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https://read.qxmd.com/read/30776863/-investigation-of-hearing-loss-and-speech-recognition-ability-of-the-elderly-and-analysis-of-its-high-risk-factors
#1
H L Zhang, X C Gong, X J Hao, J Deng, H Y Liu, D Wu, X X Huo, R Guo
Objective: To investigate the hearing loss and speech disorders in the elderly, to analyze the risk factors of the elderly deafness, as well as to provide reference for the clinical research of the elderly deafness. Methods: From March 2016 to March 2018, 913 elderly people, who were tested for hearing and speech disorders, were examined by a unified questionnaire to investigate the demographic data of the subjects and the related factors of deafness, and the hearing and speech recognition tests were carried out...
February 7, 2019: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/30776862/-study-on-the-relationship-between-age-related-hearing-loss-and-cognitive-impairment
#2
T X Diao, Q H Han, H J Shan, X Q Wu, Y J Lin, Q Li, G H Wang, Y Y Jing, X Ma, M Shen, L S Yu, L Han, Y X Wang
Objective: To investigate the correlation between age-related hearing loss and cognitive impairment. Methods: 201 elderly patients, who were admitted to the Department of Otorhinolaryngology of Peking University People's Hospital from March 1, 2017 to March 31, 2017, were evaluated with hearing screening and the Montreal Cognitive Assessment Scale. Among them, 101 were female and 100 were male, aged 60-90 years old. Taking the cognitive level as the dependent variable, and taking the age, sex, education, occupation, marital status, residence, and average hearing loss (average hearing threshold of 500, 1 000, 2 000, and 4 000 Hz), as well as the length of conscious hearing loss as the independent variables, the single factor analysis and multivariate linear regression analysis were used to screen the main factors affecting the cognitive level of the elderly...
February 7, 2019: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/30776853/the-influence-of-stereoelectronic-effects-on-the-1-j-c-f-spin-spin-coupling-constant-in-fluorinated-heterocyclic-compounds
#3
Josué M Silla, Laize A F Andrade, Matheus P Freitas
The Perlin effect and its analog for fluorinated compounds (the fluorine Perlin-like effect) manifest on one-bond C-H (C-F for the fluorine Perlin-like effect) spin-spin coupling constants (SSCC´s) in six-membered rings. These effects can be useful to probe the stereochemistry (axial or equatorial) of the C-H and C-F bonds, respectively. The origin of these effects has been debatable in the literature as being due to hyperconjugative interactions, dipolar effects and induced current density. Accordingly, a variety of model compounds has been used to probe such effects, since the cyclohexanone carbonyl group and the endocyclic heteroatom lone pairs play different roles on the above-mentioned effects...
February 18, 2019: Magnetic Resonance in Chemistry: MRC
https://read.qxmd.com/read/30776800/characteristics-of-high-cardiovascular-risk-in-1-7-million-chinese-adults
#4
Jiapeng Lu, Yuan Lu, Hao Yang, Wuhan Bilige, Yetong Li, Wade Schulz, Frederick A Masoudi, Harlan M Krumholz
Background: As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited. Objective: To assess the prevalence and treatment of high CVD risk as well as variations in risk across population subgroups. Design: National project of CVD screening and management. Setting: 141 county-level regions in all 31 provinces of China...
February 19, 2019: Annals of Internal Medicine
https://read.qxmd.com/read/30776793/postnatal-nutritional-intakes-and-hyperglycemia-as-determinants-of-blood-pressure-at-6-5-years-of-age-in-children-born-extremely-preterm
#5
Itay Zamir, Elisabeth Stoltz Sjöström, Anna-Karin Edstedt Bonamy, Lilly-Ann Mohlkert, Mikael Norman, Magnus Domellöf
BACKGROUND: Adverse developmental programming by early-life exposures might account for higher blood pressure (BP) in children born extremely preterm. We assessed associations between nutrition, growth and hyperglycemia early in infancy, and BP at 6.5 years of age in children born extremely preterm. METHODS: Data regarding perinatal exposures including nutrition, growth and glycemia status were collected from the Extremely Preterm Infants in Sweden Study (EXPRESS), a population-based cohort including infants born <27 gestational weeks during 2004-2007...
