keyword
https://read.qxmd.com/read/38537225/a-randomized-noninferiority-trial-to-compare-enteral-to-parenteral-phosphate-replacement-on-biochemistry-waste-and-environmental-impact-and-healthcare-cost-in-critically-ill-patients-with-mild-to-moderate-hypophosphatemia
#1
JOURNAL ARTICLE
Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
OBJECTIVES: Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste. DESIGN: Prospective, randomized, parallel group, noninferiority clinical trial. SETTING: Single center, 42-bed state trauma, medical and surgical ICUs, from April 20, 2022, to July 1, 2022. PATIENTS: Patients with serum phosphate concentration between 0.3 and 0.75 mmol/L. INTERVENTIONS: We randomized patients to either enteral or IV phosphate replacement using electronic medical record-embedded program...
March 25, 2024: Critical Care Medicine
https://read.qxmd.com/read/38537006/effect-of-mode-of-delivery-on-postpartum-health-related-quality-of-life
#2
JOURNAL ARTICLE
Esra Keles, Leyla Kaya, Neşe Yakşi, Zahide Kaya
OBJECTIVE: The aim of the study was to explore the impact of mode of delivery on health-related quality of life in mothers. METHODS: This cross-sectional study was conducted between May and August 2022 on healthy singleton pregnant women aged between 18 and 45 years. Data on socio-demographic variables, clinic features, pregnancy and birth characteristics, and neonatal outcomes were collected. Health-related quality of life was assessed by using EQ-5D-5L questionnaire...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#3
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536762/the-impact-of-musculoskeletal-ill-health-on-quality-of-life-and-function-after-critical-care-a-multicentre-prospective-cohort-study
#4
JOURNAL ARTICLE
O D Gustafson, E B King, M M Schlussel, A Arnold, C Wade, P S Nicol, M J Rowland, H Dawes, M A Williams
Physical disability is a common component of post-intensive care syndrome, but the importance of musculoskeletal health in this population is currently unknown. We aimed to determine the musculoskeletal health state of intensive care unit survivors and assess its relationship with health-related quality of life; employment; and psychological and physical function. We conducted a multicentre prospective cohort study of adults admitted to intensive care for > 48 h without musculoskeletal trauma or neurological insult...
March 27, 2024: Anaesthesia
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#5
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536629/association-of-premorbid-glp-1ra-and-sglt-2i-prescription-alone-and-in-combination-with-covid-19-severity
#6
JOURNAL ARTICLE
Klara R Klein, Trine J Abrahamsen, Anna R Kahkoska, G Caleb Alexander, Christopher G Chute, Melissa Haendel, Stephanie S Hong, Hemalkumar Mehta, Richard Moffitt, Til Stürmer, Kajsa Kvist, John B Buse
INTRODUCTION: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use of glucagon-like peptide-1 receptor agonist (GLP-1RA) monotherapy, sodium-glucose cotransporter-2 inhibitor (SGLT-2i) monotherapy, and concomitant GLP1-RA/SGLT-2i therapy on the severity of outcomes in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
March 27, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38536623/gut-barrier-dysfunction-and-the-risk-of-icu-acquired-bacteremia-a-case-control-study
#7
JOURNAL ARTICLE
Meri R J Varkila, Diana M Verboom, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
BACKGROUND: Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin. METHODS: We conducted a nested case-control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536563/machine-learning-in-risk-prediction-of-continuous-renal-replacement-therapy-after-coronary-artery-bypass-grafting-surgery-in-patients
#8
JOURNAL ARTICLE
Qian Zhang, Peng Zheng, Zhou Hong, Luo Li, Nannan Liu, Zhiping Bian, Xiangjian Chen, Hengfang Wu, Sheng Zhao
OBJECTIVES: This study aimed to develop machine learning models for risk prediction of continuous renal replacement therapy (CRRT) following coronary artery bypass grafting (CABG) surgery in intensive care unit (ICU) patients. METHODS: We extracted CABG patients from the electronic medical record system of the hospital. The endpoint of this study was the requirement for CRRT after CABG surgery. The Boruta method was used for feature selection. Seven machine learning algorithms were developed to train models and validated using 10 fold cross-validation (CV)...
