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Diabetes glucose control

Janina Rynarzewski, Lisa Dicks, Benno F Zimmermann, Birgit Stoffel-Wagner, Norbert Ludwig, Hans-Peter Helfrich, Sabine Ellinger
Randomized controlled trials indicate that flavanol-rich cocoa intake may improve postprandial glucose and lipid metabolism in patients with type 2 diabetes (T2D), based on studies with meals that impose a strong metabolic load. Hence, the aim of the present study was to investigate whether flavanol-rich cocoa powder ingested as part of a diabetic-suitable meal may beneficially affect glucose, lipid metabolism, and blood pressure (BP) in patients with T2D. Twelve adults with T2D, overweight/obesity, and hypertension ingested capsules with 2...
February 16, 2019: Nutrients
Hiroyuki Takahashi, Naoaki Sakata, Gumpei Yoshimatsu, Suguru Hasegawa, Shohta Kodama
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune targeting of pancreatic β-cells, and, in the advanced stage, severe hypoinsulinemia due to islet destruction. In patients with T1DM, continuous exogenous insulin therapy cannot be avoided. However, an insufficient dose of insulin easily induces extreme hyperglycemia or diabetic ketoacidosis, and intensive insulin therapy may cause hypoglycemic symptoms including hypoglycemic shock. While these insulin therapies are efficacious in most patients, some additional therapies are warranted to support the control of blood glucose levels and reduce the risk of hypoglycemia in patients who respond poorly despite receiving appropriate treatment...
February 15, 2019: Journal of Clinical Medicine
John Adulcikas, Sabrina Sonda, Shaghayegh Norouzi, Sukhwinder Singh Sohal, Stephen Myers
Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic processes that lead to abnormally high levels of blood glucose. Preceding the development of T2DM is insulin resistance (IR), a disorder associated with suppressed or delayed responses to insulin. The effects of this response are predominately mediated through aberrant cell signalling processes and compromised glucose uptake into peripheral tissue including adipose, liver and skeletal muscle. Moreover, a major factor considered to be the cause of IR is endoplasmic reticulum (ER) stress...
February 15, 2019: Nutrients
Zheng Hangping, Qiao Xiaona, Zhang Qi, Li Qingchun, Yi Na, Ji Lijin, Liu Siying, Zhang Shuo, Zhu Xiaoming, Liu Xiaoxia, Xiong Qian, David Jaimovich, Li Yiming, Lu Bin
AIMS: To evaluate the effects of a novel, low-volume, high-intensity Progressive Resistance Training (PRT) technique on blood glucose control in elderly Chinese patients with Type 2 Diabetes. MATERIALS AND METHODS: The PReTTy2 trial enrolled 300 male and female patients with Type 2 Diabetes in a randomized resistance training program with the bioDensity™ technique. 100 were control patients with no training intervention and 200 had resistance training. Anthropometry, biochemical parameters, HbA1c and fasting plasma glucose (FPG) were measured at baseline, 3- month and 6-month intervals...
February 16, 2019: Diabetes Research and Clinical Practice
Claudia Vetrani, Lutgarda Bozzetto, Marisa Giorgini, Luisa Cavagnuolo, Elpidio Di Mattia, Paola Cipriano, Anna Mangione, Annamaria Todisco, Giovanna Inghilterra, Angela Giacco, Giovanni Annuzzi, Angela A Rivellese
AIM: People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excursions in individuals with diabetes. Thus, we evaluated the acute effect of fibre-enriched buckwheat (FBP) and corn pasta (CP) on postprandial blood glucose response (PP-BGR)...
February 16, 2019: Diabetes Research and Clinical Practice
Y J Shin, H W Choung, J H Lee, I C Rhyu, H D Kim
The association between oral squamous cell carcinoma (OSCC) and periodontitis in large hospital cases with cohort controls has yet to be evaluated. The aim of this study was to investigate the association of periodontitis with OSCC across tumor location and tumor-node-metastasis (TNM) stage among Koreans ( N = 424). OSCC cases ( n = 146) were recruited from Seoul National University Dental Hospital and matched by age, sex, and smoking to controls ( n = 278) from the Yangpyeong health and periodontal cohort in Korea...
