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Francesco Doglietto, Francesco Belotti, Carlotta Ginevra Nucci, Elena Roca, Pier Paolo Mattogno, Francesca Zappa, Karol Migliorati, Pier Paolo Panciani, Giannantonio Spena, Claudio Cereda, Claudio Cornali, Marco Maria Fontanella
BACKGROUND: Three-dimensional (3D), high-definition (HD) endoscopy has been recently introduced in neurosurgery and its value extensively discussed in endonasal skull base surgery. There is no reported clinical series on the use of a recent 3D-HD ventriculoscope. OBJECTIVE: Aim of this study is to describe our initial experience with this novel device. METHODS: Patients consecutively operated on from June 2016 to June 2018 with a 3D-HD ventriculoscope were prospectively collected...
February 11, 2019: World Neurosurgery
Se In Sung, Yun Sil Chang, Jisook Kim, Jin Hwa Choi, So Yoon Ahn, Won Soon Park
This study aimed to determine the natural course of patent ductus arteriosus (PDA) with noninterventional conservative management and whether the presence and/or prolonged duration of hemodynamically significant (HS) PDA increased the risk of mortality and morbidities in extremely preterm (EPT) infants. We retrospectively reviewed the medical records of EPT infants born at 23-28 weeks of gestation (n = 195) from January 2011 to June 2014, when PDA was managed with noninterventional conservative treatment. We stratified infants into three subgroups of 23-24, 25-26, and 27-28 weeks and analyzed the prevalence and natural evolution of HS PDA, defined as ventilator dependency and PDA size ≥2 mm...
2019: PloS One
Qing Huang, Lan-Ying Lin, Xian-Zhong Lin
BACKGROUND The aim of this study was to evaluate the effectiveness and safety of remifentanil-based fast-track anesthesia for intraoperative device closure of atrial septal defects (ASDs). MATERIAL AND METHODS The clinical data of 152 pediatric patients who received intraoperative device closure of ASD in our hospital from January 2015 to December 2017 were retrospectively analyzed. Patients were divided into 2 groups: group F (remifentanil-based fast-track anesthesia group, n=72) and group C (fentanyl-based routine anesthesia group, n=80)...
February 13, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Marc A Ward, Tareq Hassan, James S Burdick, Steven G Leeds
BACKGROUND: Endoluminal vacuum therapy (EVAC) is an emerging procedure used to treat anastomotic leaks and/or perforations that would otherwise require surgery. The aim of this study was to determine time to proficiency in EVAC and the cost effectiveness of the procedure. METHODS: We retrospectively reviewed a prospectively maintained IRB approved database for all patients undergoing EVAC after esophageal and gastric complications between October 2013 and December 2017...
February 11, 2019: Surgical Endoscopy
Yusuke Watanabe, Koji Hozawa, Hisaaki Ishiguro, Sunao Nakamura
Pseudoaneurysm was caused at the puncture site of the left groin after percutaneous coronary intervention. Balloon tamponade was attempted for hemostasis at the aneurysmal site. However, hemostasis was not achieved. Next, direct puncture of the pseudoaneurysm was tried. A 0.014-inch guidewire was crossed from the neck of the pseudoaneurysm to the left common femoral artery. The wire was replaced with a 0.035-inch guidewire. An 8F Angio-Seal (Terumo Interventional Systems, Somerset, NJ) was inserted, and a collagen plug was deployed at the neck of the pseudoaneurysm...
March 2019: Journal of Vascular Surgery Cases and Innovative Techniques
Mariano Oscar Abrego, Javier Eduardo Sanchez Saba, Carolina Halliburton, Danilo Roger Eric Taype, Carlos Federico Sancineto
Introduction: Fasciitis of the limb and toxic-shock syndrome due to Streptococcus Pyogenes infection is considered a surgical emergency. This condition may occur in previously healthy patients. It is a life-threatening condition with high morbidity rates when treatment is delayed due to poor diagnosis and non-surgical intervention. Case Report: 17-year-old male patient sustained a minor ankle trauma while skating. Initials findings were a 1cm wound in relation with his left lateral malleolus and moderate swelling...
September 2018: Journal of Orthopaedic Case Reports
Kaivan Vaidya, Chinmay Khandkar, David Celermajer
A patent foramen ovale (PFO) is a remnant interatrial communication, best diagnosed with transoesophageal echocardiography (TOE) and bubble study. Although quite common and often asymptomatic, PFO is associated with cryptogenic stroke and migraine. Approximately one-half of patients with a cryptogenic stroke have a PFO, and the dilemma regarding whether or not to proceed with percutaneous device closure, to reduce the risk of future recurrent events due to paradoxical embolism, has been subject to debate for nearly two decades...
