keyword
https://read.qxmd.com/read/38541237/an-intra-hospital-spread-of-colistin-resistant-k-pneumoniae-isolates-epidemiological-clinical-and-genetic-analysis
#1
JOURNAL ARTICLE
Georgi Popivanov, Rumyana Markovska, Ivanka Gergova, Marina Konaktchieva, Roberto Cirocchi, Kirien Kjossev, Ventsislav Mutafchiyski
Background and Objective: Klebsiella pneumoniae appears to be a significant problem due to its ability to accumulate antibiotic-resistance genes. After 2013, alarming colistin resistance rates among carbapenem-resistant K. pneumoniae have been reported in the Balkans. The study aims to perform an epidemiological, clinical, and genetic analysis of a local outbreak of COLr CR-Kp. Material and Methods: All carbapenem-resistant and colistin-resistant K. pneumoniae isolates observed among patients in the ICU unit of Military Medical Academy, Sofia, from 1 January to 31 October 2023, were included...
March 21, 2024: Medicina
https://read.qxmd.com/read/38534677/assessing-the-microbial-quality-of-shrimp-xiphonaeus-kroyeri-and-mussels-perna-perna-illegally-sold-in-the-vit%C3%A3-ria-region-brazil-and-investigating-the-antimicrobial-resistance-of-escherichia-coli-isolates
#2
JOURNAL ARTICLE
Daniella Tosta Link, Gustavo Guimarães Fernandes Viana, Lívia Pasolini Siqueira, Carolina Magri Ferraz, Romário Alves Rodrigues, Luis Antonio Mathias, Marita Vedovelli Cardozo, Gabriel Augusto Marques Rossi
The consumption of seafood is crucial for food security, but poor hygiene along the food production chain can result in low microbiological quality, posing significant risks for public health and seafood quality. Thus, this study aimed to assess the microbiological quality and antimicrobial sensitivity of E. coli from 69 samples of illegally marketed shrimp and mussels in the Vitória Region, Brazil. These foods exhibited poor microbiological quality due to high counts of mesophilic, psychrotrophic, and enterobacteria microorganisms...
March 6, 2024: Antibiotics
https://read.qxmd.com/read/38402189/escherichia-coli-and-their-potential-transmission-of-carbapenem-and-colistin-resistant-genes-in-camels
#3
JOURNAL ARTICLE
Marwa Youseef, Fatma Karam, Mona Kadry, Mahmoud Elhariri, Rehab Elhelw
BACKGROUND: Camels harbouring multidrug-resistant Gram-negative bacteria are capable of transmitting various microorganisms to humans. This study aimed to determine the distribution of anti-microbial resistance among Escherichia coli (E. coli) isolated from the feces of apparently healthy camels in Egyptian abattoirs. Additionally, we sought to characterize Shiga toxin-producing E. coli (STEC) strains, assess their virulence potential, and investigate the possibility of camels spreading carbapenem- and colistin-resistant E...
February 24, 2024: BMC Microbiology
https://read.qxmd.com/read/38165462/molecular-detection-of-shiga-toxin-and-extended-spectrum-beta-lactamase-esbl-producing-escherichia-coli-isolates-from-sheep-and-goats
#4
JOURNAL ARTICLE
Tsepo Ramatla, Mpho Tutubala, Tshepang Motlhaping, Lara de Wet, Prudent Mokgokong, Oriel Thekisoe, Kgaugelo Lekota
BACKGROUND: The Shiga toxin (Stx)-producing Escherichia coli (STEC) have become important global public health concerns. This study investigated the prevalence, antimicrobial resistance profile, and extended-spectrum beta-lactamase-producing E. coli in sheep and goat faeces. METHODS AND RESULTS: A total of 53 E. coli isolates were confirmed by PCR targeting the uidA [β-D glucuronidase] gene. The Shiga toxin genes stx1 and stx2, as well as bfpA, vir, eaeA, lt and aafII virulence genes, were detected in this study...
January 2, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38154746/induction-of-proteome-changes-involved-in-the-cloning-of-mcr-1-and-mcr-2-genes-in-escherichia-coli-dh5-%C3%AE-strain-to-evaluate-colistin-resistance
#5
JOURNAL ARTICLE
Hadi Feizi, Maryam Alizadeh, Hadi Azimi, Ehsaneh Khodadadi, Fadhil S Kamounah, Khudaverdi Ganbarov, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Hossein Samadi Kafil
BACKGROUND: Plasmid genes, termed mobile colistin resistance-1 (mcr-1) and mobile colistin resistance-2 (mcr-2), are associated with resistance to colistin in Escherichia coli. These mcr genes result in a range of protein modifications contributing to colistin resistance. This study aims to discern the proteomic characteristics of E. coli carrying mcr-1 and mcr-2 genes. Furthermore, it evaluates the expression levels of various proteins under different conditions (with and without colistin)...