February 18, 2019: Pediatric Research
https://read.qxmd.com/read/30776747/dna-methylation-profiling-implicates-exposure-to-pcbs-in-the-pathogenesis-of-b-cell-chronic-lymphocytic-leukemia
#6
Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali, Rachel S Kelly, Ingvar A Bergdahl, Hannu Kiviranta, Roel C H Vermeulen, Florentin Spaeth, Dennie G A J Hebbels, Jos C S Kleinjans, Theo M C M de Kok, Domenico Palli, Paolo Vineis, Soterios A Kyrtopoulos
OBJECTIVES: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. METHODS: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene. RESULTS: We identified 650 CpG sites whose methylation correlates strongly (FDR < 0...
February 15, 2019: Environment International
https://read.qxmd.com/read/30776742/venous-physiology-predicts-dehydration-in-the-pediatric-population
#7
Patrick C Bonasso, Kevin W Sexton, Md Abul Hayat, Jingxian Wu, Hanna K Jensen, Morten O Jensen, Jeffrey M Burford, Melvin S Dassinger
BACKGROUND: No standard dehydration monitor exists for children. This study attempts to determine the utility of Fast Fourier Transform (FFT) of a peripheral venous pressure (PVP) waveform to predict dehydration. MATERIALS AND METHODS: PVP waveforms were collected from 18 patients. Groups were defined as resuscitated (serum chloride ≥ 100 mmol/L) and hypovolemic (serum chloride < 100 mmol/L). Data were collected on emergency department admission and after a 20 cc/kg fluid bolus...
February 15, 2019: Journal of Surgical Research
https://read.qxmd.com/read/30776732/spastic-dystonia-in-stroke-subjects-prevalence-and-features-of-the-neglected-phenomenon-of-the-upper-motor-neuron-syndrome
#8
Carlo Trompetto, Antonio Currà, Luca Puce, Laura Mori, Carlo Serrati, Francesco Fattapposta, Giovanni Abbruzzese, Lucio Marinelli
OBJECTIVE: Spastic dystonia is one of the positive phenomena of the upper motor neuron syndrome (UMNS). It is characterised by the inability to relax a muscle leading to a spontaneous, although stretch-sensitive, tonic contraction. Although spastic dystonia is a recognized cause of muscle hypertonia, its prevalence among hypertonic muscles of stroke subjects has never been investigated. Differently from spasticity, which is an exaggerated stretch reflex, spastic dystonia is viewed as an efferent phenomenon, due to an abnormal central drive to motoneurons...
February 6, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/30776709/the-first-night-effect-during-polysomnography-and-patients-estimates-of-sleep-quality
#9
Jong-Ho Byun, Keun Tae Kim, Hye-Jin Moon, Gholam K Motamedi, Yong Won Cho
We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48.9%, 30.5% slept as usual, and 20.6% had RFNE. The highest incidences of FNE were seen in OSA, simple snoring, hypersomnia, and in men...
February 6, 2019: Psychiatry Research
https://read.qxmd.com/read/30776659/kiss1-in-regulation-of-metastasis-and-response-to-antitumor-drugs
#10
REVIEW
Cristina Corno, Paola Perego
Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure. Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental efforts revealed that the metastatic cascade is a complex process that involves multiple positive and negative regulators. In this respect, several metastasis suppressor genes have been described. Here, we review the role of the metastasis suppressor KiSS1 in regulation of metastasis and in response to antitumor agents. Physiologically, KiSS1 plays a key role in the activation of the hypothalamic-pituitary-gonadal axis regulating puberty and reproductive functions...
February 11, 2019: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://read.qxmd.com/read/30776644/cyclosporin-a-inhibits-differentiation-and-activation-of-monocytic-cells-induced-by-27-hydroxycholesterol
#11
Yonghae Son, Jeongyoon Choi, Boyoung Kim, Young Chul Park, Seong-Kug Eo, Hyok-Rae Cho, Sun Sik Bae, Chi Dae Kim, Koanhoi Kim
27-Hydroxycholesterol (27OHChol) is a bioactive molecule that induces monocytic cell activation and differentiation and thereby participates in immune responses under hypercholesterolemic condition. However, it is unknown whether cyclosporin A (CsA), an immunosuppressant, affects biological effects of 27OHChol. In this study, we investigated whether CsA alters 27OHChol-induced cellular and molecular responses using the human monocyte/macrophage THP-1 cells. Treatment of the cells with CsA resulted in decreased expression of the mDC-specific markers (CD80, CD83 and CD88) induced by 27OHChol...
