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CD2 positive B cell precursor acute Lymphoblastic leukemia with an early switch to the monocytic lineage

L Slamova, J Starkova, E Fronkova, M Zaliova, L Reznickova, F W van Delft, E Vodickova, J Volejnikova, Z Zemanova, K Polgarova, G Cario, M Figueroa, T Kalina, K Fiser, J P Bourquin, B Bornhauser, M Dworzak, J Zuna, J Trka, J Stary, O Hrusak, E Mejstrikova
Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we describe a novel BCP-ALL subset, switching BCP-ALL or swALL, which demonstrated monocytosis early during treatment. Despite their monocytic phenotype, 'monocytoids' share immunoreceptor gene rearrangements with leukemic B lymphoblasts. All swALLs demonstrated BCP-ALL with CD2 positivity and no MLL alterations, and the proportion of swALLs cases among BCP-ALLs was unexpectedly high (4%)...
March 2014: Leukemia
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