keyword
https://read.qxmd.com/read/38328937/p53-acetylation-exerts-critical-roles-in-pressure-overload-induced-coronary-microvascular-dysfunction-and-heart-failure-in-mice
#1
JOURNAL ARTICLE
Xiaochen He, Aubrey C Cantrell, Quinesha A Williams, Wei Gu, Yingjie Chen, Jian-Xiong Chen, Heng Zeng
BACKGROUND: Coronary microvascular dysfunction (CMD) has been shown to contribute to cardiac hypertrophy and heart failure (HF) with preserved ejection fraction. At this point, there are no proven treatments for CMD. METHODS: We have shown that histone acetylation may play a critical role in the regulation of CMD. By using a mouse model that replaces lysine with arginine at residues K98, K117, K161, and K162R of p53 (p534KR ), preventing acetylation at these sites, we test the hypothesis that acetylation-deficient p534KR could improve CMD and prevent the progression of hypertensive cardiac hypertrophy and HF...
February 8, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/37967006/p53-responsive-cmbl-reprograms-glucose-metabolism-and-suppresses-cancer-development-by-destabilizing-phosphofructokinase-pfkp
#2
JOURNAL ARTICLE
Yingdan Huang, Chen Xiong, Chunmeng Wang, Jun Deng, Zhixiang Zuo, Huijing Wu, Jianping Xiong, Xiaohua Wu, Hua Lu, Qian Hao, Xiang Zhou
Aerobic glycolysis is critical for cancer progression and can be exploited in cancer therapy. Here, we report that the human carboxymethylenebutenolidase homolog (carboxymethylenebutenolidase-like [CMBL]) acts as a tumor suppressor by reprogramming glycolysis in colorectal cancer (CRC). The anti-cancer action of CMBL is mediated through its interactions with the E3 ubiquitin ligase TRIM25 and the glycolytic enzyme phosphofructokinase-1 platelet type (PFKP). Ectopic CMBL enhances TRIM25 binding to PFKP, leading to the ubiquitination and proteasomal degradation of PFKP...
November 14, 2023: Cell Reports
https://read.qxmd.com/read/36810848/the-klf7-pfkl-acadl-axis-modulates-cardiac-metabolic-remodelling-during-cardiac-hypertrophy-in-male-mice
#3
JOURNAL ARTICLE
Cao Wang, Shupei Qiao, Yufang Zhao, Hui Tian, Wei Yan, Xiaolu Hou, Ruiqi Wang, Bosong Zhang, Chaofan Yang, Fuxing Zhu, Yanwen Jiao, Jiaming Jin, Yue Chen, Weiming Tian
The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close correlation between glycolysis and fatty acid oxidation and underlying mechanism by which causes cardiac pathological remodelling remain unclear. We confirm that KLF7 simultaneously targets the rate-limiting enzyme of glycolysis, phosphofructokinase-1, liver, and long-chain acyl-CoA dehydrogenase, a key enzyme for fatty acid oxidation...
February 21, 2023: Nature Communications
https://read.qxmd.com/read/36170569/effects-of-endurance-training-on-metabolic-enzyme-activity-and-transporter-proteins-in-skeletal-muscle-of-ovariectomized-mice
#4
JOURNAL ARTICLE
Kenya Takahashi, Y U Kitaoka, Yutaka Matsunaga, Hideo Hatta
PURPOSE: Estrogen deficiency or insufficiency can occur under several conditions, leading to negative health outcomes. To establish an effective countermeasure against estrogen loss, we investigated the effects of endurance training on ovariectomy (OVX)-induced metabolic disturbances. METHODS: Female Institute of Cancer Research mice underwent OVX or sham operations. On day 7 of recovery, the mice were randomized to remain either sedentary or undergo 5 wk of treadmill running (15-20 m·min -1 , 60 min, 5 d·wk -1 )...
February 1, 2023: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/35661764/proteomics-of-restenosis-model-in-ldlr-deficient-hamsters-coupled-with-the-proliferative-rat-vascular-smooth-muscle-cells-reveals-a-new-mechanism-of-vascular-remodeling-diseases
#5
JOURNAL ARTICLE
Zhao-Kun Hu, Jiang-Ling Niu, Jia-Jie Lin, Yu Guo, Li-Hua Dong
A major pathological mechanism involved in vascular remodeling diseases is the proliferation and migration of vascular smooth muscle cells. The lipid distribution of golden hamsters is similar to that of humans, which makes them an excellent study model for studying the pathogenesis and molecular characteristics of vascular remodeling diseases. We performed proteomic analysis on Sprague Dawley rat VSMCs (rVSMCs) and restenosis hamsters with low-density lipoprotein receptor (LDLR) deficiency as part of this study...