February 15, 2019: International Immunopharmacology
https://read.qxmd.com/read/30776642/anti-hyperalgesia-effect-of-nanchelating-based-nano-particle-rac1-can-be-mediated-via-liver-hepcidin-expression-modulation-during-persistent-inflammation
#12
Vida Nazemian, Somayeh Kalanaky, Homa Manaheji, Etrat Houshmandi, Mola Mohammadi, Jalal Zaringhalam, Somayeh Mirjafai
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder accompanied with hyperalgesia, edema and pain. At least 30% of the patients failed to respond to the available treatments and medications, which yet have a lot of serious adverse effects on patients. So, using novel technologies to produce more efficient medications is needed. According to the role of iron manipulation in inflammatory process, we have synthetized RAc1 nano particle, which contains zinc and has iron chelating property...
February 15, 2019: International Immunopharmacology
https://read.qxmd.com/read/30776608/long-term-treatment-with-kefir-probiotics-ameliorates-cardiac-function-in-spontaneously-hypertensive-rats
#13
Mirian A Silva-Cutini, Simone A Almeida, Andrews M Nascimento, Gláucia R Abreu, Nazaré S Bissoli, Dominik Lenz, Denise C Endringer, Girlandia A Brasil, Ewelyne M Lima, Vinicia C Biancardi, Tadeu U Andrade
This work evaluated the effects of long-term kefir treatment in cardiac function (cardiac contractility and calcium-handling proteins) and the central nervous system (CNS) control of the sympathetic signaling in spontaneously hypertensive rats (SHR). Male normotensive rats [Wistar Kyoto rats (WKYs)] and SHRs were divided into three groups: WKYs and SHRs treated with vehicle, and SHRs treated with milk fermented by the grains of kefir (5%; SHR-Kefir; oral gavage, 0.3 ml/100 g daily/9 weeks). At the end of treatment, mean arterial pressure (MAP) and heart rate (HR) were measured by direct arterial catheterization...
January 18, 2019: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/30776574/maternal-high-fat-diet-impairs-leptin-signaling-and-up-regulates-type-1-cannabinoid-receptor-with-sex-specific-epigenetic-changes-in-the-hypothalamus-of-newborn-rats
#14
Mariana M Almeida, Camilla P Dias-Rocha, Clara F Reis-Gomes, Haimei Wang, Georgia C Atella, Aline Cordeiro, Carmen C Pazos-Moura, Lisa Joss-Moore, Isis H Trevenzoli
Maternal nutritional imbalances trigger developmental adaptations involving early epigenetic mechanisms associated with adult chronic disease. Maternal high-fat (HF) diet promotes obesity and hypothalamic leptin resistance in male rat offspring at weaning and adulthood. Leptin resistance is associated with over activation of the endocannabinoid system (ECS). The ECS mainly consists of endocannabinoids derived from n-6 fatty acids and cannabinoid receptors (CB1 coded by Cnr1 and CB2 coded by Cnr2). The CB1 activation in hypothalamus stimulates feeding and appetite for fat while CB2 activation seems to play an immunomodulatory role...
February 8, 2019: Psychoneuroendocrinology
https://read.qxmd.com/read/30776565/in-situ-overhauser-enhanced-nuclear-magnetic-resonance-at-less-than-1-%C3%AE-t-using-an-atomic-magnetometer
#15
Hyun Joon Lee, Seong-Joo Lee, Jeong Hyun Shim, Han Seb Moon, Kiwoong Kim
The development of atomic magnetometers has led to nuclear magnetic resonance (NMR) in zero and ultralow magnetic fields without using cryogenic sensors. However, in-situ detection, meaning that a sample locates in the detection space beside a vapor cell, has been conducted only with parahydrogen-induced polarization. Other hyperpolarization techniques remain unexplored yet. In this work, we demonstrate that Overhauser dynamic nuclear polarization allows in-situ NMR detection with an atomic magnetometer at less than 1 μT...
February 10, 2019: Journal of Magnetic Resonance
https://read.qxmd.com/read/30776524/low-cross-reactivity-between-cisplatin-and-other-platinum-salts
#16
Justine Pasteur, Laure Favier, Corinne Pernot, Mathieu Guerriaud, Charlotte Bernigaud, Côme Lepage, Jean-Louis Jouve, Nicolas Isambert, Evelyne Collet
BACKGROUND: Hypersensitivity reactions to platinum salts (PS) (cisplatin (CI), carboplatin (CA) and oxaliplatin (OX)) can be severe and their incidence is increasing due to their widespread use in cancer treatment. OBJECTIVE: To determine the rate of cross-reactivity between platinum salts and whether CI can be administered without prior allergy testing in patients with a history of CA or OX hypersensitivity. METHODS: From September 2002 to April 2016, patients with suspected immediate PS hypersensitivity were tested and cross-reactivity between the three PS was evaluated...
