keyword
https://read.qxmd.com/read/38505191/perioperative-treatment-with-rivaroxaban-and-dabigatran-on-changes-of-coagulation-and-platelet-activation-biomarkers-following-left-atrial-appendage-closure
#1
JOURNAL ARTICLE
Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv
Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). The study was designed to investigate the changes and presence of coagulation activation biomarkers between different antithrombotic strategies following LAAC. A total of 120 nonvalvular atrial fibrillation patients intolerant of long-term anticoagulants, who underwent successful WATCHMAN closure implantation, were enrolled (rivaroxaban, n = 82; dabigatran, n = 38)...
2024: Cardiovascular Therapeutics
https://read.qxmd.com/read/38504482/left-atrial-appendage-occlusion-on-the-need-of-a-numerical-model-to-simulate-the-implant-procedure
#2
JOURNAL ARTICLE
Francesca Danielli, Francesca Berti, Benigno Marco Fanni, Emanuele Gasparotti, Simona Celi, Giancarlo Pennati, Lorenza Petrini
Left atrial appendage occlusion (LAAO) is a percutaneous procedure to prevent thromboembolism in patients affected by atrial fibrillation. Despite its demonstrated efficacy, the LAA morphological complexity hinders the procedure, resulting in postprocedural drawbacks (device-related thrombus and peri-device leakage). Local anatomical features may cause difficulties in the device's positioning and affect the effectiveness of the device's implant. The current work proposes a detailed FE model of the LAAO useful to investigate implant scenarios and derive clinical indications...
March 19, 2024: International Journal for Numerical Methods in Biomedical Engineering
https://read.qxmd.com/read/38492735/left-atrial-appendage-closure-in-patients-with-mechanical-mitral-valve-prosthesis-a-multicenter-italian-pilot-study
#3
JOURNAL ARTICLE
Alberto Preda, Davide Margonato, Carlo Gaspardone, Vincenzo Rizza, Ciro Vella, Lorenzo Rampa, Alessandra Marzi, Fabrizio Guarracini, Paolo Della Bella, Eustachio Agricola, Achille Gaspardone, Matteo Montorfano, Patrizio Mazzone
INTRODUCTION: In patients with atrial fibrillation (AF) on vitamin K antagonist (VKA) therapy and therapeutical INR range the incidence of cardiac thromboembolism is not negligible and the subgroup carrying a mechanical prosthetic mitral valve (PMV) has the highest risk. We aimed to assess the long-term effects of left atrial appendage closure (LAAC) in AF patients carriers of mechanical PMV who experienced a failure of VKA therapy. METHODS: In this retrospective, multicenter study, patients underwent LAAC because of thrombotic events including TIA/stroke, systemic embolism and evidence of left atrial appendage thrombosis/sludge despite VKA therapy were enrolled...
March 14, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38477017/should-left-atrial-appendage-closure-be-considered-in-resistant-left-atrial-appendage-thrombus-cases-former-foe-new-ally
#4
JOURNAL ARTICLE
Ahmet Hakan Ates, Ahmet Kivrak, Ugur Nadir Karakulak, Cem Coteli, Hikmet Yorgun, Mehmet Levent Sahiner, Ergun Barıs Kaya, Kudret Aytemir
BACKGROUND: The study explores left atrial appendage closure (LAAC) as a safe and effective alternative to anticoagulation for atrial fibrillation (AF) patients at high bleeding risk. Complications, such as cardioembolic events due to left atrial appendage thrombus (LAAT), highlight the need for alternative stroke prevention strategies. AIMS: This research assesses LAAC's safety and efficacy in patients with LAAT, aiming to offer valuable insights into its potential as a viable option for stroke prevention in such cases...
