keyword
Keywords "Hypercalcaemia" OR "Hypercalc...

"Hypercalcaemia" OR "Hypercalcemia" AND "Treatment"

https://read.qxmd.com/read/38007710/-a-rare-cause-of-kidney-injury-vitamin-d3-intoxication
#1
JOURNAL ARTICLE
Dávid Hutkai, Miklós Bodor
The beneficial effects of vitamin D3 treatment are known, and its side effects are documented. In connection with the case presentation, we would like to sum up the dangers of excessive vitamin D supplementation, and to draw attention to the shortcomings experienced in everyday medical practice. We discuss the tests required to create a diagnosis of vitamin D intoxication, the differential diagnosis, and present the possible treatment strategies. A 57-year-old female patient was admitted to hospital in November 2020 due to complaints of nausea, vomiting, diarrhea and general weakness...
November 26, 2023: Orvosi Hetilap
https://read.qxmd.com/read/37638278/the-impact-of-moderate-hypophosphatemia-on-the-clinical-management-of-primary-hyperparathyroidism
#2
JOURNAL ARTICLE
Elif Güneş, Mutlu Güneş
Background and objective The impact of moderate hypophosphatemia (hypoP) on primary hyperparathyroidism (PHPT) and its use as an independent surgical criterion has not been adequately evaluated in the literature. In light of this, we conducted this study to address the scarcity of data on this topic. Methods We conducted a retrospective evaluation of data related to 164 (133 females and 31 males) patients with PHPT who met the criteria for inclusion in the study. HypoP, which is indicated by phosphorus (P) levels lower than 2...
August 2023: Curēus
https://read.qxmd.com/read/37532015/characteristics-of-hospitalised-patients-with-hypercalcaemia-in-the-province-of-malaga-a-longitudinal-retrospective-multicentre-study
#3
JOURNAL ARTICLE
Guillermo Ropero-Luis, Almudena López-Sampalo, Jaime Sanz-Cánovas, Alberto Ruiz-Cantero, Ricardo Gómez-Huelgas
BACKGROUND AND OBJECTIVE: There are limited studies analyzing hypercalcemia in hospitalized patients. Our objectives were to describe the clinical characteristics of hospitalized patients with hypercalcemia, estimate its prevalence in the hospital setting, analyze the rate of correction of hypercalcemia, and identify prognostic variables. MATERIALS AND METHODS: Observational, longitudinal, retrospective, and bicentric study. Adult patients admitted to two hospitals in Málaga (2014-2018) with a diagnosis of hypercalcemia were included...
July 31, 2023: Revista Clínica Espanõla
https://read.qxmd.com/read/37408692/hypercalcemia-in-metastatic-parathyroid-carcinoma-followed-by-hypocalcemia-after-resection-a-case-report
#4
Takuya Ohashi, Mitsumasa Kawago, Yoshimitsu Hirai, Yumi Yata, Aya Fusamoto, Hideto Iguchi, Takahito Nakaya, Megumi Kiyoi, Miwako Miyasaka, Mari Kawaji, Yuki Furuta, Yoshiharu Nishimura
A 72-year-old man was diagnosed with hypercalcaemia 13 years ago. He was diagnosed with hyperparathyroidism associated with a parathyroid tumour and surgery was performed. Postoperatively, his serum calcium levels, which had once normalized, rose again. Medical treatment for hypercalcaemia failed to control the condition. A chest computed tomography showed multiple pulmonary nodules which were diagnosed as pulmonary metastases of parathyroid carcinoma. The tumour was considered to be the cause of the hypercalcaemia and volume reduction surgery was performed...