December 26, 2023: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38138083/characteristics-whole-genome-sequencing-and-pathogenicity-analysis-of-escherichia-coli-from-a-white-feather-broiler-farm
#6
JOURNAL ARTICLE
Shaopeng Wu, Lulu Cui, Yu Han, Fang Lin, Jiaqi Huang, Mengze Song, Zouran Lan, Shuhong Sun
Avian colibacillosis, caused by avian Escherichia coli ( E. coli ), has historically been one of the most prevalent infectious diseases in large-scale poultry production, causing growth delays and mortality in chickens, resulting in huge economic losses. In recent years, the widespread use of antibiotics has led to the emergence of multidrug resistance in E. coli as a significant global problem and long-term challenge. Resistant E. coli can be transmitted to humans through animal products or the environment, which presents significant public health concerns and food safety issues...
December 7, 2023: Microorganisms
https://read.qxmd.com/read/38138079/predominance-of-multidrug-resistant-gram-negative-bacteria-isolated-from-supermarket-retail-seafood-in-japan
#7
JOURNAL ARTICLE
Christian Xedzro, Toshi Shimamoto, Tadashi Shimamoto
Reports have documented antimicrobial usage in aquaculture, and the aquatic ecosystem can be considered a genetic storage site for antibiotic-resistant bacteria. This study assessed the prevalence of antimicrobial resistance (AMR) among Gram-negative bacteria recovered from retail seafood in Hiroshima, Japan. A total of 412 bacteria were isolated and screened for the presence of β-lactamases, acquired carbapenemases, and mobile colistin-resistance ( mcr ) genes. Forty-five (10.9%) isolates were dominated by Morganella (28%), Proteus (22%), Aeromonas (14%), Citrobacter (8%), and Escherichia (8%) and carried AMR genes...
December 7, 2023: Microorganisms
https://read.qxmd.com/read/38059867/an-update-on-the-prevalence-of-colistin-and-carbapenem-resistant-gram-negative-bacteria-in-aquaculture-an-emerging-threat-to-public-health
#8
JOURNAL ARTICLE
Roa Memesh, Muhammad Yasir, Ruth G Ledder, Hosam Zowawi, Andrew J McBain, Esam I Azhar
Aquaculture has been recognized as a hotspot for the emergence and spread of antimicrobial resistance genes (ARGs) conferring resistance to clinically-important antibiotics. This review gives insights into studies investigating the prevalence of colistin and carbapenem resistance (CCR) among Gram-negative bacilli in aquaculture. Overall, a high incidence of CCR has been reported in aquatic farms in several countries, with CCR being more prevalent among opportunistic human pathogens such as Acinetobacter nosocomialis, Shewanella algae, Photobacterium damselae, Vibrio spp...
December 6, 2023: Journal of Applied Microbiology
https://read.qxmd.com/read/37699212/colistin-resistance-in-multidrug-resistant-escherichia-coli-isolated-from-retail-broiler-meat-in-bangladesh
#9
JOURNAL ARTICLE
Chandan Nath, Tridip Das, Md Sirazul Islam, F M Yasir Hasib, Shuvo Singha, Avijit Dutta, Himel Barua, Md Zohorul Islam
The emergence of colistin resistance in Escherichia coli is a global public health concern. Contaminated food can accelerate the spread of colistin-resistant E. coli to humans. This study aimed to detect and characterize colistin-resistant E. coli from broiler meat in Bangladesh. We analyzed 136 pooled broiler meat samples from 240 carcasses collected from 40 live bird markets in urban and rural areas and 8 metropolitan supermarkets. The mean count of E. coli in broiler meat samples collected from rural retail shops, metropolitan supermarkets, and urban retail shops was 5...
September 12, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/37653554/frequencies-of-mobilized-colistin-resistance-mcr-1-2-genes-in-clinically-isolated-escherichia-coli-a-cross-sectional-study
#10
JOURNAL ARTICLE
Bahman Mirzaei, Aida Ebrahimi, Bahareh Hariri, Zahra Sokouti, Niloufar Kazemi, Narges Moradi
OBJECTIVE: Escherichia coli (E. coli) is an opportunistic bacterium, which is globally recognized for its high prevalence and antimicrobial resistance (AMR). The presence of colistin-resistant representative mcr- 1, 2 genes in multi-drug resistant (MDR) clinically isolated E. coli is the main goal of this survey. After biochemically and molecular confirmation tests, susceptibility testing, biofilm formation, and minimum inhibitory concentration to colistin were performed on 100 E. coli isolates...
