keyword
https://read.qxmd.com/read/38457866/lc-ms-ms-determination-of-atropine-toxicity-pre-analytical-effect-of-blood-collection-tube-and-analytical-matrix
#1
JOURNAL ARTICLE
Faten Farouk, Ehab Elkady
Atropine (ATR) intoxication is a recurrent case in emergency departments. The diagnosis is dependent on clinical evaluation and is supported by analytical assessment. The assay is limited by the rapid degradation/metabolism of ATR into TRP as well as the preanalytical factors impairing correct detection and diagnosis. In this study, an HPLC-MS/MS method was optimized for the simultaneous determination of ATR and TRP. The effect of analytical matrix and the impact of blood-collection tube type on the ATR analytical signal were investigated...
February 23, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38440038/pre-medications-for-non-emergency-tracheal-intubation-in-the-united-states-neonatal-intensive-care-units
#2
JOURNAL ARTICLE
Mahmoud A Ali, Muppala Prasanth Raju, Greg Miller, Niraj Vora, Madhava Beeram, Venkata Raju, Ashith Shetty, Vinayak Govande, Nguyen Nguyen, Arpitha Chiruvolu
BACKGROUND: Premedication in neonates undergoing elective intubation effectively minimizes the negative physiological events of bradycardia, systemic hypertension, intracranial hypertension, and hypoxia. Premedication decreases procedure-related pain and discomfort. This study aimed to evaluate the current practice of pre-intubation medications for non-emergent intubations in preterm and term neonates in the United States. STUDY DESIGN: A cross-sectional survey (Appendix) was sent via e-mail to all level 3 and 4 Neonatal Intensive Care Units (NICUs) of the Organization of Neonatal Perinatal Medicine Training Program Directors (ONTPD), NICU directors with pediatric residency only, and Baylor Scott and White Health, Mednax, and Envision health services systems...
February 2024: Curēus
https://read.qxmd.com/read/38403566/hypertensive-emergency-secondary-to-atropine
#3
P R Carvalho, F Gonçalves, P Magalhães, J I Moreira
Atropine, a competitive antagonist of acetylcholine muscarinic receptors, is commonly used to treat severe bradycardia by blocking parasympathetic activity. We present a rare case of hypertensive emergency following atropine administration, with only one previous report in the literature. A 78-year-old woman with essential hypertension and hypercholesterolemia was admitted to the cardiac intensive care unit for non-ST segment elevation myocardial infarction. During coronary angiography, an occlusion of the right coronary artery was identified...
February 24, 2024: Hipertensión y Riesgo Vascular
https://read.qxmd.com/read/38373878/brash-syndrome-with-a-complete-heart-block-a-case-report
#4
JOURNAL ARTICLE
Habtamu Mesele Gebray, Abirham Eneyew Abeje, Abayneh Tunta Boye
INTRODUCTION: BRASH syndrome (Bradycardia, Renal failure, Atrioventricular (AV) nodal blocking agent, Shock and Hyperkalemia) is a recently emerging diagnosis that describes the profound bradycardia seen in patients on AV nodal blockers who present with acute kidney injury (AKI) and hyperkalemia. CASE PRESENTATION: We present a case of a 68 years old female patient with past history of hypertension taking atenolol and Enalapril presented to emergency department with the complaint of loss of consciousness of 02 hours duration...
February 19, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38344520/benzodiazepine-and-zolpidem-induced-bradycardia-a-case-report
#5
Ivan Ivanov, Rachel Kirzhner, Brenda Sokup, Yan Sun
Benzodiazepines and zolpidem are commonly used in suicide attempts. They have previously been thought to have very few side effects outside of central nervous system depression, and are considered relatively safe even in overdoses. Cardiovascular manifestations of these overdoses are exceedingly rare. We depict a case where an unknown woman appearing to be in her 50s presented to our emergency department somnolent after a large ingestion of alprazolam, clonazepam, and zolpidem. During the evaluation, the patient became bradycardic to 35 beats per minute on the monitor, which responded to atropine administration...
