keyword
https://read.qxmd.com/read/38440323/controlled-release-hydrogel-loaded-with-magnesium-based-nanoflowers-synergize-immunomodulation-and-cartilage-regeneration-in-tendon-bone-healing
#1
JOURNAL ARTICLE
Jintao Li, Haolin Ke, Xiangcheng Lei, Jiexin Zhang, Zhicheng Wen, Zhisheng Xiao, Huabin Chen, Juncheng Yao, Xuan Wang, Zhengnong Wei, Hongrui Zhang, Weilun Pan, Yan Shao, Yitao Zhao, Denghui Xie, Chun Zeng
Tendon-bone interface injuries pose a significant challenge in tissue regeneration, necessitating innovative approaches. Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment of such injuries. In this study, we aimed to develop a temperature-sensitive composite hydrogel capable of providing sustained release of magnesium ions (Mg2+ ). We synthesized magnesium-Procyanidin coordinated metal polyphenol nanoparticles (Mg-PC) through a self-assembly process and integrated them into a two-component hydrogel...
June 2024: Bioactive Materials
https://read.qxmd.com/read/37959358/rehabilitation-of-soccer-players-knee-injuries-cartilage-reconstruction-anterior-cruciate-ligament-surgery-and-intensive-recovery-a-pilot-study
#2
JOURNAL ARTICLE
Bartłomiej Kacprzak, Karolina Rosińska
Knee injuries, particularly anterior cruciate ligament (ACL) damage and cartilage defects, are highly prevalent among athletes and affect their sports performance and long-term joint function. The purpose of this research was to evaluate the effectiveness of a comprehensive combination therapy approach for individuals with ACL and cartilage injuries. Twelve professional soccer players aged 18 to 30 years underwent bone-tendon-bone ACL reconstruction, microfracture cartilage repair surgery, and hyaluronic acid scaffold treatment...
November 1, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37867219/macroporous-granular-hydrogels-functionalized-with-aligned-architecture-and-small-extracellular-vesicles-stimulate-osteoporotic-tendon-to-bone-healing
#3
JOURNAL ARTICLE
Wei Song, Zhijie Ma, Xin Wang, Yifei Wang, Di Wu, Chongyang Wang, Dan He, Lingzhi Kong, Weilin Yu, Jiao Jiao Li, Haiyan Li, Yaohua He
Osteoporotic tendon-to-bone healing (TBH) after rotator cuff repair (RCR) is a significant orthopedic challenge. Considering the aligned architecture of the tendon, inflammatory microenvironment at the injury site, and the need for endogenous cell/tissue infiltration, there is an imminent need for an ideal scaffold to promote TBH that has aligned architecture, ability to modulate inflammation, and macroporous structure. Herein, a novel macroporous hydrogel comprising sodium alginate/hyaluronic acid/small extracellular vesicles from adipose-derived stem cells (sEVs) (MHA-sEVs) with aligned architecture and immunomodulatory ability is fabricated...
October 22, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37841358/bmp2-and-gdf5-for-compartmentalized-regeneration-of-the-scapholunate-ligament
#4
JOURNAL ARTICLE
Hayman Lui, Cedryck Vaquette, Janet M Denbeigh, Randy Bindra, Andre J van Wijnen, Sanjeev Kakar
Background  Chronic injuries to the scapholunate ligament (SLIL) alter carpal kinematics and may progress to early degenerative osteoarthritis. To date, there is no consensus for the best method for SLIL reconstruction. This study aims to assess the use of growth factors (bone morphogenetic protein [BMP]2 and growth and differentiation factor 5 [GDF5]) for compartmentalized regeneration of bone and ligament in this multiphasic scaffold in a rabbit knee model. Case Description  A total of 100 µg of BMP2 and 30 µg of GDF5 were encapsulated into a heparinized gelatin-hyaluronic acid hydrogel and loaded into the appropriate compartment of the multiphasic scaffold...