July 30, 2022: Journal of Proteomics
https://read.qxmd.com/read/35530161/targeting-pfkl-with-penfluridol-inhibits-glycolysis-and-suppresses-esophageal-cancer-tumorigenesis-in-an-ampk-foxo3a-bim-dependent-manner
#6
JOURNAL ARTICLE
Cancan Zheng, Xiaomei Yu, Yiyao Liang, Yidong Zhu, Yan He, Long Liao, Dingkang Wang, Yanming Yang, Xingfeng Yin, Ang Li, Qingyu He, Bin Li
As one of the hallmarks of cancer, metabolic reprogramming leads to cancer progression, and targeting glycolytic enzymes could be useful strategies for cancer therapy. By screening a small molecule library consisting of 1320 FDA-approved drugs, we found that penfluridol, an antipsychotic drug used to treat schizophrenia, could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma (ESCC). Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol...
March 2022: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/35459213/gc-ms-based-13-c-metabolic-flux-analysis-resolves-the-parallel-and-cyclic-photomixotrophic-metabolism-of-synechocystis-sp-pcc-6803-and-selected-deletion-mutants-including-the-entner-doudoroff-and-phosphoketolase-pathways
#7
JOURNAL ARTICLE
Dennis Schulze, Michael Kohlstedt, Judith Becker, Edern Cahoreau, Lindsay Peyriga, Alexander Makowka, Sarah Hildebrandt, Kirstin Gutekunst, Jean-Charles Portais, Christoph Wittmann
BACKGROUND: Cyanobacteria receive huge interest as green catalysts. While exploiting energy from sunlight, they co-utilize sugar and CO2 . This photomixotrophic mode enables fast growth and high cell densities, opening perspectives for sustainable biomanufacturing. The model cyanobacterium Synechocystis sp. PCC 6803 possesses a complex architecture of glycolytic routes for glucose breakdown that are intertwined with the CO2 -fixing Calvin-Benson-Bassham (CBB) cycle. To date, the contribution of these pathways to photomixotrophic metabolism has remained unclear...
April 22, 2022: Microbial Cell Factories
https://read.qxmd.com/read/34985130/hereditary-myopathies-associated-with-hematological-abnormalities
#8
REVIEW
Grayson Beecher, Mark D Fleming, Teerin Liewluck
The diagnostic evaluation of a patient with suspected hereditary muscle disease can be challenging. Clinicians rely largely on clinical history and examination features, with additional serological, electrodiagnostic, radiologic, histopathologic, and genetic investigations assisting in definitive diagnosis. Hematological testing is inexpensive and widely available, but frequently overlooked in the hereditary myopathy evaluation. Hematological abnormalities are infrequently encountered in this setting; however, their presence provides a valuable clue, helps refine the differential diagnosis, tailors further investigation, and assists interpretation of variants of uncertain significance...
April 2022: Muscle & Nerve
https://read.qxmd.com/read/34903775/nutrient-metabolism-in-the-liver-and-muscle-of-juvenile-blunt-snout-bream-megalobrama-amblycephala-in-response-to-dietary-methionine-levels
#9
JOURNAL ARTICLE
Ke Ji, Hualiang Liang, Mingchun Ren, Xianping Ge, Liangkun Pan, Heng Yu
A 75-day rearing trial was designed to study the response of juvenile Megalobrama amblycephala to dietary methionine (Met) levels. Three practical diets with graded Met levels (0.40%, 0.84% and 1.28% dry matter) were prepared to feed the juvenile fish. The results showed that the 0.84% Met diet significantly improved the growth compared with 0.40% diets. Compared with 0.84% and 1.28% Met, 0.40% Met significantly increased the hepatic lipid content, while decreasing the muscular lipid and glycogen contents. 0...
December 13, 2021: Scientific Reports
https://read.qxmd.com/read/34880332/post-translational-modifications-by-sirt3-de-2-hydroxyisobutyrylase-activity-regulate-glycolysis-and-enable-nephrogenesis
#10
JOURNAL ARTICLE
Luca Perico, Marina Morigi, Anna Pezzotta, Daniela Corna, Valerio Brizi, Sara Conti, Cristina Zanchi, Fabio Sangalli, Piera Trionfini, Sara Buttò, Christodoulos Xinaris, Susanna Tomasoni, Carlamaria Zoja, Giuseppe Remuzzi, Ariela Benigni, Barbara Imberti
Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose self-renewal and differentiation require a relatively repressed chromatin state. More recently, NAD+ -dependent deacetylase sirtuins (SIRTs) have emerged as possible regulators that link epigenetic processes to the metabolism. Here, we discovered a novel role for the NAD+ -dependent deacylase SIRT3 in kidney development...
