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Influenza 2017-18

Johannes Westhofen, Marie-Therese Puth, Henrike Steudel, Eva Münster, Klaus Weckbecker
OBJECTIVE: For the first time, the level of knowledge and attitude towards vaccinations in general as well as seasonal influenza vaccination of midwife trainees in Germany was assessed. METHODS: The cross-sectional study was conducted between May and July 2017. The written standardized questionnaire was completed by all midwife-trainees in North Rhine-Westphalia. The statistical analysis included frequency tables and multiple logistic regression models. RESULTS: All of the 10 Schools for Midwifery in North Rhine-Westphalia participated in the survey and 315 questionnaires (response rate: 95...
February 20, 2019: Das Gesundheitswesen
Yuemei Hu, Kai Chu, Nathalie Lavis, Xiaoling Li, Bill Liang, Shuzhen Liu, Ming Shao, Jean-Denis Shu, Cynthia Tabar, Sandrine Samson
Seasonal influenza causes substantial morbidity and mortality in China, which largely results from limited vaccine accessibility and poor vaccination coverage. Since 2013, Sanofi Pasteur's facilities in Shenzhen, China have produced a trivalent inactivated influenza vaccine (Shz-IIV3) for each influenza season according to Chinese pharmacopeia requirements. However, the immunogenicity of Shz-IIV3 has not been compared to existing Chinese trivalent inactivated influenza vaccines (IIV3s). Here, we describe the results of a phase IV, observer-blind, randomized study to evaluate whether the immunogenicity of Shz-IIV3 was non-inferior to a comparator IIV3 (Hualan Biological Engineering Inc) also manufactured and licensed in China...
February 19, 2019: Human Vaccines & Immunotherapeutics
Helen Ding, Katherine E Kahn, Carla L Black, Alissa O'Halloran, Peng-Jun Lu, Walter W Williams
INTRODUCTION: Pregnant women are at increased risk for severe illness from influenza and influenza-related complications. Vaccinating pregnant women is the primary strategy to protect them and their infants from influenza. This study aims to assess influenza vaccination coverage during three influenza seasons (2012-2015) from a national probability-based sampling survey and evaluate potential factors that influence vaccination uptake among pregnant women. METHODS: Data from the 2012 through 2015 National Health Interview Surveys were analyzed in 2017...
February 15, 2019: American Journal of Preventive Medicine
Joshua D Doyle, Jessie R Chung, Sara S Kim, Manjusha Gaglani, Chandni Raiyani, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Arnold S Monto, Emily T Martin, Edward A Belongia, Huong Q McLean, Angie Foust, Wendy Sessions, LaShondra Berman, Rebecca J Garten, John R Barnes, David E Wentworth, Alicia M Fry, Manish M Patel, Brendan Flannery
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months ( Effectiveness of seasonal influenza vaccine varies by season. During each influenza season since 2004-05, CDC has estimated the effectiveness of seasonal influenza vaccine to prevent laboratory-confirmed influenza associated with medically attended acute respiratory illness (ARI). This interim report uses data from 3,254 children and adults enrolled in the U...
February 15, 2019: MMWR. Morbidity and Mortality Weekly Report
Michelle M Hughes, Joshua D Doyle, Keegan McCaffrey, Melissa McMahon, Melanie Spencer, Karen Martin, Gregg M Reed, Anna E Carmack, Shikha Garg, Melissa Rolfes, Carrie Reed, Matthew Biggerstaff
No abstract text is available yet for this article.
February 15, 2019: MMWR. Morbidity and Mortality Weekly Report
Chiharu Kawakami, Seiya Yamayoshi, Miki Akimoto, Kazuya Nakamura, Hideka Miura, Seiichiro Fujisaki, David J Pattinson, Kohei Shimizu, Hiroki Ozawa, Tomoko Momoki, Miwako Saikusa, Atsuhiro Yasuhara, Shuzo Usuku, Ichiro Okubo, Takahiro Toyozawa, Shigeo Sugita, Derek J Smith, Shinji Watanabe, Yoshihiro Kawaoka
BACKGROUND: Influenza A(H3N2) virus rapidly evolves to evade human immune responses, resulting in changes in the antigenicity of haemagglutinin (HA). Therefore, continuous genetic and antigenic analyses of A(H3N2) virus are necessary to detect antigenic mutants as quickly as possible. AIM: We attempted to phylogenetically and antigenically capture the epidemic trend of A(H3N2) virus infection in Yokohama, Japan during the 2016/17 and 2017/18 influenza seasons. METHODS: We determined the HA sequences of A(H3N2) viruses detected in Yokohama, Japan during the 2016/17 and 2017/18 influenza seasons to identify amino acid substitutions and the loss or gain of potential N-glycosylation sites in HA, both of which potentially affect the antigenicity of HA...