March 13, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38468182/a-device-related-fistula-between-coronary-artery-and-left-atrial-appendage-following-left-atrial-appendage-closure-case-presentation
#5
Xiaohua Liu, Yizhou Xu
INTRODUCTION: Left atrial appendage (LAA) closure (LAAC) is considered a viable alternative to anticoagulation therapy for stroke prevention in nonvalvular atrial fibrillation, we report a case with a less common shunt resulting from a device-related coronary artery-appendage fistula (CAAF) following LAAC. METHODS AND RESULTS: A 67-year-old male with a history of LAAC was referred to our emergency room with recurrent chest pain and palpitations and was diagnosed with ischemic angina pectoris...
March 11, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38459842/-left-atrial-appendage-closure-with-various-types-of-surgical-technique-and-its-results
#6
REVIEW
Eiichi Ohba, Yoshinori Kuroda, Masahiro Mizumoto, Ai Ishizawa, Daisuke Watanabe, Shingo Nakai, Kimihiro Kobayashi, Tetsuro Uchida
BACKGROUND: Occlusion of the left atrial appendage( LAA) may prevent stroke in patients with atrial fibrillation. In this study, we reviewed various types of LAA occlusion techniques and results of patients underwent surgical LAA closure. METHODS: Between 2004 and 2022, 182 patients who underwent surgical LAA closure were enrolled in this study. RESULTS: The surgical LAA closure consisted of 90 cases of closure device, AtriCure, 63 cases of surgical excision, 13 cases of stapler excision, 3 cases of ligation, and 13 cases of internal suture ligation...
January 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38448258/embolization-of-percutaneous-left-atrial-appendage-closure-devices-timing-management-and-clinical-outcomes
#7
JOURNAL ARTICLE
Sophie Eppinger, Kerstin Piayda, Roberto Galea, Marcus Sandri, Moniek Maarse, Ahmet Güner, Can Y Karabay, Ashish Pershad, Wern Y Ding, Adel Aminian, Ibrahim Akin, Karapet V Davtyan, Ivan A Chugunov, Eloi Marijon, Liesbeth Rosseel, Thomas Robert Schmidt, Nicolas Amabile, Kasper Korsholm, Juha Lund, Enio Guerios, Ignacio J Amat-Santos, Giacomo Boccuzzi, Christopher R Ellis, Avi Sabbag, Henning Ebelt, Brian Clapp, Hana Vaknin Assa, Amos Levi, Jakob Ledwoch, Sonja Lehmann, Oh-Hyun Lee, George Mark, Wendy Schell, Domenico G Della Rocca, Andrea Natale, Ole de Backer, Joelle Kefer, Pablo P Esteban, Mark Abelson, Pradhum Ram, Pamela Moceri, Jose G Galache Osuna, Xavier Millán Alvarez, Ignacio Cruz-Gonzalez, Tom de Potter, Moubarak Ghassan, Andrey Osadchiy, Weita Chen, Sandeep K Goyal, Francesco Giannini, Máximo Rivero-Ayerza, Shazia Afzal, Christian Jung, Carsten Skurk, Martin Langel, Mark Spence, Evgeny Merkulov, Mathieu Lempereur, Seung Y Shin, Jules Mesnier, Heather L McKinney, Brian T Schuler, Sebastien Armero, Livia Gheorghe, Marco B M Ancona, Lino Santos, Jacques Mansourati, Luis Nombela-Franco, Francesco Nappi, Michael Kühne, Achille Gaspardone, Jesper van der Pals, Matteo Montorfano, Juan Fernández-Armenta, James E Harvey, Josep Rodés-Cabau, Norbert Klein, Sajjad A Sabir, Jung-Sun Kim, Stephane Cook, Ran Kornowski, Antti Saraste, Jens E Nielsen-Kudsk, Dhiraj Gupta, Lucas Boersma, Lorenz Räber, Kolja Sievert, Horst Sievert, Stefan Bertog
BACKGROUND: Left atrial appendage (LAA) occluder embolization is an infrequent but serious complication. OBJECTIVES: We aim to describe timing, management and clinical outcomes of device embolization in a multi-center registry. METHODS: Patient characteristics, imaging findings and procedure and follow-up data were collected retrospectively. Device embolizations were categorized according to 1) timing 2) management and 3) clinical outcomes...