October 2023: Journal of Wrist Surgery
https://read.qxmd.com/read/37681499/the-effect-of-combining-ha-and-hdf-on-tendon-healing
#5
JOURNAL ARTICLE
Sung-Min Rhee, Saewha Jeon, Jikhyon Han, Yun Hee Kim, Hyeon Jang Jeong, Joo Hyun Park, Joo Han Oh
BACKGROUND: The incidence of rotator cuff tears is rapidly increasing, and operative techniques for rotator cuff repair have been developed. However, the rates of postoperative retear remain high. PURPOSE/HYPOTHESIS: The purpose was to determine the effects of human dermal fibroblasts (HDFs) with hyaluronic acid (HA) on tendon-to-bone healing in a rabbit model of chronic rotator cuff tear injury. It was hypothesized that HA would enhance HDF proliferation and that a combination of HA and HDFs would produce a synergistic effect on the healing of repaired rotator cuff tendons of rabbits...
September 8, 2023: American Journal of Sports Medicine
https://read.qxmd.com/read/37587815/mechanism-of-action-of-collagen-and-epidermal-growth-factor-a-review-on-theory-and-research-methods
#6
JOURNAL ARTICLE
Mohamad Hesam Shahrajabian, Wenli Sun
The most abundant protein found in mammals is collagen, and there are around 28 different types of collagen found in the human body, but there are five types, namely, Type I, Type II, Type III, Type V, and Type X, most generally applied in supplements, and the five common types of collagen are available in various forms and form different sources, which result in various potential benefits. The epidermal growth factor is one of the main growth factor proteins in the skin, which has an important function in the production of collagen, hyaluronic acid, and elastin to keep the skin healthy and dense appearance...
August 16, 2023: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/37462389/mimicking-the-tendon-microenvironment-to-enhance-skeletal-muscle-adhesion-and-longevity-in-a-functional-microcantilever-platform
#7
JOURNAL ARTICLE
Himanshi Jangir, James J Hickman
Microcantilever platforms are functional models for studying skeletal muscle force dynamics in vitro. However, the contractile force generated by the myotubes can cause them to detach from the cantilevers, especially during long-term experiments, thus impeding the chronic investigations of skeletal muscles for drug efficacy and toxicity. To improve the integration of myotubes with microcantilevers, we drew inspiration from the elastomeric proteins, elastin and resilin, that are present in the animal and insect worlds, respectively...
July 18, 2023: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/37330074/cocktail-like-gradient-gelatin-hyaluronic-acid-bioimplant-for-enhancing-tendon-bone-healing-in-fatty-infiltrated-rotator-cuff-injury-models
#8
JOURNAL ARTICLE
Wei Ji, Fei Han, Xian Feng, Lei Shi, Hongdong Ma, Yue Lu, Ran Tao
The regeneration of enthesis tissue (native tendon-bone interface) at the post-surgically repaired rotator cuff remains a challenge for clinicians, especially with the emergence of degenerative affection such as fatty infiltration that exacerbate poor tendon-bone healing. In this study, we proposed a cocktail-like hydrogel with a four-layer structure (BMSCs+gNC@GH) for enhancing fatty infiltrated tendon-bone healing. As collagen and hyaluronic acid are the main biomacromolecules that constitute the extracellular matrix of enthesis tissue, this hydrogel was composed of UV-curable gelatin/hyaluronic acid (GelMA/HAMA) dual network gel (GH) with nanoclay (NC) and stem cells loaded...
July 31, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37163655/reduced-time-to-skin-grafting-in-chronic-wounds-using-an-esterified-hyaluronic-acid-matrix-and-negative-pressure-wound-therapy
#9
JOURNAL ARTICLE
Tracy Robertson, Leonard Benitez
INTRODUCTION: The use of NPWT and eHAM can aid in the closure of chronic wounds with exposed bone and tendon. OBJECTIVE: The authors examined the time to skin grafting and wound closure in 10 patients after treatment with either NPWT with eHAM (group 1, n = 5) or NPWT without eHAM (group 2, n = 5). RESULTS: The average time to closure was similar between group 1 and group 2 (15.2 weeks vs 14.6 weeks) despite a nearly twofold greater initial wound area...
May 2023: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/37106661/response-to-mechanical-properties-and-physiological-challenges-of-fascia-diagnosis-and-rehabilitative-therapeutic-intervention-for-myofascial-system-disorders
#10
REVIEW
Yuya Kodama, Shin Masuda, Toshinori Ohmori, Akihiro Kanamaru, Masato Tanaka, Tomoyoshi Sakaguchi, Masami Nakagawa
Damage to the fascia can cause significant performance deficits in high-performance sports and recreational exercise and may contribute to the development of musculoskeletal disorders and persistent potential pain. The fascia is widely distributed from head to toe, encompassing muscles, bones, blood vessels, nerves, and internal organs and comprising various layers of different depths, indicating the complexity of its pathogenesis. It is a connective tissue composed of irregularly arranged collagen fibers, distinctly different from the regularly arranged collagen fibers found in tendons, ligaments, or periosteum, and mechanical changes in the fascia (stiffness or tension) can produce changes in its connective tissue that can cause pain...
