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Procalcitonin and CRP

Su-Yan Zhuo, Li Liao
OBJECTIVE: To study the expression of high-mobility group box 1 (HMGB1) in neonates with sepsis and its role in the pathogenesis of neonatal sepsis. METHODS: A total of 62 neonates with sepsis were enrolled as the sepsis group, 66 neonates with local infection were enrolled as the local infection group, and 70 healthy neonates were enrolled as the healthy control group. Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-17 (IL-17), interleukin-23 (IL-23), C-reactive protein (CRP) and procalcitonin (PCT) were measured...
February 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Y Xia, Y Wang, H W He, X L Hong, Q Z An, H M Zhang, Y Long
Objective: To investigate the ability of white blood cell (WBC), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the super-elderly patients with bloodstream infection. Methods: It was a retrospective study. A total of 77 patients (≥85 years) admitted to the ICU of Peking Union Medical College Hospital from June, 2016 to December, 2017 were enrolled. The patients included 67 males and 10 females, with an age of 85-105 years and the average age was (92±5) years. According to the results of blood culture, patients were divided into positive blood culture group ( n= 50) and negative blood culture group ( n= 27)...
January 29, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Dominique Pepper, Junfeng Sun, Chanu Rhee, Judith Welsh, John H Powers, Robert L Danner, Sameer S Kadri
BACKGROUND: Procalcitonin (PCT)-guided antibiotic discontinuation appears to decrease antibiotic use in critically ill patients, but its impact on survival remains less certain. METHODS: We searched PubMed, EMBASE, Scopus, Web of Science, and CENTRAL for RCTs of PCT-guided antibiotic discontinuation in critically ill adults reporting survival or antibiotic duration. Searches were conducted without language restrictions from inception to 07/23/2018. Two reviewers independently conducted all review stages; another adjudicated differences...
February 14, 2019: Chest
Cristian Palmiere, Silke Grabherr
Postmortem biochemical investigations in vitreous humor samples collected before and after performing multiphase postmortem computed tomography angiography were performed in the past and demonstrated that specific contrast material injection allowed perfusion and radiological identification of the main vessels of the eye to be obtained without any changes in vitreous humor composition. In the study presented herein, we aimed to test whether the injection of the same contrast material using the same postmortem angiography protocol might influence pericardial fluid composition...
February 2, 2019: Forensic Science International
M Benedetti, P Ciano, I Pergolini, S Ciotti, G Guercioni, G Ruffo, F Borghi, A Patriti, P Del Rio, M Scatizzi, S Mancini, G Garulli, A Carrara, F Pirozzi, S Scabini, A Liverani, G Baiocchi, R Campagnacci, A Muratore, G Longo, M Caricato, R Macarone Palmieri, N Vettoretto, M Ceccaroni, S Guadagni, E Bertocchi, D Cianflocca, M Lambertini, U Pace, M Baraghini, L Pandolfini, R Angeloni, A Lucchi, G Martorelli, G Tirone, M Motter, A Sciuto, A Martino, A P Luzzi, T Di Cesare, S Molfino, A Maurizi, P Marsanic, F Tomassini, S Santoni, G T Capolupo, P Amodio, E Arici, M Clementi, B Ruggeri, M Catarci
BACKGROUND: Anastomotic leakage (AL) is a dreaded major complication after colorectal surgery. There is no uniform definition of anastomotic dehiscence and leak. Over the years many risk factors have been identified (distance of anastomosis from anal verge, gender, BMI, ASA score) but none of these allows an early diagnosis of AL. The DUtch LeaKage (DULK) score, C reactive protein (CRP) and procalcitonin (PCT) have been identified as early predictors for anastomotic leakage starting from postoperative day (POD) 2-3...
January 2019: Il Giornale di Chirurgia
Janneke Evelyne Stalenhoef, Cees van Nieuwkoop, Darius Cameron Wilson, Willize Elizabeth van der Starre, Tanny J K van der Reijden, Nathalie Manon Delfos, Eliane Madeleine Sophie Leyten, Ted Koster, Hans Christiaan Ablij, Johannes Jan Willem van 't Wout, Jaap Tamino van Dissel
BACKGROUND: A reduction in duration of antibiotic therapy is crucial in minimizing the development of antimicrobial resistance, drug-related side effects and health care costs. The minimal effective duration of antimicrobial therapy for febrile urinary tract infections (fUTI) remains a topic of uncertainty, especially in male patients, those of older age or with comorbidities. Biomarkers have the potential to objectively identify the optimal moment for cessation of therapy. METHODS: A secondary analysis of a randomized placebo-controlled trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands...
