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Keywords continuous versus intermittent...

continuous versus intermittent infusion of vancomycin

https://read.qxmd.com/read/22479005/comparison-of-continuous-and-intermittent-iv-infusion-of-vancomycin-systematic-review
#21
JOURNAL ARTICLE
Sally S K Man, Roxane R Carr, Mary H H Ensom
BACKGROUND: There is some evidence that administration of vancomycin by continuous infusion has pharmacokinetic and pharmacodynamic advantages over traditional intermittent dosing. Whether these advantages translate into clinical efficacy remains controversial. OBJECTIVE: To review the literature comparing continuous infusion of vancomycin and conventional intermittent IV dosing in terms of efficacy and safety. METHODS: A literature search was conducted in the PubMed/MEDLINE and Embase databases and the Cochrane Central Register of Controlled Trials, and by means of the Google search engine, and the reference lists of pertinent articles were searched manually...
September 2010: Canadian Journal of Hospital Pharmacy
https://read.qxmd.com/read/22028203/continuous-versus-intermittent-infusion-of-vancomycin-for-the-treatment-of-gram-positive-infections-systematic-review-and-meta-analysis
#22
REVIEW
Maria Adriana Cataldo, Evelina Tacconelli, Elisabetta Grilli, Federico Pea, Nicola Petrosillo
OBJECTIVES: To summarize available evidence on the effect of continuous infusion (CoI) of vancomycin compared with intermittent infusion (InI) in adult patients with Gram-positive infections. METHODS: MEDLINE, EMBASE and Cochrane databases were searched. Randomized clinical trials (RCTs) and observational studies that comparatively assessed CoI and InI of vancomycin in terms of mortality, clinical cure, toxicity rates and serum drug exposure [trough concentration (C(min)) for InI and steady-state concentration (C(ss)) for CoI; area under the curve at 24 h (AUC(24)) for both] were included...
January 2012: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/20592532/management-of-staphylococcus-aureus-bacteremia-and-endocarditis-progresses-and-challenges
#23
REVIEW
Winfried V Kern
PURPOSE OF REVIEW: Staphylococcus aureus is among the leading causes of community-acquired as well as healthcare-associated and hospital-acquired bacteremia and endocarditis. The purpose of this review was to analyze most recent data relevant to the clinical management of S. aureus bacteremia (SAB) and endocarditis. RECENT FINDINGS: Population-based studies have shown that the incidence of SAB has not decreased in the last years and that healthcare-associated and nosocomial cases continue to account for at least half of SAB...
August 2010: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/20301996/comparison-of-continuous-infusion-versus-intermittent-infusion-of-vancomycin-in-patients-with-methicillin-resistant-staphylococcus-aureus
#24
RANDOMIZED CONTROLLED TRIAL
Sutep Jaruratanasirikul, Jakrawadee Julamanee, Teeratad Sudsai, Phanvasri Saengsuwan, Monchana Jullangkoon, Natnicha Ingviya, Roongrueng Jarumanokul
OBJECTIVE: To compare the pharmacokinetics of vancomycin administration by continuous infusion and intermittent infusion. MATERIAL AND METHOD: A prospective, randomized, two-way crossover study of 12 patients with methicillin-resistant Staphylococcus aureus infections was conducted. All patients were randomized to receive vancomycin in both regimens consecutively: (i) infusion of 15 mg/kg of vancomycin as a loading dose for 1 h followed by 30 mg/kg of vancomycin as a continuous infusion over 24 h for 48 h; and (ii) intermittent infusion of 15 mg/kg of vancomycin for 1 h every 12 h for 48 h...
February 2010: Journal of the Medical Association of Thailand
https://read.qxmd.com/read/19744837/nephrotoxicity-of-continuous-versus-intermittent-infusion-of-vancomycin-in-outpatient-parenteral-antimicrobial-therapy
#25
JOURNAL ARTICLE
Paul R Ingram, David C Lye, Dale A Fisher, Wei-Ping Goh, Vincent H Tam
Intravenous (i.v.) vancomycin is increasingly used as outpatient parenteral antimicrobial therapy (OPAT). Despite the potential advantages of administration by continuous infusion (CI) compared with intermittent infusion (II), the relative nephrotoxicity of these two modes of delivery has not been well established. We compared the rate of nephrotoxicity of vancomycin given by CI and II. A retrospective cohort study of OPAT patients receiving i.v. vancomycin between January 2004 to June 2008 was performed. All patients had a normal baseline serum creatinine concentration...
December 2009: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/19602966/influence-of-vancomycin-on-renal-function-in-critically-ill-patients-after-cardiac-surgery-continuous-versus-intermittent-infusion
#26
JOURNAL ARTICLE
Doris Hutschala, Christian Kinstner, Keso Skhirdladze, Florian Thalhammer, Markus Müller, Edda Tschernko
BACKGROUND: Vancomycin is frequently used in clinical practice to treat severe wound and systemic infections caused by Gram-positive bacteria after cardiac surgery. The drug is excreted almost entirely by glomerular filtration and might exhibit nephrotoxic side effects. This study compared the nephrotoxic impact of vancomycin during continuous versus intermittent administration. METHODS: The authors analyzed 149 patients admitted to the intensive care unit during a 5-yr period...
August 2009: Anesthesiology
https://read.qxmd.com/read/16122681/continuous-versus-intermittent-intravenous-administration-of-antibiotics-a-meta-analysis-of-randomised-controlled-trials
#27
REVIEW
Sofia K Kasiakou, George J Sermaides, Argyris Michalopoulos, Elpidoforos S Soteriades, Matthew E Falagas
Intermittent intravenous administration of antibiotics is the first-line approach in the management of severe infections worldwide. However, the potential benefits of alternate modes of administration of antibiotics, including continuous intravenous infusion, deserve further evaluation. We did a meta-analysis of randomised controlled trials comparing continuous intravenous infusion with intermittent intravenous administration of the same antibiotic regimen. Nine randomised controlled trials studying beta-lactams, aminoglycosides, and vancomycin were included...
