keyword
https://read.qxmd.com/read/36175843/poisoning-with-central-stimulant-drugs-an-observational-study-from-oslo-norway
#21
JOURNAL ARTICLE
Erlend Ingebrigtsen, Per Sverre Persett, Mette Brekke, Fridtjof Heyerdahl, Knut Erik Hovda, Odd Martin Vallersnes
BACKGROUND: The use of central stimulant drugs causes significant morbidity. We describe poisonings with central stimulant drugs and compare the different central stimulants concerning combinations with other drugs, treatment, and clinical course.  METHODS: Patients presenting from 1 October 2013 to 31 March 2016 with poisoning related to the recreational use of central stimulant drugs were retrospectively included at a primary care emergency outpatient clinic and at a hospital emergency department in Oslo, Norway...
September 29, 2022: International Journal of Emergency Medicine
https://read.qxmd.com/read/36153361/comparison-of-two-injectable-anaesthetic-protocols-in-egyptian-fruit-bats-rousettus-aegyptiacus-undergoing-gonadectomy
#22
JOURNAL ARTICLE
Martina Amari, Federica Alessandra Brioschi, Vanessa Rabbogliatti, Federica Di Cesare, Alessandro Pecile, Alessia Giordano, Pierangelo Moretti, William Magnone, Francesco Bonato, Giuliano Ravasio
Egyptian fruit bats have gained increasing interest being a natural reservoir for emerging zoonotic viruses. Anaesthesia is often required to allow safe handling of bats. We aimed to compare the sedative and cardiopulmonary effects of two balanced anaesthetic protocols in bats undergoing gonadectomy. Group DK (n = 10) received intramuscular dexmedetomidine (40 µg/kg) and ketamine (7 mg/kg), whereas group DBM (n = 10) received intramuscular dexmedetomidine (40 µg/kg), butorphanol (0.3 mg/kg) and midazolam (0...
September 24, 2022: Scientific Reports
https://read.qxmd.com/read/36150891/altered-behavioral-responses-show-gaba-sensitivity-in-muscleblind-like-2-deficient-mice-implications-for-cns-symptoms-in-myotonic-dystrophy
#23
JOURNAL ARTICLE
Kamyra S Edokpolor, Anwesha Banerjee, Zachary T McEachin, Jingsheng Gu, Adam Kosti, Juan D Arboleda, Paul S García, Eric T Wang, Gary J Bassell
Considerable evidence from mouse models and human postmortem tissue suggests loss of Muscleblind-like protein 2 (MBNL2) function in brain is a major driver of central nervous system symptoms in Myotonic Dystrophy Type 1 (DM1). Increased hypersomnia, fatigue, and surgical complications associated with general anesthesia suggest possible sensitivity to GABAergic inhibition in DM1. To test the hypothesis that MBNL2 depletion leads to behavioral sensitivity to GABAA -R modulation, Mbnl2 KO and WT littermates were treated with the anesthetic sevoflurane, the benzodiazepine diazepam, the imidazopyridine zolpidem, and the benzodiazepine rescue agent, flumazenil (Ro 15-1788), and assessed for various behavioral metrics...
September 22, 2022: ENeuro
https://read.qxmd.com/read/36112237/general-anesthesia-with-remimazolam-for-a-pediatric-patient-with-melas-and-recurrent-epilepsy-a-case-report
#24
JOURNAL ARTICLE
Yusuke Yamadori, Yuki Yamagami, Yukihisa Matsumoto, Mari Koizumi, Akiyo Nakamura, Daiskuke Mizuta, Kyoko Yasuda, Gotaro Shirakami
BACKGROUND: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disease. We report here the safe use of remimazolam in a pediatric MELAS patient. CASE PRESENTATION: A 10-year-old girl (118 cm, 16 kg) was scheduled for an open gastrostomy to improve nutrition and epileptic seizure control. We induced and maintained general anesthesia with remimazolam, remifentanil, fentanyl, and rocuronium. We also performed a bilateral subcostal transversus abdominis plane block before the surgery...
September 16, 2022: JA Clinical Reports
https://read.qxmd.com/read/36076100/recall-of-extubation-after-remimazolam-anesthesia-with-flumazenil-antagonism-during-emergence-a-retrospective-clinical-study
#25
JOURNAL ARTICLE
Tsunehisa Sato, Soichiro Mimuro, Tadayoshi Kurita, Mayumi Kobayashi, Matsuyuki Doi, Takasumi Katoh, Yoshiki Nakajima
PURPOSE: This study was performed to examine and compare the incidence of extubation recall in surgical patients who underwent remimazolam anesthesia with flumazenil antagonism during emergence and in those who underwent propofol anesthesia. METHODS: One hundred sixty-three patients who underwent surgery using general endotracheal or supraglottic airway anesthesia with propofol (n = 97) or remimazolam (n = 66) were retrospectively analyzed...