February 2019: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Hannah E Segaloff, Maya Leventer-Roberts, Dan Riesel, Ryan E Malosh, Becca S Feldman, Yonat Shemer-Avni, Calanit Key, Arnold S Monto, Emily T Martin, Mark A Katz
Background: Influenza vaccine effectiveness (VE) varies by season, circulating influenza strain, age, and geographic location. There have been few studies of influenza VE among hospitalized children, particularly in Europe and the Middle East. Methods: We estimated VE against influenza hospitalization among children six months to eight years at Clalit Health Services hospitals in Israel in the 2015-16, 2016-17, and 2017-18 influenza seasons using the test-negative design...
February 11, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jeffrey Cheng, Congwen Zhao, Hui-Jie Lee
OBJECTIVE: Quantify the rates influenza vaccination and RSV prophylaxis for children with airway stenosis and/or other disorders and assess impact on resource utilization. METHODS: This was a retrospective study with data extracted from Duke Enterprise Data Unified Content Explorer (DEDUCE) between January 1, 2006 and December 1, 2017. Children aged 18 years and younger with at least one diagnosis code for airway stenosis and/or disorders were included. The index date was defined as the first date of airway stenosis/disorders diagnosis...
February 6, 2019: International Journal of Pediatric Otorhinolaryngology
Jesse E Harris, Punit J Shah, Vijay Korimilli, Htut Win
Background: With the increased number of influenza cases observed during the 2017 - 2018 season, patients may be at a greater risk of cardiac related complications as a sequela of viral illness. We described the frequency of troponin elevations in patients with influenza infection during the 2017 - 2018 influenza season. Methods: This was a retrospective, single-center observational study. All patients aged 18 years or older and had laboratory confirmed influenza viral infection were included in the study...
March 2019: IJC Heart & Vasculature
Melahat Melek Oguz
Children are at higher risk of influenza complications. The goals of this article are, estimating influenza vaccination coverage of Health Care Workers (HCWs) in tertiary children hospital, evaluating attitudes and practices of HCWs and evaluating whether HCWs vaccination uptake improved with onsite vaccination campaign. This was a before-after trial, which was carried out in a tertiary children hospital at 2017-2018 influenza season. The vaccination team visited all participants and collected information about previous vaccination uptake, attitudes and beliefs of HCWs by means of an anonymous questionnaire...
February 8, 2019: Human Vaccines & Immunotherapeutics
Marianne E Yee, Nitya Bakshi, Sara H Graciaa, Peter A Lane, Robert C Jerris, Yun F Wang, Inci Yildirim
BACKGROUND: Children with sickle cell disease (SCD) are at increased risk for invasive infection with encapsulated bacteria. Antibiotic prophylaxis and immunizations against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) have decreased the overall incidence of invasive infections and have shifted distribution of serotypes causing disease toward those not covered by immunizations. We sought to determine the current incidence of invasive H. influenzae infections in children with SCD and to describe the clinical features and management of these infections...
February 5, 2019: Pediatric Blood & Cancer
Naïm Ouldali, Corinne Levy, Philippe Minodier, Laurence Morin, Sandra Biscardi, Marie Aurel, François Dubos, Marie Alliette Dommergues, Ellia Mezgueldi, Karine Levieux, Fouad Madhi, Laure Hees, Irina Craiu, Chrystèle Gras Le Guen, Elise Launay, Ferielle Zenkhri, Mathie Lorrot, Yves Gillet, Stéphane Béchet, Isabelle Hau, Alain Martinot, Emmanuelle Varon, François Angoulvant, Robert Cohen
Importance: In several countries, 5 years after 13-valent pneumococcal conjugate vaccine (PCV13) implementation, serotype replacement has been reported for invasive pneumococcal disease, which raises concerns about the long-term outcome of PCV13 implementation. The long-term effect of vaccination on community-acquired pneumonia (CAP) remains unknown. Objective: To assess the long-term outcome of PCV13 implementation on CAP in children. Design, Setting, and Participants: This quasi-experimental, population-based, interrupted time-series analysis was based on a prospective multicenter study conducted from June 2009 to May 2017 in 8 French pediatric emergency departments...
February 4, 2019: JAMA Pediatrics
O N Titova, M A Petrova, N A Shklyarevich, N A Kuzubova, A L Aleksandrov, L F Kovaleva, A G Kozyrev, V D Kulikov
AIM: To assess the efficacy and safety of Arbidol in the influenza and ARVI preventing in patients with asthma and chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: This study was an open label and prospective during epidemic period of 2016-2017 years. 100 outpatients aged 18 to 80 years with verified asthma and/or COPD, were enrolled to therapy group, and received oral umifenovir 200 mg once daily for 14 days and then 200 mg twice a week for 3 weeks...
