keyword
Keywords "Airway" OR "Difficult Airway"...

"Airway" OR "Difficult Airway" OR "Surgical Airway"

https://read.qxmd.com/read/38547428/eosinophil-expression-of-triggering-receptor-expressed-on-myeloid-cells-1-trem-1-restricts-type-2-lung-inflammation
#1
JOURNAL ARTICLE
Jayden L Bowen, Kathy Keck, Sankar Baruah, Kathy H Nguyen, Andrew L Thurman, Alejandro A Pezzulo, Julia Klesney-Tait
Asthma affects 25 million Americans and recent advances in treatment are effective for only a portion of severe asthma patients. Triggering Receptor Expressed on Myeloid cells 1 (TREM-1), an innate receptor that canonically amplifies inflammatory signaling in neutrophils and monocytes, plays a central role in regulating lung inflammation. It is unknown how TREM-1 contributes to allergic asthma pathology. Utilizing a murine model of asthma, flow cytometry revealed TREM-1+ eosinophils in the lung tissue and airway during allergic airway inflammation...
March 28, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38547381/precision-medicine-to-personalize-medicine-in-allergic-airway-disease
#2
JOURNAL ARTICLE
Jean Kim
PURPOSE OF REVIEW: The purpose of this study is to understand the approach to precision medicine and personalized medicine in the management of allergic airway disease. RECENT FINDINGS: Identification of biomarkers as key tools used in precision medicine has led to the development of multiple biologic drugs being used as new treatments for allergic airway disease. SUMMARY: In addition to these advances, there is still much needed effort to improve the feasibility and utility of integrating biologic omics data of precision medicine with physicochemical, behavioral, psychological, and social data to deliver optimized treatments that is personalized for each individual...
March 28, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547129/human-airway-organoids-and-multimodal-imaging-based-toxicity-evaluation-of-1-nitropyrene
#3
JOURNAL ARTICLE
Yingyan Zhou, Cun Li, Yanyan Chen, Yifei Yu, Xin Diao, Raymond Chiu, Jiacheng Fang, Yuting Shen, Jianing Wang, Lin Zhu, Jie Zhou, Zongwei Cai
Despite significant advances in understanding the general health impacts of air pollution, the toxic effects of air pollution on cells in the human respiratory tract are still elusive. A robust, biologically relevant in vitro model for recapitulating the physiological response of the human airway is needed to obtain a thorough understanding of the molecular mechanisms of air pollutants. In this study, by using 1-nitropyrene (1-NP) as a proof-of-concept, we demonstrate the effectiveness and reliability of evaluating environmental pollutants in physiologically active human airway organoids...
March 28, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38546911/enhanced-revision-rhinoplasty-with-processed-costal-cartilage-guided-by-preoperative-computed-tomography-and-3d-scanning
#4
JOURNAL ARTICLE
Pawel Szychta
BACKGROUND: Revision rhinoplasty presents unique challenges, particularly in achieving structural integrity and aesthetic harmony. This study explores the efficacy of costal grafts in addressing these challenges, focusing on anatomical corrections and patient outcomes. MATERIALS AND METHODS: A prospective analysis was conducted on patients undergoing revision rhinoplasty with costal grafts. An algorithmic approach was applied to tailor the surgical technique to individual anatomical needs, documented through pre- and postoperative assessments, including CT imaging and 3D scanning...
March 28, 2024: Maxillofacial Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546544/true-incidence-of-marginal-mandibular-nerve-palsy-following-neonatal-mandibular-distraction-osteogenesis
#5
JOURNAL ARTICLE
Sarah Myers, Justin W Beiriger, Madeleine K Bruce, Sayna Matinrazm, Lucas Dvoracek, Anjali Raghuram, Zhazira Irgebay, Anne E Glenney, Joseph Mocharnuk, Nicolás M Kass, John Smetona, Joseph E Losee, Jesse A Goldstein
INTRODUCTION: In children with PRS, MDO is routinely performed to alleviate airway obstruction; however, it involves risk of injury to the MMN. We hypothesize that MMN palsy incidence following MDO, reported at 1-15%, is underestimated. This study investigates the true incidence of MMN palsy after MDO to better guide follow-up care and improve treatment of this complication. METHODS: A retrospective review of PRS patients who underwent MDO at a single, tertiary pediatric hospital between September 2007 and March 2021 was conducted...
March 25, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546511/a-case-series-of-the-royal-perth-hospital-cannula-first-approach-in-the-can-t-intubate-can-t-oxygenate-scenario
#6
JOURNAL ARTICLE
Andrew Mb Heard, David A Lacquiere, Helen L Gordon, Scott G Douglas, Hans J Avis
At the Royal Perth Hospital, we have been developing and teaching a can't intubate, can't oxygenate (CICO) rescue algorithm for over 19 years, based on live animal simulation. The algorithm involves a 'cannula-first' approach, with jet oxygenation and progression to scalpel techniques if required in a stepwise fashion. There is little reported experience of this approach to the CICO scenario in humans. We present eight cases in which a cannula-first Royal Perth Hospital approach was successfully implemented during an airway crisis...
