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"Pacing" AND "Emergency"

Steven G DuBois, Laura B Corson, Kimberly Stegmaier, Katherine A Janeway
Cancer treatment decisions are increasingly based on the genomic profile of the patient's tumor, a strategy called "precision oncology." Over the past few years, a growing number of clinical trials and case reports have provided evidence that precision oncology is an effective approach for at least some children with cancer. Here, we review key factors influencing pediatric drug development in the era of precision oncology. We describe an emerging regulatory framework that is accelerating the pace of clinical trials in children as well as design challenges that are specific to trials that involve young cancer patients...
March 15, 2019: Science
Hadley S Sauers-Ford, Michelle Y Hamline, Leah Tzimenatos, Heather McKnight, Charlaine M Hamilton, Maureen G McKennan, Jennifer L Rosenthal
BACKGROUND: Our 121-bed children's hospital is a quaternary care referral center for a 33-county region. Referring hospitals asked for Pediatric Acute Care Education Sessions (PACES). To determine which topics to prioritize for these sessions, nominal group technique (NGT) methods were used to obtain stakeholder-prioritized consensus on education topics. METHODS: Five NGT sessions were conducted over 6 weeks at referring hospitals throughout central and northern California...
March 8, 2019: Hospital Pediatrics
Adam P Hasenfratz, Samuel L Jaccard, Alfredo Martínez-García, Daniel M Sigman, David A Hodell, Derek Vance, Stefano M Bernasconi, Helga Kikki F Kleiven, F Alexander Haumann, Gerald H Haug
From 1.25 million to 700,000 years ago, the ice age cycle deepened and lengthened from 41,000- to 100,000-year periodicity, a transition that remains unexplained. Using surface- and bottom-dwelling foraminifera from the Antarctic Zone of the Southern Ocean to reconstruct the deep-to-surface supply of water during the ice ages of the past 1.5 million years, we found that a reduction in deep water supply and a concomitant freshening of the surface ocean coincided with the emergence of the high-amplitude 100,000-year glacial cycle...
March 8, 2019: Science
Alessandro Allegra, Caterina Musolino, Elisabetta Pace, Vanessa Innao, Eleonora Di Salvo, Maria Ferraro, Marco Casciaro, Giovanna Spatari, Gennaro Tartarisco, Andrea Gaetano Allegra, Sebastiano Gangemi
Glycative stress influences tumor progression. The aim of the present study was to evaluate the advanced glycation end products/soluble receptor of advanced glycation end products (AGE/sRAGE) axis in patients with multiple myeloma (MM). Blood samples were taken from 19 patients affected by MM and from 16 sex-matched and age-matched healthy subjects. AGE and sRAGE axis were dosed in patients with MM and matched with controls. AGEs were measured by spectrofluorimetric methods. Blood samples for the determination of sRAGE were analyzed by ELISA...
March 4, 2019: Antioxidants (Basel, Switzerland)
Luis Romero, Enric Alvarez-Lacalle, Yohannes Shiferaw
In this study, we analyze a nonlinear map model of intracellular calcium (Ca) and voltage in cardiac cells. In this model, Ca release from the sarcoplasmic reticulum (SR) occurs at spatially distributed dyadic junctions that are diffusively coupled. At these junctions, release occurs with a probability that depends on key variables such as the SR load and the diastolic interval. Using this model, we explore how nonlinearity and stochasticity determine the spatial distribution of Ca release events within a cardiac cell...
February 2019: Chaos
Jay D Pruetz, Jennifer C Miller, Gerald E Loeb, Michael J Silka, Yaniv Bar-Cohen, Ramen H Chmait
Congenital complete heart block (CCHB) is a life-threatening medical condition in the unborn fetus with insufficiently validated prenatal interventions. Maternal administration of medications aimed at decreasing the immune response in the fetus and beta-agonists intended to increase fetal cardiac output have shown only marginal benefits. Anti-inflammatory therapies cannot reverse CCHB, but may decrease myocarditis and improve heart function. Advances in prenatal diagnosis and use of strict surveillance protocols for delivery timing have demonstrated small improvements in morbidity and mortality...
March 1, 2019: Birth defects research
Philip L Mar, Subodh R Devabhaktuni, Gopi Dandamudi
PURPOSE OF REVIEW: His bundle pacing (HBP) has continued to emerge as a viable alternative to both right ventricular pacing (RVP) and cardiac resynchronization therapy. In recent years, a considerable amount of research has been published with regard to using HBP to treat congestive heart failure (CHF) and this article presents a concise yet comprehensive review of this literature. RECENT FINDINGS: Studies have demonstrated that HBP is useful for CHF patients who are non-responders to biventricular pacing (BiVP) or have a history of previously failed coronary sinus lead placement, right/left bundle branch block cardiomyopathy, or pacing-induced cardiomyopathy...
