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("ECG" OR "EKG") AND "Brugada"

Yihan Yang, Dan Hu, Frederic Sacher, Kengo F Kusano, Xinye Li, Hector Barajas-Martinez, Mélèze Hocini, Yanda Li, Yonghong Gao, Hongcai Shang, Yanwei Xing
Background: SCN5A with Brugada syndrome (BrS) is not commonly considered as an independent risk marker for subsequent cardiac events. However, the risk of SCN5A combined with other clinical characteristics has not been fully investigated. Objectives: The aim of this study is to investigate and evaluate risk stratification and related risk factors of SCN5A in BrS. Methods: The databases of PubMed, EMBASE, Cochrane Library, MEDLINE, Chinese National Knowledge Infrastructure (CNKI) and Wanfang Data were searched for related studies published from January 2002 to May 2018 followed by meta-analysis...
2019: Frontiers in Physiology
Stephanie Fuentes Rojas, Ayah Oglat, Hilda Mariana Gonzalez Bonilla, Omar Jeroudi, Whitney Sharp, Miguel Valderrábano, Paul Antonio Schurmann
Brugada syndrome is an inherited arrhythmia that increases a patient's risk of sudden cardiac death. Certain pharmacologic agents may induce a transient Brugada pattern on surface electrocardiogram (EKG). One of these is loperamide, an over-the-counter agent commonly used to manage diarrhea. We report the case of a patient who experienced EKG changes that mimicked Brugada pattern after excessive intake of loperamide.
October 2018: Methodist DeBakey Cardiovascular Journal
Peter V Bui, Nathan L Haas, Nicholas W C Herrman, Matthew Macias, Victoria Hoch, William Schaeffer, Christopher Wallace
BACKGROUND: Brugada pattern on electrocardiography (ECG) can manifest as type 1 (coved pattern) and type 2 (saddleback pattern). Brugada syndrome represents an ECG with Brugada pattern in a patient with symptoms or clinical factors, including syncope, cardiac arrest, ventricular dysrhythmias, and family history. Brugada syndrome is caused by a genetic channelopathy, but the Brugada pattern may be drug-induced. Epinephrine-induced Brugada pattern has not been reported previously. CASE REPORT: A 63-year-old man developed anaphylaxis secondary to a bee sting, had a transient loss of consciousness, and self-administered intramuscular epinephrine...
February 9, 2019: Journal of Emergency Medicine
Sophie I Mavrogeni, Konstantinos Tsarouhas, Demetrios A Spandidos, Christina Kanaka-Gantenbein, Flora Bacopoulou
Athletic pre-participation screening is essential for minimizing the risk for sudden cardiac death (SCD) in athletes participating in either competitive or leisure sporting activities. The primary causes of SCD in young athletes (<35 years of age) include hypertrophic cardiomyopathy, congenital anomalies of the coronary artery and arrhythmogenic right ventricular cardiomyopathy. Other abnormalities, such as malignant arrhythmia due to blunt trauma to the chest (commotio cordis), myocarditis, valvular disease, aortic rupture (in Marfan syndrome) and ion channelopathies (catecholaminergic polymorphic ventricular tachycardia, Brugada syndrome, long or short QT syndrome), also contribute to a lesser degree to SCD...
February 2019: Experimental and Therapeutic Medicine
Tomomi Nagayama, Satoshi Nagase, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Takashi Noda, Takeshi Aiba, Hiroshi Takaki, Masaru Sugimachi, Wataru Shimizu, Teruo Noguchi, Satoshi Yasuda, Shiro Kamakura, Kengo Kusano
BACKGROUND: Spontaneous type 1 electrocardiogram (ECG) in the right precordial lead is a dominant predictor of ventricular fibrillation (VF) in Brugada syndrome (BrS). In some BrS patients with VF, however, spontaneous type 1 ECG is undetectable, even in repeated ECG and immediately after VF. This study investigated differences between BrS patients with spontaneous or drug-induced type 1 ECG. Methods and Results: We evaluated 15 BrS patients with drug-induced (D-BrS) and 29 with spontaneous type 1 ECG (SP-BrS)...
January 12, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
Xianpei Wang, Lu Zhang, Chuanyu Gao, Sha Wu, Jialu Zhu
BACKGROUND: ST-segment elevation (STE) and an increased Tpeak-Tend interval (Tp-e) have prognostic value for malignant arrhythmia events (MAEs) in patients with ST-segment elevation myocardial infarction (STEMI) and Brugada syndrome. Whether STE could predict MAEs and has an electrophysiological relationship with Tp-e in electrocardiogram (ECG) of vasospastic angina (VA) patients needs to be elucidated. METHODS: Sixty-five patients with VA and 23 patients with VA complicated by MAEs were enrolled...
