Rehan Khan, Weizhen Ji, Jeisac Guzman-Rivera, Abhilasha Madhvi, Tracy Andrews, Benjamin Richlin, Christian Suarez, Sunanda Gaur, William Cuddy, Aalok R Singh, Hulya Bukulmez, David Kaelber, Yukiko Kimura, Usha Ganapathi, Ioannis E Michailidis, Rahul Ukey, Sandra Moroso-Fela, John K Kuster, Myriam Casseus, Jason Roy, Lawrence C Kleinman, Daniel B Horton, Saquib A Lakhani, Maria Laura Gennaro
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investigate innate immune functions in MIS-C, we stimulated ex vivo peripheral blood cells from MIS-C patients with agonists of Toll-like receptors (TLR), key innate immune response initiators. We found severely dampened cytokine responses and elevated gene expression of negative regulators of TLR signaling...
February 5, 2024: medRxiv