February 28, 2019: Current Heart Failure Reports
Nicole T Jiam, Mickael L Deroche, Patpong Jiradejvong, Charles J Limb
Cochlear implant (CI) biomechanical constraints result in impoverished spectral cues and poor frequency resolution, making it difficult for users to perceive pitch and timbre. There is emerging evidence that music training may improve CI-mediated music perception; however, much of the existing studies involve time-intensive and less readily accessible in-person music training paradigms, without rigorous experimental control paradigms. Online resources for auditory rehabilitation remain an untapped potential resource for CI users...
February 27, 2019: Journal of the Association for Research in Otolaryngology: JARO
Karin Musier-Forsyth
Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of specific amino acids to cognate tRNAs for use in protein synthesis. This historical function of ARSs and tRNAs is fairly well understood. However, ARSs and tRNAs also perform non-canonical functions that are continuing to be unveiled at a rapid pace. The expanded functions of these essential molecules of life range from roles in retroviral replication to stimulation of mTOR activity; DNA repair, splicing, transcriptional and translational regulation; and other aspects of cellular homeostasis...
February 24, 2019: Journal of Biological Chemistry
Mahmoud Aljurf, Daniel Weisdorf, Feras Alfraih, Jeff Szer, Carlheinz Müller, Dennis Confer, Shahrukh Hashmi, Nicolaus Kröger, Bronwen E Shaw, Hildegard Greinix, Mohamed A Kharfan-Dabaja, Lydia Foeken, Adriana Seber, Syed Ahmed, Areej El-Jawahri, Moheeb Al-Awwami, Yoshiko Atsuta, Marcelo Pasquini, Amr Hanbali, Hazzaa Alzahrani, Shinichiro Okamoto, Eliane Gluckman, Mohamad Mohty, Yoshihisa Kodera, Mary Horowitz, Dietger Niederwieser, Riad El Fakih
Hematopoietic cell transplantation (HCT) activity is increasing at an unprecedented pace with > 50,000 allogeneic transplants occurring annually worldwide. Establishing a functional HCT donor registry can be very challenging with respect to ethnicities, financial, technical, and geopolitical issues. Extensive planning steps are essential to overcome the expected challenges while establishing the registry, and to maintain its functionality. A few strategies can help move past those challenges and push the development of such registries forward...
February 18, 2019: Bone Marrow Transplantation
Kenneth Ladd Seldeen, Yonas Z Redae, Ramkumar Thiyagarajan, Reem Nagi Berman, Merced Marie Leiker, Bruce Robert Troen
High intensity interval training (HIIT) is emerging as a therapeutic approach to prevent, delay, or ameliorate frailty. In particular short session HIIT, with regimens less than or equal to 10 min is of particular interest as several human studies feature routines as short as a few minutes a couple times a week. However, there is a paucity of animal studies that model the impacts of short session HIIT. Here, we describe a methodology for an individually tailored and progressive short session HIIT regimen of 10 min given 3 days a week for aged mice using an inclined treadmill...
February 2, 2019: Journal of Visualized Experiments: JoVE
Ana Sjaus, Ashraf Fayad
The need for temporary cardiac pacing may occur in emergency and elective situations and may require transvenous right ventricular lead placement. The treatment of bradyarrhythmias presents the most common perioperative emergency indication. Intraoperatively, temporary rapid right ventricular pacing is accepted as a safe, titratable, and highly reliable method to achieve deliberate hypotension, and it has become a routine practice in the anesthetic management of cardiovascular interventions. The navigation of the lead into the right ventricle often requires fluoroscopy to guide placement and to confirm position...
January 16, 2019: Journal of Cardiothoracic and Vascular Anesthesia
Azzurra Ruggeri, Douglas B Markant, Todd M Gureckis, Maria Bretzke, Fei Xu
This paper investigates whether active control of study leads to enhanced learning in 5- to 11-year-old children. In Experiments 1 and 2, participants played a simple memory game with the instruction to try to remember and later recognize a set of 64 objects. In Experiment 3, the goal was to learn the French names for the same objects. For half of the materials presented, participants could decide the order and pacing of study (Active condition). For the other half, they passively observed the study decisions of a previous participant (Yoked condition)...