December 2022: Journal of Anesthesia
https://read.qxmd.com/read/35688053/outcomes-of-patients-treated-with-low-dose-flumazenil-for-benzodiazepine-detoxification-a-description-of-26-participants
#26
RANDOMIZED CONTROLLED TRIAL
T MacDonald, A T Gallo, G Basso-Hulse, G K Hulse
INTRODUCTION: Benzodiazepines are commonly prescribed for a variety of indications and can be employed in the short- and long-term. While they are efficacious, issues arise from long-term use with the emergence of dependence and tolerance to doses within the therapeutic range and beyond. Discontinuation from benzodiazepines can be problematic for patients and may result in a withdrawal syndrome, which can be protracted and last months to years. METHODS: 26 participants received low-dose subcutaneous flumazenil infusions (4 mg/24 h for approximately eight days) as part of a randomised control crossover trial...
August 1, 2022: Drug and Alcohol Dependence
https://read.qxmd.com/read/35330416/effect-of-flumazenil-on-emergence-agitation-after-orthognathic-surgery-a-randomized-controlled-trial
#27
JOURNAL ARTICLE
Young Hyun Koo, Geun Joo Choi, Hyun Kang, Yong Hun Jung, Young Cheol Woo, Young-Jun Choi, Chong Wha Baek
Flumazenil, a gamma-aminobutyric acid receptor antagonist, can promote arousal even under general anesthesia without the use of benzodiazepines. We hypothesized that flumazenil could promote arousal and reduce emergence agitation in patients undergoing orthognathic surgery with sevoflurane anesthesia. One hundred and two patients were randomly allocated to the control or flumazenil group. Saline or flumazenil was administered at the end of the surgery. The incidence of emergence agitation was measured by using Aono's four-point scale, with scores of 3 and 4 indicating emergence agitation...
March 7, 2022: Journal of Personalized Medicine
https://read.qxmd.com/read/34743200/gaba-a-and-nmda-receptor-density-alterations-and-their-behavioral-correlates-in-the-gestational-methylazoxymethanol-acetate-model-for-schizophrenia
#28
JOURNAL ARTICLE
Amanda Kiemes, Felipe V Gomes, Diana Cash, Daniela L Uliana, Camilla Simmons, Nisha Singh, Anthony C Vernon, Federico Turkheimer, Cathy Davies, James M Stone, Anthony A Grace, Gemma Modinos
Hippocampal hyperactivity driven by GABAergic interneuron deficits and NMDA receptor hypofunction is associated with the hyperdopaminergic state often observed in schizophrenia. Furthermore, previous research in the methylazoxymethanol acetate (MAM) rat model has demonstrated that repeated peripubertal diazepam administration can prevent the emergence of adult hippocampal hyperactivity, dopamine-system hyperactivity, and associated psychosis-relevant behaviors. Here, we sought to characterize hippocampal GABAA and NMDA receptors in MAM-treated rats and to elucidate the receptor mechanisms underlying the promising effects of peripubertal diazepam exposure...
November 6, 2021: Neuropsychopharmacology
https://read.qxmd.com/read/34704354/reversal-effects-of-atipamezole-flumazenil-and-4-aminopyridine-on-bradycardia-and-increases-in-blood-pressures-induced-by-medetomidine-midazolam-and-ketamine-in-isoflurane-anesthetized-cats
#29
JOURNAL ARTICLE
Hirokazu Kamohara, Toshiko Kamohara, Yoshiaki Hikasa
OBJECTIVE: To investigate the effects of a fixed dose of atipamezole (AT), flumazenil (FL), and 4-aminopyridine (AP), both alone and in combination, on changes in arterial blood pressure and heart rate induced by medetomidine (ME), midazolam (MI), and ketamine (KE) under isoflurane anesthesia with controlled ventilation in healthy cats. DESIGN: Prospective experimental study. SETTING: University animal research facility. ANIMALS: Healthy adult mixed-breed cats were used for 8 investigation groups (6 cats per group), with ≥2 weeks between interventions...