February 14, 2019: BMC Infectious Diseases
Xing Lıu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
Background/aim: 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients...
February 11, 2019: Turkish Journal of Medical Sciences
Lorenz Weidhase, Daniel Wellhöfer, Gero Schulze, Thorsten Kaiser, Tim Drogies, Ulrike Wurst, Sirak Petros
BACKGROUND: The aim of this study was to evaluate whether Interleukin-6 (IL-6) could be a faster indicator of treatment success in adults with severe sepsis and septic shock compared to procalcitonin (PCT) and C-reactive protein (CRP). METHODS: Data from adult patients with severe sepsis and septic shock managed at the medical intensive care unit (ICU) of the University Hospital Leipzig between September 2009 and January 2012 were analyzed retrospectively. Values for CRP, PCT and IL-6 on admission as well as after 24 and 48-72 h were collected...
February 13, 2019: BMC Infectious Diseases
Deng Li, Minglei Sha, Lei Chen, Yinglong Xiao, Jun Lu, Yi Shao
To evaluate the role of preoperative procalcitonin (PCT) levels in predicting postoperative fever after mini-percutaneous nephrolithotomy (mini-PCNL) in patients with a negative baseline urine culture. Between January 2014 and October 2017, 329 patients with a negative baseline urine culture and who underwent mini-PCNL were enrolled in this study. Patients were stratified into the control or febrile group based on a body temperature either less than or greater than 38 °C, respectively. Demographic and perioperative data were compared between the groups, and variables found to be statistically significant were included in a binary logistic regression analysis...
February 12, 2019: Urolithiasis
Elena María Rincón-López, María Luisa Navarro Gómez, Teresa Hernández-Sampelayo Matos, Jesús Saavedra-Lozano, Yurena Aguilar de la Red, Belén Hernández Rupérez, Elena Cela de Julián
INTRODUCTION: The rate of bacterial infections in children with sickle cell disease (SCD) has decreased in recent years, mainly due to penicillin prophylaxis and vaccination. OBJECTIVES: To determine the rate of severe bacterial infection (SBI) in a cohort of children with SCD and to describe low-risk factors for confirmed SBI (CSBI) and acute chest syndrome (ACS). METHODS: This 11-year retrospective cohort study included children with febrile SCD admitted to a reference hospital in Spain...
February 10, 2019: Pediatric Blood & Cancer
Xiaohui Wu, Chunju Zhou, Ling Jin, Hui Liu, Jinrong Liu, Shunying Zhao
BACKGROUND: Primary pulmonary lymphoma (PPL) is a rare disease, especially in children. We analyse the clinical features of PPL in 4 children to strengthen a understanding of it. RESULTS: We reported a case series of 4 pediatric patients with PPLs including three diffuse large B-cell lymphomas and one natural killer-T cell lymphoma. All patients presented with unknown fever and cough as well as weight loss and fatigue. The white blood cell count was reduced in three patients and increased in the other one...
February 8, 2019: Orphanet Journal of Rare Diseases
Xiao-Wen Wang, Xing-Guo Niu, Jin-Xiu Li, Si-Sen Zhang, Xian-Fa Jiao
INTRODUCTION: This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS: A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general information, biochemical findings, and postoperative 30-day mortality of these patients were statistically analyzed. RESULTS: The SOFA scores, C-reactive protein (CRP), and procalcitonin (PCT) at postoperative day (POD) 3, 5, and 7 were significantly higher in the sepsis group than in the non-sepsis group, and the differences were statistically significant...
February 5, 2019: Advances in Therapy
Liyin Qiu, Mian Pan, Ronglian Zhang, Kunhai Ren
BACKGROUND: Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. OBJECTIVE: To investigate the diagnostic value of maternal peripheral blood platelet-to-white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA-related preterm birth. METHODS: A total of 400 patients with preterm birth were enrolled in this study: non-HCA group (n = 193) and HCA group (n = 207), and 87 full-term pregnancies were enrolled as the control...