September 2005: Lancet Infectious Diseases
https://read.qxmd.com/read/15513395/high-versus-standard-dose-vancomycin-for-osteomyelitis
#28
JOURNAL ARTICLE
Emmanuelle Boffi El Amari, Albert Vuagnat, Richard Stern, Mathieu Assal, Philippe Denormandie, Pierre Hoffmeyer, Louis Bernard
It is important to identify the optimal dosage and best method of infusion of parenteral vancomycin to be used over a several week period for the treatment of osteomyelitis. A retrospective study was undertaken to compare a high dose vancomycin treatment (HD: 40 mg/kg/d) with a standard dose treatment (SD: 20 mg/kg/d), and also to compare the modality of infusion using either intermittent vancomycin infusion (IVI) or continuous vancomycin infusion (CVI). 89 patients with Gram-positive cocci osteomyelitis requiring vancomycin treatment were followed, and the outcome and therapeutic safety were compared...
2004: Scandinavian Journal of Infectious Diseases
https://read.qxmd.com/read/12435665/in-vivo-efficacy-of-continuous-infusion-versus-intermittent-dosing-of-linezolid-compared-to-vancomycin-in-a-methicillin-resistant-staphylococcus-aureus-rabbit-endocarditis-model
#29
JOURNAL ARTICLE
Cédric Jacqueline, Eric Batard, Lucia Perez, David Boutoille, Antoine Hamel, Jocelyne Caillon, Marie-France Kergueris, Gilles Potel, Denis Bugnon
Linezolid is the first drug issued from the oxazolidinones, a novel class of antimicrobial agents with potent activity against gram-positive pathogens. A rabbit endocarditis model was used to compare the in vivo activities of different linezolid regimens mimicking intermittent dosing of 10 mg/kg of body weight every 12 h for 5 days or continuous (constant-rate) infusion of a daily dose of 20 mg/kg (for 5 days) or 40 mg/kg (for 3 and 5 days) and the activities of intermittent dosing and continuous infusion of vancomycin (for 5 days)...
December 2002: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/12078436/-the-use-of-glycopeptides-in-intensive-care-and-anaesthesia
#30
JOURNAL ARTICLE
R Gauzit
With the objective of clarifying the modes of using glycopeptides in intensive care, a survey with a declared intention was performed in June 2001, in the form of a postal questionnaire; it was possible to exploit 742 answers. Analysis of the results showed that 15% of the doctors completing the questionnaire had not employed glycopeptides within the past six months. Preference was given to vancomycin, and 65% of practitioners prescribed this drug only, while 1% of them only prescribed teicoplanin. For vancomycin, a central route is used in 9 out of 10 cases, with a preference for continuous infusion (69% versus 48%)...
May 2002: Annales Françaises D'anesthèsie et de Rèanimation
https://read.qxmd.com/read/11751129/bal9141-a-novel-extended-spectrum-cephalosporin-active-against-methicillin-resistant-staphylococcus-aureus-in-treatment-of-experimental-endocarditis
#31
JOURNAL ARTICLE
J M Entenza, P Hohl, I Heinze-Krauss, M P Glauser, P Moreillon
The therapeutic efficacy of BAL9141 (formerly Ro 63-9141), a novel cephalosporin with broad in vitro activity that also has activity against methicillin-resistant Staphylococcus aureus (MRSA), was investigated in rats with experimental endocarditis. The test organisms were homogeneously methicillin-resistant S. aureus strain COL transformed with the penicillinase-encoding plasmid pI524 (COL Bla+) and homogeneously methicillin-resistant, penicillinase-producing isolate P8-Hom, selected by serial exposure of parent strain P8 to methicillin...
January 2002: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/11502515/continuous-versus-intermittent-infusion-of-vancomycin-in-severe-staphylococcal-infections-prospective-multicenter-randomized-study
#32
RANDOMIZED CONTROLLED TRIAL
M Wysocki, F Delatour, F Faurisson, A Rauss, Y Pean, B Misset, F Thomas, J F Timsit, T Similowski, H Mentec, L Mier, D Dreyfuss
A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections. A multicenter, prospective, randomized study was designed to compare CIV (targeted plateau drug serum concentrations of 20 to 25 mg/liter) and intermittent infusions of vancomycin (IIV; targeted trough drug serum concentrations of 10 to 15 mg/liter) in 119 critically ill patients with MRS infections (bacteremic infections, 35%; pneumonia, 45%)...
September 2001: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/10796456/vancomycin-for-prophylaxis-against-sepsis-in-preterm-neonates
#33
REVIEW
A P Craft, N N Finer, K J Barrington
BACKGROUND: Nosocomial, late onset sepsis occurs in up to 50% of infants of less than 1000gm at birth. The commonest organism isolated is coagulase negative staphylococcus (CoNS). A number of studies have evaluated the efficacy or prophylactic low dose vancomycin given either as a continuous infusion added to the infant's hyperalimentation fluid or by intermittent intravenous administration and these studies in very low birth weight infants are the subject of this review. OBJECTIVES: To evaluate the safety and efficacy of vancomycin prophylaxis for the prevention of late-onset sepsis, coagulase negative staphylococcal sepsis, mortality, and effects on length of stay, total vancomycin exposure, evidence of vancomycin toxicity, and the development of vancomycin resistant organisms in the preterm neonate...
2000: Cochrane Database of Systematic Reviews
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