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peripheral vascular intervention

Chethan M Puttarajappa, Amit D Tevar, Sundaram Hariharan, Saul J Silver, Prem Soman, Shelly Hendrick, Girish Mour, Christine M Wu
BACKGROUND: The Utility of coronary angiography in patients with diabetes mellitus undergoing kidney transplant evaluation is unclear. Predictors of critical angiography lesions in these patients will aid in appropriate use of angiography. METHODS: Single center study of 80 patients with ≥ 15 years of diabetes mellitus who underwent a screening coronary angiography despite a negative cardiac stress test. Risk factors for needing coronary intervention (CI) (percutaneous or bypass grafting) were analyzed...
February 18, 2019: Clinical Transplantation
Laurien C M Noortman, Eero A Haapala, Tim Takken
There are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory fitness in children and young adults with a Fontan circulation. Altogether, 17 Fontan patients and 26 healthy controls (16 females and 27 males aged 8-40 years) participated in this cross-sectional study. The cardiorespiratory fitness was assessed by cardiopulmonary exercise testing on a cycle ergometer and was defined as the standard deviation scores (SDS) of peak oxygen uptake per body mass (VO2peak /kg) based on the national reference values and assessed with cardiopulmonary exercise testing on a cycle ergometer...
February 15, 2019: Pediatric Cardiology
Hanaa Dakour-Aridi, Manasi Arora, Besma Nejim, Satinderjit Locham, Mahmoud B Malas
OBJECTIVE: Drug abuse may affect lower extremity vessels due to ischemia following intra-arterial injections, vasospasm, arterial and venous pseudoaneurysms, arteriovenous fistulae, vasculitis and complicated abscesses. Little is known about the outcomes of Lower Extremity Bypass (LEB) for peripheral arteries disease (PAD) in patients with a history of drug abuse disorder. The aim of this study is to evaluate the outcomes of LEB in this patient population. METHODS: A retrospective study of the Premier Healthcare Database 2009-2015 was performed...
February 12, 2019: Annals of Vascular Surgery
Ibrahim Al-Zakwani, Ekram Al-Siyabi, Najib Alrawahi, Arif AlMulla, Abdullah Alnaeemi, Abdulla Shehab, Mohammed Zubaid
OBJECTIVE: To evaluate the association between peripheral artery disease (PAD) and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) in the Arabian Gulf. METHODS: Data was analyzed from 4044 consecutive patients diagnosed with ACS admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013. PAD was defined as any of the following: claudication, amputation for arterial vascular insufficiency, vascular reconstruction, bypass surgery, or percutaneous intervention in the extremities, documented aortic aneurysm or ankle brachial index of < 0...
February 10, 2019: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Arshad Khan, Stephen Brienesse, Andrew Boyle, Nicholas Collins
While coronary artery bypass grafting remains an essential component of revascularization therapy, the use of venous conduits in the form of saphenous vein grafts is associated with a number of late sequelae, including graft stenosis and occlusion. The recognition of saphenous vein graft aneurysm, typically a late complication, may be associated with adverse outcomes. We describe the percutaneous therapy of saphenous vein graft aneurysm, utilizing contemporary devices, including newer generation covered stents, and the use of devices more commonly used in peripheral vascular intervention, reflecting the dilated nature of vein grafts...
February 9, 2019: Catheterization and Cardiovascular Interventions
Tim Kaufeld, Eric Beckmann, Fabio Ius, Nurbol Koigeldiev, Wiebke Sommer, Bakr Mashaqi, Felix N Fleissner, Thierry Siemeni, Jacob Ono Puntigam, Jessica Kaufeld, Axel Haverich, Christian Kuehn
BACKGROUND: Venoarterial extracorporeal membrane oxygenation support is a well-established tool in the care of severe refractory cardiac and respiratory failure. The application of this support may serve as a bridge to transplant, recovery or to implantation of a ventricular assist device. Venoarterial extracorporeal membrane oxygenation support can be administered through an open surgical access via the common femoral or axillary artery or a percutaneous approach using Seldinger technique...
February 8, 2019: Perfusion
Patrick Meybohm, Simone Lindau, Sascha Treskatsch, Roland Francis, Claudia Spies, Markus Velten, Maria Wittmann, Erdem Gueresir, Christian Stoppe, Ana Kowark, Mark Coburn, Sixten Selleng, Marcel Baschin, Gregor Jenichen, Melanie Meersch, Thomas Ermert, Alexander Zarbock, Peter Kranke, Markus Kredel, Antonia Helf, Rita Laufenberg-Feldmann, Marion Ferner, Eva Wittenmeier, Karl-Heinz Gürtler, Peter Kienbaum, Marcel Gama de Abreu, Michael Sander, Michael Bauer, Timo Seyfried, Matthias Gruenewald, Suma Choorapoikayil, Markus M Mueller, Erhard Seifried, Oana Brosteanu, Holger Bogatsch, Dirk Hasenclever, Kai Zacharowski
BACKGROUND: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. The purpose of the study is to evaluate whether elderly surgical patients may benefit from a liberal red blood cell (RBC) transfusion strategy compared to a restrictive transfusion strategy...