August 2023: Respirology Case Reports
https://read.qxmd.com/read/37033238/cancer-related-hypercalcemia-and-potential-treatments
#5
REVIEW
Elvina Almuradova, Irfan Cicin
Cancer-related hypercalcemia is a common finding typically seen in patients with advanced cancer and occurs in about 20 to 30 percent of cases. The most common cause of hypercalcemia in hospitalized patients is hypercalcemia due to malignancy.This clinical problem is seen in patients with both solid tumors and patients with hematologic malignancies. Hypercalcemia is associated with a poor prognosis in oncology patients. This pathologic condition can occur due to many different mechanisms but is usually caused by abnormal calcium use resulting from bone resorption, intestinal absorption, or renal excretion...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/36810677/surgical-management-and-denosumab-for-aneurysmal-bone-cysts-of-the-spine-in-an-australian-tertiary-paediatric-centre
#6
JOURNAL ARTICLE
Joel A Vanderniet, Dionysios Tsinas, Christie-Lee Wall, Christian M Girgis, Kevin London, Corinne Keane, Julie Briody, Sally Hibbert, Myra Poon, Bhavna Padhye, Andrew Biggin, Luciano Dalla-Pozza, Randolph J Gray, Craig F Munns
Aneurysmal bone cysts (ABC) are rare osteolytic, benign but often locally aggressive tumours of the long bones or vertebrae. For spinal ABC, surgical management, embolisation or sclerotherapy alone often carry high morbidity and/or high recurrence rates. Interruption of receptor activator of nuclear factor-kappa B ligand (RANKL) signalling holds promise as an effective therapeutic strategy for these tumours. We aimed to review the approach to surgical management and evaluate the efficacy and safety of denosumab for ABC of the spine in children...
February 21, 2023: Calcified Tissue International
https://read.qxmd.com/read/35908214/a-cyp24a1-g%C3%A3-n-terhess%C3%A3-gi-hypercalcaemi%C3%A3-t-okoz%C3%A3-defektusa
#7
JOURNAL ARTICLE
Andrea Györkös, Judit Tőke, Gábor Sohár, Mónika Kovács, Jenő Goldfinger, György Vajda, Tibor Kalmár, Miklós Tóth
Hypercalcemia is a rare condition in pregnancy. It is most commonly caused by primary hyperparathyroidism and parathyroid hormone-related peptid (PTHrP)-producing malignant tumours, less frequently by increased intestinal calcium absorption, vitamin D intoxication, milk-alkali syndrome, and granulomatous diseases or lymphomas, in which vitamin D 1α-hydroxylase expression is increased. Rarely, gestational hypercalcaemia may be caused by a disorder of vitamin D catabolism caused by loss-of-function mutations in the CYP24A1 gene...
July 31, 2022: Orvosi Hetilap
https://read.qxmd.com/read/35331976/denosumab-for-central-giant-cell-granuloma-in-an-australian-tertiary-paediatric-centre
#8
JOURNAL ARTICLE
Joel A Vanderniet, Christie-Lee Wall, Anna Mullins, Kevin London, Lydia Lim, Sally Hibbert, Julie Briody, Bhavna Padhye, Myra Poon, Andrew Biggin, Luciano Dalla-Pozza, Craig F Munns
BACKGROUND: Central giant cell granulomas (CGCG) are rare osteolytic, benign but often locally aggressive tumours of bone. Surgical curettage may not be possible in extensive lesions and resection carries high morbidity, especially in growing children, and previous medical therapies have had variable efficacy and high recurrence rates. Interruption of receptor activator of nuclear factor-kappa B ligand (RANKL) signalling holds promise as an effective therapeutic strategy for these tumours...
June 2022: Bone
https://read.qxmd.com/read/35087007/milk-alkali-syndrome-the-forgotten-diagnosis-for-altered-sensorium
#9
JOURNAL ARTICLE
W L Yap, A Rahman, K A Baharuddin
Milk-alkali syndrome (MAS) is one of the causes of hypercalcaemia. We report a case of a 75-year-old lady with a history of thyroidectomy, presented with an altered mental state and had an extremely high calcium concentration of 4.96mmol/L. The hypercalcemia was attributed to the ingestion of large doses of calcium supplements, including calcium carbonate and calcium lactate, leading to MAS. She was managed with intravenous fluids, diuretics and withdrawal of calcium supplements. The patient responded well to treatment and regained consciousness...
January 2022: Medical Journal of Malaysia
https://read.qxmd.com/read/35074396/what-an-endocrinologist-should-know-for-patients-receiving-lithium-therapy
#10
REVIEW
Magalie Haissaguerre, Marie-Christine Vantyghem
Lithium is an efficient treatment of bipolar disorder. Besides renal insufficiency, many endocrine side effects are described such as the occurrence of thyroid disorders, hypercalcaemia and nephrogenic diabetes insipidus. Lithium inhibits the secretion of thyroid hormones. The prevalence of goiter is 4 times more common in Lithium-treated patients compared as to the general population. Hypothyroidism (8-20%) is more frequent in women and in case of pre-existing thyroid autoimmunity. Grave's disease and other hyperthyroidisms are sometimes reported...