March 2022: Journal of Veterinary Emergency and Critical Care
https://read.qxmd.com/read/34183454/availability-of-antidotes-in-moroccan-hospitals-a-national-survey
#30
JOURNAL ARTICLE
Rachid Eljaoudi, Youssef Moutaouakkil, Badr Adouani, Yasmina Tadlaoui, Sofia Boukria, Mina Ait El Cadi, Jamal Lamsaouri, Yasser Bousliman
AIM: The lack of availability of antidotes is a challenge for hospitals all over the world. The objective of our study was to investigate the availability of antidotes in Moroccan hospitals. METHODS: A cross-sectional, questionnaire-based study was conducted from November 2018 to April 2019. The questionnaire was sent to 25 hospitals in order to investigate the availability of 42 selected antidotes based on the International Programme on Chemical Safety list. RESULTS: The survey response rate was 68%...
June 28, 2021: European Journal of Hospital Pharmacy. Science and Practice
https://read.qxmd.com/read/33741413/anxiolytic-like-effect-of-brominated-compounds-from-the-marine-sponge-aplysina-fulva-on-adult-zebrafish-danio-rerio-involvement-of-the-gabaergic-system
#31
JOURNAL ARTICLE
Hozana Patrícia S de F Cesário, Francisca Crislândia O Silva, Maria Kueirislene A Ferreira, Jane Eire S A de Menezes, Hélcio S Dos Santos, Carlos E S Nogueira, Karísia S B de L Silva, Eduardo Hajdu, Edilberto R Silveira, Otília Deusdênia L Pessoa
Benzodiazepines are commonly used to treat disorders of the central nervous system, including anxiety. However, due to their adverse effects, there is a continuing interest in discovering new safe and effective drugs. Marine natural products have emerged as a prolific source of bioactive nitrogenated compounds. Aiming to discover new biologically active natural compounds, the marine sponge Aplysina fulva, a nitrogen-bearing heterocyst producer, was investigated. The main isolated compounds (4, 6, and 9) were evaluated on adult zebrafish (Danio rerio)...
March 16, 2021: Neurochemistry International
https://read.qxmd.com/read/33625620/remimazolam-for-a-patient-with-myotonic-dystrophy-type-1-who-underwent-endoscopic-retrograde-cholangiopancreatography-under-general-anesthesia-a-case-report
#32
JOURNAL ARTICLE
Masakazu Fukuda, Shunsuke Tachibana, Noriaki Nishihara, Michiaki Yamakage
BACKGROUND: Remimazolam is a benzodiazepine receptor agonist with an ultra-short-acting anesthetic effect. We used remimazolam for anesthesia in a patient with myotonic dystrophy type 1 who underwent endoscopic retrograde cholangiopancreatography (ERCP). CASE PRESENTATION: A 58-year-old woman received ERCP under general anesthesia. She had impaired respiratory function due to myotonic dystrophy type I and was at a risk of respiratory complications after anesthesia...
February 24, 2021: JA Clinical Reports
https://read.qxmd.com/read/33477960/an-in-vivo-study-of-a-rat-fluid-percussion-induced-traumatic-brain-injury-model-with-11-c-pbr28-and-18-f-flumazenil-pet-imaging
#33
JOURNAL ARTICLE
Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, Zhimin Wang, Mathangi Palanivel, Kian Chye Ng, Jia Lu, Jan Carlstedt-Duke, Christer Halldin, Balázs Gulyás
Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET) have made it possible to map certain features of TBI-induced cellular and molecular changes equally in humans and animals. The PET imaging technique is an apt supplement to nanotheranostic-based treatment alternatives that are emerging to tackle TBI...
January 19, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/32025939/airway-emergency-during-general-anesthesia-in-a-child-with-plastic-bronchitis-following-fontan-surgery-a-case-report
#34
JOURNAL ARTICLE
Hirofumi Nakamoto, Satoru Kayama, Mae Harada, Takahiro Honjo, Kinuko Kubota, Shigehito Sawamura
BACKGROUND: Plastic bronchitis (PB) is a complication of Fontan surgery, results in the formation of mucus plug in the tracheobronchial tree, causing potentially fatal airway obstruction. We report critical airway emergency during general anesthesia in a child with plastic bronchitis. CASE PRESENTATION: A 5-year-old boy was scheduled for intrapulmonary lymphatic embolization through percutaneous catheterization under general anesthesia. He underwent Fontan surgery at the age of 2 and frequently developed respiratory failure due to plastic bronchitis...