February 28, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38402694/late-device-related-thrombus-associated-with-occult-malignancy-years-after-left-atrial-appendage-closure
#8
Ahmad O Armouti, Sheyar Amin, David Z Rose
INTRODUCTION: The use of Left Atrial Appendage (LAA) occluder devices has been on the rise in patients with atrial fibrillation. Studies regarding the long-term risks of occluder devices remain sparse. MATERIALS & METHODS: In this brief report, we discuss the unusual case of an 85-year-old female with long-term complication from Left Atrial Appendage (LAA) closure: Device-Related Thrombus (DRT) about two years after insertion. RESULTS: Compared to the expected stroke rate without anticoagulation, patients with DRT on their LAAO device still had a 28 % relative reduction in ischemic stroke...
February 2, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38354181/safety-and-efficacy-of-percutaneous-watchman-2-5-device-versus-amplatzer-amulet-for-left-atrial-appendage-closure-in-patients-with-non-valvular-atrial-fibrillation-a-systematic-review-and-study-level-meta-analysis
#9
JOURNAL ARTICLE
Farah Yasmin, Eman Ali, Abdul Moeed, Farwa Zaidi, Muhammad Umar, Vikash Virwani
INTRODUCTION: In patients with non-valvular atrial fibrillation (NVAF), mechanical occlusion of the left atrial appendage (LAA) using a permanently implanted device may be an effective alternative to oral anti-coagulants (OAC). To facilitate left atrial appendage closure (LAAC), multiple percutaneous devices have been proposed. Watchman Generation 2.5 and Amplatzer Amulet are the two most popular used devices for preventing stroke in patients with NVAF. We sought to compare safety and efficacy outcomes between Watchman 2...
2024: PloS One
https://read.qxmd.com/read/38344419/complex-percutaneous-transcatheter-closure-of-incomplete-surgical-ligation-of-the-left-atrial-appendage-a-case-report
#10
Michele Tomaselli, Giuseppe Verolino, Paolo Sganzerla, Mara Gavazzoni
BACKGROUND: Incomplete surgical left atrial appendage (LAA) closure, in the form of incompletely surgically ligated LAA (ISLL), increases thrombo-embolic risk in patients with atrial fibrillation (AF). Although its management is not standardized, the percutaneous closure of ISLL could be an alternative in patients with contraindication for anticoagulants. We present the case of a percutaneous transcatheter LAA device implantation in a patient with AF and ISLL, complicated by severe anaemia...
February 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38332926/the-use-of-percutaneous-left-atrial-appendage-occluder-device-in-a-patient-with-prior-surgical-ligation-with-incomplete-exclusion-a-case-report
#11
Raef Fadel, Essaq Khan, Waddah Maskoun
BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and the most common cause of cardioembolic stroke. The left atrial appendage (LAA) is the main source of thrombus formation in patients with AF. Therapies include use of percutaneous LAA closure devices, or surgical LAA occlusion (LAAO). Despite these options, complete closure of the LAA is not always achieved, and residual communication between the LAA and atrium may result in increased thrombus formation...
February 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38329512/comparison-of-left-atrial-appendage-measurements-between-conventional-transesophageal-echocardiography-and-virtual-tee-reconstructed-from-computed-tomography-for-pre-procedural-planning-of-device-closure
#12
JOURNAL ARTICLE
Natsuki Cho, Yoshifumi Nakajima, Shunsuke Kubo, Hidehiko Hara, Mamoru Nanasato, Maiko Hozawa, Akio Doi, Yoshihiro Morino
For pre-procedural planning of left atrial appendage (LAA) closure, sizing is crucial. Although transesophageal echocardiography (TEE) is a standard modality, cardiac computed tomography (CT) is also widely used. The virtual TEE (V-TEE) that our group developed enables us to reconstruct images similar to TEE images from CT images. The software should be helpful to understand and plan the procedure strategy. Accordingly, we investigated the utility of V-TEE. Sixty-six patients at 4 participating sites who completed both CT and TEE prior to LAA closure were included...