August 2022: Annales D'endocrinologie
https://read.qxmd.com/read/34931708/primary-hyperparathyroidism-in-adults-part-i-assessment-and-medical-management-position-statement-of-the-endocrine-society-of-australia-the-australian-new-zealand-endocrine-surgeons-and-the-australian-new-zealand-bone-and-mineral-society
#11
JOURNAL ARTICLE
Frances Milat, Sabashini K Ramchand, Madhuni Herath, Justin Gundara, Simon Harper, Stephen Farrell, Christian M Girgis, Roderick Clifton-Bligh, Hans G Schneider, Sunita M C De Sousa, Anthony J Gill, Jonathan Serpell, Kim Taubman, James Christie, Richard W Carroll, Julie A Miller, Mathis Grossmann
OBJECTIVE: To formulate clinical consensus recommendations on the presentation, assessment, and management of primary hyperparathyroidism (PHPT) in adults. METHODS: Representatives from relevant Australian and New Zealand Societies used a systematic approach for adaptation of guidelines (ADAPTE) to derive an evidence-informed position statement addressing nine key questions. RESULTS: PHPT is a biochemical diagnosis. Serum calcium should be measured in patients with suggestive symptoms, reduced bone mineral density or minimal trauma fractures, and in those with renal stones...
December 21, 2021: Clinical Endocrinology
https://read.qxmd.com/read/34511419/huge-cutaneous-abscess-and-severe-symptomatic-hypercalcaemia-secondary-to-mycobacterium-kansasii-infection-in-an-immunocompetent-patient
#12
JOURNAL ARTICLE
Sarocha Vivatvakin, Kamalas Amnuay, Chusana Suankratay
Mycobacterium kansasii is among the most common non-tuberculous mycobacteria causing human infections. Apart from pulmonary infection, the most common infection caused by M. kansasii is skin and soft tissue infection, and it is very rare in immunocompetent people. In this report, we present a case of a huge cutaneous abscess caused by M. kansasii A 63-year-old man living in Bangkok presented with progressive pain at the left lateral chest wall for 3 weeks and altered mentation for a few days. Examination revealed a non-tender fluctuated cutaneous mass 20×10 cm in size...
September 12, 2021: BMJ Case Reports
https://read.qxmd.com/read/34464024/prognostic-indicators-for-na%C3%A3-ve-canine-non-indolent-t-cell-lymphoma-treated-with-combination-lomustine-vincristine-procarbazine-and-prednisolone-chemotherapy
#13
JOURNAL ARTICLE
John Blaxill, Peter Buzzacott, Jessica Finlay
Lomustine, vincristine, procarbazine and prednisolone (LOPP) chemotherapy has been suggested to be an effective treatment for dogs with naïve non-indolent T-cell lymphoma (TCL). Studies evaluating prognostic factors for dogs with TCL treated with LOPP chemotherapy are lacking. The aim of this retrospective study was to assess potential prognostic factors for canine naïve non-indolent TCL treated with the LOPP protocol. This was a retrospective cohort study of naïve non-indolent TCL treated with the LOPP chemotherapy protocol at a single specialty veterinary oncology clinic...
March 2022: Veterinary and Comparative Oncology
https://read.qxmd.com/read/33786294/negative-cerebrospinal-fluid-%C3%AE-d-glucan-levels-as-an-indicator-for-treatment-cessation-ahead-of-biochemical-resolution-a-case-report-of-candida-glabrata-meningitis
#14
Liang En Wee, Crystal Shie Lyeen Wong, Ai Ling Tan, Helen May-Lin Oh
Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side effect of the prolonged fluconazole treatment, prompted early treatment cessation. A negative cerebrospinal fluid (CSF) β-d-glucan supported the decision of treatment cessation despite incomplete resolution of CSF biochemical parameters. No disease relapse was encountered after 2 years post-treatment...