August 31, 2023: BMC Research Notes
https://read.qxmd.com/read/37641085/characteristics-and-genomic-epidemiology-of-colistin-resistant-enterobacterales-from-farmers-swine-and-hospitalized-patients-in-thailand-2014-2017
#11
JOURNAL ARTICLE
Adhiratha Boonyasiri, Lauren M Brinkac, Elita Jauneikaite, Richard C White, Chris Greco, Chakkraphong Seenama, Teerawit Tangkoskul, Kevin Nguyen, Derrick E Fouts, Visanu Thamlikitkul
BACKGROUND: Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics. However, the increased use of colistin in clinical and livestock farming settings in Thailand and China, has led to the inevitable emergence of colistin resistance. To better understand the rise of colistin-resistant strains in each of these settings, we characterized colistin-resistant Enterobacterales isolated from farmers, swine, and hospitalized patients in Thailand...
August 28, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37627715/carbapenem-resistant-gram-negative-bacilli-characterization-in-a-tertiary-care-center-from-el-bajio-mexico
#12
JOURNAL ARTICLE
Jose Raul Nieto-Saucedo, Luis Esaú López-Jacome, Rafael Franco-Cendejas, Claudia Adriana Colín-Castro, Melissa Hernández-Duran, Luis Raúl Rivera-Garay, Karina Senyase Zamarripa-Martinez, Juan Luis Mosqueda-Gómez
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a major public health concern. We aimed to evaluate the prevalence of CR-GNB and the frequency of carbapenemase-encoding genes in a tertiary referral center from El Bajio, Mexico. A cross-sectional study was conducted between January and October 2022; Gram-negative bacilli (GNB) were screened for in vitro resistance to at least one carbapenem. CR-GNB were further analyzed for carbapenemase-production through phenotypical methods and by real-time PCR for the following genes: bla KPC , bla GES , bla NDM , bla VIM , bla IMP , and bla OXA-48 ...
August 8, 2023: Antibiotics
https://read.qxmd.com/read/37601372/the-occurrence-and-molecular-detection-of-mcr-1-and-mcr-5-genes-in-enterobacteriaceae-isolated-from-poultry-and-poultry-meats-in-malaysia
#13
JOURNAL ARTICLE
Md Rezaul Karim, Zunita Zakaria, Latiffah Hassan, Nik Mohd Faiz, Nur Indah Ahmad
The advent of antimicrobials-resistant (AMR), including colistin-resistant bacteria, poses a significant challenge to animal and human health, food safety, socio-economic growth, and the global environment. This study aimed to ascertain the colistin resistance prevalence and molecular mechanisms of colistin resistance in Enterobacteriaceae . The colistin resistance was determined using broth microdilution assay, PCR; and Sanger sequencing of mcr genes responsible for colistin resistance in Enterobacteriaceae ( n  = 627), including Escherichia coli (436) , Salmonella spp...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37508213/mobile-colistin-resistance-mcr-gene-containing-organisms-in-poultry-sector-in-low-and-middle-income-countries-epidemiology-characteristics-and-one-health-control-strategies
#14
REVIEW
Madubuike Umunna Anyanwu, Ishmael Festus Jaja, Charles Odilichukwu R Okpala, Emmanuel Okechukwu Njoga, Nnenna Audrey Okafor, James Wabwire Oguttu
Mobile colistin resistance ( mcr ) genes ( mcr -1 to mcr -10) are plasmid-encoded genes that threaten the clinical utility of colistin (COL), one of the highest-priority critically important antibiotics (HP-CIAs) used to treat infections caused by multidrug-resistant and extensively drug-resistant bacteria in humans and animals. For more than six decades, COL has been used largely unregulated in the poultry sector in low- and middle-income countries (LMICs), and this has led to the development/spread of mcr gene-containing bacteria (MGCB)...
June 28, 2023: Antibiotics
https://read.qxmd.com/read/37471208/do-pathogenic-escherichia-coli-isolated-from-gallus-gallus-in-south-africa-carry-co-resistance-toward-colistin-and-carbapenem-antimicrobials
#15
JOURNAL ARTICLE
Ibrahim Zubairu Hassan, Daniel N Qekwana, Vinny Naidoo
Colistin and carbapenems are critically important antimicrobials often used as a last resort to manage multidrug-resistant bacterial infections in humans. With limited alternatives, resistance to these antimicrobials is of concern as organisms could potentially spread horizontally rendering treatments ineffective. The aim of this study was to investigate co-resistance to colistin and carbapenems among Escherichia coli isolated from poultry in South Africa. Forty-six E. coli strains obtained from clinical cases of breeder and broiler chickens were used...
