Shuyi Zhong, Tiffany W Y Ng, Danuta M Skowronski, A Danielle Iuliano, Nancy H L Leung, Ranawaka A P M Perera, Faith Ho, Vicky J Fang, Yat Hung Tam, Dennis K M Ip, Fiona G Havers, Alicia M Fry, Eduardo Aziz-Baumgartner, Ian G Barr, Malik Peiris, Mark G Thompson, Benjamin J Cowling
BACKGROUND: Annual influenza vaccination is recommended for older adults but repeated vaccination with standard-dose influenza vaccine has been linked to reduced immunogenicity and effectiveness, especially against A(H3N2) viruses. METHODS: Community-dwelling Hong Kong adults aged 65-82 years were randomly allocated to receive 2017/18 standard-dose quadrivalent, MF59-adjuvanted trivalent, high-dose trivalent, and recombinant-HA quadrivalent vaccination. Antibody response to unchanged A(H3N2) vaccine antigen was compared among participants with and without self-reported prior year (2016/17) standard-dose vaccination...
November 10, 2023: Journal of Infectious Diseases