January 3, 2019: Journal of Electrocardiology
Anat Milman, Aviram Hochstadt, Antoine Andorin, Jean-Baptiste Gourraud, Frederic Sacher, Philippe Mabo, Sung-Hwan Kim, Giulio Conte, Elena Arbelo, Tsukasa Kamakura, Takeshi Aiba, Carlo Napolitano, Carla Giustetto, Isabelle Denjoy, Jimmy J M Juang, Shingo Maeda, Yoshihide Takahashi, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Camilla H Jespersen, Yanushi D Wijeyeratne, Jean Champagne, Leonardo Calo, Zhengrong Huang, Yuka Mizusawa, Pieter G Postema, Ramon Brugada, Arthur A M Wilde, Gan-Xin Yan, Elijah R Behr, Jacob Tfelt-Hansen, Kenzo Hirao, Christian Veltmann, Antoine Leenhardt, Domenico Corrado, Fiorenzo Gaita, Silvia G Priori, Kengo F Kusano, Masahiko Takagi, Pietro Delise, Josep Brugada, Pedro Brugada, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
Aims: Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce. Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients' characteristics...
December 24, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Enes Elvin Gul, Sohaib Haseeb, Osama Al Amoudi, Adrian Baranchuk
Brugada phenocopies (BrP) are clinical entities that are characterized by ECG patterns identical to those of Brugada syndrome, but are the result of various clinical conditions. We describe the case of a 41-year-old male who exhibited BrP due to a left ventricular aneurysm in the context of chronic coronary artery disease.
November 2018: Journal of Electrocardiology
Manli Yu, Qin Zhang, Xinmiao Huang, Xianxian Zhao
We herein describe a case of an acute pericarditis, in which type 1 Brugada phenocopy (BrP) was documented. The patient was referred to our hospital due to severe chest pain. The twelve-lead electrocardiogram (ECG) on admission showed type 1 Brugada ECG pattern (coved-type) in the precordial leads. Echocardiography only showed mild pericardial effusion. However, his ST segment elevation returned to normal and chest discomfort disappeared 3 weeks later. Our report addresses the possibility that the coved-type ST-segment elevation cannot be a sensitive finding for Brugada syndrome (BrS)...
November 2018: Journal of Electrocardiology
T T Shen, J Geng, B B Yuan, C Chen, X J Zhou, Q J Shan
Objective: To investigate the risk factors of ventricular arrhythmias in patients with Brugada syndrome. Methods: Clinical data of 60 Brugada syndrome patients admitted in the department of cardiology of the First Affiliated Hospital of Nanjing Medical University from March 2003 to December 2016 were collected and retrospectively analyzed. The age at diagnosis was (43.2±13.1) years (0.6-83.0 years), 98.3% were males ( n= 59), and the patients were followed up to (92±41) months (12-169 months). The 12-lead surface electrocardiogram (ECG) recorded at the time of diagnosis and showing the highest type 1 ST elevation, either spontaneously or after provocative drug test, was used for the analysis...
November 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Rubén Casado Arroyo, Juan Sieira, Maciej Kubala, Decebal Gabriel Latcu, Shigo Maeda, Pedro Brugada
During last centuries, Early Repolarization pattern has been interpreted as an ECG manifestation not linked to serious cardiovascular events. This view has been challenged on the basis of sporadic clinical observations that linked the J-wave with ventricular arrhythmias and sudden cardiac death. The particular role of this characteristic pattern in initiating ventricular fibrillation has been sustained by clinical descriptions of a marked and consistent J-wave elevation preceding the onset of the ventricular arrhythmia...
2018: Frontiers in Cardiovascular Medicine
Richard G Bennett, Haris M Haqqani, Antonio Berruezo, Paolo Della Bella, Francis E Marchlinski, Chi-Jen Hsu, Saurabh Kumar
Arrhythmogenic cardiomyopathy (ACM) is now commonly used to describe any form of non-hypertrophic, progressive cardiomyopathy characterised by fibrofatty infiltration of the ventricular myocardium. Right ventricular (RV) involvement refers to the classical arrhythmogenic right ventricular cardiomyopathy, but left ventricular, or bi-ventricular involvement are now recognised. ACM is mostly hereditary and associated with mutations in genes encoding proteins of the intercalated disc. ACM classically manifests as ventricular arrhythmias, and sudden death may be the first presentation of the disease...
October 24, 2018: Heart, Lung & Circulation
Douglas Robinson, Gregory Hand, Jason Ausman, Anthony Hackett
BACKGROUND: Brugada pattern is a well-known pathological finding on electrocardiogram (ECG) which increases the likelihood of cardiac arrest due to ventricular arrhythmia. These cases generally present in younger patients without evidence of an electrolyte abnormality, structural heart disease, or cardiac ischemia. In many instances, this pattern is either hidden on initial presentation or presents as an incidental finding on an EKG. Often times the Brugada syndrome leads to sudden cardiac death or more rarely can be unmasked with a class 1A or 1C anti-arrhythmic agent...