July 20, 2023: Foodborne Pathogens and Disease
https://read.qxmd.com/read/37360531/more-than-mcr-canonical-plasmid-and-transposon-encoded-mobilized-colistin-resistance-genes-represent-a-subset-of-phosphoethanolamine-transferases
#16
JOURNAL ARTICLE
Ahmed Gaballa, Martin Wiedmann, Laura M Carroll
Mobilized colistin resistance genes ( mcr ) may confer resistance to the last-resort antimicrobial colistin and can often be transmitted horizontally. mcr encode phosphoethanolamine transferases (PET), which are closely related to chromosomally encoded, intrinsic lipid modification PET (i-PET; e.g., EptA, EptB, CptA). To gain insight into the evolution of mcr within the context of i-PET, we identified 69,814 MCR-like proteins present across 256 bacterial genera (obtained by querying known MCR family representatives against the National Center for Biotechnology Information [NCBI] non-redundant protein database via protein BLAST)...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37342731/emergence-of-multidrug-resistant-non-fermenting-gram-negative-bacilli-in-a-tertiary-care-teaching-hospital-of-central-india-is-colistin-resistance-still-a-distant-threat
#17
JOURNAL ARTICLE
Mitisha Soni, Garima Kapoor, Nagaraj Perumal, Deepti Chaurasia
Purpose Multidrug-resistant (MDR) organisms are being increasingly reported from India. This study aimed to determine the antibiotic susceptibility pattern of non-fermenting Gram-negative bacilli (NF-GNB) isolated from all the clinical samples to estimate the prevalence of MDR MDR NF-GNB and to screen for colistin-resistance genes among all colistin-resistant strains. Materials and methods This prospective study conducted from January 2021 to July 2022 at a tertiary care teaching hospital in central India identified MDR NF-GNB from clinical samples using standard procedures and antimicrobial susceptibility testing conducted as per Clinical Laboratory Standards Institute (CLSI) guidelines...
May 2023: Curēus
https://read.qxmd.com/read/37260682/characterization-of-two-novel-colistin-resistance-gene-mcr-1-variants-originated-from-moraxella-spp
#18
JOURNAL ARTICLE
Yongliang Che, Renjie Wu, Hongjie Li, Longbai Wang, Xuemin Wu, Qiuyong Chen, Rujing Chen, Lunjiang Zhou
This study aimed to characterize two novel mcr-1 variants, mcr-1.35 and mcr-1.36 , which originated from Moraxella spp. that were isolated from diseased pigs in China. The Moraxella spp. carrying novel mcr-1 variants were subjected to whole-genome sequencing (WGS) and phylogenetic analysis based on the 16S rRNA gene. The mcr-1 variants mcr-1.35 and mcr-1.36 were characterized using phylogenetic analysis, a comparison of genetic environments, and protein structure prediction. The WGS indicated that two novel mcr-1 variants were located in the chromosomes of three Moraxella spp...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37247207/prevalence-of-antibiotic-resistant-pathogenic-bacteria-and-level-of-antibiotic-residues-in-hospital-effluents-in-selangor-malaysia-protocol-for-a-cross-sectional-study
#19
JOURNAL ARTICLE
Sophia Karen Bakon, Zuraifah Asrah Mohamad, Mohd Azerulazree Jamilan, Hazimah Hashim, Mohamed Yazid Kuman, Rafiza Shaharudin, Norazah Ahmad, Nor Asiah Muhamad
BACKGROUND: Antimicrobial resistance (AMR) has emerged as a major global public health challenge due to the overuse and misuse of antibiotics for humans and animals. Hospitals are among the major users of antibiotics, thereby having a large contribution to AMR. OBJECTIVE: The aim of this study is to determine the prevalence of antibiotic-resistant pathogenic bacteria and the level of antibiotic residues in the hospital effluents in Selangor, Malaysia. METHODS: A cross-sectional study will be performed in the state of Selangor, Malaysia...
May 29, 2023: JMIR Research Protocols
https://read.qxmd.com/read/37107633/occurrence-of-high-risk-clonal-lineages-st58-st69-st224-and-st410-among-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolated-from-healthy-free-range-chickens-gallus-gallus-domesticus-in-a-rural-region-in-tunisia
#20
JOURNAL ARTICLE
Saloua Benlabidi, Anis Raddaoui, Sana Lengliz, Sarah Cheriet, Paul Hynds, Wafa Achour, Taoufik Ghrairi, Mohamed Salah Abbassi
Antimicrobial-resistant Escherichia coli isolates have emerged in various ecologic compartments and evolved to spread globally. We sought to (1.) investigate the occurrence of ESBL-producing E. coli (ESBL-Ec) in feces from free-range chickens in a rural region and (2.) characterize the genetic background of antimicrobial resistance and the genetic relatedness of collected isolates. Ninety-five feces swabs from free-range chickens associated with two households (House 1/House 2) in a rural region in northern Tunisia were collected...
April 6, 2023: Genes
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