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Fahad Al-Majid, Zahid Shakoor, Mazin Barry
Background and Objectives: Variations in immune reconstitution following antiretroviral treatment (ART) among HIV patients have previously been observed. This study aims at assessing immune reconstitution after successful ART among HIV-infected Saudi patients. Methods: This retrospective study of 240 HIV-infected patients was performed between May 2010 and June 2015 in the HIV center at King Saud Hospital, Riyadh. Data were extracted for CD4, CD8 cell, and CD3/HLA-DR counts along with the viral load from patient records before and after four years of successful ART...
2019: Canadian Journal of Infectious Diseases & Medical Microbiology
AbdulKarim-Talaq Mohammad, Ahmed Saud Abdulhameed, Ali H Jawad
A crosslinked chitosan-glyoxal/TiO2 nanocomposite (CCG/TNC) was synthesized by loading different ratios of TiO2 nanoparticles into polymeric matrix of crosslinked chitosan-glyoxal (CCG) to be a promising biosorbent for methyl orange (MO). Box-Behnken design (BBD) in response surface methodology (RSM) was applied to optimize various process parameters, viz., loading of TiO2 nanoparticles into CCG polymeric matrix (A: 0%-50%), adsorbent dose (B: 0.04-0.14 g/50 mL), solution pH (C: 4-10), and temperature (D: 30-50 °C)...
February 5, 2019: International Journal of Biological Macromolecules
Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan
Background: More than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail. Colorectal, breast, and prostate cancers have been a scrupulous spot of center, altogether, these three malignancies report for approximately 35% of cancer cases and 20% of cancer demises in the United States, and as such are a chief public health apprehension. The aim was to evaluate antitumor activity of Vitamin D-Nanoemulsion (NVD) in colorectal cancer cell lines and HCT116 xenograft model in a comprehensive approach...
2019: Cell & Bioscience
Jawad I Arshad, Asma Saud, Darrell E White, Natalie A Afshari, Rony R Sayegh
PURPOSE: To help clinicians diagnose and manage unilateral recalcitrant chronic bacterial conjunctivitis secondary to a retained soft contact lens and describe the first report of Gram-negative bacteria causing this condition. METHODS: Chart review of successive cases presenting with unilateral chronic conjunctivitis with positive cultures and a retained contact lens. RESULTS: Three cases were identified and described. Culturing of the retained contact lenses grew Pseudomonas aeruginosa in the first case, Achromobacter xylosoxidans in the second, and Staphylococcus epidermidis in the third...
February 1, 2019: Eye & Contact Lens
Hussein A Almehdar, Nawal Abd El-Baky, Abdulqader A Alhaider, Saud A Almuhaideb, Abdullah A Alhaider, Raed S Albiheyri, Vladimir N Uversky, Elrashdy M Redwan
Lactoferrin is an iron-binding glycoprotein present in various secretions (e.g., milk, tears, saliva, pancreatic juice), which performs multiple functions, with one of them being the antimicrobial defense. Purified camel lactoferrins (cLfs) from different Saudi camel clans, as well as human and bovine lactoferrins (hLf or bLf) were tested as antimicrobial agents against Salmonella enterica serovar Typhi (S. Typhi). All cLfs showed superior antibacterial potentials relative to hLf or bLf, while there was no noticeable difference in the antimicrobial capabilities between the cLfs from different camel clans...
February 5, 2019: Probiotics and Antimicrobial Proteins
Fahd A Aljarbou, Mazen Aldosimani, Riyadh I Althumairy, Abdullah A Alhezam, Abdullah I Aldawsari
OBJECTIVES: To evaluate the relationship of the first and second mandibular molar roots to the inferior alveolar canal (IAC) and cortical plates using cone beam computed tomography (CBCT) in the Saudi population. Methods: Scans of 60 patients were collected retrospectively from the dental hospital database in King Saud University, Riyadh, Kingdom of Saudi Arabia. Measurements of the right and left first and second mandibular molars for each dental root and the mandibular bone thickness were determined...