January 21, 2020: JA Clinical Reports
https://read.qxmd.com/read/31927603/tolerance-and-dependence-following-chronic-alprazolam-treatment-quantitative-observation-studies-in-female-rhesus-monkeys
#35
JOURNAL ARTICLE
Angela N Duke, Donna M Platt, James K Rowlett
RATIONALE: In order to understand mechanisms underlying tolerance and dependence following chronic benzodiazepine treatments, quantitative and reproducible behavioral models of these phenomena are required. OBJECTIVES: This research evaluated the ability of chronic treatment with a commonly prescribed benzodiazepine, alprazolam, to induce tolerance to sedative effects and physical dependence using a novel set of behavioral measurements in rhesus monkeys. METHODS: Four female rhesus monkeys (Macaca mulatta) were implanted with chronic intravenous catheters and administered i...
April 2020: Psychopharmacology
https://read.qxmd.com/read/31724037/development-of-an-electronic-trigger-tool-at-a-children-s-hospital-within-an-academic-medical-center
#36
JOURNAL ARTICLE
Megan Fortenberry, Johlee Odinet, Pooja Shah, Cameron McKinzie, Kristin Murphy, Cassidy Beach Faircloth, Christopher Falato, Ashley Pappas
PURPOSE: To evaluate the validity and reliability of select recommended triggers, defined as flags found on review of the medical record that prompt further investigation to determine the presence or absence of an adverse drug event (ADE), selected from a list initially constructed based on severity, frequency, and detectability of triggers within a pediatric population. METHODS: This was a single-center, retrospective cohort analysis of pediatric patients admitted to University of North Carolina (UNC) Children's Hospital who received trigger-associated medications between January 2015 and December 2016...
November 13, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/31615421/acute-poisoning-related-to-the-recreational-use-of-prescription-drugs-an-observational-study-from-oslo-norway
#37
JOURNAL ARTICLE
Marit Mæhle Grimsrud, Mette Brekke, Victoria Lykke Syse, Odd Martin Vallersnes
BACKGROUND: Recreational use of prescription drugs is widespread. We describe acute poisonings related to the recreational use of prescription drugs. METHODS: Retrospective observational study. We retrospectively registered all patients presenting from October 2013 through March 2015 at a primary care emergency outpatient clinic in Oslo, Norway, with an acute poisoning related to recreational drug use. We registered demographic data, toxic agents taken, clinical course and treatment...
October 15, 2019: BMC Emergency Medicine
https://read.qxmd.com/read/30348014/occurrence-and-time-course-of-nps-benzodiazepines-in-sweden-results-from-intoxication-cases-in-the-strida-project
#38
JOURNAL ARTICLE
Matilda Bäckberg, Madeleine Pettersson Bergstrand, Olof Beck, Anders Helander
CONTEXT: In recent years, many unclassified benzodiazepines (BZD) have appeared through online sale as new psychoactive substances (NPS). This study describes bioanalytical and clinical data related to intoxications involving NPS BZD ("designer BZD") in the Swedish STRIDA project. STUDY DESIGN: Case series of consecutive patients with admitted or suspected intake of NPS presenting to hospitals all over Sweden for emergency treatment in 2012-2016. PATIENTS AND METHOD: Urine samples collected in the STRIDA project were analyzed for 28 NPS BZD, using immunoassay and liquid chromatography-high-resolution mass spectrometry ...
March 2019: Clinical Toxicology
https://read.qxmd.com/read/29703020/flumazenil-reduces-respiratory-complications-during-anesthesia-emergence-in-children-with-preoperative-upper-respiratory-tract-infections
#39
JOURNAL ARTICLE
Ruiqiang Sun, Guolin Wang, Xuesong Gao, Shuzhen Wang
Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction.To evaluate the effect of flumazenil on the occurrence of respiratory complications during anesthesia emergence of children with preoperative URI.This was a prospective study of 164 consecutive pediatric patients who underwent strabismus surgery under general anesthesia at the Tianjin Eye Hospital between August 2016 and April 2017...
April 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29480352/metabolomics-profile-in-abat-deficiency-pre-and-post-treatment
#40
JOURNAL ARTICLE
Mary Kay Koenig, Penelope E Bonnen
Metabolomic profiling is an emerging technology in the clinical setting with immediate diagnostic potential for the population of patients with Inborn Errors of Metabolism. We present the metabolomics profile of two ABAT deficiency patients both pre- and posttreatment with flumazenil. ABAT deficiency, also known as GABA-transaminase deficiency, is caused by recessive mutations in the gene ABAT and leads to encephalopathy of variable severity with hypersomnolence, hypotonia, hypomyelination, and seizures. Through metabolomics screening of multiple patient tissues, we identify 2-pyrrolidinone as a biomarker for GABA that is informative in plasma, urine, and CSF...
February 27, 2018: JIMD Reports
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