December 2018: Cardiovascular Diagnosis and Therapy
Paul C Tang, Jonathan W Haft, Matthew A Romano, Abbas Bitar, Reema Hasan, Maryse Palardy, Xiaoting Wu, Keith Aaronson, Francis D Pagani
OBJECTIVE: To investigate whether preoperative echocardiography findings determine postoperative continuous-flow left ventricular assist device outcomes. METHODS: From January 2003 to June 2017, 490 patients received a durable, continuous-flow left ventricular assist device. Two-step clustering of parameters including heart rate and preoperative echocardiographic findings (ie, left ventricular [LV] ejection fraction, right ventricular [RV] function, aortic insufficiency, mitral regurgitation [MR], tricuspid regurgitation [TR]) was performed and identified 5 distinct clusters associated with LV failure: group 1: moderate right ventricular dysfunction (RVD), severe MR and mild TR (n = 110); group 2: severe RVD, severe MR and TR (n = 64); group 3: moderate RVD and severe aortic insufficiency (n = 16); group 4: mild RVD and mild valvular pathology (n = 163); and group 5: moderate-severe RVD and mild valvular pathology (n = 137)...
December 11, 2018: Journal of Thoracic and Cardiovascular Surgery
Shaoquan Pu, Qian Lü, Zeyu Zhao, Dan Hu, Xiang Chen, Hanfen Chen, Yueliang Zhu, Yongqing Xu
Objective: To investigate the effectiveness of self-made limb chronic wound closure device in the treatment of scarred lower limbs and complex skin and soft tissue defects. Methods: Between January 2014 and January 2017, 29 patients with complex fractures of the lower extremities and skin and soft tissue defects were treated. There were 19 males and 10 females with an average age of 31.1 years (range, 21-66 years). The causes of injury included 14 cases of traffic accidents, 5 cases of falling from height, 4 cases of heavy object crushing injury, 4 cases of mechanical crushing injury, and 2 cases of exposed steel plate after fracture...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Courtney L Furlough, Ashish K Jain, Karen J Ho, Heron E Rodriguez, Tadaki M Tomita, Mark K Eskandari
OBJECTIVE: Cryopreserved human arterial allografts are a recognized acceptable alternative for vascular reconstruction when other traditional conduits are either unavailable or contraindicated. We reviewed our experience using cryopreserved arterial allografts for peripheral artery reconstructions in contaminated and infected surgical fields. METHODS: A single-center, retrospective review was conducted of 57 patients who underwent a peripheral vascular reconstruction using a cryopreserved arterial allograft from January 2002 through July 2017...
February 5, 2019: Journal of Vascular Surgery
Marek Roslan, Marcin Markuszewski, Wojciech Piaskowski, Wojciech Polom, Slawomir Letkiewicz
INTRODUCTION: Male / female sex reassignment surgery is performed on transsexuals, and includes removal of the male external genitalia, and creation of the neovagina from the skin of the penis, usually allowing sexual intercourse (1, 2). The incidence of the prolapse of the neovagina is not known; however, such complication is observed relatively rarely (3, 4). the long-term outcomes of prolapse treatment in transsexual patients are not available in the literature. The purpose of this study was to demonstrate laparoscopic sacrocolpopexy to repair a neovagina prolapse in a patient after male-to-female sex reassignment surgery...
January 25, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rafael Giraldo
Modulation of liquid-liquid and liquid-hydrogel phase transitions is central to avoid the cytotoxic aggregation of proteins in eukaryotic cells, but knowledge on its relevance in bacteria is limited. Here the power of optogenetics to engineer proteins as light-responsive switches has been used to control the balance between solubility and aggregation for LOV2-WH1, a chimera between the plant blue light-responsive domain LOV2 and the bacterial prion-like protein RepA-WH1. These proteins were first linked by fusing, as a continuous α-helix, the C-terminal photo-transducer Jα helix in LOV2 with the N-terminal domain-closure α1 helix in RepA-WH1, and then improved for light-responsiveness by including mutations in the Jα moiety...
February 2, 2019: Journal of Molecular Biology
Damien Kenny, Andreas Eicken, Ingo Dähnert, Younes Boudjemline, Horst Sievert, Martin Be Schneider, Tommaso Gori, Ziyad M Hijazi
AIMS: The aim of this study was to compare the efficacy and safety of the Occlutech Figulla Flex II Occluder (OFFII) with the Amplatzer Septal Occluder (ASO) in patients > 8kg undergoing transcatheter ASD closure. METHODS AND RESULTS: Randomized, controlled, multi-center prospective clinical trial with randomization 2:1 in favor of the OFFII. Primary efficacy endpoint was the rate of successful device placement and defect closure without major complications at hospital discharge...