March 28, 2024: Anaesthesia and Intensive Care
https://read.qxmd.com/read/38546350/the-protective-effects-of-arctiin-in-asthma-by-attenuating-airway-inflammation-and-inhibiting-p38-nf-%C3%AE%C2%BAb-signaling
#7
JOURNAL ARTICLE
Lang Yuan, Chao Sun
Asthma is a common chronic inflammatory disease of the airways, which affects millions of people worldwide. Arctiin, a bioactive molecule derived from the traditional Chinese Burdock, has not been previously reported for its effects on asthma in infants. In this study, an asthma model was established in mice by stimulation with ovalbumin (OVA). Bronchoalveolar lavage (BALF) was collected from OVA-challenged mice and the cells were counted. Lung tissue was harvested for hematoxylin-eosin (HE) staining and measurement of Wet/Dry weight ratios...
March 27, 2024: Aging
https://read.qxmd.com/read/38546304/isolated-laryngeal-angioedema-in-a-patient-with-long-term-ace-inhibitor-use-a-case-report
#8
JOURNAL ARTICLE
Carney Flinn, Inna Massaro
INTRODUCTION: Angiotensin converting enzyme (ACE) inhibitor-associated angioedema is the most common cause of angioedema seen in the emergency department (ED) and can be associated with a high morbidity. Most cases occur within months of initiation of an ACE inhibitor and are associated with facial and/or oropharyngeal swelling. We present a case of isolated laryngeal edema requiring intubation following 10 years of ACE inhibitor therapy. CASE REPORT: An 82-year-old female, who was on lisinopril therapy for 10 years, presented to the ED with shortness of breath and a sensation that her throat was swelling...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546283/significant-airway-obstruction-by-carbonaceous-fibrin-casts-in-a-child-with-smoke-inhalation-injury
#9
JOURNAL ARTICLE
Annemarie G Wolfe, Paul C Stillwell, Livia A Veress
No abstract text is available yet for this article.
March 28, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38546250/antenatally-detected-thoracic-lesions-prognosis-management-and-outcome
#10
JOURNAL ARTICLE
Md Mokarram Ali, Nilesh Tank, Monika Bawa
BACKGROUND: Foetal thoracic lesions are uncommon, with the incidence of 1 in 15,000 live births. Antenatal monitoring of these lesions is required to prognosticate the parents about the postnatal outcome of the lesions and about the well-being of the baby. Foetal ultrasound and magnetic resonance imaging (MRI) are the modalities to detect these lesions and follow-up during pregnancy and postnatally. Congenital pulmonary adenomatoid malformations (CPAM), congenital diaphragmatic hernia (CDH) and bronchopulmonary sequestrations (BPS) are the commonly detected foetal thoracic lesions...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546008/mask-interfaces-and-devices-for-home-noninvasive-ventilation-in-children
#11
JOURNAL ARTICLE
Sonia Khirani, Vivian Ducrot
Home noninvasive ventilation (NIV), including continuous (CPAP) and bilevel (BPAP) positive airway pressure, is increasingly used in children worldwide. In this narrative review, we present a comprehensive summary of the equipment available for home NIV in pediatrics, excluding neonates. NIV may be challenging in young children, as the majority of the equipment has been developed for adults. Regarding the interfaces, only a few masks have been specifically developed for young children in recent years, while older children may benefit from a large variety of interfaces...
March 28, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38545924/a-prospective-pragmatic-non-inferiority-study-of-emergency-intubation-success-with-the-single-use-i-view-versus-standard-reusable-video-laryngoscope
#12
JOURNAL ARTICLE
Steven G Schauer, Brit J Long, Michael D April, Daniel Resnick-Ault, Jessica Mendez, Allyson A Arana, Jill J Bastman, William T Davis, Joseph K Maddry, Adit A Ginde, Vikhyat S Bebarta
INTRODUCTION: Video laryngoscope (VL) technology improves first-pass success. The novel i-view VL device is inexpensive and disposable. We sought to determine the first-pass intubation success with the i-view VL device versus the standard reusable VL systems in routine use at each site. METHODS: We performed a prospective, pragmatic study at two major emergency departments (EDs) when VL was used. We rotated i-view versus reusable VL as the preferred device of the month based on an a priori schedule...
March 28, 2024: Transfusion
https://read.qxmd.com/read/38545670/virtual-reality-simulation-of-airway-management-post-cleft-palate-surgery-a-model-for-sustainable-and-equitable-education
#13
JOURNAL ARTICLE
Alexandra N Verzella, Allison L Diaz, Matteo Laspro, Andre Alcon, Jill Schechter, Aaron Oliker, Anne Arnold, Roberto L Flores
BACKGROUND: The effectiveness of virtual-reality (VR) simulation-based training in cleft surgery has not been tested. The purpose of this study was to evaluate learners' acceptance of VR simulation in airway management of a pediatric patient post-cleft palate repair. METHODS: This VR simulation was developed through collaboration between BioDigital and Smile Train. 26 medical students from a single institution completed 10 min of standardized VR training and 5 min of standardized discussion about airway management post-cleft palate repair...