January 2024: Curēus
https://read.qxmd.com/read/38344049/calcium-channel-blocker-overdose
#6
JOURNAL ARTICLE
Jessica G Andrusaitis, Alan Givertz
AUDIENCE: Emergency medicine residents and medical students on emergency medicine rotation. BACKGROUND: Calcium channel blocker (CCB) overdoses can be severe with potentially serious adverse outcomes. CCBs work by blocking the calcium channels on smooth and cardiac muscle tissue. At low dose ranges, dihydropyridine CCBs (such as nifedipine, amlodipine, and nicardipine) block the L-type calcium receptors in the peripheral vasculature, whereas non-dihydropyridine CCBs (such as: verapamil and diltiazem) affect the L-type calcium receptors in the myocardium...
January 2024: Journal of education & teaching in emergency medicine
https://read.qxmd.com/read/38332961/current-practices-and-safety-of-medication-use-during-pediatric-rapid-sequence-intubation
#7
JOURNAL ARTICLE
Sarah A Bisesi, Sierra D Stauber, David J Hutchinson, Nicole M Acquisto
OBJECTIVES: This study aimed to characterize medication-related practices during and immediately -following rapid sequence intubation (RSI) in pediatric care units across the United States and to evaluate adverse drug events. METHODS: This was a multicenter, observational study of medication practices surrounding intubation in pediatric and neonatal intensive care unit (NICU) and emergency department patients across the United States. RESULTS: A total of 172 patients from 13 geographically diverse institutions were included...
2024: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38186486/the-challenge-of-managing-refractory-psychosis-amid-multiple-medication-side-effects-a-case-report-and-review-of-the-literature
#8
Alejandro Rodulfo, Sabina Goldstein, Zina Meriden
Antipsychotics are the mainstay for the treatment of schizophrenia and other psychotic disorders; however, these agents are associated with an extensive side effect profile that may complicate treatment outcomes. We present the case of a 35-year-old woman with a history of schizoaffective disorder and five prior psychiatric hospitalizations. The patient first presented to the hospital for disorganized behavior, in addition to poor sleep, auditory hallucinations, and racing thoughts in the context of medication nonadherence...
December 2023: Curēus
https://read.qxmd.com/read/38132643/efficacy-and-safety-of-isoprenaline-during-unstable-third-degree-atrioventricular-block
#9
JOURNAL ARTICLE
Manuel De Lazzari, Nicolò Martini, Federico Migliore, Filippo Donato, Luciano Babuin, Giuseppe Tarantini, Martina Perazzolo Marra, Luisa Cacciavillani, Emanuele Bertaglia, Andrea Bortoluzzi, Vito Cianci, Domenico Corrado, Sabino Iliceto, Alessandro Zorzi
Unstable and symptomatic complete atrioventricular block represents a potentially fatal condition that requires prompt therapy while waiting for definitive pacemaker implantation. Although transcutaneous pacing is included in acute management, it could be a difficult approach due to its painfulness and the occasional failure of mechanical capture. Drug therapy is a feasible choice, and current guidelines encompass the use of atropine, dopamine, or epinephrine. Isoprenaline has never been investigated in this setting, and no specific indication of its use has been provided despite its potentially more favorable pharmacological profile...
November 25, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38125255/resurgence-to-life-a-case-report-on-inpatient-rehabilitation-in-organophosphate-poisoning-followed-by-intermediate-syndrome
#10
Pallavi R Bhakaney, Vaishnavi D Yadav, Aditi A Nagore, Chaitanya A Kulkarni
Organophosphate poisoning (OPP) results from the occupational, accidental, or suicidal intake of organophosphate pesticides (OPs). There is a huge limitation in the available literature on OPP cases and the role of physiotherapy in such cases. We report a case of a 33-year-old farmer, found in a state of ingested insecticide and admitted to the emergency department. The patient had two to three episodes of vomiting, associated with continuous tremors in his hands and legs. Immediately infused with atropine, the patient's general condition deteriorated, and he was intubated with an endotracheal tube...
November 2023: Curēus
https://read.qxmd.com/read/38084292/pattern-and-outcome-of-acute-organophosphate-poisoning-at-health-facilities-of-harari-region-eastern-ethiopia
#11
JOURNAL ARTICLE
Barkot Tadesse, Haregeweyn Kibret, Helina Heluf, Sinetibeb Mesfin, Yordanos Alemu
INTRODUCTION: Pesticides are frequently used by plant cultivars to control pests that could affect yield. Although many local farmers in Eastern Ethiopia use organophosphate insecticides extensively for the production of khat, the pattern and treatment outcome of acute poisoning of these organophosphates has been poorly quantified and reported in this region. MATERIALS AND METHOD: A cross-sectional study design was employed at two public hospitals found in Harari region, Ethiopia...
