoplasms
#10
Mehmet Gencturk, Kerem Ozturk, Emiro Caicedo-Granados, Faqian Li, Zuzan Cayci
PURPOSE: To evaluate the potential contribution of quantitative DWI parameters including ADCmean and ADCratio values to help in distinguishing the histopathological types of sinonasal neoplasms. METHODS: This retrospective study included 83 patients (50 males, 33 females; mean age 61 years) with pathologically proven untreated sinonasal neoplasms who have undergone diffusion-weighted MRI imaging from February 2010 to August 2017. Diffusion-weighted MRI was performed on a 3 T unit with b factors of 0 and 1000 s/mm2 , and ADC maps were generated...
February 7, 2019: Clinical Imaging
https://read.qxmd.com/read/30769221/evaluation-of-brain-volume-alterations-in-hcv-infected-patients-after-interferon-free-therapy-a-pilot-study
#11
Ewelina Marciniewicz, Przemysław Podgórski, Tomasz Pawłowski, Krzysztof Małyszczak, Katarzyna Fleischer-Stępniewska, Brygida Knysz, Marta Waliszewska-Prosół, Agnieszka Żelwetro, Weronika Rymer, Małgorzata Inglot, Maria Ejma, Marek Sąsiadek, Joanna Bladowska
The study was performed to evaluate cerebral volume changes in HCV-infected subjects before and after interferon-free therapy with direct-acting antiviral agents (DAA). We aimed also to estimate the impact of successful DAA therapy on the neuropsychological state of patients. Eleven HCV genotype 1 (GT1) patients treated with ombitasvir/paritaprevir (boosted with ritonavir) and dasabuvir, with or without ribavirin underwent brain magnetic resonance (MR) before and 24 weeks after completion of therapy. All patients achieved sustained viral response...
February 7, 2019: Journal of the Neurological Sciences
https://read.qxmd.com/read/30769214/the-effect-of-transversus-abdominis-plane-block-on-acute-and-chronic-pain-after-inguinal-hernia-repair-a-randomised-controlled-trial
#12
Kassiani Theodoraki, Panagiota Papacharalampous, Athanasia Tsaroucha, Antonios Vezakis, Eriphilli Argyra
BACKGROUND: This prospective double-blind randomized study aimed at evaluating the short- and long-term postoperative analgesic efficacy of the ultrasound-guided tranversus abdominis plane (TAP) block in inguinal hernia repair under general anesthesia. METHODS: Sixty patients undergoing inguinal hernia repair were allocated to TAP block with either ropivacaine 0.75% 20 mL or placebo 20 mL. Postoperatively, they had access to a patient-controlled analgesia (PCA) device administering 1 mg doses of morphine as rescue analgesia...
February 12, 2019: International Journal of Surgery
https://read.qxmd.com/read/30769213/pontine-hemorrhage-accompanied-by-neuromyelitis-optica-spectrum-disorder
#13
Hikaru Kamo, Yuji Ueno, Mizuho Sugiyama, Nobukazu Miyamoto, Kazuo Yamashiro, Ryota Tanaka, Kazumasa Yokoyama, Nobutaka Hattori
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder caused by antibody to aquaporin-4 (AQP4). NMOSD can infrequently present as a complication of posterior reversible encephalopathy syndrome (PRES). Moreover, few cases of NMOSD patients with brain hemorrhage have been reported. We report a rare case of PRES together with NMOSD recurrence, subsequent to pontine hemorrhage after intravenous methylprednisolone (IVMP) therapy. A 51-year-old Japanese woman, with a history of hypertension and dyslipidemia, and recurrent episodes of left visual acuity disorder related to AQP4-positive NMOSD, developed blindness in the left eye...
February 1, 2019: Journal of Neuroimmunology
https://read.qxmd.com/read/30769212/the-expansion-of-circulating-il-6-and-il-17-secreting-follicular-helper-t-cells-is-associated-with-neurological-disabilities-in-neuromyelitis-optica-spectrum-disorders
#14
Clarice Monteiro, Gabriel Fernandes, Taissa M Kasahara, Priscila O Barros, Aleida S O Dias, Ana Carolina R A Araújo, Alice M M Ornelas, Renato S Aguiar, Regina Alvarenga, Cleonice A M Bento
Due to their function in assisting B cells, TFH cells may be involved in the production of pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the proportion of IL-6+ and IL-17+ TFH cell subsets was higher in NMOSD patients than healthy individuals. The frequency of both TFH cell subsets were directly associated with disease activity. By contrast, NMOSD patients with a higher proportion of IL-10+ TFH cell subsets showed a lower neurological disabilities score. In summary, all findings suggest that expansion of peripheral IL-6+ and IL-17+ TFH cells may be involved in the severity of NMOSD...