April 14, 2023: Bioengineering
https://read.qxmd.com/read/36911205/injectable-fhe-bp-composites-hydrogel-with-enhanced-regenerative-capacity-of-tendon-bone-interface-for-anterior-cruciate-ligament-reconstruction
#11
JOURNAL ARTICLE
Eunshinae Cho, Yi Qiao, Changan Chen, Junjie Xu, Jiangyu Cai, Yamin Li, Jinzhong Zhao
Features of black phosphorous (BP) nano sheets such as enhancing mineralization and reducing cytotoxicity in bone regeneration field have been reported. Thermo-responsive FHE hydrogel (mainly composed of oxidized hyaluronic acid (OHA), poly-ε-L-lysine (ε-EPL) and F127) also showed a desired outcome in skin regeneration due to its stability and antibacterial benefits. This study investigated the application of BP-FHE hydrogel in anterior cruciate ligament reconstruction (ACLR) both in in vitro and in vivo , and addressed its effects on tendon and bone healing...
2023: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/36756167/evidence-for-utilization-of-injectable-biologic-augmentation-in-primary-rotator-cuff-repair-a-systematic-review-of-data-from-2010-to-2022
#12
REVIEW
Olivia J Bono, Bryan Jenkin, Julianne Forlizzi, Albert Mousad, Stephen Le Breton, Meghan MacAskill, Krishna Mandalia, Kai Mithoefer, Arun Ramappa, Glen Ross, Sarav S Shah
BACKGROUND: Biologic healing after rotator cuff repair remains a significant challenge. Injectable biologic augmentation may improve tissue quality at the suture-tendon interface. PURPOSE: To investigate the effect of injectable biologic supplementation in rotator cuff repair and to assess the quality and adherence to evolving reporting standards. STUDY DESIGN: Systematic review; Level of evidence, 3. METHODS: A systematic review was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
February 2023: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/36177802/off-label-uses-of-hyaluronic-acid-fillers-a-review
#13
REVIEW
Poonam Tapsale, Belma Türsen, Ümit Türsen
Food and Drug Administration approved indications of hyaluronic acid fillers include some facial wrinkles or skin folds like naso-labial folds, perioral wrinkles, volumization of lip, cheek, chin, and dorsal region of the hands, also acne scars and lipoatrophy of human immunodeficiency virus positive patients. This article reviews the off-label indications of hyaluronic acid fillers such as connective tissue disorders (lupus erythematosus, scleroderma, and dermatomyositis), lipoatrophy associated with other diseases, breast volumization, giving volume to buttocks and the feet, implant into bone, tendon, ligament or muscle, injection to glabella, nose, periorbital region, forehead, or neck...
November 2022: Dermatologic Therapy
https://read.qxmd.com/read/36082312/controlled-vitamin-d-delivery-with-injectable-hyaluronic-acid-based-hydrogel-for-restoration-of-tendinopathy
#14
JOURNAL ARTICLE
Da-Seul Kim, Jun Hyuk Kim, Seung-Woon Baek, Jun-Kyu Lee, So-Yeon Park, Bogyu Choi, Tae-Hyung Kim, Kyunghoon Min, Dong Keun Han
Tendinopathy is a term used to describe tendon disorders that are marked by pain and a loss of function. Recent studies demonstrated that inflammation plays an important role throughout the broad spectrum of tendinopathy. Conventional treatments such as steroid injections, analgesics, and physical modalities simply give pain relief and do not alter the disease progression without the tendon regeneration effect. Tenocytes are responsible for maintaining the tendon matrix and understanding how they function is essential to studying new treatments for tendinopathy...
