Feng Shan, Anthony R Cillo, Carly Cardello, Daniel Y Yuan, Sheryl R Kunning, Jian Cui, Caleb Lampenfeld, Asia M Williams, Alexandra P McDonough, Arjun Pennathur, James D Luketich, John M Kirkwood, Robert L Ferris, Tullia C Bruno, Creg J Workman, Panayiotis V Benos, Dario A A Vignali
Human regulatory T cells (Tregs ) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in tumors and peripheral blood from patients with head and neck squamous cell carcinomas (HNSCC) and those in nontumor tonsil tissues and peripheral blood from healthy donors...
September 15, 2023: Science Immunology