Joanna L Stollings, Christina S Boncyk, Caroline I Birdrow, Wencong Chen, Rameela Raman, Deepak K Gupta, Dan M Roden, Erika L Rivera, Amelia W Maiga, Shayan Rakhit, Pratik P Pandharipande, E Wesley Ely, Timothy D Girard, Mayur B Patel
IMPORTANCE: Antipsychotic medications, often prescribed for delirium in intensive care units (ICUs), may contribute to QTc interval prolongation. OBJECTIVE: To determine whether antipsychotics increase the QTc interval in patients with delirium in the ICU. DESIGN, SETTING, AND PARTICIPANTS: An a priori analysis of a randomized clinical trial in medical/surgical ICUs within 16 centers across the US was conducted. Participants included adults with delirium in the ICU with baseline QTc interval less than 550 ms...
January 2, 2024: JAMA Network Open