Silvia Di Agostino, Valeria Canu, Sara Donzelli, Claudio Pulito, Andrea Sacconi, Federica Ganci, Fabio Valenti, Frauke Goeman, Stefano Scalera, Francesca Rollo, Anna Bagnato, Maria Grazia Diodoro, Enrico Vizza, Mariantonia Carosi, Beatrice Rufini, Orietta Federici, Manuel Giofrè, Fabio Carboni, Paola Muti, Gennaro Ciliberto, Sabrina Strano, Mario Valle, Giovanni Blandino
Hyperthermic intraperitoneal administration of chemotherapy (HIPEC) increases local drug concentrations and reduces systemic side effects associated with prolonged adjuvant intraperitoneal exposure in patients affected by either peritoneal malignancies or metastatic diseases originating from gastric, colon, kidney, and ovarian primary tumors. Mechanistically, the anticancer effects of HIPEC have been poorly explored. Herein we documented that HIPEC treatment promoted miR-145-5p expression paired with a significant downregulation of its oncogenic target genes c-MYC, EGFR, OCT4, and MUC1 in a pilot cohort of patients with ovarian peritoneal metastatic lesions...
August 19, 2023: Cell Death & Disease