December 8, 2021: Scientific Reports
https://read.qxmd.com/read/34627331/confounding-factors-in-the-diagnosis-and-clinical-course-of-rare-congenital-hemolytic-anemias
#11
REVIEW
Bruno Fattizzo, Juri Alessandro Giannotta, Nicola Cecchi, Wilma Barcellini
Congenital hemolytic anemias (CHAs) comprise defects of the erythrocyte membrane proteins and of red blood cell enzymes metabolism, along with alterations of erythropoiesis. These rare and heterogeneous conditions may generate several difficulties from the diagnostic point of view. Membrane defects include hereditary spherocytosis and elliptocytosis, and the group of hereditary stomatocytosis; glucose-6-phosphate dehydrogenase and pyruvate kinase, are the most common enzyme deficiencies. Among ultra-rare forms, it is worth reminding other enzyme defects (glucosephosphate isomerase, phosphofructokinase, adenylate kinase, triosephosphate isomerase, phosphoglycerate kinase, hexokinase, and pyrimidine 5'-nucleotidase), and congenital dyserythropoietic anemias...
October 9, 2021: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/34487754/in-vivo-deep-network-tracing-reveals-phosphofructokinase-mediated-coordination-of-biosynthetic-pathway-activity-in-the-myocardium
#12
JOURNAL ARTICLE
Kyle L Fulghum, Timothy N Audam, Pawel K Lorkiewicz, Yuting Zheng, Michael Merchant, Timothy D Cummins, William L Dean, Teresa A Cassel, Teresa W M Fan, Bradford G Hill
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the fate of glucose-derived carbon in murine hearts in vivo. PFK1 activity was regulated by cardiac-specific overexpression of kinase- or phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase transgenes in mice (termed GlycoLo or GlycoHi mice, respectively)...
January 2022: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/34432198/pfkfb3-gene-deletion-in-endothelial-cells-inhibits-intraplaque-angiogenesis-and-lesion-formation-in-a-murine-model-of-venous-bypass-grafting
#13
JOURNAL ARTICLE
Paola Perrotta, Margreet R de Vries, Bart Peeters, Pieter-Jan Guns, Guido R Y De Meyer, Paul H A Quax, Wim Martinet
Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP) angiogenesis, which promotes atherogenesis and formation of unstable plaques. Graft neovessels are mainly composed of endothelial cells (ECs) that largely depend on glycolysis for migration and proliferation. In the present study, we aimed to investigate whether loss of the glycolytic flux enzyme phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) in ECs inhibits IP angiogenesis and as such prevents unstable plaque formation...
February 2022: Angiogenesis
https://read.qxmd.com/read/34399701/genome-wide-survey-of-the-phosphofructokinase-family-in-cassava-and-functional-characterization-in-response-to-oxygen-deficient-stress
#14
JOURNAL ARTICLE
Haiyan Wang, Pingjuan Zhao, Xu Shen, Zhiqiang Xia, Xincheng Zhou, Xin Chen, Cheng Lu, WenquanWang
BACKGROUND: Glycolytic pathway is common in all plant organs, especially in oxygen-deficient tissues. Phosphofructokinase (PFK) is a rate-limiting enzyme in the glycolytic pathway and catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Cassava (M. esculenta) root is a huge storage organ with low amount of oxygen. However, less is known about the functions of PFK from M. esculenta (MePFK). We conducted a systematic analysis of MePFK genes to explore the function of the MePFK gene family under hypoxic stress...
August 16, 2021: BMC Plant Biology
https://read.qxmd.com/read/34204849/neonatal-vitamin-c-and-cysteine-deficiencies-program-adult-hepatic-glutathione-and-specific-activities-of-glucokinase-phosphofructokinase-and-acetyl-coa-carboxylase-in-guinea-pigs-livers
#15
JOURNAL ARTICLE
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie
Premature neonates are submitted to an early-life oxidative stress from parenteral nutrition, which is vitamin C (VC) deficient and induces low endogenous levels of glutathione. The oxidative stress caused by these deficiencies may permanently affect liver glycolysis and lipogenesis. This study evaluates the short- and long-term effects of neonatal VC and cysteine deficient diets on redox and energy metabolism. Three-day-old Hartley guinea pigs from both sexes were given a regular or a deficient diet (VC, cysteine, or both) until week 1 of life...