February 8, 2024: Heart and Vessels
https://read.qxmd.com/read/38310499/first-experience-with-amulet-in-the-united-states-early-insights-from-emerge-laa-postapproval-study
#13
JOURNAL ARTICLE
Mohamad Alkhouli, James V Freeman, Christopher R Ellis, Atman P Shah, Hemal Gada, Megan Coylewright, Monica Lo, Akash Makkar, Himanshu Agarwal, Dhanunjaya Lakkireddy
BACKGROUND: The Food and Drug Administration approved the Amulet occluder (Abbott) after demonstrating safety and effectiveness in the Amulet IDE (AMPLATZER Amulet LAA Occluder) trial. OBJECTIVES: The aim of the EMERGE Left Atrial Appendage study is to evaluate early postapproval outcomes of the Amulet occluder in the United States using data from the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry. METHODS: Patients with a commercial Amulet occluder implant attempt between Food and Drug Administration approval (August 14, 2021) and December 31, 2022, were included...
January 19, 2024: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/38283554/a-decade-later-long-term-results-of-the-first-percutaneous-epicardial-closure-of-the-left-atrial-appendage-using-the-lariat-device
#14
JOURNAL ARTICLE
Marian Burysz, Michalina Malec-Litwinowicz, Jakub Batko, Radoslaw Litwinowicz, Mariusz Kowalewski, Bogus Aw Kapelak, Krzysztof Bartus
INTRODUCTION: Over the past decade, left atrial appendage occlusion (LAAO) has emerged as an established alternative to oral anticoagulation for patients diagnosed with atrial fibrillation (AF). The LARIAT device stands as the sole available epicardial system for complete percutaneous left atrial appendage (LAA) closure. AIM: To present the extended outcomes (spanning over 9 years of observation) in patients with AF who underwent epicardial LAAO. The presented results constitute the longest observation in world literature...
December 2023: Polish Journal of Cardio-Thoracic Surgery
https://read.qxmd.com/read/38272283/left-atrial-appendage-closure-in-patients-with-left-atrial-appendage-thrombus-guided-by-intracardiac-echocardiography
#15
JOURNAL ARTICLE
Binhao Wang, Huimin Chu, Zhao Wang, Guohua Fu, Yibo Yu, Mingjun Feng, Xianfeng Du
BACKGROUND: Data regarding left atrial appendage closure (LAAC) in patients with left atrial appendage (LAA) thrombus are limited. Recently published cases have mostly been guided by transesophageal echocardiography (TEE). Intracardiac echocardiography (ICE) is now widely used during LAAC procedures. OBJECTIVE: This is the first study to report the feasibility of LAAC in patients with LAA thrombus guided by ICE. METHODS: Patients with persistent LAA thrombus despite anticoagulation or contraindications to anticoagulation who underwent a modified ICE-guided LAAC procedure between June 2021 and April 2023 were included...
January 23, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38238125/impact-of-left-atrial-appendage-orifice-diameter-on-the-safety-and-efficacy-of-left-atrial-appendage-closure-using-the-lambre-device
#16
JOURNAL ARTICLE
Weidong Zhuo, Binhao Wang, Guohua Fu, Yibo Yu, Mingjun Feng, Jing Liu, Xianfeng Du, Huimin Chu
BACKGROUND: The diameter and shape of the left atrial appendage (LAA) orifices may influence occluder selection and the outcomes of left atrial appendage closure (LAAC) procedure. This study aimed to evaluate the impact of LAA orifice diameter on the safety and efficacy of LAAC using the LAmbre device. METHODS: A total of 133 patients with nonvalvular atrial fibrillation (AF) who underwent LAAC with the LAmbre device between June 2018 and June 2020 were included in this study...