January 25, 2019: Journal of Neuroimmunology
https://read.qxmd.com/read/30769180/blood-lead-levels-and-timing-of-male-sexual-maturity-a-longitudinal-study-of-russian-boys
#15
Paige L Williams, Andrea Bellavia, Susan A Korrick, Jane S Burns, Mary M Lee, Oleg Sergeyev, Russ Hauser
BACKGROUND: Higher blood lead levels (BLLs) have been linked to neurologic deficits and impaired growth, but few studies have evaluated their association with timing of sexual maturity or pubertal progression in boys. METHODS: In a longitudinal cohort of Russian boys enrolled at age 8-9 and followed to adulthood, BLLs were measured at study entry, and pubertal staging (genitalia and pubic hair) and testicular volume (TV) measurements were obtained annually. We used interval-censored regression models to estimate differences between boys with higher BLL (≥5 μg/dL) and lower BLL in mean ages at sexual maturity (genitalia stage 5, pubic hair stage 5, or TV ≥ 20 mL) and duration of pubertal progression (onset to maturity), adjusting for potential confounders...
February 12, 2019: Environment International
https://read.qxmd.com/read/30769167/roles-of-ventral-versus-dorsal-pathways-in-language-production-an-awake-language-mapping-study
#16
S K Ries, V Piai, D Perry, S Griffin, K Jordan, R Henry, R T Knight, M S Berger
Human language is organized along two main processing streams connecting posterior temporal cortex and inferior frontal cortex in the left hemisphere, travelling dorsal and ventral to the Sylvian fissure. Some views propose a dorsal motor versus ventral semantic division. Others propose division by combinatorial mechanism, with the dorsal stream responsible for combining elements into a sequence and the ventral stream for forming semantic dependencies independent of sequential order. We acquired data from direct cortical stimulation in the left hemisphere in 17 neurosurgical patients and subcortical resection in a subset of 10 patients as part of awake language mapping...
February 11, 2019: Brain and Language
https://read.qxmd.com/read/30769159/thioredoxin-system-as-a-gatekeeper-in-caspase-6-activation-and-nuclear-lamina-integrity-implications-for-alzheimer-s-disease
#17
Md Imamul Islam, Pandian Nagakannan, Olamide Ogungbola, Jelena Djordjevic, Benedict C Albensi, Eftekhar Eftekharpour
Recent reports in pathophysiology of neurodegenerative diseases (ND) have linked nuclear lamina degradation/deficits to neuronal cell death. Lamin-B1 damage is specifically involved in this process leading to nuclear envelope invagination and heterochromatin rearrangement. The underlying mechanisms involved in these events are not yet defined. In this study, while examining the effect of Thioredoxin-1(Trx1) inhibition on cell death in a model of oxidative stress, we noted robust nuclear invagination in SH-SY5Y cells...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769145/directional-tuning-for-eye-and-arm-movements-in-overlapping-regions-in-human-posterior-parietal-cortex
#18
Caterina Magri, Sara Fabbri, Alfonso Caramazza, Angelika Lingnau
A network of frontal and parietal regions is known to be recruited during the planning and execution of arm and eye movements. While movements of the two effectors are typically coupled with each other, it remains unresolved how information is shared between them. Here we aimed to identify regions containing neuronal populations that show directional tuning for both arm and eye movements. In two separate fMRI experiments, the same participants were scanned while performing a center-out arm or eye movement task...
February 12, 2019: NeuroImage
https://read.qxmd.com/read/30769143/exploring-the-involvement-of-tac2-in-the-mouse-hippocampal-stress-response-through-gene-networking
#19
Mike Hook, Fuyi Xu, Elena Terenina, Wenyuan Zhao, Athena Starlard-Davenport, Pierre Mormede, Byron C Jones, Megan K Mulligan, Lu Lu
Tac2 is expressed in a number of areas throughout the brain, including the hippocampus. However, knowledge about its function has been only well explored in the hypothalamus in the context of reproductive health. In this study, we identified and validated increased hippocampal Tac2 mRNA expression in response to chronic mild stress in mice. Expression quantitative trait locus (eQTL) analysis showed Tac2 is cis-regulated in the hippocampus. Using a systems genetics approach, we constructed a Tac2 co-expression network to better understand the relationship between Tac2 and the hippocampal stress response...
February 12, 2019: Gene
https://read.qxmd.com/read/30769142/mir-3099-promotes-neurogenesis-and-inhibits-astrogliogenesis-during-murine-neural-development
#20
Shahidee Zainal Abidin, Sze-Zheng Fam, Chan-Eng Chong, Syahril Abdullah, Pike-See Cheah, Norshariza Nordin, King-Hwa Ling
MicroRNA-3099 is highly expressed during neuronal differentiation and development of the central nervous system. Here we characterised the role of miR-3099 during neural differentiation and embryonic brain development using a stable and regulatable mouse embryonic stem cell culture system for miR-3099 expression and in utero electroporation of miR-3099 expression construct into E15.5 embryonic mouse brains. In the in vitro system, miR-3099 overexpression upregulated gene related to neuronal markers such as Tuj1, NeuN, GAT1, vGluT1 and vGluT2...
February 12, 2019: Gene
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