March 28, 2024: Cleft Palate-craniofacial Journal
https://read.qxmd.com/read/38545634/safety-of-nebulized-ciprodex-for-postoperative-management-of-tracheal-resection
#14
JOURNAL ARTICLE
Jason S Chwa, Elizabeth A Shuman, Karla O'Dell
OBJECTIVE: Anastomotic complications after tracheal resection/cricotracheal resection (TR/CTR), such as granulation tissue formation, can lead to severe morbidity. The off-label use of nebulized ciprofloxacin-dexamethasone (Ciprodex) for granulation tissue prophylaxis has anecdotally been used after TR/CTR, especially in pediatric patients. However, its use in the adult population, and its safety and side effect profile post-TR/CTR has not been reported. This study aims to characterize the incidence of adverse side effects associated with nebulized Ciprodex in post-TR/CTR patients...
March 28, 2024: Laryngoscope
https://read.qxmd.com/read/38545557/combined-allergic-bronchopulmonary-mycosis-and-eosinophilic-granulomatosis-with-polyangiitis-a-case-report-and-literature-review
#15
Ning Cui, Jingluan Wang, Yanmei Shao, Jingming Zhao, Zhaozhong Cheng
A 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases coexisting in the disease process...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38545546/effect-of-elexacaftor-tezacaftor-ivacaftor-on-nasal-potential-difference-and-lung-function-in-phe508del-rats
#16
JOURNAL ARTICLE
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Introduction: Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies has led to significant health improvements in individuals with this mutation. While numerous animal models of CF exist, few have a CFTR mutation that is amenable to the triple combination therapy elexacaftor-tezacaftor-ivacaftor (ETI). Methods: To determine the responsiveness of Phe508del rats to ETI, a baseline nasal potential difference was measured...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38545241/sleep-restfulness-in-patients-with-obstructive-sleep-apnea-undergoing-continuous-positive-airway-pressure-therapy
#17
JOURNAL ARTICLE
Satoshi Hamada, Jumpei Togawa, Hironobu Sunadome, Tadao Nagasaki, Naomi Takahashi, Toyohiro Hirai, Susumu Sato
Objective  Sleep restfulness is closely associated with mortality. Thus, it is an important sleep-related symptom in the general population. However, it is rarely evaluated in patients with obstructive sleep apnea (OSA) syndrome. The present study examined the importance of sleep restfulness in patients with OSA receiving continuous positive airway pressure (CPAP) therapy. Materials and Methods  We administered sleep-related questionnaires, which included items such as subjective sleep duration and sleep restfulness, to 775 patients with OSA receiving CPAP therapy...
March 2024: Sleep Science
https://read.qxmd.com/read/38545237/assessment-of-impact-of-dietary-patterns-on-obstructive-sleep-apnea-patients
#18
JOURNAL ARTICLE
Fatma Esra Gunes, Kadriye Agan, Sule Aktac, Derya Karadeniz, Gulin Sunter, Ezgi Vural, Gulcin Benbir-Senel
Objective  Obstructive sleep apnea syndrome (OSAS) is characterized by episodic cessations of breathing due to upper airway obstruction during sleep, which may cause disturbances in dietary patterns resulting from appetite-related hormonal changes. The aim of the present study was to investigate the relationship between OSAS and nutritional and dietary patterns. Materials and Methods  A total of 20 female and 53 male OSAS patients aged > 30 years were enrolled. Demographic data, as well as data on smoking and alcohol habits, were noted, anthropometric measures were made, and a questionnaire regarding chronic diseases including OSAS and four questionnaires on recent food intake frequency and content of nutrition were filled out...
March 2024: Sleep Science
https://read.qxmd.com/read/38545207/investigation-of-the-effect-of-types-of-two-different-air-filtered-full-face-masks-used-in-chemical-biological-radiological-nuclear-cbrn-events-on-endotracheal-intubation-time-a-randomized-controlled-study
#19
JOURNAL ARTICLE
Orhan Delice, Muhammet Özkul
INTRODUCTION: Healthcare personnel may have to intervene with the injured using personal protective equipment depending on the environmental conditions.In injuries occurring in chemical, biological, radiological and nuclear (CBRN) events, healthcare personnel may have to intervene in the injured using personal protective equipment.The equipment used may lead to limitations, especially in cases requiring advanced airway intervention such as intubation. In this study, the effects of personal protective equipment on the intubation times of healthcare personnel were investigated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545098/the-effects-of-vitamin-d-supplementation-on-inflammatory-biomarkers-in-patients-with-asthma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Asmae El Abd, Harika Dasari, Philippe Dodin, Helen Trottier, Francine M Ducharme
BACKGROUND: While the association between vitamin D and several inflammatory biomarkers in asthma patients has been extensively reported, it remains unclear whether supplementation modifies these biomarkers. This review aims to evaluate the impact of vitamin D supplementation on inflammatory biomarkers measured in vivo in individuals with asthma. METHODS: We conducted a systematic review of randomized controlled trials (RCTs) published until November 2022 in six electronic databases evaluating the impact of vitamin D supplementation (any dose, form, administration route, frequency, or duration) compared to placebo in children or adults...
2024: Frontiers in Immunology
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