February 12, 2019: Cognition
Olgun Elicin, Nikola Cihoric, Eugenia Vlaskou Badra, Mahmut Ozsahin
Head and neck cancer (HNC) is an immunosuppressive disease that demonstrates heterogeneous molecular characteristics and features of tumor-host interaction. Beside radiotherapy and surgery, the current standard of care in systemic treatment involves the use of cytotoxic chemotherapy, monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs). There are also other modalities being developed under the category of immunotherapy, but they are overshadowed by the recent advancements of immune checkpoint inhibitors...
February 14, 2019: Expert Opinion on Investigational Drugs
Bart Bartels, Laura E Habets, Marloes Stam, Renske I Wadman, Camiel A Wijngaarde, Marja A G C Schoenmakers, Tim Takken, Erik H J Hulzebos, W Ludo van der Pol, Janke F de Groot
BACKGROUND: Fatigability has emerged as an important dimension of physical impairment in patients with Spinal Muscular Atrophy (SMA). At present reliable and valid outcome measures for both mildly and severely affected patients are lacking. Therefore the primary aim of this study is the development of clinical outcome measures for fatigability in patients with SMA across the range of severity. METHODS: We developed a set of endurance tests using five methodological steps as recommended by the 'COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN)...
February 9, 2019: BMC Neurology
Robert Sowerby, Andrea Gail Lantz, Daniela Ghiculete, Aaron Hong, Monica Farcas, Keith Barrett, Jason Y Lee, Michael Ordon, Kenneth Pace, John D'A Honey
INTRODUCTION Routine pre-operative electrocardiogram (ECG) before shockwave lithotripsy (SWL) is frequently performed despite recommendations against its use in asymptomatic patients undergoing low risk surgical procedures. This study assesses if routine pre-operative ECG prior to SWL is useful in patients at low risk for cardiac complications. MATERIALS AND METHODS A retrospective study of SWL at our centre (2003-2013) reviewed all cardiac-related pre-operative cancellations, intra-operative complications, post-operative admissions, and emergency department presentations in patients at low risk for cardiac complications...
February 6, 2019: Journal of Endourology
Parikshit S Sharma, Pugazhendhi Vijayaraman
Permanent His bundle pacing (PHBP) has shown significant clinical benefits in patients requiring ventricular pacing compared with conventional right ventricular pacing. There is an emerging role for PHBP in patients with interventricular dyssynchrony. This article reviews the mechanisms and the available data on the use of PHBP in overcoming dyssynchrony.
March 2019: Cardiac Electrophysiology Clinics
Xiaohe Tian, Sajid Hussain, Cesare de Pace, Lorena Ruiz-Pérez, Giuseppe Battaglia
Zinc is a biocompatible element that exists as the second most abundant transition metal ion and an indispensable trace element in the human body. Compared to traditional metal-organic complexes systems, d10 metal ZnII complexes not only exhibit a large Stokes shift and good photon stability but also possess strong emission and low cytotoxicity with a relatively small molecular weight. The use of ZnII complexes has emerged in the last decade as a versatile and convenient tool for numerous biological applications, including bioimaging, molecular and protein recognition, as well as photodynamic therapy...
February 4, 2019: Chemistry, An Asian Journal
Josue Ortiz-Medina, Zhipeng Wang, Rodolfo Cruz-Silva, Aaron Morelos-Gomez, Feng Wang, Xiangdong Yao, Mauricio Terrones, Morinobu Endo
With the advent of carbon nanotechnology, which initiated significant research efforts more than two decades ago, novel materials for energy harvesting and storage have emerged at an amazing pace. Nevertheless, some fundamental applications are still dominated by traditional materials, and it is especially evident in the case of catalysis, and environmental-related electrochemical reactions, where precious metals such as Pt and Ir are widely used. Several strategies are being explored for achieving competitive and feasible metal-free carbon nanomaterials, among which doping and defect engineering approaches within nanocarbons are recurrent and promising...
January 27, 2019: Advanced Materials
Katherine Douglass, Amanda Williams
Background: The specialty of emergency medicine (EM) is developing worldwide at a rapid pace. While more and more postgraduate training programs are developing, a major gap persists in numbers and availability of well-trained academic faculty members. This article describes a pilot faculty development program (FDP) aimed to develop advanced academic skills among a group of EM physicians in India. Methods: A FDP was developed with foundations in adult learning principles, using a combined approach of online and in-person didactic sessions...
January 2019: AEM Education and Training
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