January 17, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38192271/a-giant-left-atrial-appendage-a-case-report-on-the-feasibility-of-closure-with-a-custom-made-device
#17
Federico Barocelli, Filippo Luca Gurgoglione, Marco Covani, Maria Alberta Cattabiani, Luigi Vignali
BACKGROUND: Transcatheter left atrial appendage occlusion (LAAO) is a valuable therapeutic option for stroke prevention in patients with atrial fibrillation (AF) at high bleeding risk. However, complex LAA anatomies sometimes preclude the adoption of commercially available LAAO devices. The design of a custom-made LAAO device is a promising strategy in these cases. However, few examples of custom-made devices in case of giant LAAs have been reported. CASE SUMMARY: An 85-year-old man with permanent AF with CHA2 DS2 -VASc 4 and recurrent active gastrointestinal major bleedings was referred for transcatheter LAAO at Parma University Hospital after multidisciplinary team evaluation...
January 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38192059/cardiac-computed-tomography-angiography-for-assessment-of-endothelial-insufficiency-of-left-atrial-appendage-disc-like-occluder
#18
JOURNAL ARTICLE
Zhiyong Duan, Genling Shi, Bin Wang, Yongjian Shen, Mengshi Xie, Zhenzhou Zhang, Xixi Dai, Weifeng Yao, Yunfei Liu, Hongyu Shi
INTRODUCTION: This study was performed to explore the diagnostic value of cardiac computed tomography angiography (CCTA) for endothelial insufficiency (EIS) of a left atrial appendage (LAA) disc-like occluder. METHODS: Fifty-nine patients with nonvalvular atrial fibrillation who underwent placement of an LAA disc-like occluder (LAmbre; Lifetech Scientific) in our hospital were retrospectively analyzed. Patients who were found to have contrast agent entering the LAA at the 3-month postoperative CCTA examination underwent Hounsfield unit (HU) measurement of the LAA and construction of a three-dimensional (3D) model of the device for preliminary discernment between peri-device leakage (PDL) and EIS...
January 8, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38182966/risk-factors-clinical-implications-and-management-of-peridevice-leak-following-left-atrial-appendage-closure-a-systematic-review
#19
REVIEW
Baraa Helal, Jibran Khan, Dalia AlJayar, Mohammad Salman Khan, Mohamad S Alabdaljabar, Zain Ul Abideen Asad, Christopher V DeSimone, Abhishek Deshmukh
BACKGROUND: Left atrial appendage closure (LAAC) is a treatment modality for stroke prevention in patients with atrial fibrillation (AF). One of the potential complications of LAAC is a peri-device leak (PDL), which could potentially increase the risk of thromboembolism formation. METHODS: This systematic review was done according to PRISMA guidelines. Using four databases, all primary studies through April 2022 that met selection criteria were included. Outcomes of interest were studies reporting on PDL characteristics, risk factors and management...
January 6, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/38093820/watchmen-a-case-report-highlighting-the-closure-of-a-bilobed-left-atrial-appendage-using-two-watchman-flx-devices
#20
Abhinav Sood, Jagadeesh K Kalavakunta, Venu Gourineni, Vishal Gupta
BACKGROUND: Left atrial appendage occlusion (LAAO) performed percutaneously has emerged as a widely accepted method for stroke prevention, offering a viable alternative to anticoagulation. Numerous studies have demonstrated the effectiveness and safety of this procedure. However, in certain cases, the use of a single LAAO device may not adequately achieve optimal closure due to variations in the anatomy of the left atrial appendage (LAA). CASE SUMMARY: In this manuscript, we highlight the successful closure of a bilobed LAA with a large ostium utilizing two WATCHMAN™ FLX devices and using the double sheath technique...
December 2023: European Heart Journal. Case Reports
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