February 19, 2019: Journal of Dental Research
Jonathan D Douros, Jingjing Niu, Sophia M Sdao, Trillian Gregg, Kelsey H Fisher-Wellman, Manish S Bharadwaj, Anthony Molina, Ramamani Arumugam, Mackenzie D Martin, Enrico Petretto, Matthew J Merrins, Mark A Herman, Jenny Tong, Jonathan E Campbell, David D'Alessio
Bariatric surgeries including vertical sleeve gastrectomy (VSG) ameliorate obesity and diabetes. Weight-loss and accompanying increases to insulin sensitivity contribute to improved glycemia after surgery, however, studies in humans also suggest weight-independent actions of bariatric procedures to lower blood glucose, possibly by improving insulin secretion. To evaluate this hypothesis, we compared VSG operated mice with pair-fed, sham-surgical controls (PF-Sham) 2 weeks after surgery. This paradigm yielded similar post-operative body weight and insulin sensitivity between VSG and calorically restricted PF-Sham animals...
February 19, 2019: JCI Insight
Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu
BACKGROUND: Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of runt-related transcription factor 2 (Runx2) and transcriptional co-activator with PDZ-binding domain (TAZ) during this process. METHODS: After establishing a high-fat and high-glucose mouse model, a 1 mm × 1...
February 18, 2019: Journal of Orthopaedic Surgery and Research
L Huang, S Tepaamorndech, C P Kirschke, Y Cai, J Zhao, Xiaohan Cao, Andrew Rao
BACKGROUND: A genome-wide mapping study using male F2 zinc transporter 7-knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B6) background identified a quantitative trait locus (QTL) on chromosome 7, which had a synergistic effect on body weight gain and fat deposit with the znt7-null mutation. RESULTS: The genetic segment for body weight on mouse chromosome 7 was investigated by newly created subcongenic znt7-KO mouse strains carrying different lengths of genomic segments of chromosome 7 from the 129P1 donor strain in the B6 background...
February 18, 2019: BMC Genetics
Suzanne M de la Monte, Ming Tong, Lori A Daiello, Brian R Ott
BACKGROUND: Brain insulin resistance is a well-recognized abnormality in Alzheimer's disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity. OBJECTIVE: This study was designed to determine whether systemic and central nervous system (CNS) insulin resistant disease states emerge together and thus may be integrally related...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Ahmet Altan, Mutan Hamdi Aras, İbrahim Damlar, Hasan Gökçe, Oğuzhan Özcan, Cansu Alpaslan
Purpose: This study aims to investigate the histopathological and biochemical effects of the topical application of Hypericum perforatum on the healing of surgical wounds created in the oral mucosa of rats with experimentally induced diabetes mellitus. Materials and methods: The study was carried out on 48 adult male Wistar albino rats. The animals were divided into two main groups as control and study groups. Two main groups were divided into three subgroups according to the sacrification days...
September 2018: European oral research
Satoshi Ida, Ryutaro Kaneko, Kazuya Murata
In the present study, we aimed to investigate the effects of continuous glucose monitoring (CGM) on blood glucose levels, body weight, blood pressure, and hypoglycaemia in patients with type 2 diabetes mellitus using a meta-analysis of randomized controlled trials (RCTs). A literature search was performed using MEDLINE, Cochrane Controlled Trials Registry, and RCTs using CGM in patients with type 2 diabetes mellitus were then selected. Statistical analysis included calculation of the standardized mean difference (SMD) or risk ratio and 95% confidence intervals (CIs) using a random effects model...
2019: Journal of Diabetes Research
S Ashwin Kumar, P V Krishnam Raju, K V T Gopal, T Narayana Rao
Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. Materials and Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls...