June 2021: Medical Mycology Case Reports
https://read.qxmd.com/read/33715600/severe-hypercalcaemia-and-acute-renal-failure-in-an-infant-with-subcutaneous-fat-necrosis
#15
JOURNAL ARTICLE
Tülay İnce Becerir, Ayça Altincik, Bayram Özhan, Selçuk Yüksel
Subcutaneous fat necrosis (SFN) in the newborn is a form of panniculitis which presents with erythematous nodules and indurated plaques. Severe life-threatening hypercalcaemia can occur as a late complication. A 2-month-old girl presented with severe hypercalcaemia and acute renal injury as a complication of SFN. She was admitted to hospital with the chief complaint of failure to thrive. She had a history of therapeutic hypothermia. After successful treatment of the hypercalcaemia with bisphosphonates, the acute renal injury recovered spontaneously...
August 2021: Paediatrics and International Child Health
https://read.qxmd.com/read/33008295/peptide-receptor-radionuclide-therapy-controls-inappropriate-calcitriol-secretion-in-a-pancreatic-neuro-endocrine-tumor-a-case-report
#16
JOURNAL ARTICLE
Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype, Christophe M Deroose
BACKGROUND: Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D. Although inappropriate tumoral secretion of calcitriol is typically associated with lymphomas and some ovarian germ cell tumors, we present a case of calcitriol overproduction-induced hypercalcemia due to a pancreatic neuroendocrine tumor. The high expression of somatostatin receptors on this neuroendocrine neoplasm opened up the opportunity to treat the patient with radiolabelled somatostatin analogs, which successfully controlled the refractory hypercalcaemia and calcitriol levels...
October 2, 2020: BMC Gastroenterology
https://read.qxmd.com/read/32776272/hypercalcaemia-after-treatment-with-denosumab-in-children-bisphosphonates-as-an-option-for-therapy-and-prevention
#17
JOURNAL ARTICLE
Carmen Sydlik, Hans Roland Dürr, Susanne Bechtold-Dalla Pozza, Claudia Weißenbacher, Julia Roeb, Heinrich Schmidt
BACKGROUND: Pharmacologic options for treatment of osteolytic diseases especially in children are limited. Although not licensed for use, denosumab, a fully humanized antibody to RANKL, is used in children with good effects. Among others, one possible indication are giant cell tumors and aneurysmatic bone cysts. However, there are reports of severe hypercalcemia during weeks to months after termination of denosumab, that are rarely seen in adults. METHODS: We collected data of four patients, aged 6-17 years, who experienced severe hypercalcemia after completion of treatment with denosumab for unresectable giant cell tumors of bone or aneurysmal bone cysts and methods of their treatment...
October 2020: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/30755423/posterior-reversible-encephalopathy-syndrome-due-to-hypercalcaemia-a-rare-cause
#18
JOURNAL ARTICLE
Nandakrishna Bolanthakodi, Sudha Vidyasagar, Muralidhar Varma, Avinash Holla
Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey et al in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism...
February 11, 2019: BMJ Case Reports
https://read.qxmd.com/read/30396880/comparison-of-treatment-regimens-in-management-of-severe-hypercalcemia-due-to-vitamin-d-intoxication-in-children
#19
JOURNAL ARTICLE
Korcan Demir, Hakan Döneray, Cengiz Kara, Zeynep Atay, Semra Çetinkaya, Atilla Çayır, Ahmet Anık, Erdal Eren, Ahmet Uçaktürk, Gülay Can Yılmaz, Ayça Törel Ergür, Mustafa Kendirci, Zehra Aycan, Abdullah Bereket, Murat Aydın, Zerrin Orbak, Behzat Özkan
Objective: No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate as first-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospective study assessing clinical characteristics and treatment results. Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia (serum calcium level >10...
May 28, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30093752/lithium-induced-symptomatic-hypercalcemia-and-hyperparathyroidism-in-a-patient-with-bipolar-affective-disorder-a-case-report-and-review-of-literature
#20
JOURNAL ARTICLE
Gnanaselvam Pamathy, Umesh Jayarajah, Tshering Wangmo, Anura S K Banagala
Lithium induced primary hyperparathyroidism is an uncommon endocrine side effect of long term lithium therapy. We studied the case of a 67-year-old female patient on long term lithium therapy for bipolar affective disorder, who developed resistant hypercalcaemia and parathyroid adenoma which required parathyroidectomy. Furthermore, the effect of chronic lithium therapy on parathyroid glands and serum calcium levels, its pathogenesis, and management were reviewed. Periodic monitoring of serum calcium levels in patients on long term lithium therapy should be practiced...
July 2018: Indian Journal of Psychological Medicine
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