March 27, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#9
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536534/serial-daily-lactate-levels-association-with-30-day-outcome-in-cardiogenic-shock-patients-treated-with-va-ecmo-a-post-hoc-analysis-of-the-hypo-ecmo-study
#10
JOURNAL ARTICLE
Bruno Levy, Nicolas Girerd, Guillaume Baudry, Kevin Duarte, Samuel Cuau, Jan Bakker, Antoine Kimmoun
BACKGROUND: Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS), their significance in VA-ECMO-treated patients remains inconclusive. METHODS: We conducted a post hoc analysis of data from the HYPO-ECMO trial, which compared normothermia to moderate hypothermia in CS patients supported by VA-ECMO. We examined daily lactate levels collected over a week to assess their correlation with 30-day mortality...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#11
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38536421/assessing-lung-recruitability-does-it-help-with-peep-settings
#12
EDITORIAL
Luciano Gattinoni, Francesca Collino, Luigi Camporota
No abstract text is available yet for this article.
March 27, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38536223/assessment-of-patient-safety-in-a-low-resource-health-care-system-proposal-for-a-multimethod-study
#13
JOURNAL ARTICLE
Ghazal Haque, Fozia Asif, Fasih Ali Ahmed, Farwa Ayub, Sabih Ul Hassan Syed, Nousheen Akber Pradhan, Malika Hameed, Muhammad Muneeb Ullah Siddiqui, Shafaq Mahmood, Tahani Zaidi, Sameen Siddiqi, Asad Latif
BACKGROUND: The high prevalence of adverse events (AEs) globally in health care delivery has led to the establishment of many guidelines to enhance patient safety. However, patient safety is a relatively nascent concept in low- and middle-income countries (LMICs) where health systems are already overburdened and underresourced. This is why it is imperative to study the nuances of patient safety from a local perspective to advocate for the judicious use of scarce public health resources...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536008/ethical-issues-surrounding-appropriate-care-for-older-persons-in-the-intensive-care-unit
#14
JOURNAL ARTICLE
Jean-Louis Vincent
Increasing numbers of older patients are being admitted to the Intensive Care Unit (ICU) as the world's population ages. The biological process of ageing, senescence, results in altered ability to maintain normal homeostasis and organ function, including of the cardiovascular, immune, and neuromuscular systems. This contributes towards increased frailty in older patients, associated with functional limitations and increased vulnerability. Although widely defined using chronological age, the concept of "old age" is thus multifactorial, including biological, but also psychological and sociocultural aspects, which should all be taken into account when considering what is appropriate in terms of ICU admission and management...
March 27, 2024: Panminerva Medica
https://read.qxmd.com/read/38535968/east-meets-west-effect-of-acupuncture-on-lactation-and-maternal-quality-of-life
#15
JOURNAL ARTICLE
Cindy Baker-Fox, Jennifer Hayakawa, Ruth McCarty, Michelle Hart, John Schomberg, Smriti Shamapant, Christine Bixby
Objective: To evaluate the impact of acupuncture as part of a traditional Chinese medicine (TCM) treatment plan on lactation and maternal well-being in pump-dependent mothers of hospitalized neonates during the first 30 days after delivery. Study Design: This single-center study was conducted in a level IV regional neonatal intensive care unit with access to integrative health services. Sixty-six mothers were prospectively enrolled in two nonparallel groups: (1) Standard lactation support and (2) standard lactation support augmented with acupuncture...