February 2019: Saudi Medical Journal
Wael Mansy, Nermin H Ibrahim, Somaya Al-Gawhary, Sarah S Alsubaie, Manal M Abouelkheir, Amal Fatani, Fadwa Abd Al Reheem, Heba El Awady, Enas A Zakaria
There is a significant association exists between vitamin D deficiencies, low respiratory tract infections, and certain types of VDR gene polymorphism. Various studies are being conducted to prove any such link between the different clinical conditions due to disturbed vitamin D regulation and VDR gene polymorphisms. The present study analyzed the presence of vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in Saudi pediatric patient suffering from acute lower respiratory tract infection (ALRTI) cases...
February 5, 2019: Molecular Biology Reports
Flavia Cristina Drumond Andrade, Ligiana Pires Corona, Yeda Aparecida de Oliveira Duarte
OBJECTIVES: To investigate the differences in life expectancy with and without cognitive impairment (CI) by educational levels and sex in Brazil. DESIGN: Longitudinal observational study. SETTING: The sample was drawn from three waves (2000, 2006, and 2010) of the Health, Well-Being, and Aging Study (Saúde, bem-estar e envelhecimento; SABE) collected in São Paulo, Brazil. PARTICIPANTS: Adults aged 60 years and older (N = 2116)...
February 4, 2019: Journal of the American Geriatrics Society
Shorouk Faleh Dannoon, Wadha Al-Fouzan, Saud Ashwee Alenezi, Asma'a Alosaimi, Mohammad Alhusain, Abdelhamid Helmy Elgazzar
Objective: The aim of this study is to investigate the effect of microbiological characteristics of causative organisms on the scintigraphic patterns of labeled-white blood cells (WBC) scan in cases of proven osteomyelitis. Materials and Methods: Retrospective analysis of 25 patients referred with suspected osteomyelitis and had both bone and labeled-WBC scans performed and complete records of the microbiological culture of the causative organism. The bone and labeled-WBC scans were retrieved and reviewed by two nuclear medicine physicians...
January 2019: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Saud Abdulaziz Almojaly, Rana Sulaiman Al-Hamdan, Ali Alrahlah, Osama A Qutub, Sulaiman Alnajashi, Fahim Vohra, Tariq Abduljabbar
BACKGROUND: To explore the surface modification of dentin using Er,Cr:YSGG phototherapy and bonding system on the shear bond strength and microleakage scores at two different distances and times of laser irradiation. MATERIALS AND METHODS: Ninety disease-free third molars were collected for the experiment. The four laser groups were divided on the basis of non-contact mode distance and time of irradiation: Group-I: Distance of 1 mm with duration of 60 s; Group-II: Distance of 1 mm with duration of 120 s; Group-III: Distance of 2 mm with duration of 60 s and; Group-IV: Distance of 2 mm with duration of 120 s...
October 26, 2018: Photodiagnosis and Photodynamic Therapy
Abdul Haseeb, Enjun Xia, Shah Saud, Ashfaq Ahmad, Hamid Khurshid
This study intends to examine the impact of ICTs (i.e., internet usage and mobile cellular subscriptions), globalization, electricity consumption, financial development, and economic growth on environmental quality by using 1994-2014 panel data of BRICS economies. This study employed a second-generation panel unit root test accounting for the presence of cross-sectional dependence and indicated that carbon dioxide emissions, electricity consumption, financial development, internet usage, mobile usage, globalization, and economic growth have integration of order one...
February 1, 2019: Environmental Science and Pollution Research International
Mariana Ribeiro Costa Portugal, Flavia Barbosa Brito, Cintia Chaves Curioni, Flavia Fioruci Bezerra, Eduardo Faerstein, Josely Correa Koury
OBJECTIVE: Phase angle (PhA) is determined by bioelectrical impedance (BIA) and it is interpreted as an index of cell membrane integrity. Smokers are susceptible to systemic oxidative stress and often adopt unhealthy habits, which may contribute to cellular damage. This unfavorable conjuncture may result in lower PhA in smokers. The aim of this study was to investigate the association between PhA and smoking status. METHODS: This cross-sectional study included 247 (48%) adult men...