February 4, 2019: Trials
Y Y Jin, R Bai, M Ye, H Ai, Y J Zeng, S P Nie
Objective: To explore the risk factors and prognoses of new-onset atrial fibrillation (NOAF) in patients with acute myocardial infarction (AMI). Methods: A total of 468 patients with AMI were admitted into Beijing Anzhen Hospital for emergency pereutaneous coronary intervention (PCI). According to the NOAF occurred during hospitalization, the patients were divided into two groups: the NOAF ( n= 37) group and the non-NOAF ( n= 431) group. Parameters including general clinical conditions, coronary lesions, echocardiography, biochemical markers, C-reactive protein (CRP) , N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and myocardial markers were collected...
February 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Elizabeth Liao, Naomi Eisenberg, Anish Kaushal, Janice Montbriand, Kong-Teng Tan, Graham Roche-Nagle
The Vascular Quality Initiative (VQI) is a national cooperative quality-improvement initiative designed to evaluate processes of care and outcomes in vascular surgery. The purpose of this report is to show the utility of such a database to provide insight into the standard of care provided, to highlight areas of local quality improvement, to benchmark our data against local, regional and national trends, and to ultimately improve safety in Canadian patients undergoing vascular surgery. We present the history of the database, its spread in the Canadian health care system and examples of quality improvements achieved from analyses of data recorded and retrieved from the VQI...
February 1, 2019: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Anna Altermatt, Laura Gaetano, Stefano Magon, Lorena Bauer, Regina Feurer, Hans Gnahn, Julia Hartmann, Christian L Seifert, Holger Poppert, Jens Wuerfel, Ernst-Wilhelm Radue, Ludwig Kappos, Till Sprenger
BACKGROUND: Subcortical T2-weighted (T2w) lesions are very common in older adults and have been associated with dementia. However, little is known about the strategic lesion distribution and how lesion patterns relate to vascular risk factors and cognitive impairment. AIM: The aim of this study was to analyze the association between T2w lesion load and location, vascular risk factors, and cognitive impairment in a large cohort of older adults. METHODS: 1017 patients participating in a large prospective cohort study (INtervention project on cerebroVAscular disease and Dementia in the district of Ebersberg, INVADE II) were analyzed...
January 24, 2019: NeuroImage
Deidra J H Mountain, Stacy S Kirkpatrick, Joshua D Arnold, M Ryan Buckley, Michael M McNally, Scott L Stevens, Michael B Freeman, Oscar H Grandas
BACKGROUND: Intimal hyperplasia (IH) is the most common indicator for secondary intervention in peripheral vascular disease. Matrix metalloproteinases (MMPs) play a role in IH development due to their degradation of the extracellular matrix. Doxycycline, a member of the tetracycline family of antibiotics, is a potent MMP inhibitor. We have previously shown doxycycline inhibits MMP activity and VSMC migration in vitro. We hypothesized that doxycycline would decrease MMP activity in vivo and inhibit the development of IH in a rodent model of vascular injury...
January 23, 2019: Annals of Vascular Surgery
Lobsang Marcia, Dennis Y Kim
BACKGROUND: Early identification of peripheral vascular injuries is crucial to prevent acute limb ischemia and amputation. We sought to identify predictors of vascular injury in patients with blunt lower extremity fractures. METHODS: A single institutional retrospective analysis of patients with blunt lower extremity fractures at a university-affiliated, County hospital over a 2-year period was performed. Patients with lower extremity vascular injury were compared to patients without...
January 23, 2019: Annals of Vascular Surgery
Vanessa D de Mello, Ingrid Dahlman, Maria Lankinen, Sudhir Kurl, Leena Pitkänen, David E Laaksonen, Ursula S Schwab, Arja T Erkkilä
BACKGROUND/OBJECTIVES: Molecular mechanisms linking fish and vegetable oil intakes to their healthy metabolic effects may involve attenuation of inflammation. Our primary aim was to examine in a randomized controlled setting whether diets enriched in fatty fish (FF), lean fish (LF) or ALA-rich camelina sativa oil (CSO) differ in their effects on the mRNA expression response of selected inflammation-related genes in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) in subjects with impaired fasting glucose...