January 2019: Indian Dermatology Online Journal
Fatemeh Sadeghi, Saedeh Salehi, Ali Kohanmoo, Masoumeh Akhlaghi
Background: Due to high content of fructose, honey has been introduced as a suitable natural sweetener for patients with type 2 diabetes. We investigated the effect of honey consumption on glycemic control and anthropometric measures of patients with type 2 diabetes. Methods: This randomized controlled crossover clinical trial was conducted on 53 patients with type 2 diabetes. The participants were randomly divided into groups of control (weight maintenance diet) or treatment (weight maintenance diet +50 g/day honey) for 8 weeks...
2019: International Journal of Preventive Medicine
Farideh Mohsenzadeh-Ledari, Ziba Taghizadeh, Zahra Motaghi, Afsaneh Keramat, Mahmood Moosazadeh, Ali Najafi
Metabolic syndrome (MetS), a series of symptoms, including abdominal obesity, impaired glucose tolerance and insulin metabolism, hypertension, and dyslipidemia, is considered as the risk of developing cardiovascular disease and diabetes that can predispose a pregnant women to serious health problem, women in the developed as well as the developing countries. This study was aimed to investigate the effects of appropriate interventions on pregnant women with indicators of MetS to further improve the outcome of pregnancy...
2019: International Journal of Preventive Medicine
Naeti Suksomboon, Nalinee Poolsup, Wei Lin
Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors. Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Carib-bean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Oscar D Sánchez, Eduardo Ruiz-Velázquez, Alma Y Alanís, Griselda Quiroz, Luis Torres-Treviño
The effect of meal on blood glucose concentration is a key issue in diabetes mellitus because its estimation could be very useful in therapy decisions. In the case of type 1 diabetes mellitus (T1DM), the therapy based on automatic insulin delivery requires a closed-loop control system to maintain euglycaemia even in the postprandial state. Thus, the mathematical modelling of glucose metabolism is relevant to predict the metabolic state of a patient. Moreover, the eating habits are characteristic of each person, so it is of interest that the mathematical models of meal intake allow to personalise the glycaemic state of the patient using therapy historical data, that is, daily measurements of glucose and records of carbohydrate intake and insulin supply...
February 2019: IET Systems Biology
Zdenek Sumnik, Agnieszka Szypowska, Violeta Iotova, Natasa Bratina, Valentino Cherubini, Gun Forsander, Sujata Jali, Joao Felipe Raposo, Gordana Stipančic, Andriani Vazeou, Henk Veeze, Karin Lange
BACKGROUND: Frequent use of modern diabetes technologies increases the chance for optimal type 1 diabetes (T1D) control. Limited reimbursement influences the access of patients with T1D to these modalities and could worsen their prognosis. We aimed to describe the situation of reimbursement for insulins, glucometers, insulin pumps (CSII) and continuous glucose monitoring (CGM) for children with T1D in European countries participating in the SWEET Project and to compare data from EU countries with data from our previous study in 2009...
February 17, 2019: Pediatric Diabetes
P Choudhary, F Campbell, N Joule, P Kar
In both adults and children with diabetes, technologies such as continuous subcutaneous insulin infusion using insulin pumps and continuous glucose monitoring can help improve diabetes control, reduce hypoglycaemia and improve quality of life. Access to these technologies in the UK is very variable. Some technologies are recommended by the National Institute for Health and Care Excellence, while others have not been appraised, and new technologies are emerging all the time. Additionally, different guidelines for adults and children further complicate access to diabetes technology in the transition from paediatric to adult care...
February 17, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
Eisei Hori, Chigusa Kikuchi, Kenro Imaeda, Naotsuka Okayama, Tadashi Suzuki, Tamihide Matsunaga
It is reported that statins have inconsistent effects on glycemic status and adiponectin concentrations in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the effect of statins on these variables in patients with T2DM and hypercholesterolemia. A control group comprising 24 patients with T2DM but without hypercholesterolemia was observed for more than 12 weeks, while 24 patients with T2DM and hypercholesterolemia were treated with statins for the same period (statin group). The percentage changes in the glycemic status (blood glucose and glycated hemoglobin [HbA1c]), and levels of plasma adiponectin (total and high molecular weight [HMW]) were compared between the two groups...
February 15, 2019: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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