October 27, 2018: Nutrition
Hana A Alzamil, Manan A Alhakbany, Nora A Alfadda, Sarah M Almusallam, Hazzaa M Al-Hazzaa
BACKGROUND: Few studies have reported valid comprehensive data on lifestyle habits of Saudi college females. In addition, studies on sedentary behaviors (SBs) and the duration of sleep of Saudi college students are rare. Saudi females appear to be less physically active and therefore, at a higher risk of noncommunicable diseases (NCDs). Therefore, the purpose of this study was to investigate lifestyle patterns of Saudi college females, including physical activity (PA), SBs, duration of sleep, and dietary habits...
January 2019: Journal of Family & Community Medicine
Paras Bikram Singh, Pradip Saud, Douglas Cram, Kumar Mainali, Arjun Thapa, Nar Bahadur Chhetri, Laxman Prasad Poudyal, Hem Sagar Baral, Zhigang Jiang
Himalayan musk deer ( Moschus leucogaster ; hereafter musk deer) are endangered as a result of poaching and habitat loss. The species is nocturnal, crepuscular, and elusive, making direct observation of habitat use and behavior difficult. However, musk deer establish and repeatedly use the same latrines for defecation. To quantify musk deer habitat correlates, we used observational spatial data based on presence-absence of musk deer latrines, as well as a range of fine spatial-scale ecological covariates. To determine presence-absence of musk deer, we exhaustively searched randomly selected forest trails using a 20-m belt transect in different study sites within the Neshyang Valley in the Annapurna Conservation Area...
January 2019: Ecology and Evolution
Saud H AlDubayan, Louise C Pyle, Marija Gamulin, Tomislav Kulis, Nathanael D Moore, Amaro Taylor-Weiner, Anis A Hamid, Brendan Reardon, Bradley Wubbenhorst, Rama Godse, David J Vaughn, Linda A Jacobs, Stefanie Meien, Mislav Grgic, Zeljko Kastelan, Sarah C Markt, Scott M Damrauer, Daniel J Rader, Rachel L Kember, Jennifer T Loud, Peter A Kanetsky, Mark H Greene, Christopher J Sweeney, Christian Kubisch, Katherine L Nathanson, Eliezer M Van Allen, Douglas R Stewart, Davor Lessel
Importance: Approximately 50% of the risk for the development of testicular germ cell tumors (TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet been identified. It is hypothesized that inherited pathogenic DNA repair gene (DRG) alterations may drive susceptibility to TGCTs. Objective: To systematically evaluate the enrichment of germline pathogenic variants in the mendelian cancer predisposition DRGs in patients with TGCTs vs healthy controls...
January 24, 2019: JAMA Oncology
Valter Cordeiro Barbosa Filho, Alexsandra da Silva Bandeira, Giseli Minatto, Jair Gomes Linard, Jaqueline Aragoni da Silva, Rafael Martins da Costa, Sofia Wolker Manta, Soraya Anita Mendes de Sá, Thiago Sousa Matias, Kelly Samara da Silva
Promoting healthy lifestyle factors (e.g., physical activity, healthy eating, less screen time) among young people is a relevant and challenging step toward reducing non-communicable diseases. This study aimed to evaluate the effect of a multicomponent intervention on lifestyle factors among adolescents from schools in low Human Development Index (HDI < 0.500) areas. The Fortaleça sua Saúde program was conducted with 548 adolescents aged 11⁻18 years old in the intervention group and 537 in the control group...