January 9, 2019: Nutrition & Diabetes
Joan Webster, Sonya Osborne, Claire M Rickard, Nicole Marsh
BACKGROUND: US Centers for Disease Control guidelines recommend replacement of peripheral intravenous catheters (PIVC) no more frequently than every 72 to 96 hours. Routine replacement is thought to reduce the risk of phlebitis and bloodstream infection. Catheter insertion is an unpleasant experience for patients and replacement may be unnecessary if the catheter remains functional and there are no signs of inflammation or infection. Costs associated with routine replacement may be considerable...
January 23, 2019: Cochrane Database of Systematic Reviews
Jonas Kersting, Lars Kamper, Marco Das, Patrick Haage
BACKGROUND:  Because of the demographic change, lower extremity peripheral artery disease (PAD) is becoming increasingly relevant with respect to health economics. PAD patients often suffer from multiple diseases. Consequently, therapy is commonly complex and requires an interdisciplinary approach. Because of rapid technical developments, interventional endovascular therapy regimens play an increasingly important role. METHOD:  Review and literature search on the basis of the current German S3 guidelines on the therapy of PAD as well as international guidelines...
January 21, 2019: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Claudia Hacke, Sascha Ketelhut, Ulrike Wendt, Götz Müller, Claudia Schlesner, Kerstin Ketelhut
Several activity interventions in preschool settings exist, but little attention has been paid to effects on hemodynamic factors. The study aimed to assess the effectiveness of an exercise program on health-related outcomes including blood pressure (BP) and markers of vascular function in preschoolers, with focus on socioeconomic background. A cluster-randomized controlled trial, with preschool as unit of randomization and children as unit of analysis. Preschools with 3-to 6-yr-old children, stratified by social area, were randomly allocated to: intervention (3 clusters, n=92) including 2d·wk-1 /45min (6 months) exercise lessons, or control (2 clusters, n=43)...
January 21, 2019: Scandinavian Journal of Medicine & Science in Sports
Ki Hong Choi, Taek Kyu Park, Jihoon Kim, Young-Guk Ko, Cheol Woong Yu, Chang-Hwan Yoon, Jae-Hwan Lee, Pil-Ki Min, Yoon Seok Koh, In-Ho Chae, Donghoon Choi, Seung-Hyuk Choi
Background With advances in peripheral artery disease ( PAD ) treatments such as endovascular treatment ( EVT ), personalized patient assessment is important. Data on sex differences in clinical outcome for PAD patients undergoing EVT have been limited, and studies have produced conflicting results. This study sought to compare midterm clinical outcomes between women and men in a large population of patients with PAD undergoing EVT . Methods and Results The K- VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Disease) registry is a nationwide, multicenter, observational study that includes 3073 PAD patients undergoing EVT ...
January 22, 2019: Journal of the American Heart Association
Xiu-Hong Qin, Xiang Ma, Shi-Feng Fang, Zhen-Zhen Zhang, Jian-Min Lu
Fungal keratitis is a relatively common ocular disease requiring positive medical management combined with surgical intervention. Interleukin-17 (IL-17) was reported to promote the activation and mobilization of neutrophile granulocyte to foci of inflammation. This study investigated the effect of IL-17 production from Th17 cells on the progression of fungal keratitis. A mouse model of fungal keratitis induced by Candida albicans was successfully constructed to detect infiltration of inflammatory cells in corneal tissues by hematoxylin-eosin (HE) staining and immunohistochemistry...
January 20, 2019: Cell Cycle
Ange Landela Luzolo, Dieudonné Mumba Ngoyi
Malaria remains of significant public health concern under the tropics, causing millions of deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which harbors several distinct species. Human infection occurs during the blood meal of an infected female mosquito belonging to the Anopheles genus. It is estimated that around 1 % of children infected with Plasmodium falciparum develops a more severe form of malaria, which may eventually lead to cerebral complications including cerebral malaria (CM)...
January 15, 2019: Brain Research Bulletin
Ramon L Varcoe, Sharath Paravastu, Shannon D Thomas, Michael H Bennet
BACKGROUND: Endovascular treatment below-the-knee is safe and effective but limited by poor potency. Coronary DES may play a role in providing mechanical scaffolding and deliver anti-proliferative drug to the site of vascular barotrauma to reduce the incidence of restenosis. Our aim was to evaluate and compare the use of contemporary drug-eluting stents (DES) with standard endovascular-therapies for atherosclerotic disease of infrapopliteal arteries. METHODS: We performed a meta-analysis of randomised controlled trials comparing DES with conventional treatment for symptomatic peripheral artery disease (search date 30 August 2017)...
January 16, 2019: International Angiology: a Journal of the International Union of Angiology
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