February 1, 2019: Catheterization and Cardiovascular Interventions
Ozlem Elkiran, Cemsit Karakurt, Gulendam Kocak, Cagatay Taskapan
Introduction: There is a concern about release of nickel and titanium after implantation of nitinol-containing devices. Objective: To evaluate serum nickel and titanium release after implantation of Amplatzer occluder. Materials and methods: In 38 pediatric patients with no history of nickel sensitivity, blood samples were drawn 24 hours before and 24 hours, 1, 3, 6, and 12 months after implantation. Nickel and titanium concentrations were measured by atomic absorption spectrophotometry...
2019: Cardiology Research and Practice
Fei Zhang, Yifeng Yang, Qin Wu, Wancun Jin, Haisong Bu, Sijie Wu, Tianli Zhao, Shijun Hu
OBJECTIVE: To evaluate safety and effectiveness of intraoperative device closure for secundum atrial septal defect (ASD) not referred to percutaneous closure. DESIGN AND PATIENTS: From April 2010 to December 2018, 231 secundum ASD children (≤14 years) directly recommended to surgical repair were enrolled in this study. These patients were divided into two groups according to the parents' choice based on surgeons' recommendation. Follow-up evaluations were adopted at 2 weeks, 3 months, 6 months, and 12 months after the procedure and yearly thereafter...
February 4, 2019: Congenital Heart Disease
Alexis D Rounds, Karen E Burtt, Hyuma A Leland, Ram K Alluri, Ido Badash, Ketan M Patel, Joseph N Carey
Background: Lower extremity trauma accounts for over 300,000 injuries annually. While soft tissue transfer is a well-accepted practice for open fracture coverage, functional outcomes remain unclear. Hypothesis: This study investigates functional outcomes following soft tissue reconstruction for open tibial fractures. Materials and methods: A retrospective review of a prospectively maintained database of open tibia fractures requiring soft tissue reconstruction was performed at an urban level 1 trauma center between October 2013 and March 2015...
January 2019: Journal of Clinical Orthopaedics and Trauma
Protap Mahanta, Farhana Anwar, Ronald A Coutu
In microelectromechanical systems (MEMS) switches, the microcontact is crucial in determining reliability and performance. In the past, actual MEMS devices and atomic force microscopes (AFM)/scanning probe microscopes (SPM)/nanoindentation-based test fixtures have been used to collect relevant microcontact data. In this work, we designed a unique microcontact support structure for improved post-mortem analysis. The effects of contact closure timing on various switching conditions (e.g., cold-switching and hot-switching) was investigated with respect to the test signal...
January 30, 2019: Sensors
Vojtěch Pavlík, Martin Sojka, Mária Mazúrová, Vladimír Velebný
OBJECTIVES: The majority of human chronic wounds contain bacterial biofilms, which produce proteases and retard the resolution of inflammation. This in turn leads to elevated patient protease activity. Chronic wounds progressing towards closure show a reduction in proteolytic degradation. Therefore, the modulation of protease activity may lead to the faster healing of chronic wounds. Antimicrobials are used to control biofilm-based infection; however, some of them also exhibit the inhibition of matrix metalloproteinases and bacterial proteases...
2019: PloS One
Yasuhiro Tanabe, Yukio Sato, Masaki Izumo, Yuki Ishibashi, Takumi Higuma, Tomoo Harada, Yoshihiro J Akashi
The current guidelines recommend a minimum of 6 months of antithrombotic and antibiotic prophylaxis following septal occluding device placement for transcatheter closure of atrial septal defect. Full neoendothelialization is thought to be completed within 6 months of device implantation; however, there is no method available that can assess the level of neoendothelialization in vivo. This report therefore evaluates endothelialization in vivo and demonstrates that 6 months of postimplantation prophylactic therapy may not provide sufficient time for adequate endothelialization...
February 2019: Journal of Invasive Cardiology
Chak-Yu So, Yat-Yin Lam, Gary Shing-Him Cheung, Kevin Ka-Ho Kam, Anna Kin-Yin Chan, Alex Pui-Wai Lee, Bryan P Yan
Although reported failure rates of the Watchman device are low, the ballshaped device is not suitable for shallow and multilobed left atrial appendages (LAAs). The LAmbre device is available in two configurations - standard (cover 4-6 mm larger in diameter than the umbrella) and special (cover 12- 14 mm larger than the umbrella) - which allows the closure of a wide range of LAA anatomies. This case illustrates that the LAmbre device can be used for complex LAA anatomies that are not suitable for the Watchman device...
February 2019: Journal of Invasive Cardiology
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