January 18, 2019: International Journal of Environmental Research and Public Health
Ali Abusharaha, Abdulaziz A Alturki, Saud A Alanazi, Raied Fagehi, Naji Al-Johani, Gamal A El-Hiti, Ali M Masmali
Objective: To assess the tear-evaporation rate in thyroid-gland patients using a VapoMeter. Methods: Twenty thyroid gland patients aged 18-43 years (mean 34.3±6.3 years) completed the study. Additionally, an age-matched control group of 20 patients aged 18-43 years (32.2±5.1 years) was enrolled in the study for comparison purposes. An Ocular Surface Disease Index dry-eye questionnaire was completed, followed by a test to determine the tear-evaporation rate using the VapoMeter...
2019: Clinical Ophthalmology
Francesca Ferrua, Stefania Galimberti, Virginie Courteille, Mary Anne Slatter, Claire Booth, Despina Moshous, Benedicte Neven, Stephane Blanche, Alexandra Laberko, Anna Shcherbina, Dmitry Balashov, Elena Soncini, Fulvio Porta, Hamoud Al-Mousa, Bandar Al-Saud, Hasan Al-Dhekri, Rand Arnaout, Renata Formankova, Yves Bertrand, Andrzej Lange, Joanne Smart, Beata Wolska-Kusnierz, Victor M Aquino, Christopher C Dvorak, Anders Fasth, Fanny Fouyssac, Carsten Heilmann, Manfred Hoenig, Catharina Schuetz, Jadranka Kelečić, Robbert G M Bredius, Arjan C Lankester, Caroline A Lindemans, Felipe Suarez, Kathleen E Sullivan, Michael H Albert, Krzysztof Kałwak, Vincent Barlogis, Monica Bhatia, Victoria Bordon, Wojciech Czogala, Laura Alonso, Figen Dogu, Jolanta Gozdzik, Aydan Ikinciogullari, Gergely Kriván, Per Ljungman, Isabelle Meyts, Peter Mustillo, Angela R Smith, Carsten Speckmann, Mikael Sundin, Steven John Keogh, Peter John Shaw, Jaap Jan Boelens, Ansgar S Schulz, Petr Sedlacek, Paul Veys, Nizar Mahlaoui, Ales Janda, E Graham Davies, Alain Fischer, Morton J Cowan, Andrew Richard Gennery
BACKGROUND: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT). OBJECTIVE: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics...
January 17, 2019: Journal of Allergy and Clinical Immunology
Adil Nasir Althobaity, Saud Abdullah Alkabbaa, Sarah S Aljaied, Mohammed M AlKahtani
Background: Polydactyly is considered to be one of the common congenital hand anomalies. Classification of congenital hand anomalies by Swanson groups similar forms of deficits affected by specific embryological failures. Each type of polydactyly has its separate classification. This case series suggested classification that could include the radial and ulnar variants of polydactyly in one classification and direct the management in algorithmic approach. Methods: Case series of 11 cases, who were diagnosed with polydactyly of the hand consecutively at King Abdulaziz Medical City in Jeddah, Saudi Arabia...
December 2018: Plastic and Reconstructive Surgery. Global Open
Manzer H Siddiqui, Saud Alamri, Mutahhar Y Al-Khaishany, M Nasir Khan, Abdullah Al-Amri, Hayssam M Ali, Ibrahim A Alaraidh, Abdulaziz A Alsahli
Melatonin, a natural agent, has multiple functions in animals as well as in plants. However, its possible roles in plants under abiotic stress are not clear. Nowadays, soil salinity is a major threat to global agriculture because a high soil salt content causes multiple stresses (hyperosmotic, ionic, and oxidative). Therefore, the aim of the present study was to explore: (1) the involvement of melatonin in biosynthesis of photosynthetic pigments and in regulation of photosynthetic enzymes, such as carbonic anhydrase (CA) and ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco); (2) the role of melatonin in osmoregulation by proline and carbohydrate metabolism; and (3) the function of melatonin in the antioxidant defense system under salinity...
January 16, 2019: International Journal of Molecular Sciences
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