February 2019: American Journal of Emergency Medicine
János Tomcsányi
An Asian patient was admitted with palpitation. The ECG showed coved-shaped type Brugada pattern with QRS-fragmentations. Early recognition and risk stratification are the most important issues in Brugada syndrome. Orv Hetil. 2018; 159(45): 1848-1850.
November 2018: Orvosi Hetilap
Kristopher S Pfirman, Corey A White, Abiy Kelil, Hemant C Modi
BACKGROUND Brugada syndrome is a cardiac disorder associated with sudden death due to sodium channelopathy, most commonly the SCN5a mutation. There are 3 different patterns of electrocardiogram (ECG) changes characterized as type I, II, and III. ECG patterns consist of variations of incomplete RBBB and ST elevation in anterior precordial leads only. Treatment, if warranted, consists of implantable cardioverter-defibrillator. CASE REPORT A 63-year-old male presented with abdominal pain for 4 days that was persistent, and after further imaging, he was found to have hepatic metastases from a stage IV small cell carcinoma of the lung...
November 3, 2018: American Journal of Case Reports
Jonathan R Skinner, Annika Winbo, Dominic Abrams, Jitendra Vohra, Arthur A Wilde
Forty per cent (40%) of sudden unexpected natural deaths in people under 35 years of age are associated with a negative autopsy, and the cardiac ion channelopathies are the prime suspects in such cases. Long QT syndrome (LQTS), Brugada syndrome (BrS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) are the most commonly identified with genetic testing. The cellular action potential driving the heart cycle is shaped by a specific series of depolarising and repolarising ion currents mediated by ion channels...
October 4, 2018: Heart, Lung & Circulation
Ahmed Karim Talib, Masahiko Takagi, Akira Shimane, Makoto Nakano, Tatsuya Hayashi, Katsunori Okajima, Minami Kentaro, Koji Fukada, Shinya Kowase, Kenji Kurosaki, Junichi Nitta, Mitsushiro Nishizaki, Yoshiaki Yui, Ali Talib, Nobuyuki Sato, Yuichiro Kawamura, Naoyuki Hasebe, Satoshi Aita, Eikou Sai, Yuki Komatsu, Kenji Kuroki, Takashi Kaneshiro, Xu Dongzu, Kazuko Tajiri, Miyako Igarashi, Hiro Yamasaki, Nobuyuki Murakoshi, Koji Kumagai, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma
Background Both endocardial trigger elimination and epicardial substrate modification are effective in treating ventricular fibrillation (VF) in Brugada syndrome. However, the primary approach and the characteristics of patients who respond to endocardial ablation remain unknown. Methods Among 123 symptomatic Brugada syndrome patients (VF, 63%; syncope, 37%), ablation was performed in 21 VF/electrical storm patients, the majority of whom were resistant to antiarrhythmic drugs. Results Careful endocardial mapping revealed that 81% of the patients had no specific findings, whereas 19% of the patients, who experienced the most frequent VF episodes with notching of the QRS in lead V1 , had delayed low-voltage fractionated endocardial electrograms...
August 2018: Circulation. Arrhythmia and Electrophysiology
Gary Tse, Ka Hou Christien Li, Guangping Li, Tong Liu, George Bazoukis, Wing Tak Wong, Matthew T V Chan, Martin C S Wong, Yunlong Xia, Konstantinos P Letsas, Gary Chin Pang Chan, Yat Sun Chan, William K K Wu
Background: Brugada syndrome (BrS) is a cardiac ion channelopathy that predisposes affected individuals to sudden cardiac death (SCD). Type 1 BrS is thought to take a more malignant clinical course than non-type 1 BrS. We hypothesized that the degrees of abnormal repolarization and conduction are greater in type 1 subjects and these differences can be detected by electrocardiography (ECG). Methods: Electrocardiographic data from spontaneous type 1 and non-type 1 BrS patients were analyzed. ECG parameters were measured from leads V1 to V3...
2018: Frontiers in Cardiovascular Medicine
David P Fitzgerald, Srikant Das, Matthew P Malone, B Shane Holland, Stephen M Schexnayder
Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. The patient received cardiopulmonary resuscitation and was successfully defibrillated...
October 17, 2018: Pediatric Emergency Care
Michelle T Lee, Naddi Marah
About 350,000 cases of out-of-hospital cardiac arrest (OHCA) occur yearly in the United States. Unfortunately, even with treatment from emergency medical service (EMS) staff and hospitalization, only 12% survive past discharge for multiple reasons. Classically, Brugada syndrome (BrS) initially presents as a new syncopal episode in young males without obstructive coronary artery disease (CAD). However, in this case report, a patient who emergently presented with a ST-elevation myocardial infarction (STEMI) challenges the stereotypical presentation...
2018: Case Reports in Cardiology
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