June 12, 2021: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/33485935/aphid-estrogen-related-receptor-controls-glycolytic-gene-expression-and-fecundity
#16
JOURNAL ARTICLE
Woo-Ram Park, Da Jung Lim, Hyunkyu Sang, Eunae Kim, Jae-Hak Moon, Hueng-Sik Choi, In Seon Kim, Don-Kyu Kim
Aphids, the major insect pests of agricultural crops, reproduce sexually and asexually depending upon environmental factors such as the photoperiod and temperature. Nuclear receptors, a unique family of ligand-dependent transcription factors, control insect development and growth including morphogenesis, molting, and metamorphosis. However, the structural features and biological functions of the aphid estrogen-related receptor (ERR) are largely unknown. Here, we cloned full-length cDNA encoding the ERR in the green peach aphid, Myzus persicae, (Sulzer) (Hemiptera: Aphididae) (MpERR) and demonstrated that the MpERR modulated glycolytic gene expression and aphid fecundity...
March 2021: Insect Biochemistry and Molecular Biology
https://read.qxmd.com/read/33082514/the-deubiquitinase-josd2-is-a-positive-regulator-of-glucose-metabolism
#17
JOURNAL ARTICLE
Lyudmila Krassikova, Boxi Zhang, Divya Nagarajan, André Lima Queiroz, Merve Kacal, Evangelos Samakidis, Helin Vakifahmetoglu-Norberg, Erik Norberg
Cancer cells undergo complex metabolic alterations. The mechanisms underlying the tuning of cancer metabolism are under active investigation. Here, we identify the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by displaying comprehensive effects on glucose catabolism. We found that JOSD2 directly controls a metabolic enzyme complex that includes Aldolase A, Phosphofructokinase-1 and Phosphoglycerate dehydrogenase, in vitro and in vivo. Further, JOSD2 expression, but not a catalytically inactive mutant, deubiquitinates and stabilizes the enzyme complex, thereby enhancing their activities and the glycolytic rate...
March 2021: Cell Death and Differentiation
https://read.qxmd.com/read/32457639/exploring-the-factors-contributing-to-the-high-ultimate-ph-of-broiler-pectoralis-major-muscles-affected-by-wooden-breast-condition
#18
JOURNAL ARTICLE
Giulia Baldi, Con-Ning Yen, Morgan R Daughtry, Jocelyn Bodmer, Brian C Bowker, Hong Zhuang, Massimiliano Petracci, David E Gerrard
The elevated ultimate pH (pH u ) found in wooden breast (WB) meat suggests an altered muscular energetic status in WB but also could be related to a prematurely terminated post-mortem pH decline. The aims of this study were to explore the factors contributing to the elevated pH u and establish whether the occurrence of WB defect alters muscle post-mortem carbohydrate metabolism and determine if the contractile apparatus reflects such changes. A total of 24 carcasses from Ross 308 male chickens were obtained from a commercial producer and harvested using commercial processing procedures...
2020: Frontiers in Physiology
https://read.qxmd.com/read/32117019/beneficial-effects-of-ketogenic-diet-on-phosphofructokinase-deficiency-glycogen-storage-disease-type-vii
#19
Minna E Similä, Mari Auranen, Päivi Liisa Piirilä
Background: A deficiency of muscle phosphofructokinase (PFKM) causes a rare metabolic muscle disease, the Tarui disease (Glycogen storage disease type VII, GSD VII) characterized by exercise intolerance with myalgia due to an inability to use glucose as an energy resource. No medical treatment for GSD VII currently exists. The aim of this study was to determine whether a dietary intervention with excessive fat intake would benefit GSD VII. Patient and Methods: A ketogenic diet (KD) intervention implemented as a modified Atkins diet was established for one patient with PFKM deficiency, with a low late lactate response and very high ammonia levels associated with exercise...
2020: Frontiers in Neurology
https://read.qxmd.com/read/31984519/immunometabolism-in-the-development-of-rheumatoid-arthritis
#20
REVIEW
Cornelia M Weyand, Jörg J Goronzy
In rheumatoid arthritis (RA), breakdown of self-tolerance and onset of clinical disease are separated in time and space, supporting a multi-hit model in which emergence of autoreactive T cells is a pinnacle pathogenic event. Determining factors in T cell differentiation and survival include antigen recognition, but also the metabolic machinery that provides energy and biosynthetic molecules for cell building. Studies in patients with RA have yielded a disease-specific metabolic signature, which enables naive CD4 T cells to differentiate into pro-inflammatory helper T cells that are prone to invade into tissue and elicit inflammation through immunogenic cell death...
March 2020: Immunological Reviews
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