January 2022: Journal of Tissue Engineering
https://read.qxmd.com/read/36050573/tendon-injections-upper-extremity
#15
REVIEW
Flávio Duarte Silva, Fernando Zorzenoni, Lucas Nakasone Matos da Silva, Afranio Dos Reis Teixeira Neto, Marco Tulio Gonzalez, Alípio Gomes Ormond Filho, Júlio Brandão Guimarães
Imaging-guided tendon procedures aim to reduce pain and increase function by controlling inflammation and stimulating healing. Ultrasound is the preferable guiding modality due to its high resolution and real-time demonstration of the tendinous anatomy and needle positioning. The technique includes appropriate patient positioning, which varies depending on the targeted tendon, as well as sterile and proper draping. For most procedures, we prefer the "in-plane" approach, which demonstrates the entire needle as it advances through different tissue layers...
May 2023: Skeletal Radiology
https://read.qxmd.com/read/35337954/three-dimensionally-printed-recombinant-three-dimensionally-printed-recombinant-human-parathyroid-hormone-soaked-nanofiber-sheet-accelerates-tendon-to-bone-healing-in-a-rabbit-model-of-a-chronic-rotator-cuff-tear
#16
JOURNAL ARTICLE
Jian Han, Sung Min Rhee, Young Won Kim, Suk Hee Park, Joo Han Oh
BACKGROUND: Recombinant human parathyroid hormone (rhPTH) promotes tendon-to-bone healing in humans and animals with rotator cuff tear (RCT). However, problems regarding repeated systemic rhPTH injections in humans exist. This study was conducted to evaluate the effect of topical rhPTH administration using three-dimensionally (3D) printed nanofiber sheets on tendon-to-bone healing in a rabbit RCT model compared to that of direct topical rhPTH administration. METHODS: Eighty rabbits were randomly assigned to five groups (n = 16 each)...
March 22, 2022: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/34632158/diagnostic-imaging-features-cytological-examination-and-treatment-of-lymphocytic-tenosynovitis-of-the-common-digital-extensor-tendon-sheath-in-an-eventing-horse
#17
Metha Chanda, Chaiya Klinphayom, Thanasak Sungsuwan, Wittaya Senarat, Ekkalak Thongkham, Attapon Kamlangdee, Napaporn Senarat
In horses, the structures at the dorsal aspect of the carpus, including the digital extensor tendons, their related tendon sheaths, and bones, are vulnerable to injury because of their superficial location. Injuries to these structures may result in lameness of the affected limb(s) and reduce a horse's athletic performance. A 13-year-old eventing horse that routinely underwent regular exercise exhibited dorsolateral distension of the right carpus. An effusion insensitive to compression was observed in the affected area...
December 2021: Veterinary and Animal Science
https://read.qxmd.com/read/34530924/outcomes-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-in-enhancing-tendon-graft-healing-in-anterior-cruciate-ligament-reconstruction-an-exploratory-study
#18
JOURNAL ARTICLE
Sang Won Moon, Sinhyung Park, Minkyung Oh, Joon Ho Wang
BACKGROUND: The study investigated whether allogeneic human umbilical cord blood-derived MSCs (hUCB-MSCs) could be safely used without treatment-related adverse events, reducing tunnel enlargement, and improve clinical results in human anterior cruciate ligament (ACL) reconstruction. METHODS: Thirty patients were enrolled consecutively. They were divided into three groups by randomization. In the negative control group, ACL reconstruction surgery without additional treatment was performed...
September 16, 2021: Knee Surgery & related Research
https://read.qxmd.com/read/34353568/nonoperative-and-operative-soft-tissue-and-cartilage-regeneration-and-orthopaedic-biologics-of-the-knee-an-orthoregeneration-network-on-foundation-review
#19
JOURNAL ARTICLE
Derrick M Knapik, Aghogho Evuarherhe, Rachel M Frank, Matthias Steinwachs, Scott Rodeo, Marcus Mumme, Brian J Cole
Orthoregeneration is defined as a solution for orthopedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include: drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes...
August 2021: Arthroscopy
https://read.qxmd.com/read/34293441/nonoperative-and-operative-soft-tissue-cartilage-and-bony-regeneration-and-orthopaedic-biologics-of-the-shoulder-an-orthoregeneration-network-on-foundation-review
#20
REVIEW
Nolan B Condron, Benjamin S Kester, John M Tokish, Matthias A Zumstein, Reuben Gobezie, Markus Scheibel, Brian J Cole
Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes...
October 2021: Arthroscopy
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