Physical acitvity

Nowadays, there are robust clinical and pathophysiological evidence supporting the beneficial effects of physical activity on cardiovascular (CV) system. Thus, the physical activity is considered a key strategy for CV prevention. In fact, exercise training exerts favourable effects on all risk factors for CV diseases (i.e. essential hypertension, type 2 diabetes mellitus, hypercholesterolemia, obesity, metabolic syndrome, etc…). In addition, all training modalities such as the aerobic (continuous walking, jogging, cycling, etc...

A method capable of identifying novel synthetic targets for small molecule lead optimization has been developed. The FRESH (FRagment-based Exploitation of modular Synthesis by vHTS) approach relies on a multistep synthetic route to a target series of compounds devised by a close collaboration between synthetic and computational chemists. It combines compound library generation, quantitative structure-acitvity relationship construction, fragment processing, virtual high throughput screening and display of results within the Pipeline Pilot framework...

BACKGROUND: During the treatment of severely injured patients, rehabilitation takes an important role. In this study we examined the present structures in acute care hospitals, which influence the process of rehabiliation. MATERIALS AND METHODS: The data was captured in a questionnaire. The questions deal with the personal and structural situation of acute care hospitals in Germany. The questionnaires were sent to all clinics, which are registered in the TraumaNetwork DGU...

The tumor suppressor p53 plays a central role in sensing damaged DNA and orchestrating the consequent cellular responses. However, how DNA damage leads to the activation of p53 is still poorly understood. In this study, we have found that the p38 mitogen-activated protein kinase (MAPK) plays a key role in the activation of p53 by genotoxic stress when provoked by chemotherapeutic agents. Indeed, we found that blockade of p38 prevents stimulation of the transcriptional activity of p53 and that activation of the p38 pathway is sufficient to stimulate p53 function...

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Two groups of men consumed two levels of protein (1.4 and 2.8 g/kg body weight) during a 40-day experimental period. Physical activity and the sweat rates were fairly high during the entire experimental phase. Urinary nitrogen excretions remained fairly constant for both groups during the training and heavy physical activity periods. Nitrogen balances were positive exclusive or inclusive of the daily sweat nitrogen losses showing nitrogen retention. The essentially unchanged blood hemoglobin and serum protein levels showed that the control group was receiving an adequate protein intake to maintain nitrogen equilibrium, under conditions of fairly heavy physical acitvity...

The changes in the metabolism of proteins, carbohydrates, fats, water and minerals as well as in the acitvity of enzymes of skeletal muscles during hypokinesia are discussed. The methods used to reverse metabolic disorders in skeletal muscles are recommended and evaluated. Among the suggested methods-the diet with predominant proteins, hypoxia, anabolic steroids and physical exercises-the latter seem to be most promising.