2023: SAGE Open Medicine
https://read.qxmd.com/read/38059735/evaluating-airway-management-in-patients-with-trisomy-21-in-the-picu-and-cardiac-icu-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Eric J Wilsterman, Marianne E Nellis, Josep Panisello, Awni Al-Subu, Ryan Breuer, Dai Kimura, Conrad Krawiec, Palen P Mallory, Sholeen Nett, Erin Owen, Simon J Parsons, Ronald C Sanders, Annery Garcia-Marcinkiewicz, Natalie Napolitano, Justine Shults, Vinay Nadkarni, Akira Nishisaki
OBJECTIVES: Children with trisomy 21 often have anatomic and physiologic features that may complicate tracheal intubation (TI). TI in critically ill children with trisomy 21 is not well described. We hypothesize that in children with trisomy 21, TI is associated with greater odds of adverse airway outcomes (AAOs), including TI-associated events (TIAEs), and peri-intubation hypoxemia (defined as > 20% decrease in pulse oximetry saturation [Spo2]). DESIGN: Retrospective database study using the National Emergency Airway Registry for Children (NEAR4KIDS)...
December 7, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38012561/observation-of-the-effect-of-posterior-scleral-reinforcement-combined-with-orthokeratology-and-0-01-atropine-in-the-treatment-of-congenital-myopia-a-case-report
#13
JOURNAL ARTICLE
Chunxiao Yan, Fangkun Zhao, Shang Gao, Xiaoyu Liu, Taorui Yu, Yanan Mu, Lijun Zhang, Jun Xu
BACKGROUND: Myopia has recently emerged as a significant threat to global public health. The high and pathological myopia in children and adolescents could result in irreversible damage to eye tissues and severe impairment of visual function without timely control. Posterior scleral reinforcement (PSR) can effectively control the progression of high myopia by limiting posterior scleral expansion, improving retrobulbar vascular perfusion, thereby stabilizing the axial length and refraction of the eye...
November 28, 2023: BMC Ophthalmology
https://read.qxmd.com/read/38004321/plant-production-protocols-from-seeds-of-threatened-atropa-baetica-and-widespread-a-belladonna-both-rich-in-alkaloids
#14
JOURNAL ARTICLE
Elena Copete, Miguel A Copete, Esmeralda Martínez-Duro, Alejandro Santiago, Pablo Ferrandis, José M Herranz
Members of the genus Atropa contain various tropane alkaloids, including atropine ((±)-hyoscyamine) and scopolamine, which possess medicinal properties. Preserving the diverse genetic background of wild populations via optimal plant production from seeds could be essential for avoiding the loss of potential uses. We analyzed the germination ecology of two Atropa species comprising the threatened A. baetica and widespread A. belladonna to determine the: (1) influence of temperature, light, and seed age on germination patterns; (2) effects of cold stratification and gibberellic acid (GA3 ); (3) phenology of seedling emergence in outdoor conditions; (4) phenology of dormancy break and loss of viability in buried seeds; and (5) ability to form persistent soil seed banks...
November 8, 2023: Life
https://read.qxmd.com/read/37996184/patients-with-atrioventricular-block-transported-by-a-physician-staffed-helicopter-in-japan-from-2015-to-2020
#15
JOURNAL ARTICLE
Youichi Yanagawa, Keiki Abe, Marika Nunotani, Ikuto Takeuchi, Hiroki Nagasawa, Ken-Ichi Muramatsu, Hiromichi Ohsaka, Kouhei Ishikawa, Satoru Suwa
OBJECTIVE: We retrospectively investigated the current status of patients with atrioventricular block (AVB) who had been transported by the physician-staffed helicopter emergency medical service and their final outcome using data from the Japan Doctor Helicopter Registry (JDHR) system. METHODS: The following details of the dispatch activity were collected from the database of the JDHR: age and sex, vital signs when emergency medical technicians encountered the patient at the scene and on arrival at the receiving hospitals, contents of the medical intervention, new cardiac arrest during transportation, the main etiology of AVB, and the number of deaths in 1 month...