February 4, 2019: Journal of Clinical Laboratory Analysis
M Feng, S L Zhang, Z J Liang, Y L Wang, X C Zhao, C Gao, H Guo, J Luo
OBJECTIVE: To investigate the diagnostic role of complement C3, complement C4, C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), neutrophil CD64 (nCD64) index, lymphocyte subsets and their combination in differentiating bacterial infection from disease relapse in systemic lupus erythematosus (SLE). METHODS: The above biomarkers in 36 hospitalized SLE patients with bacterial infection and 45 with lupus flare without infection were retrospectively studied...
February 2, 2019: Lupus
Alberto García-Salido, A Martínez de Azagra-Garde, M A García-Teresa, G De Lama Caro-Patón, M Iglesias-Bouzas, M Nieto-Moro, I Leoz-Gordillo, C Niño-Taravilla, M Sierra-Colomina, G J Melen, M Ramírez-Orellana, A Serrano-González
The CD64 receptor has been described as an interesting bacterial infection biomarker. Its expression has not been studied in previously healthy children admitted to pediatric critical care unit (PICU). Our objective was firstly to describe the CD64 expression and secondly study its diagnostic accuracy to discriminate bacterial versus viral infection in this children. We made a prospective double-blind observational study (March 2016-February 2018). A flow cytometry (FC) was done from peripheral blood at PICU admission...
February 2, 2019: European Journal of Clinical Microbiology & Infectious Diseases
Björn Kleibrink, Christian Taube
Respiratory tract infections and acute bronchitis are one of the major indications for which antibiotics are prescribed. As most of respiratory tract infections are caused by viruses and antibiotic therapy is rarely indicated. Reasons for the unnecessary prescription of antibiotics in this patient population are false expectations regarding the course and duration of common cold symptoms and especially coughing. After exclusion of severe diseases acute coughing should be treated with a symptom-oriented therapy...
February 2019: Deutsche Medizinische Wochenschrift
E V Reznik, M P Prushkovskaya, E D Presnova, N A Novikova, R A Ivaschenko, E I Dedov, A E Nikitin, I G Nikitin
Borreliosis after sucking ticks is an acute problem in the world. People do not go to doctors after that often, which leads to the development of various complications. Thrombosis of veins of various localization can be one of them. Thrombosis of the portal vein represents a significant problem too with high morbidity and mortality. The risk factors for splanchnic vein thrombosis include infections, but its relationship with borreliosis has not been studied. А 34-year-old man with chronic helicobacter-associated gastritis and gallstones was hospitalized due to development during the last 11 days of epigastric pain and fever to 38...
November 22, 2018: Terapevticheskiĭ Arkhiv
Xin Ge, Peng Li, Zhigang Wu
The aim of this study was to investigate the clinical diagnostic value of combined detection of serum C-reactive protein (CRP) and procalcitonin (PCT) for bacterial infectious diseases in children. It was a case control study carried out from October 2016 to March 2018. A total of 150 children with bacterial infectious disease were assigned to the observation group, and 150 healthy children without infectious diseases were assigned to the control group. The research showed that CRP and PCT levels, positive rates of CRP and PCT detection in observation group were higher than those in control group (p<0...
February 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Leming Tan, Cheng Yang, Xukai Yang, Yangmin Wang, Gaoping Cai, Zhigang Cao, Chuang Huang, Dongbo Xu
OBJECTIVE: To analyze the association of the clinical inflammatory indices with the severity of urinary sepsis. METHODS: We reviewed the clinical data of 70 patients with urinary sepsis treated in our hospital between January, 2013 and April, 2018. All the patients were diagnosed in line with the Guidelines for Diagnosis and Treatment of Urological Diseases in China (2014 edition), including 22 patients with sepsis, 12 with hypotension and severe sepsis, 17 with septic shock, and 19 with critical septic shock...
January 30, 2019: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Xiao-Jun Xu, Ze-Bin Luo, Tian Xia, Hua Song, Shi-Long Yang, Wei-Qun Xu, Ya-Ru Ni, Ning Zhao, Yong-Min Tang
The aim of this study is to systematically compare the performance of C-reactive protein (CRP), procalcitonin (PCT) and serum cytokines in identifying pediatric cancer patients with high-risk infection. A prospective observational study was performed from January 2014 through December 2016. Consecutive pediatric cancer patients who experienced febrile illness during hospitalization were enrolled. The CRP, PCT, interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were determined within 6 h of fever onset...
January 23, 2019: Cytokine
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