March 27, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38535886/stop-in-time-how-to-reduce-unnecessary-antibiotics-in-newborns-with-late-onset-sepsis-in-neonatal-intensive-care
#16
REVIEW
Domenico Umberto De Rose, Maria Paola Ronchetti, Alessandra Santisi, Paola Bernaschi, Ludovica Martini, Ottavia Porzio, Andrea Dotta, Cinzia Auriti
The fear of missing sepsis episodes in neonates frequently leads to indiscriminate use of antibiotics, and prescription program optimization is suggested for reducing this inappropriate usage. While different authors have studied how to reduce antibiotic overprescription in the case of early onset sepsis episodes, with different approaches being available, less is known about late-onset sepsis episodes. Biomarkers (such as C-reactive protein, procalcitonin, interleukin-6 and 8, and presepsin) can play a crucial role in the prompt diagnosis of late-onset sepsis, but their role in antimicrobial stewardship should be further studied, given that different factors can influence their levels and newborns can be subjected to prolonged therapy if their levels are expected to return to zero...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535883/sustaining-the-continued-effectiveness-of-an-antimicrobial-stewardship-program-in-preterm-infants
#17
JOURNAL ARTICLE
Tommaso Zini, Francesca Miselli, Chiara D'Esposito, Lucia Fidanza, Riccardo Cuoghi Costantini, Lucia Corso, Sofia Mazzotti, Cecilia Rossi, Eugenio Spaggiari, Katia Rossi, Licia Lugli, Luca Bedetti, Alberto Berardi
BACKGROUND: There are wide variations in antibiotic use in neonatal intensive care units (NICUs). Limited data are available on antimicrobial stewardship (AS) programs and long-term maintenance of AS interventions in preterm very-low-birth-weight (VLBW) infants. METHODS: We extended a single-centre observational study carried out in an Italian NICU. Three periods were compared: I. "baseline" (2011-2012), II. "intervention" (2016-2017), and III. "maintenance" (2020-2021)...
March 7, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535717/knowledge-level-of-icu-nurses-regarding-nutritional-assessment-of-critically-ill-patients-a-systematic-review
#18
REVIEW
Vicente Doménech Briz, Vicente Gea-Caballero, Elena Chover-Sierra, Michal Czapla, Piotr Fehler, Antonio Rodríguez-Calvo, María Luisa Ballestar-Tarín, Patricia Marín-Maicas, Ana Cristina Cabellos-García, Marta Pardo-Bosch, Raúl Juárez-Vela, Antonio Martínez-Sabater
BACKGROUND: Nutritional assessment on admission of critical patients is of vital importance to determine critical patients in whom there is a risk of malnutrition. Currently, it has been detected in most of the patients admitted to the Intensive Care Unit (ICU) that 60% of the daily calories are not achieved. Nurses play an essential role in the comprehensive assessment of the patient, including the nutritional area; however, significant deficits have been detected in some knowledge regarding Enteral Nutrition (EN)...
March 8, 2024: Nursing Reports
https://read.qxmd.com/read/38535612/fungemia-by-wickerhamomyces-anomalus-a-narrative-review
#19
REVIEW
Petros Ioannou, Stella Baliou, Diamantis P Kofteridis
Wickerhamomyces anomalus has been previously classified as Hansenula anomala , Pichia anomala , and Candida pelliculosa and was recently reclassified in the genus Wickerhamomyces after phylogenetic analysis of its genetic sequence. An increasing number of reports of human infections by W. anomalus have emerged, suggesting that this microorganism is an emerging pathogen. The present review aimed to provide data on the epidemiology, antifungal resistance, clinical characteristics, treatment, and outcomes of fungemia by W...
March 21, 2024: Pathogens
https://read.qxmd.com/read/38535577/-staphylococcus-capitis-central-line-associated-bloodstream-infections-in-the-neonatal-intensive-care-unit-a-single-center-four-year-experience-in-central-line-management-during-sepsis-treatment
#20
JOURNAL ARTICLE
Anna Sala, Valentina Pivetti, Alessandra Vittorini, Claudia Viggiano, Francesca Castoldi, Valentina Fabiano, Gianluca Lista, Francesco Cavigioli
Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). Staphylococcus capitis is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus...
March 7, 2024: Pathogens
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