2023: Air Medical Journal
https://read.qxmd.com/read/37977906/swot-analysis-of-ortho-k-practice-in-india
#16
JOURNAL ARTICLE
Yeshwant Saoji, Anitha Arvind, Akshaya C Balakrishnan, Rajesh S Joshi, Lakshmi Shinde
PURPOSE: Orthokeratology (ortho-K) has been well established as a methodology for myopia correction and control its progression. A SWOT analysis serves as a strategic planning tool for intervention hence the purpose of this study to establish and implement ortho-K practice in India. METHOD: The study was conducted between December 2020 and June 2021. A prospective questionnaire-based study was conducted to elicit the responses in the SWOT study. Based on focus group discussion a set of five statements under strengths, weaknesses, opportunities and threats were identified...
November 15, 2023: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://read.qxmd.com/read/37937676/atropine-does-not-prevent-hypoxemia-and-bradycardia-in-tracheal-intubation-in-the-pediatric-emergency-department-observational-study
#17
JOURNAL ARTICLE
Vitor Emanoel de Lemos Carvalho, Thomaz Bittencourt Couto, Bruno Marcelo Herculano Moura, Cláudio Schvartsman, Amélia Gorete Reis
OBJECTIVE: The benefit of atropine in pediatric tracheal intubation is not well established. The objective of this study was to evaluate the effect of atropine on the incidence of hypoxemia and bradycardia during tracheal intubations in the pediatric emergency department. METHODS: This is a single-center observational study in a tertiary pediatric emergency department. Data were collected on all tracheal intubations in patients from 31 days to incomplete 20 years old, performed between January 2016 and September 2020...
2023: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/37909585/venomous-snakes-of-medical-importance-in-the-brazilian-state-of-rio-de-janeiro-habitat-and-taxonomy-against-ophidism
#18
JOURNAL ARTICLE
B R Duque, S F Bruno, V Ferreira, T B Guedes, C Machado, B Hamdan
Snakebite envenoming is a major global health problem that kills or disables half a million people in the world's poorest countries. Identifying the biting snake and its habitat use is key to understanding snakebite eco-epidemiology and optimizing its clinical management. To prevent and combat the neglected snakebite disease, we characterize the morphology, geographic distribution, habitat use, and snakebites of medically important venomous snakes in the state of Rio de Janeiro (Brazil). Despite Philodryas spp...
2023: Brazilian Journal of Biology
https://read.qxmd.com/read/37787913/viral-inhibitory-potential-of-hyoscyamine-in-japanese-encephalitis-virus-infected-embryonated-chicken-eggs-involving-multiple-signaling-pathways
#19
JOURNAL ARTICLE
Arghyadeep Bhattacharjee, Rahul Naga, Manish Saha, Srabani Karmakar, Abhishek Pal, Souvik Roy
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. The emergence of new genotypes of the virus and a high rate of mutation make it necessary to develop alternative treatment strategies against this deadly pathogen. Although the antiviral properties of Atropa belladonna and some of its active components, such as atropine and scopolamine, have been studied, the effect of another important component, hyoscyamine, against JEV infection has not yet been investigated. In this study, we investigated the antiviral effect of hyoscyamine against JEV and its immunomodulatory activity in embryonated chicken eggs...
October 3, 2023: Archives of Virology
https://read.qxmd.com/read/37721023/2023-american-heart-association-focused-update-on-the-management-of-patients-with-cardiac-arrest-or-life-threatening-toxicity-due-to-poisoning-an-update-to-the-american-heart-association-guidelines-for-cardiopulmonary-resuscitation-and-emergency-cardiovascular
#20
REVIEW
Eric J Lavonas, Peter D Akpunonu, Ann M Arens, Kavita M Babu, Dazhe Cao, Robert S Hoffman, Christopher O Hoyte, Maryann E Mazer-Amirshahi, Andrew Stolbach, Maude St-Onge, Trevonne M Thompson, George Sam Wang, Amber V Hoover, Ian R Drennan
In this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical poisoning from benzodiazepines, β-adrenergic receptor antagonists (also known as β-blockers), L-type calcium channel antagonists (commonly called calcium channel blockers), cocaine, cyanide, digoxin and related cardiac glycosides, local anesthetics, methemoglobinemia, opioids, organophosphates and carbamates, sodium channel antagonists (also called sodium channel blockers), and sympathomimetics...
October 17, 2023: Circulation
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