February 15, 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30776511/subtotal-parathyroidectomy-vs-total-parathyroidectomy-with-autotransplantation-for-secondary-hyperparathyroidism-in-dialysis-patients-short-and-long-term-outcomes
#17
Polina V Zmijewski, Jonathan A Staloff, Madeline J Wozniak, Peter J Mazzaglia
BACKGROUND: Two operations are performed for management of secondary hyperparathyroidism, subtotal parathyroidectomy (SPTX) and total parathyroidectomy with autotransplantation (TPTX- AT). There is no consensus among endocrine surgeons regarding which operation is the preferred treatment. This study compares the short and long term outcomes of SPTX and TPTX-AT for dialysis patients with secondary hyperparathyroidism. STUDY DESIGN: This is a retrospective review of 46 dialysis patients undergoing parathyroidectomy from 2006- 2017 at a 719 bed tertiary care hospital...
February 15, 2019: Journal of the American College of Surgeons
https://read.qxmd.com/read/30776495/race-ethnicity-does-not-moderate-the-relationship-between-adverse-life-experiences-and-temporal-summation-of-the-nociceptive-flexion-reflex-and-pain-results-from-the-oklahoma-study-of-native-american-pain-risk-ok-snap
#18
Cassandra A Sturycz, Natalie Hellman, Michael F Payne, Bethany L Kuhn, Burkhart Hahn, Edward W Lannon, Shreela Palit, Yvette M Güereca, Tyler A Toledo, Joanna O Shadlow, Jamie L Rhudy
Adverse life experiences (ALEs) are associated with hyperalgesia and chronic pain, but the underlying mechanisms are poorly understood. One potential mechanism is hyperexcitability of spinal neurons (i.e., central sensitization). Given that Native Americans (NA) are more likely to have ALEs, and have a higher prevalence of chronic pain, the relationship between ALEs and spinal hyperexcitability might contribute to their pain risk. The present study assessed temporal summation of the nociceptive flexion reflex (TS-NFR; correlate of spinal hyperexcitability) and pain (TS-Pain) in 246 healthy, pain-free non-Hispanic whites (NHW) and Native Americans (NA)...
February 15, 2019: Journal of Pain: Official Journal of the American Pain Society
https://read.qxmd.com/read/30776493/pi3k-akt-signaling-pathway-may-be-involved-in-mcp-1-induced-p2x4r-expression-in-cultured-microglia-and-cancer-induced-bone-pain-rats
#19
Ying Yan, Yongxin Liang, Tao Ding, Haichen Chu
P2X4 receptor (P2X4R), a subtype of P2 purinergic receptors, is an ATP-gated receptor through which activity of spinal microglia instigates pain hypersensitivity in various pain conditions. Accumulating evidence indicates that monocyte chemoattractant protein-1 (MCP-1) plays an important role in chronic pain facilitation, and it could stimulate microglia activation and involve in regulating P2X4R expression. However, the mechanism of MCP-1 in regulating the expression of P2X4R in microglia is poorly understood, and whether MCP-1 can aggravate pain via up-regulating spinal P2X4R expression in Cancer-induced Bone Pain (CIBP) remains unclear...
February 15, 2019: Neuroscience Letters
https://read.qxmd.com/read/30776465/high-throughput-transcriptome-seq-and-small-rna-seq-reveal-novel-functional-genes-and-micrornas-for-early-embryonic-arrest-in-humans
#20
Wenmei Yang, Zhaoyi Lu, Zhifu Zhi, Liling Liu, Lingjie Deng, Xiaoli Jiang, Lihong Pang
Early Embryonic Arrest (EEA) is one of the major causes of female infertility. Genetic factors including specific genes and miRNAs may play pivotal roles on EEA. However, it is not well defined what genes and micro RNAs participate the pathophysiological alterations of EEA. In this work, we compared the Transcriptome -Seq and microRNA profiles from three pairs of villi (three EEA patients and three normal pregnancy, NP). We first confirmed the array data by qPCR with ten randomly selected differentially expressed genes and ten differentially expressed miRNAs in villi from 20 EEA and 20 NP controls...
February 15, 2019: Gene
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