August 27, 2018: Terapevticheskiĭ Arkhiv
Sultan Aydin Köker, Bengü Demirağ, Neryal Tahta, Nuri Bayram, Yeşim Oymak, Tuba H Karapinar, Salih Gözmen, Mine Düzgöl, Hazer Erçan Bozyer, Canan Vergin, İlker Devrim
BACKGROUND: Acute viral respiratory infections are common causes of febrile episodes in children. There are still limited data about distribution of acute viral respiratory infections in children with cancer. OBJECTIVE: The first aim of this study was to evaluate the viral etiology and seasonality of acute viral respiratory infection in pediatric patients with cancer in a 3-year study. Our second aim was to evaluate the impact of viral infections on delaying the patients' chemotherapy or radiotherapy...
January 25, 2019: Journal of Pediatric Hematology/oncology
Angela Gentile, María Florencia Lucion, María Del Valle Juarez, María Soledad Areso, Julia Bakir, Mariana Viegas, Alicia Mistchenko
BACKGROUND: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infection (ALRI) in children. We aimed to describe the clinical-epidemiological pattern and risk factors for mortality associated with RSV infection. METHODS: A prospective, cross-sectional study of ALRI in children admitted to the Children's Hospital among 2000-2017. Viral diagnosis was made by fluorescent antibody techniques or real time-PCR. We compared clinical-epidemiological characteristics of RSV infection in non-fatal versus fatal cases...
January 10, 2019: Pediatric Infectious Disease Journal
Luca Marchetti, Claudia Gandolfo, Enivarco Maglioni, Martina Contorni, Fabio Arena, Maria Grazia Cusi
Seasonal influenza A (IA) and B (IB) viruses co-circulate every year, causing respiratory tract infections in individuals of all ages. Recently, the association between laboratory-confirmed influenza infection and acute myocardial infarction has been clearly demonstrated. However, most of the reported cases of fulminant myocarditis had been associated with influenza virus type A infection. Here we report the case of a 44 y/o man who experienced myocarditis with cardiogenic shock [requiring percutaneous extracorporeal membrane oxygenation (ECMO) support], following influenza B virus infection, which circulated widely in Italy in 2017-18...
January 21, 2019: New Microbiologica
Enrique Gutiérrez-González, José M Cantero-Escribano, Lidia Redondo-Bravo, Isabel San Juan-Sanz, Ana Robustillo-Rodela, Emilio Cendejas-Bueno, Influenza Working Group
BACKGROUND: Identifying risk factors for complications or death associated with influenza remains crucial to target preventive interventions. Scores like the Charlson comorbidity index (CCI) may be of help. The aims of this study were to assess the effect of vaccination and comorbidities on severe influenza disease and influenza-related death among hospitalized patients during the season 2016/17; and to evaluate the validity of the CCI to predict death among these patients. METHODS: Data from adult patients (≥18 years old) with influenza infection admitted to La Paz University Hospital (LPUH) were recorded during the 2016/17 epidemic...
January 19, 2019: Journal of Infection and Public Health
Larisa V Gubareva, Vasiliy P Mishin, Mira C Patel, Anton Chesnokov, Ha T Nguyen, Juan De La Cruz, Sarah Spencer, Angela P Campbell, Mallory Sinner, Heather Reid, Rebecca Garten, Jackie M Katz, Alicia M Fry, John Barnes, David E Wentworth
The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4-10-fold reduced susceptibility to baloxavir...
January 2019: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Awad A Shehata, Mahmoud E Sedeik, Ahmed R Elbestawy, Mohamed A Zain El-Abideen, Hytham H Ibrahim, Walid H Kilany, Ahmed Ali
A total of 50 poultry farms of commercial broilers (N = 39) and commercial layers (N = 11) suffered from respiratory problems and mortality during the period from January 2016 to December 2017 were investigated. Also, samples were collected from quail (N = 4), Bluebird (Sialis, N = 1), and Greenfinch (Chloris chloris, N = 1) for analysis. Respiratory viral pathogens were screened by PCR and positive samples were subjected to virus isolation and genetic identification. Antigenic relatedness of isolated avian influenza (AI) H5 subtype was evaluated using cross-hemagglutination inhibition...
January 22, 2019: Poultry Science
Linna Huang, Nannan Zhang, Xu Huang, Shuyu Xiong, Yingying Feng, Yi Zhang, Min Li, Qingyuan Zhan
INTRODUCTION: There has been a rapid increase in the number of influenza and invasive pulmonary aspergillosis (IPA) co-infection. OBJECTIVES: To explore the risk factors and predictors of a poor prognosis in influenza and IPA co-infection. METHODS: We included patients with confirmed influenza during the 2017 to 2018 influenza season and cases of influenza and IPA co-infection in the literature. RESULTS: A total of 64 patients with influenza infection were admitted to ICU...
January 20, 2019: Clinical Respiratory Journal
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